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A Single-Cell Landscape of Human Liver Transplantation Reveals a Pathogenic Immune Niche Associated with Early Allograft Dysfunction

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Engineering 2024年第5期36卷 193-208页

作者： Xin Shao Zheng Wang kai Wang Xiaoyan Lu Ping Zhang Rongfang Guo Jie liao Penghui Yang Shusen Zheng Xiao Xu Xiaohui Fan Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314103China Zhejiang University School of Medicine Hangzhou 310058China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)Hospital Affiliated to Shulan International Medical CollegeZhejiang Shuren UniversityHangzhou 310000China Engineering Research Center of Innovative Anticancer Drugs Ministry of EducationHarbin 150023China

Liver transplantation(LT)is the standard therapy for individuals afflicted with end-stage liver *** notable advancements in LT technology,the incidence of early allograft dysfunction(EAD)remains a critical concern,exacerbating the current organ shortage and detrimentally affecting the prognosis of ***,the perplexing hepatic heterogeneity has impeded characterization of the cellular traits and molecular events that contribute to ***,we constructed a pioneering single-cell transcriptomic landscape of human transplanted livers derived from non-EAD and EAD patients,with 12 liver samples collected from 7 donors during the cold perfusion and portal reperfusion *** of the 75231 cells of non-EAD and EAD patients revealed an EAD-associated immune niche comprising mucosal-associated invariant T cells,granzyme B^(+)(GZMB^(+))granzyme K^(+)(GZMK^(+))natural killer cells,and S100 calcium binding protein A12^(+)(S100A12^(+))***,we verified this immune niche and its association with EAD occurrence in two independent *** findings elucidate the cellular characteristics of transplanted livers and the EAD-associated pathogenic immune niche at the single-cell level,thus,offering valuable insights into EAD onset.

关键词： Human liver transplantation Early allograft dysfunction Pathogenic immune niche Single-cell analysis Cell-cell communication

Friction between Strongly Compressed Polymer Brushes

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Chinese Journal of Polymer Science 2024年第9期42卷 1368-1374,I0008页

作者： Qi liao Institute of Chemistry Chinese Academy of SciencesBejing 100190China

We present the results of molecular dynamics simulations of steady shear between a pair of neutral polymer brushes,as well as a pair of charged polymer brushes in the strongly compressed *** results of the molecular dynamic simulations of neutral and polyelectrolyte brushes in implicit solvent including normal forces,shear forces,viscosities and friction coefficients as a function of separation between brushes,are presented in the *** comparison of the simulation results of neutral and charged brushes shows that the charged brushes is in the quasi-neutral regime,and the dependence of viscosity on the separation distance show the similar power law of neutral *** simulation results confirm that the implicit solvent simulations of polyelectrolyte brushes that ignore hydrodynamics interaction are in agreement with the scaling predictions qualitatively because of screening of hydrodynamic interaction and long-range electrostatic interactions on the correlation length *** of neutral and charged brushes show the lubrication properties that the friction coefficient decreases with the separation decreases at enough large ***,a maximum of friction coefficients is observed for polyelectrolyte brushes,which is in contrast to the neutral brushes with monotonical dependence.

关键词： Polymer brush Frictions coefficient Polyelectrolyte Lubrication

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语用迁移研究的现状及发展趋势

暨南学报（哲学社会科学版） 2007年第4期29卷 115-119页

作者：廖开洪暨南大学外国语学院广东广州510632

语用迁移研究是语际语用学与二语习得研究相结合的交叉研究领域,它研究语言习得者的母语和文化语用知识对二语习得的影响。国外语用迁移研究在语用正迁移和负迁移两个领域取得了新的进展,正迁移并不必定促进二语习得,而负迁移并不总是... 详细信息

语用迁移研究是语际语用学与二语习得研究相结合的交叉研究领域,它研究语言习得者的母语和文化语用知识对二语习得的影响。国外语用迁移研究在语用正迁移和负迁移两个领域取得了新的进展,正迁移并不必定促进二语习得,而负迁移并不总是造成负面效果。但是,语用迁移研究对语用可迁移性、语用迁移与语言水平之关系、语用迁移所导致的语言变体及语言规范等问题关注不够,加强这方面的研究,将推动语际语用学的发展。

关键词：语用迁移语用正迁移语用负迁移语用可迁移性

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复合型催化剂在循环流化床锅炉中的应用研究

广州化工 2024年第4期52卷 159-162页

作者：吴毅廖建开张耀宁陈宝霞温华洋范涛蒋榕华电(漳平)能源有限公司福建漳平364400 龙祥雨(深圳)科技有限公司广东深圳518109

复合型节煤催化剂在DG1025-17.4-Ⅱ18型循环流化床锅炉中进行应用研究,试验期间机组运行负荷为240 MW,纯凝工况运行,原煤中添加复合型催化剂的量达到0.1%时,空白期修正后标煤耗为323.51 g/kWh,添加期修正后标煤耗为314.14 g/kWh,发电标... 详细信息

复合型节煤催化剂在DG1025-17.4-Ⅱ18型循环流化床锅炉中进行应用研究,试验期间机组运行负荷为240 MW,纯凝工况运行,原煤中添加复合型催化剂的量达到0.1%时,空白期修正后标煤耗为323.51 g/kWh,添加期修正后标煤耗为314.14 g/kWh,发电标准煤耗降低了9.37 g/kWh,节煤率为2.90%,节煤效果显著。空白期和添加期比较,炉渣中可燃物含量的平均值下降26.04%,飞灰中可燃物含量的平均值下降了18.20%,说明添加复合型催化剂煤炭燃烧的更充分。排放的SO_(2)含量降低了11.22%,NO_(x)含量降低了16.76%,燃煤锅炉中添加复合型节煤催化剂既具有节煤效果,有具有显著减排效果。

关键词：复合型催化剂节煤率循环流化床锅炉减排

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刻意含混话语理解的认知语用视角

湘潭大学学报（哲学社会科学版） 2011年第6期35卷 159-160,F0003页

作者：廖开洪暨南大学外国语学院广东广州510632

尝试互补性地使用心理空间理论和关联理论来探讨刻意含混话语的认知理解过程。心理空间理论能有效地展示刻意含混含有的语用用意的构建过程,而关联理论可为刻意含混表达的语用用意提供最佳关联解释。听话人通过语用推理,可较好地理解刻... 详细信息

尝试互补性地使用心理空间理论和关联理论来探讨刻意含混话语的认知理解过程。心理空间理论能有效地展示刻意含混含有的语用用意的构建过程,而关联理论可为刻意含混表达的语用用意提供最佳关联解释。听话人通过语用推理,可较好地理解刻意含混话语的交际意图,使交际更加顺畅地进行。

关键词：刻意含混语用用意语用推理空间复合最佳关联

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含糊其辞与语用协同

湖南科技大学学报（社会科学版） 2015年第5期18卷 131-134页

作者：廖开洪暨南大学外国语学院广东广州510632

言语交际中,含糊其辞话语会产生语言协同、语境协同、信息协同、语用不协同等语用现象。语用协同既是成功交际的基础,也是言语交际顺利进行的有效运作机制。语用不协同虽会给交际带来一定的负面影响,但也不会造成交际完全失败。

关键词：含糊其辞语言协同语境协同信息协同语用不协同

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含混研究的现状、问题与展望

湖南师范大学社会科学学报 2011年第4期40卷 135-138页

作者：廖开洪暨南大学外国语学院广东广州510632

"含混"是一种常见语言现象,交际者使用含混话语,表达不确定的语用用意,以满足交际需要。本文述评前人从语言哲学、社会语用学、语际语用学、会话分析、普通语用学视角对"含混"进行的相关研究,指出含混研究中尚存的问题和提出未来对该课... 详细信息

"含混"是一种常见语言现象,交际者使用含混话语,表达不确定的语用用意,以满足交际需要。本文述评前人从语言哲学、社会语用学、语际语用学、会话分析、普通语用学视角对"含混"进行的相关研究,指出含混研究中尚存的问题和提出未来对该课题进行研究的建议。

关键词：含混语用用意研究路向

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Small Signal Stability Analysis for a DFIG-Based Offshore Wind Farms Collected Through VSC-HVDC Transmission System

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Energy and Power Engineering 2013年第4期5卷 429-433页

作者： kai liao Zhengyou He Bin Sun Yong Jia School of Electrical Engineering Southwest Jiaotong University Chengdu China

This paper modeled a doubly fed induction generator (DFIG) - based offshore wind farm integrated through a voltage source converter –based high voltage direct current (VSC-HVDC) transmission system, which is collected with infinite bus for small signal stability analysis. The control system of HVDC system is considered for the stability analysis. The impact of the VSC control parameters on the network stability is studied. The lineared dynamic model is employed to do small signal stability analysis by the eigenvalue analysis. The locus of the eigenvalue, which is corresponding to the oscillation model is studied. Time domain simulations conducted in Matlab/Simulink are used to validate the small signal stability analysis.

关键词： DFIG Offshore Wind Farm VSC-HVDC Small Signal Stability

Small-Signal Stability Analysis of Wind Power System Based on DFIG

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Energy and Power Engineering 2013年第4期5卷 418-422页

作者： Bin Sun Zhengyou He Yong Jia kai liao School of Electrical Engineering Southwest Jiaotong University Chengdu China

This paper focuses on the small-signal stability of power system integrated with DFIG-based wind farm. The model of DFIG for small-signal stability analysis has built;the 3-generator 9-bus WECC test system is modified to investigate the impacts of large scale integration of wind power on power system small-signal stability. Different oscillatory modes are obtained with their eigenvalue, frequency and damping ratio, the results from eigenvalue analysis are presented to demonstrate the small-signal stability of power system is enhanced with the increasing output of the wind farm.

关键词： Small-Signal Stability DFIG Wind Power Power System Wind Farm