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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Effect of groundwater depth on riparian plant diversity along riverside-desert gradients in the Tarim River

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Journal of Plant Ecology 2019年第3期12卷 564-573页

作者： Yong Zeng chengyi Zhao Jun Li Yan Li Guanghui Lv Tong Liu State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and GeographyChinese Academy of Sciences818 South Beijing RoadUrumqi 830011China College of Resources and Environment Sciences Xinjiang University14 Shengli RoadUrumqi 830046China University of Chinese Academy of Sciences 55 East Zhongguancun East RoadBeijing 100049China Land Science Research Center Nanjing University of Information Science&Technology219 Ningliu RoadNanjing 210044China College of Life Sciences Shihezi University4 North RoadShihezi 832003XinjiangChina

Aims Riparian plant diversity is sensitive to changes in groundwater in arid ***,little is known about how plant diversity responds to changes in environment along riverside-desert gradi-ents in riparian *** objectives were to(i)identify ri-parian plant diversity along riverside-desert gradients in Tarim desert riparian forests,(ii)analyze the impact of environment variables on plant diversity,(iii)determine the optimum groundwater depth for different plant *** Six transects 90 quadrats(with each size 100 m×100 m)distributed vertically to river bed along riverside-desert gradients~30 km in length were *** each quadrat,the morphological features of riparian plant communities were measured,and the groundwater depth,soil water,soil salinity,soil nutrient were also monitored at same *** Finding Three distinct vegetation communities were identified based on cover and richness in the tree,shrub and herb layers:the riparian zone,the transitional zone and the desert margin *** spe-cies were indicators of the three vegetation *** plant diversity was influenced by groundwater depth,distance from river,soil moisture content,soil salinity and soil nutrient by redundancy *** response to groundwater depth,the op-timal groundwater depths for species diversity,evenness and shrub cover were 2.8,2.7 and 3.7 m,***,maintaining high plant diversity requires managers to ensure stable groundwater depth for different plant life-forms rather than for some of them.

关键词： vegetation community distance from river groundwater depth Tarim River

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New evidence for possible impact of solar activity on long-term fluctuation of the earth rotation

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Chinese Science Bulletin 2001年第11期46卷 905-908页

作者： Dechun liao Xinhao liao Chinese Acad Sci Shanghai Astron Observ Shanghai 200030 Peoples R China

The long-term fluctuation of the Schwabe period (LSP) of sunspots number (SSN) has been found to have high correlation with the variation of the length-of-day (LOD) in low frequency by using the data of smoothed monthly mean SSN during 1818-1999 and the method of wavelet transform. Analyses indicate that the maximum correlation coefficient between the series of LSP and LOD during 1892-1997 is about 0.9, with a time lag of about 5 years for the LOD related to the LSP. Though the maximum correlation coefficients between the LSP and the other two LOD series (1818-1997) reduce to about 0.4, they remain over the thresholds of 95% confidence level. This suggests new evidence for possible impact of solar activity on the long-term fluctuation of the earth rotation.

关键词： variation of length-of-day sunspot number Schwabe period solar-terrestrial relationship.

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Discrete Weighted Hardy Inequalities with Different Kinds of Boundary Conditions

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Acta Mathematica Sinica,English Series 2016年第9期32卷 993-1013页

作者： Zhong Wei liao School of Mathematical Sciences Beijing Normal University Beijing 100875 P. R. China

This paper studies the weighted Hardy inequalities on the discrete intervals with four different kinds of boundary conditions. The main result is the uniform expression of the basic estimate of the optimal constant with the corresponding boundary condition. Firstly, one-side boundary condition is considered, which means that the sequences vanish at the right endpoint （ND-case）. Based on the dual method, it can be translated into the case vanishing at left endpoint （DN-case）. Secondly, the condition is the case that the sequences vanish at two endpoints （DD-case）. The third type of condition is the generality of the mean zero condition （NN-case）, which is motivated from probability theory. To deal with the second and the third kinds of inequalities, the splitting technique is presented. Finally, as typical applications, some examples are included.

关键词： Weighted Hardy inequality one-side boundary condition vanishing at two endpoints,mean zero basic estimates dual method splitting technique

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Temperature effect and thermal impact in lithium-ion batteries: A review

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Progress in Natural Science:Materials International 2018年第6期28卷 653-666页

作者： Shuai Ma Modi Jiang Peng Tao chengyi Song Jianbo Wu Jun Wang Tao Deng Wen Shang School of Materials Science and Engineering and State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University A123 Systems Research Center

Lithium-ion batteries, with high energy density(up to 705 Wh/L) and power density(up to 10,000 W/L), exhibit high capacity and great working performance. As rechargeable batteries, lithium-ion batteries serve as power sources in various application systems. Temperature, as a critical factor, significantly impacts on the performance of lithium-ion batteries and also limits the application of lithium-ion batteries. Moreover, different temperature conditions result in different adverse effects. Accurate measurement of temperature inside lithiumion batteries and understanding the temperature effects are important for the proper battery management. In this review, we discuss the effects of temperature to lithium-ion batteries at both low and high temperature *** current approaches in monitoring the internal temperature of lithium-ion batteries via both contact and contactless processes are also discussed in the review.

关键词： Lithium-ion battery Temperature effect Internal temperature Battery management Thermal management

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Efficient conversion of benzene and syngas to toluene and xylene over ZnO-ZrO_(2)&H-ZSM-5 bifunctional catalysts

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Chinese Journal of Chemical Engineering 2022年第5期35卷 203-210页

作者： Xiao Zhao Xuan Shi Zhongshun Chen Long Xu chengyi Dai Yazhou Zhang Xinwen Guo Dongyuan Yang Xiaoxun Ma School of Chemical Engineering Northwest UniversityXi’an 710069China International Science&Technology Cooperation Base for Clean Utilization of Hydrocarbon Resources Chemical Engineering Research Center of the Ministry of Education for Advanced Use Technology of Shanbei EnergyCollaborative Innovation Center for Development of Energy and Chemical Industry in Northern ShaanxiNorthwest UniversityXi’an 710069China School of Chemical Engineering Dalian University of TechnologyDalian 116024China Shaanxi Key Laboratory of Energy Chemical Process Intensification School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’an 710049China Shanxi yanchang Petroleum(Group)Corp.LtdXi’an 710000China

A series of ZnO-ZrO_(2) solid solutions with different Zn contents were synthesized by the urea coprecipitation method,which were coupled with H-ZSM-5 zeolite to form bifunctional *** a new benzene alkylation reagent,syngas was used instead of methanol to realize the efficient conversion of syngas and benzene into toluene and xylene.A suitable ratio of ZnO-ZrO_(2) led to the significant improvement in the catalytic performance,and a suitable amount of acid helped to increase the selectivity of toluene/xylene and reduce the selectivity of the by-products ethylbenzene and C^(9+) *** highest benzene conversion of 89.2%and toluene/xylene selectivity of 88.7%were achieved over 10%ZnO-ZrO_(2)&H-ZSM-5(Si/Al=23)at a pressure of 3 MPa and a temperature of 450℃.In addition,the effect of the zeolite framework structure on product distribution was *** to the molecular dynamics of aromatic hydrocarbons,H-ZSM-5 zeolites comprise 10-membered-ring pores,which are beneficial to the activation of benzene;hence,the conversion of benzene is higher.H-ZSM-35 and HMOR zeolites exhibited small eight-membered-ring channels,which were not conducive to the passage of benzene;hence,the by-product ethylbenzene exhibits a higher *** distance between the active centers of the bifunctional catalysts was the main factor affecting the catalytic performance,and the powder mixing method was more conducive to the conversion of syngas and benzene.

关键词： ZnO-ZrO_(2) Bifunctional catalysts Aromatics Alkylation of benzene Syngas

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REMARKS ON THE CAUCHY PROBLEM OF THE ONE-DIMENSIONAL VISCOUS RADIATIVE AND REACTIVE GAS

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Acta Mathematica Scientia 2020年第4期40卷 1020-1034页

作者： Yongkai liao Institute of Applied Physics and Computational Mathematics Beijing 100088China

This paper is concerned with the large-time behavior of solutions to the Cauchy problem of a one-dimensional viscous radiative and reactive *** on the elaborate energy estimates,we develop a new approach to derive the upper bound of the absolute temperature by avoiding the use of auxiliary functions Z(t)and W(t)introduced by liao and Zhao[*** Equations,2018,265(5):2076-2120].Our results also improve upon the results obtained in liao and Zhao[*** Equations,2018,265(5):2076-2120].

关键词： large-time behavior viscous radiative and reactive gas Cauchy problem large initial data

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Synthesis and Electrical Properties of Li-modified Bi_(0.5)Na_(0.5)TiO_3-BaTiO_3 Lead-free Piezoelectric Ceramics

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Journal of Materials Science & Technology 2009年第6期25卷 777-780页

作者： Yunweu liao Dingquan Xiao Institute of Applied Chemistry China West Normal University Nanchong 637002 China Department of Materials Science Sichuan University Chengdu 610064 China

Lead-free piezoelectric ceramics （1-y）Bi0.5（Na1-xLix）0.5TiO3-yBaTiO3 with x=0-0.125 and y=0.02-0.12 were fabricated by a solid-state reaction process, and their dielectric, piezoelectric and ferroelectric properties were investigated. The results show that the addition of Li^＋ significantly improves the sintering performance and piezoelectric properties of the ceramics. X-ray diffraction （XRD） patterns indicate that the ceramics possess pure perovskite structure. At room temperature, the ceramics provide high piezoelectric charge constant d33 （up to 210 pC/N）, high planar electromechanical coupling factor kp （34.5%）, large remanent polarization Pr （up to 40 μC/cm^2）, and low coercive field Ec （3.0 kV/mm）, which indicates that （1-y）Bi0.5（Na1-xLix）0.5TiO3-yBaTi03 is a good lead-free piezoelectric ceramic.

关键词： Lead-free piezoelectric ceramic Bi0.5Na0.5TiO3 Microstructure Piezoelectricity

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Boundedness of Singular Integral Operators on Herz-Morrey Spaces with Variable Exponent

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Chinese Annals of Mathematics,Series B 2020年第1期41卷 99-116页

作者： Hongbin WANG Fanghui liao School of Mathematics and Statistics Shandong University of TechnologyZibo 255049ShandongChina School of Mathematics and Computational Science Xiangtan UniversityXiangtan 411105HunanChina

Let Ω ∈ Ls(S^n-1)(s>1) be a homogeneous function of degree zero and b be a BMO function or Lipschitz function. In this paper, the authors obtain some boundedness of the Calderón-Zygmund singular integral operator T... 详细信息

关键词： Calderón-Zygmund singular integral Commutator Herz-Morrey space Variable exponent

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A new construction for involutions over finite fields

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Frontiers of Mathematics in China 2022年第4期17卷 553-565页

作者： Zhaohui ZHANG Qunying liao College of Mathematical Science Sichuan Normal UniversityChengdu610066China

In 2020,Niu et al.[***.,2020,12(2):165–185]studied the fixed points of involutions over the finite field with *** paper further discusses the relationship between the fixed points set and the non-fixed points set of two involutions f_(1)(x)and f_(2)(x)over the finite field F_(q),and then obtains a necessary and sufficient condition for that the composite function f_(1)■f_(2)(x)is also an involution over F_(q).In particular,a special class of involutions over some finite fields is determined completely.

关键词： Permutation polynomial involution fixed point non-fixed point

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