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Food Science and Human Wellness 2024年第2期13卷 698-708页

作者： Hongyun zhang Guangqiang Wang Zhiqiang Xiong Zhuan Liao Yangyan Qian Xin Song Li Sui lianzhong Ai Yongjun Xia Shanghai Engineering Research Center of Food Microbiology School of Health Science and EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China Department of Gastroenterol Digestive Endoscopy CenterShanghai HospitalShanghai 200093China

Probiotics have great potential in regulating intestinal pain.In this study,the effects of Lactobacillus plantarum AR495 on the visceral sensitivity and gut microbiota of irritable bowel syndrome(IBS)rats were studied.The results showed that tryptase released after mast cell activation and degranulation plays a key role in visceral pain,and L.plantarum AR495 reduced the stimulation of colonic mast cells and the expression of protease-activated receptor 2(PAR2)and TRPV1 in dorsal root ganglia.Research further showed that supplementation with L.plantarum AR495 increased the level of short-chain fatty acids(SCFAs)and enhanced the barrier function of the colon.In addition,the microbiota analysis of the colon indicated that L.plantarum AR495 promoted the proliferation of Bifidobacterium and inhibited the proliferation of Lachnospiraceae,which alleviated the imbalance of the intestinal microbiota caused by IBS to a certain extent.In total,L.plantarum AR495 might reduce visceral sensitivity through the Mast cell-PAR2-TRPV1 signaling pathway by maintaining the homeostasis of the intestinal barrier.

关键词： Lactobacillus plantarum Irritable bowel syndrome Visceral sensitivity Dorsal root ganglia Tryptase Microbiota

Faster structured illumination microscopy using complementary encoding-based compressive imaging

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Photonics Research 2024年第4期12卷 740-748页

作者： ZHENGQI HUANG YUNHUA YAO YILIN HE YU HE CHENGZHI JIN MENGDI GUO DALONG QI lianzhong DENG ZHENRONG SUN ZHIYONG WANG SHIAN zhang State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China School of Mathematical Sciences University of Electronic Science and Technology of ChinaChengdu 611731China Joint Research Center of Light Manipulation Science and Photonic Integrated Chip of East China Normal University and Shandong Normal University East China Normal UniversityShanghai 200241China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Structured illumination microscopy (SIM) has been widely applied to investigate intricate biological dynamics due to its outstanding super-resolution imaging speed. Incorporating compressive sensing into SIM brings the possibility to further improve the super-resolution imaging speed. Nevertheless, the recovery of the superresolution information from the compressed measurement remains challenging in experiments. Here, we report structured illumination microscopy with complementary encoding-based compressive imaging (CECI-SIM) to realize faster super-resolution imaging. Compared to the nine measurements to obtain a super-resolution image in a conventional SIM, CECI-SIM can achieve a super-resolution image by three measurements;therefore, a threefold improvement in the imaging speed can be achieved. This faster imaging ability in CECI-SIM is experimentally verified by observing tubulin and actin in mouse embryonic fibroblast cells. This work provides a feasible solution for high-speed super-resolution imaging, which would bring significant applications in biomedical research.

关键词： illumination complementary faster

Lactobacillus plantarum AR113 attenuates liver injury in D-galactose-induced aging mice via the inhibition of oxidative stress and endoplasmic reticulum stress

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Food Science and Human Wellness 2024年第2期13卷 885-897页

作者： Yongjun Xia Yujie Gong Xiangna Lin Yijin Yang Xin Song Guangqiang Wang Zhiqiang Xiong Yangyang Qian Zhuan Liao Hui zhang lianzhong Ai School of Health Science and Engineering Shanghai Engineering Research Center of Food MicrobiologyUniversity of Shanghai for Science and TechnologyShanghai 200093China College of Life Sciences Linyi UniversityLinyi 276000China Department of Gastroenterol. Digestive Endoscopy CenterChanghai HospitalShanghai 200082China

Probiotics could effectively eliminate excess reactive oxygen species(ROS)generated during aging or lipid metabolism disorders,but their mechanism is unclear.The major purpose of this study was to investigate the mechanism of Lactiplantibacillus plantarun AR113 alleviating oxidative stress injury in the D-galactose induced aging mice.The result showed that pretreatment with L.plantarun AR113 significantly relieving H_(2)O_(2)induced cytotoxicity in HepG2 cells by maintain cell membrane integrity and increasing antioxidant enzyme activities.In D-galactose induced aging mice,L.plantarun AR113 could significantly attenuate liver damage and inflammatory infiltration by promoting endogenous glutathione(GSH)synthesis and activating the Nrf2/Keap1 signaling pathway in mice,and increasing the expression of regulated phaseⅡdetoxification enzymes and antioxidant enzymes.Further analysis shown that gavage of L.plantarun AR113 could significantly reduce the expression of G protein-coupled receptor 78(GPR78)and C/EBP homologous protein(CHOP)proteins,and promote the restoration of endoplasmic reticulum(ER)homeostasis,thereby activating cell anti-apoptotic pathways.These results were also confirmed in H_(2)O_(2)-treated HepG2 experiments.It indicated that L.plantarun AR113 could inhibit D-galactose-induced liver injury through dual inhibition of ER stress and oxidative stress.L.plantarun AR113 have good application potential in anti-aging and alleviating metabolic disorders.

关键词： Lactiplantibacillus plantarun AR113 HepG2 D-galactose Oxidative stress ER stress

Numerical simulation of micro-particle deposition in a realistic human upper respiratory tract model during transient breathing cycle

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Particuology 2011年第4期9卷 424-431页

作者： Jianhua Huang lianzhong zhang Jiangsu Xuzhou Construction Machinery Research Institute XCMG Co. Ltd. Xuzhou 221004 China School of Physics Nankai University Tianjin 300071 China State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Xi' an 710075 China

An more reliable human upper respiratory tract model that consisted of an oropharynx and four generations of asymmetric tracheo-bronchial （TB） airways has been constructed to investigate the micro-particle deposition pattern and mass distribution in five lobes under steady inspiratory condition in former work by Huang and zhang （2011 ）. In the present work, transient airflow patterns and particle deposition during both inspiratory and expiratory processes were numerically simulated in the realistic human upper respiratory tract model with 14 cartilaginous rings （CRs） in the tracheal tube. The present model was validated under steady inspiratory flow rates by comparing current results with the theoretical models and pub- lished experimental data. The transient deposition fraction was found to strongly depend on breathing flow rate and particle diameter but slightly on turbulence intensity. Particles were mainly distributed in the high axial speed zones and traveled basically following the secondary flow. ＂Hot spots＂ of deposition were found in the lower portion of mouth cavity and posterior wall of pharynx/larynx during inspiration, but transferred to upper portion of mouth and interior wall of pharynx/larynx during expiration. The deposition fraction in the trachea during expiration was found to be much higher than that during inspiration because of the stronger secondary flow.

关键词： Human upper respiratory tract Transient breathing cycle Airflow pattern Micro-particle deposition

Deposition of non-spherical microparticles in the human upper respiratory tract

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Particuology 2018年第1期16卷 185-189页

作者： Lixing Jia lianzhong zhang Suyuan Yu School of Physics Nankai University Tianjin 300071 China Institute of Nuclear and New Energy Technology Tsinghua University Beijing 100084 China

We investigated the deposition pattern of microparticles with different particle diameters, shape factors, and initial flow conditions in a realistic human upper respiratory tract model. We identified a close relationship between the deposition fraction and the particle shape factor. The deposition fraction of the particles decreased sharply with increasing particle shape factor because of the decreasing drag force. We also found that the deposition varied at different positions in the upper respiratory tract. At low shape factors, the highest fraction of particles deposited at the mouth and pharynx. However, with increasing shape factor, the deposition fraction in the trachea and lungs increased. Moreover, for a given shape factor, larger particles deposited at the mouth and pharynx, which indicates that the deposition fraction of microparticles in the human upper respiratory tract is affected first and foremost by particle inertia as well as by the drag force.

关键词： Particle deposition Non-spherical microparticles Human upper airway Shape factor

Modeling micro-particle deposition in human upper respiratory tract under steady inhalation

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Particuology 2011年第1期9卷 39-43页

作者： Jianhua Huang lianzhong zhang Suyuan Yu School of Physics Nankai University Tianjin 300071 China State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Xi'an 710075 China Institute of Nuclear Energy and New Energy Technology Tsinghua University Beijing 100084 China

A representative human upper respiratory tract （URT） with idealized oral region and asymmetric tracheo- bronchial （TB） airway has been modeled, and laminar-to-turbulent airflow for typical inhalation modes as well as micro-particle transport and deposition has been simulated using CFX10.0 software from Ansys Inc. on a personal computer. The asymmetric TB airway could not be replaced by an extended straight tube as outlet of the oral region while investigating the tracheal airflow field and particle deposition. Compared to an idealized oral airway with an extended straight tube, several differences could be noted：（i） The laryngeal jet extends further down the trachea and inclines towards the anterior wall; （ii） the turbulence level in trachea is less and decays more quickly; （iii） three recirculation zones are visible with intense adverse current after the glottis; （iv） deposition of small particles in trachea is reduced due to lower turbulence. Refined unstructured mesh with densified boundary layer mesh could be a proper substitute for the structured mesh in the human URT model with asymmetric TB airway. Based on the refined unstructured mesh, the physiological structure of uvula in the soft palate is properly simulated in the present human URT model.

关键词： Human upper airway model Asymmetric tracheobronchial (TB) airway Particle deposition Computational fluid-particle dynamic simulations

Influence of the field humiture environment on the mechanical properties of 316L stainless steel repaired with Fe314

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Frontiers of Mechanical Engineering 2018年第4期13卷 513-519页

作者： lianzhong zhang Dichen LI Shenping YAN Ruidong XIE Hongliang QU State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Xi'an 710049 China

The mechanical properties of 316L stainless steel repaired with Fe314 under different temperatures and humidities without inert gas protection were studied. Results indicated favorable compatibility between Fe314 and 316L stainless steel. The average yield strength, tensile strength, and sectional contraction percentage were higher in repaired samples than in 316L stainless steel, whereas the elongation rate was slightly lower. The different conditions of humiture environment on the repair sample exerted minimal influence on tensile and yield strengths. The Fe314 cladding layer was mainly composed of equiaxed grains and mixed with randomly oriented columnar crystal and tiny pores or impurities in the tissue. Results indicated that the hardness value of Fe314 cladding layer under different humiture environments ranged within 419-451.1 HVo.2. The field humimre environment also showed minimal impact on the average hardness of Fe314 cladding layers. Furthermore, 316L stainless steel can be repaired through laser cladding by using Fe314 powder without inert gas protection under different temperatures and humidity environments.

关键词： laser cladding repaired performance tensile strength temperature and humidity environment

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小分子糖-罗望子多糖复合凝胶特性研究

中国食品学报 2024年第4期24卷 69-79页

作者：王枫艾连中赖凤羲张汇谢凡宋子波上海理工大学健康科学与工程学院、上海食品微生物工程技术研究中心上海200093 云南猫哆哩集团食品有限责任公司云南玉溪653100

探究不同小分子糖(蔗糖、果糖和葡萄糖)含量对罗望子多糖(TSP)复合凝胶特性的影响。分析小分子糖-TSP复合凝胶的流变特性、持水性、质构特性,并通过低场核磁共振技术分析其水分分布情况。结果表明:质量分数45%~60%的蔗糖和果糖及质量分... 详细信息

探究不同小分子糖(蔗糖、果糖和葡萄糖)含量对罗望子多糖(TSP)复合凝胶特性的影响。分析小分子糖-TSP复合凝胶的流变特性、持水性、质构特性,并通过低场核磁共振技术分析其水分分布情况。结果表明:质量分数45%~60%的蔗糖和果糖及质量分数40%~55%的葡萄糖能使1%(m/V)的TSP溶液形成凝胶;当蔗糖和果糖的质量分数为55%,葡萄糖质量分数为50%时,蔗糖-TSP复合凝胶的G′、持水性、硬度、内聚性和咀嚼性分别为108.39 Pa,98.20%,65.55 g,0.87和52.55 g,果糖-TSP复合凝胶的G′、持水性、硬度和咀嚼性分别为147.36 Pa,98.57%,62.29 g和44.84 g,葡萄糖-TSP复合凝胶的G′、持水性、硬度、内聚性分别为117.46 Pa,98.56%,61.86 g和48.05 g,都达到最大值,此时凝胶性质最稳定,最有嚼劲。低场核磁结果表明,当蔗糖和果糖质量分数为55%,葡萄糖质量分数为50%时,小分子糖-TSP复合凝胶半结合水含量为99.8%~100%,可能是小分子糖中的羟基与水分子形成较多的氢键,半结合水大幅度增加,TSP链之间交联增多,使得凝胶更加坚固。研究结果可为TSP在食品工业中的应用提供理论依据。

关键词：小分子糖罗望子多糖凝胶流变特性质构特性水分分布

RNF126 Quenches RNF168 Function in the DNA Damage Response

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Genomics, Proteomics & Bioinformatics 2018年第6期16卷 428-438页

作者： lianzhong zhang Zhenzhen Wang Ruifeng Shi Xuefei Zhu Jiahui Zhou Bin Peng Xingzhi Xu College of Life Sciences Capital Normal University Faculty of Life Sciences Tangshan Normal College Guangdong Key Laboratory for Genome Stability & Disease Prevention Shenzhen University Health Science Center

DNA damage response(DDR) is essential for maintaining genome stability and protecting cells from tumorigenesis. Ubiquitin and ubiquitin-like modi?cations play an important role in DDR, from signaling DNA damage to mediating DNA repair. In this report, we found that the E3 ligase ring ?nger protein 126(RNF126) was recruited to UV laser micro-irradiation-induced stripes in a RNF8-dependent manner. RNF126 directly interacted with and ubiquitinated another E3 ligase, RNF168. Overexpression of wild type RNF126, but not catalytically-inactive mutant RNF126(CC229/232 AA), diminished ubiquitination of H2 A histone family member X(H2AX),and subsequent bleomycin-induced focus formation of total ubiquitin FK2, TP53-binding protein1(53 BP1), and receptor-associated protein 80(RAP80). Interestingly, both RNF126 overexpression and RNF126 downregulation compromised homologous recombination(HR)-mediated repair of DNA double-strand breaks(DSBs). Taken together, our ?ndings demonstrate that RNF126 negatively regulates RNF168 function in DDR and its appropriate cellular expression levels are essential for HR-mediated DSB repair.

关键词： DNA repair DNA damage response Ubiquitination RNF126 RNF8 RNF168

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肝门静脉压力测量方法研究进展

中华实用诊断与治疗杂志 2024年第4期38卷 416-419页

作者：胡延山张连仲郑州大学人民医院河南省人民医院超声科河南郑州450003

目前肝硬化门静脉高压患者门静脉压力的测量方法有传统经典的经颈内静脉穿刺肝静脉压力梯度检测、基于影像学的无创评估及直接穿刺测量,其中超声引导下经皮经肝门静脉压力测量是直接获取门静脉压力值的方法,侵入性小、压力值测量准确,... 详细信息

目前肝硬化门静脉高压患者门静脉压力的测量方法有传统经典的经颈内静脉穿刺肝静脉压力梯度检测、基于影像学的无创评估及直接穿刺测量,其中超声引导下经皮经肝门静脉压力测量是直接获取门静脉压力值的方法,侵入性小、压力值测量准确,在门静脉高压患者的诊断、治疗管理及随访中有较大的应用前景。本文就肝门静脉压力测量方法的研究进展作一综述。

关键词：门静脉高压门静脉压力测量超声引导经皮门静脉穿刺