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Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1987-1999页

作者： Xueqin He Xiaorong Wang lianyi yang Zhihang yang Wenqi Yu Yazhen Wang Rui Liu Meiwan Chen Huile Gao Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China

The treatment of Alzheimer's disease(AD)is one of the most difficult challenges in neurodegenerative diseases due to the insufficient blood‒brain barrier(BBB)permeability and unsatisfactory intra-brain distribution of ***,we established an ibuprofen and FK506 encapsulated drug co-delivery system(Ibu&FK@RNPs),which can target the receptor of advanced glycation endproducts(RAGE)and response to the high level of reactive oxygen species(ROS)in *** is highly and specifically expressed on the lesion neurovascular unit of AD,this property helps to improve targeting specificity of the system and reduce unselective distribution in normal ***,these two drugs can be specifically released in astrocytes of AD lesion in response to high levels of *** a result,the cognition of AD mice was significantly improved and the quantity of Aβplaques was *** was also alleviated with structural regeneration and functional recovery of ***,the neuroinflammation dominated by NF-κB pathway was significantly inhibited with decreased NF-κB and IL-1βin the ***,Ibu&FK@RNPs can efficiently and successively target diseased BBB and astrocytes in AD *** it significantly enhances intracephalic accumulation of drugs and efficiently treats AD by anti-neuroinflammation and neuroprotection.

关键词： Receptor for advanced glycation end products ROS-responsive Blood‒brain barrier transcytosis Alzheimer’s disease Drug combination Anti-neuroinflammation Neuroprotection Nano drug delivery system

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儿童苔藓样肉芽肿性口炎1例报道及文献回顾

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口腔疾病防治 2024年第2期32卷 137-142页

作者：徐婧夏荣辉杨涟漪沈雪敏杜观环上海交通大学医学院附属第九人民医院口腔黏膜病科上海交通大学口腔医学院国家口腔医学中心国家口腔疾病临床医学研究中心上海市口腔医学重点实验室上海市口腔医学研究所上海200011

目的探讨口腔苔藓样损害的分类、临床表现、诊断、鉴别诊断及治疗,为临床提供参考。方法获得医院伦理审批及患者知情同意,报道1例儿童口腔苔藓样损害病例,结合文献对口腔苔藓样损害的诊疗进行回顾分析。结果患儿舌背反复破溃伴疼痛3年余... 详细信息

目的探讨口腔苔藓样损害的分类、临床表现、诊断、鉴别诊断及治疗,为临床提供参考。方法获得医院伦理审批及患者知情同意,报道1例儿童口腔苔藓样损害病例,结合文献对口腔苔藓样损害的诊疗进行回顾分析。结果患儿舌背反复破溃伴疼痛3年余,舌背大面积糜烂面,形状不规则,糜烂周围见珠光白色纹,左侧糜烂区伴组织增生,约1.5 cm×2.0 cm,质地韧,宽蒂。舌背白色网纹组织切取活检病理诊断为苔藓样损害;舌背增生物切除活检病理诊断为苔藓样损害伴肉芽肿性炎。根据患者口内损害特征、系统病史、用药史、组织病理学检查结果,最终诊断为苔藓样肉芽肿性口炎。文献回顾表明,口腔苔藓样损害病因不明,临床上需与口腔扁平苔藓、口腔苔藓样药物反应、口腔苔藓样接触性损害、慢性溃疡性口炎等疾病鉴别。临床上治疗口腔苔藓样损害以糖皮质激素的局部和/或全身使用为主。结论目前口腔苔藓样损害的分类和诊断仍无统一标准,主要依靠病史询问、临床表现和组织病理学检查结果,治疗方法主要为糖皮质激素的局部和/或全身使用。

关键词：口腔苔藓样损害苔藓样肉芽肿性口炎口腔扁平苔藓口腔苔藓样药物反应口腔苔藓样接触性损害移植物抗宿主病相关性苔藓样损害慢性溃疡性口炎类天疱疮样扁平苔藓儿童糖皮质激素

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区域金融发展和经济增长差异的互动研究——以甘肃省为例

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改革与战略 2009年第3期25卷 115-117页

作者：杜博张旺锋杨连燚谢雪燕兰州大学资源环境学院甘肃兰州730000

基于金融发展与经济增长理论,使用协整检验方法,对1985—2006年甘肃省金融发展和经济增长差异的关系做了实证研究。结果表明,甘肃省金融发展和经济增长差异存在长期均衡关系,金融发展加大了区域经济增长差异。最后,对实证结论做了探讨。

关键词：金融发展经济增长差异 VAR模型协整

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Frugivorous birds disperse seeds of Ligustrum lucidum,seed-feeding weevils,and parasitic wasps of weevils via endozoochory

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Integrative Zoology 2022年第5期17卷 953-958页

作者： Zhi CHEN Yongjie GUO Juan yang Jia GE lianyi LI Gao CHEN Yunnan Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Populations KunmingChina University of Chinese Academy of Sciences BeijingChina Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunmingChina

Biological invasion is considered one of the world’s most serious conservation biology *** a global review on invasive species,Richardson&Rejmanek(2011)indicated that over 40%of invasive trees and over 60%of invasive shrubs are dispersed by *** species(genus Ligustrum,Oleaceae)are typical ornithochorous species(Montaldo et al.2017;Fernandez et al.2020).

关键词： Ligustrum Richardson

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Using a Hidden Markov Model to Analyze the Flood-Season Rainfall Pattern and Its Temporal Variation over East China

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Journal of Meteorological Research 2018年第3期32卷 410-420页

作者： lianyi GUO Zhihong JIANG Weilin CHEN Key Laboratory of Meteorological Disaster of Ministry of Education Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science & Technology Joint International Research Laboratory of Climate and Environment Change Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science & Technology

The homogeneous hidden Markov model(HMM), a statistical pattern recognition method, is introduced in this paper. Based on the HMM, a 53-yr record of daily precipitation during the flood season(April-September) at 389 stations in East China during 1961-2013 is classified into six patterns: the South China(SC) pattern, the southern yangtze River(SY) pattern, the yangtze-Huai River(YH) pattern, the North China(NC) pattern, the overall wetter(OW) pattern, and the overall drier(OD) pattern. Features of the transition probability matrix of the first four patterns reveal that 1) the NC pattern is the most persistent, followed by the YH, and the SY is the least one; and 2) there exists a SY-SC-SY-YH-NC propagation process for the rain belt over East China during the flood season. The intraseasonal variability in the occurrence frequency of each pattern determines its start and end time. Furthermore,analysis of interdecadal variability in the occurrence frequency of each pattern in recent six decades has identified three obvious interdecadal variations for the SC, YH, and NC patterns in the mid-late 1970 s, the early 1990 s, and the late 1990 s. After 2000, the patterns concentrated in the southern region play a dominant role, and thus there maintains a "flooding in the south and drought in the north" rainfall distribution in eastern China. In summary, the HMM provides a unique approach for us to obtain both spatial distribution and temporal variation features of flood-season rainfall.

关键词： hidden Markov model(HMM) rainfall patterns flood season rain belt propagation interdecadal variability

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Rechargeable Na-CO_(2) Batteries Starting from Cathode of Na2CO_(3) and Carbon Nanotubes

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Research 2018年第1期2018卷 2-10页

作者： Jianchao Sun Yong Lu Hao yang Mo Han lianyi Shao Jun Chen Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071China

Na-CO_(2) batteries have attracted signifcant attentions due to their high energy density and efective utilization of greenhouse gas CO_(2).However,all reported Na-CO_(2) batteries employ excessive preloaded metal Na,which will lead to safety issues such as dendrite formation and short *** addition,the charging mechanism of reported Na-CO_(2) batteries is not very *** we report the Na-CO_(2) batteries,starting from the cathode of cheap Na2CO_(3) and multiwalled carbon nanotubes(CNTs).Due to the efective electron transfer and high reactivity,the decomposition of Na2CO_(3) and CNTs could take place under 3.8 *** charging mechanism of 2Na2CO_(3)+C�→4Na+3CO_(2) without any side reactions is revealed by in/ex situ techniques such as Raman,gas chromatograph,and optical ***-free Na can quantitatively deposit on the Super P/Al anode because of large specifc surface area and low nucleation barrier of the anode for Na *** batteries could deliver an energy density of 183 Wh kg−1(based on the whole mass of the pouch-type batteries,4 g)with stable cycling *** work reveals that safe rechargeable Na-CO_(2) batteries could be constructed by cheap Na2CO_(3) and multiwalled carbon nanotubes.

关键词： cycling charge charging

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Effect of herbal formula Xiao Pi-II on functional dyspepsia

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Journal of Traditional Chinese Medicine 2013年第3期33卷 298-302页

作者： Baohai Liu Xuehua Piao lianyi Guo Department of Gastroenterology the First Affiliated Hospital of Liaoning Medical University Department of Traditional Chinese Medicine First Affiliated Hospital of Liaoning Medical University

OBJECTIVE: To investigate the therapeutic effect of the herbal medication Xiao Pi-II on the symptoms and gastric motility of patients with functional dysepsia (FD). METHODS: A total of 180 FD patients were divided randomly and equally into Xiao Pi-II and mosapride groups. The two groups were treated with Xiao Pi-II (100 mL, t.d.s., ante cibum) and mosapride (5 mg, t. d.s., ante cibum) for 2 weeks. Before treatment and 3 days after all medication was stopped, patients responded to a questionnaire evaluating gastrointestinal symptoms and were assessed with abdominal three dimensional ultrasonography (3D-US) for gastric motility. RESULTS: Gastrointestinal symptoms (especially bloating, post-prandial fullness and eructation) were improved significantly in FD patients treated with Xiao Pi-II (P0.05). The effective rates in the Xiao Pi-II and mosapride group were 86.7% and 60.0%, respectively (P0.05) of GLER in the mosapride group. CONCLUSION: Compared with mosapride, Xiao Pi-II improved symptoms and GLER significantly in FD patients with delayed gastric emptying.

关键词： Dyspepsia Strengthening spleen Gas-tric liquid emptying rate

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Durable superamphiphobic silica aerogel surfaces for the culture of 3D cellular spheroids

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National Science Review 2019年第6期6卷 1255-1265页

作者： lianyi Xu Shuangshuang Chen Xuemin Lu Qinghua Lu School of Materials Science Institute of Energy Equipment Materials Shanghai Dianji University School of Chemical Science and Engineering Tongji University School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composite Shanghai Jiao Tong University

The 3D multicellular spheroids with intact cell–cell junctions have major roles in biological research by virtue of their unique advantage of mimicking the cellular physiological environments. In this work, a durable superamphiphobic silica aerogel surface(SSAS) has been fabricated for the upward culture of 3D multicellular spheroids. Poly(3,4-ethylenedioxythiophene)(PEDOT) was first electrodeposited on a conductive steel mesh as a first template for porous silica coating. Soot particles were then applied as a second template to construct a cauliflower-like silica aerogel nanostructure. After fluorination, a hierarchical structure with re-entrant curvature was finally fabricated as a durable superamphiphobic surface. This superamphiphobic surface also presented excellent antifouling towards biomacromolecules and cells, which has been demonstrated by the successful upward culture of cell spheroids. The upward culture makes the observation of cellular behavior in situ possible, holding great potential for 3D cellular evaluation in vitro.

关键词： cell spheroids superamphiphobicity durability electrochemistry silica aerogel

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A spurious positive Indian Ocean Dipole in 2017

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Science Bulletin 2018年第18期63卷 1170-1172页

作者： lianyi Zhang Yan Du Wenju Cai South China Sea Institute of Oceanology Chinese Academy of Sciences College of Earth Science University of Chinese Academy of Sciences Physical Oceanography Laboratory/CIMSST Ocean University of China and Qingdao National Laboratory for Marine Science and Technology Centre for Southern Hemisphere Oceans Research CSIRO Marine and Atmospheric Research

The Indian Ocean Dipole (IOD) is an intrinsic ocean-atmosphere coupled mode in the tropical Indian Ocean (IO)[1,2]. It features a sea surface temperature (SST) anomaly gradient, defined by the dipole mode index (DMI), the difference of area-averaged SST anomaly between the western tropical IO (50°–70°E, 10°N–10°S)and the southeastern tropical IO (90°–110°E, Eq.-10°S). The IOD event tends to develop and mature in the boreal summer and fall seasons. When a positive IOD (p IOD) occurs, SST warms up in the west and cools down in the east, which sets up an east-west pressure gradient. The atmosphere hence responds to the

关键词：印度洋偶极子热带印度洋海表面温度 SST 子模式 DMI 海洋

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Revisiting ENSO impacts on the Indian Ocean SST based on a combined linear regression method

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Acta Oceanologica Sinica 2021年第5期40卷 47-57页

作者： lianyi Zhang Yan Du Tomoki Tozuka Shoichiro Kido State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China University of Chinese Academy of Sciences Beijing 100049China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Department of Earth and Planetary Science Graduate School of ScienceThe University of TokyoTokyo 113-0033Japan Application Laboratory(APL) Research Institute for Value-Added-Information Generation(VAiG)Japan Agency for Marine-Earth Science and TechnologyYokohama 236-0001Japan

The El Nino-Southern Oscillation(ENSO)has great impacts on the Indian Ocean sea surface temperature(SST).In fact,two major modes of the Indian Ocean SST namely the Indian Ocean Basin(IOB)and the Indian Ocean Dipole(IOD)modes,exerting strong influences on the Indian Ocean rim countries,are both influenced by the *** on a combined linear regression method,this study quantifies the ENSO impacts on the IOB and the IOD during ENSO concurrent,developing,and decaying *** removing the ENSO impacts,the spring peak of the IOB disappears along with significant decrease in number of events,while the number of events is only slightly reduced and the autumn peak remains for the *** isolating the ENSO impacts during each stage,this study reveals that the leading impacts of ENSO contribute to the IOD development,while the delayed impacts facilitate the IOD phase switch and prompt the IOB ***,the decadal variations of ENSO impacts are various during each stage and over different *** imply that merely removing the concurrent ENSO impacts would not be sufficient to investigate intrinsic climate variability of the Indian Ocean,and the present method may be useful to study climate variabilities independent of ENSO.

关键词： Indian Ocean ENSO sea surface temperature climate modes combined linear regression

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