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Study on the vertical deformations induced by terrestrial water storage changes in Huang-Huai-Hai river basin

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Geodesy and Geodynamics 2024年第4期15卷 352-365页

作者： liansheng Deng Yugang Xiao Qusen Chen Feifei Liao Zhao Li School of Electrical and Electronic Information Engineering Hubei Polytechnic University Hubei Luojia Laboratory GNSS Research Center Wuhan University Changjiang Spatial Information Technology Engineering Co. Ltd.

Terrestrial water storage(TWS) variations are associated with water mass movements, which may cause the deformation displacements of the Global Navigation Satellite System(GNSS) stations. This study investigates the spatio-temporal TWS variations and addresses the relationship between deformation variations observed in the Huang-Huai-Hai River Basin(HHHRB) and local hydrological features. Results indicate that the vertical velocities at the GNSS stations induced by TWS changes are relatively small, and the impacts of the terrestrial water storage changes are mainly reflected in the changes of seasonal characteristics. Although there is a downward TWS trend from 2011 to 2022 in most HHHRB areas,velocities from the vertical displacements of both Gravity Recovery and Climate Experiment(GRACE) and GRACE Follow-On(GFO) and the GNSS reflect that the HHHRB is undergoing an uplift process, while the magnitude of the GRACE/GFO derived velocities is much smaller than that of the GNSS solutions.Common hydrological deformations estimated from GRACE/GFO and GNSS measurements reveal that the TWS-derived displacements can explain 54.5% of the GNSS seasonal variations, with the phases of terrestrial water storage advancing by about one month relative to GNSS common signal phases.Moreover, the decrease of the groundwater storage in the HHHRB has been accelerating since 2008. After reaching its lowest level around mid-2020, it began to rise rapidly, which might be closely related to the implementation of the South-North Water Transfer Central Project.

关键词： Terrestrial water storage GRACE GNSS Vertical deformations Huang-Huai-Hai river basin

New role of platelets in schizophrenia:predicting drug response

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General Psychiatry 2024年第2期37卷 197-206页

作者： Yamin Zhang Yanghao Zheng Peiyan Ni Sugai Liang Xiaojing Li Hua Yu Wei Wei Xueyu Qi Xueli Yu Rui Xue liansheng Zhao Wei Deng Qiang wang Wanjun Guo Tao Li Department of Neurobiology Zhejiang University School of Medicine Affiliated Mental Health Centre&Hangzhou Seventh People's HospitalHangzhouZhejiangChina Liangzhu Laboratory Zhejiang University MOE Frontier Science Center for Brain Science and Brain Machine IntegrationHangzhouZhejiangChina Mental Health Center and Psychiatric Laboratory West China Hospital of Sichuan UniversityChengduSichuanChina

Background Elevated platelet count(PLTc)is associated with first-episode schizophrenia and adverse outcomes in individuals with precursory psychosis.However,the impact of antipsychotic medications on PLTc and its association with symptom improvement remain unclear.Aims We aimed to investigate changes in PLTc levels following antipsychotic treatment and assess whether PLTc can predict antipsychotic responses and metabolic changes after accounting for other related variables.Methods A total of 2985 patients with schizophrenia were randomised into seven groups.Each group received one of seven antipsychotic treatments and was assessed at 2,4 and 6 weeks.Clinical symptoms were evaluated using the positive and negative syndrome scale(PANSS).Additionally,we measured blood cell counts and metabolic parameters,such as blood lipids.Repeated measures analysis of variance was used to examine the effect of antipsychotics on PLTc changes,while structural equation modelling was used to assess the predictive value of PLTc on PANSS changes.Results PLTc significantly increased in patients treated with aripiprazole(F=6.00,p=0.003),ziprasidone(F=7.10,p<0.001)and haloperidol(F=3.59,p=0.029).It exhibited a positive association with white blood cell count and metabolic indicators.Higher baseline PLTc was observed in non-responders,particularly in those defined by the PANSS-negative subscale.In the structural equation model,PLTc,white blood cell count and a latent metabolic variable predicted the rate of change in the PANSS-negative subscale scores.Moreover,higher baseline PLTc was observed in individuals with less metabolic change,although this association was no longer significant after accounting for baseline metabolic values.Conclusions Platelet parameters,specifically PLTc,are influenced by antipsychotic treatment and could potentially elevate the risk of venous thromboembolism in patients with schizophrenia.Elevated PLTc levels and associated factors may impede symptom improvement by promoting inflammation.Given PLTc’s easy measur

关键词： schizophrenia assessed treatment

Improved methodology for efficient establishment of the myocardial ischemia-reperfusion model in pigs through the median thoracic incision

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The Journal of Biomedical Research 2023年第4期37卷 302-312页

作者： Liuhua Zhou Jiateng Sun Tongtong Yang Sibo wang Tiankai Shan Lingfeng Gu Jiawen Chen Tianwen Wei Di Zhao Chong Du Yulin Bao Hao wang Xiaohu Lu Haoliang Sun Meng Lv Di Yang liansheng wang Department of Cardiology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Cardiac Surgery the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Medical Experimental Animal Center Nanjing Medical UniversityNanjingJiangsu 210029China

To investigate the feasibility and effectiveness of establishing porcine ischemia-reperfusion models by ligating the left anterior descending(LAD)coronary artery,we first randomly divided 16 male Bama pigs into a sham group and a model group.After anesthesia,we separated the arteries and veins.Subsequently,we rapidly located the LAD coronary artery at the beginning of its first diagonal branch through a mid-chest incision.Then,we loosened and released the ligation line after five minutes of pre-occlusion.Finally,we ligated the LAD coronary artery in situ two minutes later and loosened the ligature 60 min after ischemia.Compared with the sham group,electrocardiogram showed multiple continuous lead ST-segment elevations,and ultrasound cardiogram showed significantly lower ejection fraction and left ventricular fractional shortening at one hour and seven days post-operation in the model group.Twenty-four hours after the operation,cardiac troponin T and creatine kinase-MB isoenzyme levels significantly increased in the model group,compared with the sham group.Hematoxylin and eosin staining showed the presence of many inflammatory cells infiltrating the interstitium of the myocardium in the model group but not in the sham group.Masson staining revealed a significant increase in infarct size in the ischemia/reperfusion group.All eight pigs in the model group recovered with normal sinus heart rates,and the survival rate was 100%.In conclusion,the method can provide an accurate and stable large animal model for preclinical research on ischemia/reperfusion with a high success rate and homogeneity of the myocardial infarction area.

关键词： coronary artery ligation myocardial ischemia-reperfusion injury Bama pig animal model

Rapid progression of nonculprit coronary lesions six weeks after successful primary PCI in culprit artery:a case report

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The Journal of Biomedical Research 2014年第2期28卷 146-150页

作者： Jianjin Tang Zemu wang Dingguo Zhang liansheng wang Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Division of Cardiology The Affiliated Jiangyin Hospital of Southeast University Medical College

We report a case of a 49-year-old man who was admitted with a 3-hour history of sudden onset of substemal chest pain. Coronary angiography revealed that the left circumflex artery （LCX） was acutely and totally occluded at the mid-portion. In addition, the proximal and mid-portion of the right coronary artery （RCA） had a 60% occlusion. We inferred that the LCX was the culprit artery and primary PCI was successfully performed. Six weeks later, the patient had an eventful course with recurrence of chest pain. Coronary angiography showed no significant ste- nosis in the previous LCX lesion, while the proximal and middle potion of the RCA had a 90% occlusion. Our case demonstrates the systemic nature of acute coronary syndromes and highlights the inherent instability of coronary artery disease.

关键词： acute coronary syndrome percutaneous coronary intervention nonculprit coronary lesions

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毫米波多内导体布喇格结构电磁特性研究

电波科学学报 2024年第1期39卷 142-147页

作者：丁学用王石峰王连胜袁帅三亚学院理工学院三亚572022 三亚学院海洋通信研究所三亚572022

基于多模耦合理论,利用三维电磁仿真软件CST对毫米波双内导体和三内导体布喇格结构电磁特性分别进行了比较研究。结果表明:双内导体布喇格结构相比同轴布喇格结构可以抑制竞争模式,反射率稳定并接近1,对称性结构电磁特性优于非对称性结... 详细信息

基于多模耦合理论,利用三维电磁仿真软件CST对毫米波双内导体和三内导体布喇格结构电磁特性分别进行了比较研究。结果表明:双内导体布喇格结构相比同轴布喇格结构可以抑制竞争模式,反射率稳定并接近1,对称性结构电磁特性优于非对称性结构;随着内导体距离同轴轴心距离的增大,双内导体布喇格结构频率响应带宽变宽,且当内导体距离同轴轴心距离较远时,带宽变宽趋势明显,而反射率值趋于稳定;对于三内导体布喇格结构,随着内导体距离同轴轴心距离的增大,频率响应带宽变窄,且当内导体距离同轴轴心距离较近时,带宽变宽趋势明显。因此,可根据实际需要恰当选择毫米波多内导体布喇格结构参数,拓宽其作为反射器或者滤波器的性能,提高模式的选择性及模式的纯度,改善布喇格结构的性能。

关键词：同轴布喇格结构双内导体结构三内导体结构频率响应电场分布云图

Effects of Bivalirudin and Unfractionated Heparin on Liver and Renal Function in Chinese Patients with Coronary Artery Disease Undergoing Coronary Angiography with/without Percutaneous Coronary Intervention

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Journal of Clinical and Translational Hepatology 2021年第4期9卷 477-483页

作者： Qiaowei Jia Jia Hu Wenfeng Ji liansheng wang Enzhi Jia Department of Cardiovascular Medicine First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Cardiovascular Medicine Liyang People’s HospitalLiyangJiangsuChina

Background and Aims:Unfractionated heparin(UFH)and bivalirudin are widely used as anticoagulants in cardiovascular medicine,including for thrombosis prevention during coronary angiography(CAG)and percutaneous coronary intervention(PCI).Little is known of the effects of UFH and bivalirudin on liver and kidney function in patients subjected to these procedures.This study compared the effects of bivalirudin and UFH on liver/renal function in patients with coronary artery disease who underwent CAG,with or without PCI.Methods:The study comprised 134 consecutive patients(40–89 years-old),who underwent CAG(or CAG and PCI);among them,66 and 68 patients were subject to,respectively,bivalirudin or UFH.The following indicators of liver/renal function were measured before and after the procedures:plasma alanine aminotransferase(ALT),aspartate aminotransferase(AST),blood urea nitrogen,estimated glomerular filtration rate(eGFR),creatinine clearance,and serum creatinine.Patients were further stratified by severity of chronic kidney disease(CKD),based on original eGFR.Results:Relative to baseline,in the bivalirudin group,ALT and AST were higher after CAG(p=0.005,0.025),while blood urea nitrogen and serum creatinine were lower(p=0.049,<0.001).In the UFH group,ALT,AST,eGFR,and creatinine clearance were lower after CAG(p≤0.001,all).Patients given bivalirudin with moderate or severe CKD,but not those with mild CKD,gained significant improvement in kidney function.Conclusions:Relative to UFH,bivalirudin may better safeguard the renal function of patients with coronary artery disease who undergo CAG,especially patients with moderate-to-severe renal insufficiency.UFH may cause less liver damage than bivalirudin.

关键词： Bivalirudin Unfractionated heparin Coronary artery disease Coro-nary angiography Percutaneous coronary intervention Liver function

QSAR study on the non-monotonic dose-response curve of PCBs in chicken embryo hepatocyte bioassay

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Science China Chemistry 2009年第5期52卷 662-669页

作者： YunSong Mu AiQian Zhang ChangAn Gao SuFen Peng liansheng wang State Key Laboratory of Pollution Control and Resource Reuse School of Environment Nanjing University Nanjing 210093 China

Endocrine disrupting chemicals (EDCs) in the natural environment exhibit a unique non-monotonic dose-response curve and it is impossible to select one simple index to characterize the bilogogical activity of these compounds. Quantitative structure-activity relationship (QSAR) study on non-monotonic dose-response curve has become a real challenge presently. In order to explore the possible mechanism for the non-monotonic dose-response curve of polychlorinated biphenyls congeners (PCBs) in chicken embryo hepatocyte bioassay, AM1 method of ChemOffice was adopted to calculate necessary structure descriptors for PCBs, while the interactions between PCBs and simulated AhR ligand binding domain (LBD) were analyzed by using FlexX in SYBYL7.0. Different binding modes for PCBs have been distinguished not only from aligned conformation but also from free binding energy. Some QSAR models were established separately for both low and high doses ranges, revealing that receptor binding may predominate in the interference of the physiological function of cytochrome P4501A-P4501A in the low doses range. But with the higher doses range, the EROD suppression might be related to acute toxicity owing to molecular polarity or distribution of charges and consequently damage structure and function of chicken embryo hepatocyte.

关键词： polychlorinated biphenyls congeners (PCBs) non-monotonic dose-response curve quantitative structure-activity relationship (QSAR)

短梗长尾啮小蜂雌性生殖系统结构与卵巢发育特点

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植物保护 2024年第2期50卷 172-177,185页

作者：王晶臧连生高树立赵悦吉林农业大学植物保护学院长春130118

关于短梗长尾啮小蜂Aprostocetus brevipedicellus卵巢结构和发育的相关研究在国内外尚无报道。本研究对短梗长尾啮小蜂的雌性生殖系统结构、卵子形态及卵巢发育特点进行了观察。结果表明,短梗长尾啮小蜂雌性内生殖系统由1对卵巢、1对... 详细信息

关于短梗长尾啮小蜂Aprostocetus brevipedicellus卵巢结构和发育的相关研究在国内外尚无报道。本研究对短梗长尾啮小蜂的雌性生殖系统结构、卵子形态及卵巢发育特点进行了观察。结果表明,短梗长尾啮小蜂雌性内生殖系统由1对卵巢、1对侧输卵管、1条中输卵管、受精囊、毒囊等组成;雌性外生殖器由产卵管、产卵管鞘、内瓣和外瓣构成。同时,短梗长尾啮小蜂属于卵育型寄生蜂,雌蜂初羽化时卵巢内只含有少量成熟卵子,随着营养的补充和时间的推移,成熟卵子和总卵子数量逐渐增加,并在羽化后72 h数量达到最高值。此外,研究发现,卵巢管内成熟卵子数量和总卵子数量与雌蜂的体长均呈正相关,相关系数分别为0.936和0.941。以上研究结果为科学合理地研究和开发利用短梗长尾啮小蜂提供了理论基础。

关键词：短梗长尾啮小蜂卵巢发育雌性生殖系统卵育型寄生蜂

Holographic quantitative structure-activity relationship for prediction of the toxicity of polybrominated diphenyl ether congeners

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Science China Chemistry 2009年第12期52卷 2342-2350页

作者： XuShu Yang XiaoDong wang YiMing Zhang Si Luo Rong Li Cheng Sun liansheng wang State Key Laboratory of Pollution Control and Resources Reuse School of Environment Nanjing University Nanjing 210093 China School of Pharmacy Nanjing Medical University Nanjing 210029 China School of Basic Medical Sciences Nanjing Medical University Nanjing 210029 China

Polybrominated diphenyl ether congeners (PBDEs) might activate the AhR (aromatic hydrocarbon receptor) signal transduction,and thus might have an adverse effect on the health of humans and wildlife. Because of the limited experimental data,it is important and necessary to develop structure-based models for prediction of the toxicity of the compounds. In this study,a new molecular structure representation,molecular hologram,was employed to investigate the quantitative relationship between toxicity and molecular structures for 18 PBDEs. The model with the significant correlation and robustness (r2 = 0.991,q2LOO = 0.917) was developed. To verify the robustness and prediction capacity of the derived model,14 PBDEs were randomly selected from the database as the training set,while the rest were used as the test set. The results generated under the same modeling conditions as the optimal model are as follows:r2 = 0.988,q2LOO = 0.598,r2pred = 0.955,and RMSE (root-mean-square of errors) = 0.155,suggesting the excellent ability of the derived model to predict the toxicity of PBDEs. Furthermore,the structural features and molecular mechanism related to the toxicity of PBDEs were explored using HQSAR color coding.

关键词： polybrominated diphenyl ether congeners (PBDEs) molecular hologram quantitative structure-activity relationship prediction of toxicity