检索结果-南通市图书馆

Journal of Nanjing Medical University 2008年第4期22卷 238-242页

作者： Jianjin Tang liansheng wang Hui wang Mingwei wang Kejiang Cao Zhijian Yang Department of Cardiology the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu province China

To compare clinical outcomes and safety of eptifibatide or tirofiban in patients with acute coronary syndrome（ACS） undergoing percutaneous coronary intervention（PCI）. Methods：Thirty-six patients with ACS（unstable angina/non-ST-segment elevation myocardial infarction, UA/NSTEMI） who underwent PCI were randomly divided into two groups to receive eptifibatide or tirofiban treatment. Eptifibatide or tirofiban was predominantly initiated in the catheter laboratory before the intervention. In-hospital and 30-day MACE outcomes; bleeding as well as platelet counting were investigated in those two groups. Results：No in-hospital and 30-day MACE event occurred in the two groups. The number of ischemia leads after treatment reduced compared to that before PCI in the two groups. There was improvement in the number of ischemia leads for 24 h after administration in the tirofiban group than those in eptifibatide group（4.21 ± 2.46 vs. 3.89 ± 3.31, P =0.03）. The two groups showed no incidence of massive bleeding. Minor bleeding rates were 16.7% and 22.2% in the two groups respectively. Conclusion：Eptifibatide as an adjunct to PCI may further decrease the incidence of ischemia event in patients with ACS and improve the safety, but its long-term efficacy and side effects need further observation.

关键词： acute coronary syndrome percutaneous coronary intervention glycoprotein(GP Ⅱb/Ⅲ a) antagonist eptifibatide tirofiban

在线全文

学校读者我要写书评

暂无评论

白藜芦醇生物学活性及其在水产动物中的应用

中国水产科学 2021年第4期28卷 528-539页

作者：吴迪王连生中国水产科学研究院黑龙江水产研究所黑龙江省水生动物病害与免疫重点实验室

白藜芦醇(resveratrol, RES)是一种多酚类防御素,广泛存在于葡萄、虎杖及蓝莓等多种植物之中。RES因具有抗氧化、抗炎、抗细菌、免疫调节等生物学活性而被作为新型绿色饲料添加剂应用于水产行业中。本文综述了RES的理化性质、生物利用... 详细信息

白藜芦醇(resveratrol, RES)是一种多酚类防御素,广泛存在于葡萄、虎杖及蓝莓等多种植物之中。RES因具有抗氧化、抗炎、抗细菌、免疫调节等生物学活性而被作为新型绿色饲料添加剂应用于水产行业中。本文综述了RES的理化性质、生物利用率、生物学活性及其调节机制,并总结了RES在水产养殖中的应用。结果表明,适宜浓度的RES对水产动物的生产性能、免疫健康及脂肪代谢调节均有良好地促进作用;此外,RES还可有效防控细菌病原体对水产动物的侵染。但基于目前的研究, RES发挥生物学功能的相关机制尚未充分清楚,针对不同水产动物的适宜剂量也缺乏基础性研究,应尽快开展深入研究以期为进一步促进RES在水产动物中的应用提供参考。

关键词：白藜芦醇生物学活性水产动物

Trends and multi-model prediction of hepatitis B incidence in Xiamen

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Infectious Disease Modelling 2024年第4期9卷 1276-1288页

作者： Ruixin Zhang Hongfei Mi Tingjuan He Shuhao Ren Renyan Zhang liansheng Xu Mingzhai wang Chenghao Su School of Public Health Xiamen UniversityXiamen CityFujian ProvinceChina Department of Public Health Zhongshan Hospital(Xiamen)Fudan UniversityXiamen CityFujian ProvinceChina Department of Endemic Disease and Chronic Non-communicable Disease Prevention and Control Xiamen Center for Disease Control and PreventionXiamen CityFujian ProvinceChina Department of Occupational Health and Poison Control Xiamen Center for Disease Control and PreventionXiamen CityFujian ProvinceChina

Background:This study aims to analyze the trend of Hepatitis B incidence in Xiamen City from 2004 to 2022,and to select the best-performing model for predicting the number of Hepatitis B cases from 2023 to ***:Data were obtained from the China Information System for Disease Control and Prevention(CISDCP).The Joinpoint Regression Model analyzed temporal trends,while the Age-Period-Cohort(APC)model assessed the effects of age,period,and cohort on hepatitis B incidence *** also compared the predictive performance of the Neural Network Autoregressive(NNAR)Model,Bayesian Structural Time Series(BSTS)Model,Prophet,Exponential Smoothing(ETS)Model,Seasonal Autoregressive Integrated Moving Average(SARIMA)Model,and Hybrid Model,selecting the model with the highest performance to forecast the number of hepatitis B cases for the next five ***:Hepatitis B incidence rates in Xiamen from 2004 to 2022 showed an overall declining trend,with rates higher in men than in *** incidence rates were observed in adults,particularly in the 30-39 age ***,the period and cohort effects on incidence showed a declining ***,in the best-performing NNAR(10,1,6)[12]model,the number of new cases is predicted to be 4271 in 2023,increasing to 5314 by 2027.

关键词： Hepatitis B Temporal trends Prediction Joinpoint regression model Age-period-cohort model Neural network autoregressive model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于导向策略的C—H键活化反应的研究进展

有机化学 2018年第2期38卷 291-303页

作者：汪珊严沣汪连生朱磊湖北工程学院化学与材料科学学院孝感432000 生物质资源转化利用湖北省协同创新中心孝感432000

C—H键是有机化合物中存在最广泛的化学键之一.过渡金属催化的C—H键活化反应具有反应效率高、原子经济性高、产生废物少等优点,因此发展新的C—H键的转化类型和方法十分重要.由于分子内经常存在高度稳定且活性相似的C—H键,所以导致传... 详细信息

C—H键是有机化合物中存在最广泛的化学键之一.过渡金属催化的C—H键活化反应具有反应效率高、原子经济性高、产生废物少等优点,因此发展新的C—H键的转化类型和方法十分重要.由于分子内经常存在高度稳定且活性相似的C—H键,所以导致传统的C—H键活化反应的区域选择性很差,难以真正被应用于天然产物或者药物分子等的合成中.向反应体系中引入导向基团后,不仅可以大大提高C—H键官能化反应的活性,更可以提高区域选择性,实现高效合成单一目标产物的目的.因此,探索导向基导向的C—H键直接官能化反应具有重要意义.将从不同导向原子的角度介绍近十年导向基辅助的C—H键活化反应,并对其作用机理进行相关阐述.

关键词： C—H活化区域选择性导向基团过渡金属

在线全文

学校读者我要写书评

暂无评论

水产动物苯丙氨酸研究进展

动物营养学报 2022年第7期34卷 4189-4199页

作者：吴迪王良王连生中国水产科学研究院黑龙江水产研究所黑龙江省水生动物病害与免疫重点实验室哈尔滨150070 潍坊加易加生物科技有限公司潍坊261100

苯丙氨酸(Phe)是鱼类不能靠自身代谢合成的几种必需氨基酸之一,属芳香族氨基酸。Phe的营养和生理活性已被广泛应用于畜牧、医药和食品等领域,但Phe在水产动物中的生理活性机制尚不明晰。本文对Phe的合成与代谢、水产动物需求量及其在水... 详细信息

苯丙氨酸(Phe)是鱼类不能靠自身代谢合成的几种必需氨基酸之一,属芳香族氨基酸。Phe的营养和生理活性已被广泛应用于畜牧、医药和食品等领域,但Phe在水产动物中的生理活性机制尚不明晰。本文对Phe的合成与代谢、水产动物需求量及其在水产养殖中的应用作一综述,为全面了解各类水产动物对Phe的营养需求、代谢机制提供参考。

关键词：水产动物苯丙氨酸需求量生理活性

在线全文

学校读者我要写书评

暂无评论

鱼源宿主防御肽生物学活性及其潜在应用

动物营养学报 2021年第9期33卷 4848-4860页

作者：吴迪王连生中国水产科学研究院黑龙江水产研究所黑龙江省水生动物病害与免疫重点实验室哈尔滨150070

宿主防御肽(HDPs)是动物机体先天免疫系统的重要组成部分,具有分子质量小、热稳定性好和不易产生耐药性等特点。作为极具潜力的抗生素替代物,HDPs不仅具有抗细菌、抗真菌和抗病毒等生物学活性,还具有多种免疫调节功能。鱼类是HDPs的重... 详细信息

宿主防御肽(HDPs)是动物机体先天免疫系统的重要组成部分,具有分子质量小、热稳定性好和不易产生耐药性等特点。作为极具潜力的抗生素替代物,HDPs不仅具有抗细菌、抗真菌和抗病毒等生物学活性,还具有多种免疫调节功能。鱼类是HDPs的重要来源,然而除小部分鱼源HDPs被用于抗菌活性研究外,其余鱼源HDPs的潜在应用还未被深入研究。本文在查找已鉴定得到的鱼源HDPs数据的基础上,系统梳理并总结了鱼源HDPs的分类,探讨了其生物学活性、潜在功能与应用,以期为鱼源HDPs的进一步应用提供理论参考,也为新型绿色功能饲料添加剂与抗菌药物的开发提供指导。

关键词：鱼类宿主防御肽生物学活性潜在应用

Abiogenic hydrocarbons in commercial gases from the Songliao Basin,China

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2009年第5期52卷 213-226页

作者： wang XianBin GUO ZhanQian TUO JinCai GUO HongYan LI ZhenXi ZHUO ShengGuang JIANG HongLiang ZENG LongWei ZHANG MingJie wang liansheng LIU ChunXue YAN Hong LI LiWu ZHOU XiaoFeng wang YongLi YANG Hui wang Guang Key Laboratory of Gas Geochemistry Chinese Academy of SciencesLanzhou 730000China Daqing Oilfield Company Ltd. Daqing 163712China Institute of Earth Sciences and Information Technology Northeast University at QinhuangdaoQinhuangdao 066000China School of Earth and Environment Sciences Lanzhou UniversityLanzhou 730000China

This paper discusses the kinetic fractionation, composition and distribution characteristics of carbon and hydrogen isotopes for various alkane gases formed in different environments, by different mechanisms and from different sources in nature. It is demonstrated that the biodegradation or thermodegradation of complex high-molecule sedimentary organic material can form microbial gas or thermogenic gas. The δ13C1 value ranges from ?110% to ?50% for microbial gases but from ?50% to ?35% (even heavier) for thermogenic gases. Controlled by the kinetic isotope fractionation, both microbial and thermogenic gases have δ13C and δ D values characterized by normal distribution, i.e. δ13C1 δ 13C2> δ 13C3> δ 13C4 and $ \delta D_{CH_4 } < \delta D_{C_2 H_6 } < \delta D_{C_3 H_8 } < \delta D_{C_4 H_{10} } $ . The δ 13C values and δ D values are negatively correlated. Natural gases from 26 commercial gas wells distributed in the Xujiaweizi and Yingshan-Miaotaizi faulted depressions in the Songliao Basin, China, show δ13C1 values ranging from ?30.5% to ?16.7% with a very narrow δ D range between ?203‰?196‰ These gases are characterized by a reverse distribution of δ 13C values but a normal distribution of δ C values, and a negative correlation between their δ 13C and δ C values, indicating an abiological origin. The present study has revealed that abiogenic hydrocarbons not only exist in nature but also can make significant contribution to

关键词： generation mechanism of natural gases kinetic isotope fractionation the Songliao Basin of China commercial abiogenic hydrocarbon gaspool

Relationship between brachial-ankle pulse wave velocity and metabolic syndrome components in a Chinese population

在线全文

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2014年第4期28卷 262-268页

作者： Fang Zhou Haifeng Zhang Wenming Yao Hongbin Mei Dongjie Xu Yanhui Sheng Rong Yang Xiangqing Kong liansheng wang Jiangang Zou Zhijian Yang Xinli Li Department of Cardiology the First Affiliated Hospital of Nanjing Medical University

The purpose of this study was to assess the relationship between arterial stiffness, as measured by brachial-ankle pulse wave velocity （baPWV）, and the presence of the metabolic syndrome （MS） in a Chinese population. A total of 4,445 subjects were enrolled. The prevalence of MS in for the general population, males and females, respectively. our study population was 21.7%, 17.2% and 25.6% With adjustments for age, gender, cigarette smoking, heart rate, total cholesterol, low-density lipoprotein （LDL） cholesterol, and the use of anti-hypertensive drug, the stepwise regression analysis showed that baPWV had a significant relationship with components of MS, including systolic blood pressure （P 〈 0.001）, diastolic blood pressure （P 〈 0.001）, glucose （P 〈 0.001）, highdensity lipoprotein （HDL） cholesterol （P = 0.04）, and triglycerides （P 〈 0.001）, but no relationship with waist circumference （P = 0.25）. With an increase in the number of the MS components, baPWV increased significantly both in women and men. This study indicated that the MS is indeed a risk factor for arterial stiffness. Monitoring of baPWV in patients with MS may help in identifying persons at high risk for cardiovascular disease.

关键词： arterial stiffness brachial-ankle pulse wave velocity metabolic syndrome

Acute and mid-term results of pecutaneous transluminal septal myocardial ablation in patients with hypertrophic obstructive cardiomyopathy

在线全文

学校读者我要写书评

暂无评论

Journal of Nanjing Medical University 2007年第3期21卷 143-146页

作者： Tiebing Zhu Zhijian Yang liansheng wang Hui wang Kejiang Cao Jun Huang Wenzhu Ma Department of Cardiology the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

Objective： To assess the acute and mid-term results of cardiac function improvements and left ventricular outflow tract gradient （LVOTG）changes in 30 patients displaying hypertrophic obstructive cardiomyopathy （HOCM） treated with percutaneous transluminal septal myocardial ablation （PTSMA）. Methods： PTSMA was intended for 32 patients comprising of 13 women and 19 men （average years being 54.1 ± 15.5） to be treated in accordance with the following inclusion criteria： The New York Heart Association（NYHA） definition for cardiac functional class Ⅲ or Ⅳ ,or class Ⅱ but for whom medical therapies were not tolerated or with syncope; intraventricular septal（IVS） and left ventricular posterior wall（LVPW） hypertrophy asymmetrically associated with ratio of IVS to LVPW≥1.3 and LVOTG≥50 mm Hg at rest or ≥100 mm Hg at provocation （Valsalva maneuver）. The target vessels were determined by coronary arteriography that demonstrated more than one septal branch and probatory balloon occlusion produced greater than 50% decrease of LVOTG. Once the target vessel established, the alcohol was administrated into septal ventricular via over-the-wire balloon. LVOTG was assessed by means of echocardiography measurements immediately after procedure and 3 months. Simultaneously, cardiac function class was also evaluated. Results： Two patients were abandoned prior to intervention due to inappropriate septal target vessels and DDD Pacemakers were chosed. Immediately after the procedure, resting LVOTG was reduced from 73.8 ± 35.5 to 16.6 ± 7.8 mmHg, at provocation LVOTG from 149.3 ± 42.5 to 61.9 ± 63.0 mmHg（P 〈 0.0001 each） by echocardiography measurements. After 3 months, the mean New York Heart Association class was reduced from 2.8 ± 0.6 to 1.1 ± 1.0（P 〈 0.0001） and the LVOTG also remained decrease（28.5 ± 6.4 mmHg at rest and 75.3 ± 11.6 mmHg at provocation）. Conclusion： PTSMA is a promising nonsurgical technique for relief of symptoms and reduction of LVOTG in hypertrophic obstructive cardiomyo

关键词： hypertrophy cardiomyopathy ablation echocardiography

开槽深度和坡度对高频高阶模带宽和中心频移的影响

在线全文

学校读者我要写书评

暂无评论

电波科学学报 2022年第3期37卷 478-483页

作者：丁学用王连胜三亚学院理工学院三亚572022

为对构建太赫兹频率下高阶单模工作的同轴布喇格谐振腔提供理论依据,基于模式耦合理论,比较研究了不同开槽深度和不同开槽坡度形状及坡度角对工作在太赫兹频率高频高阶耦合模式下工作模式和竞争模式带宽、中心频率偏移特性的影响.结果表... 详细信息

为对构建太赫兹频率下高阶单模工作的同轴布喇格谐振腔提供理论依据,基于模式耦合理论,比较研究了不同开槽深度和不同开槽坡度形状及坡度角对工作在太赫兹频率高频高阶耦合模式下工作模式和竞争模式带宽、中心频率偏移特性的影响.结果表明:工作模式和竞争模式的带宽随着开槽深度的加深都变宽,但中心谐振频率点几乎没有偏移,槽深加深,带隙重叠现象会恶化,不利于模式选择;正圆锥形坡度方式时随着坡度角的增加,工作模式的中心频率点没有发生偏移,竞争模式中心频率点靠近工作模式中心频率点,不利于带隙重叠现象的抑制;倒圆锥形坡度方式时,随着坡度角的增大,竞争模式的中心频率点远离工作模式中心频率点,很好地抑制了带隙重叠;正圆锥形坡度和倒圆锥形坡度对带宽的影响都不大.这些特性有利于拓展同轴布喇格结构作为反射器和滤波器的性能.

关键词：同轴布喇格结构开槽深度开槽坡度坡度角中心频率点偏移带隙重叠