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杨韶华教授从肝论治慢性萎缩性胃炎经验

光明中医 2024年第2期39卷 248-251页

作者：李洪翠李连会杨韶华济宁市中医院脾胃病科山东济宁272000

慢性萎缩性胃炎是消化系统的常见病、难治病,属于一种癌前疾病,常常伴有肠上皮化生、上皮内瘤变及炎性反应,与胃癌的发生有密切关系。杨韶华教授从医30余年,临床经验丰富,擅长治疗慢性萎缩性胃炎等脾胃系统疾病,其从肝论治慢性萎缩性胃... 详细信息

慢性萎缩性胃炎是消化系统的常见病、难治病,属于一种癌前疾病,常常伴有肠上皮化生、上皮内瘤变及炎性反应,与胃癌的发生有密切关系。杨韶华教授从医30余年,临床经验丰富,擅长治疗慢性萎缩性胃炎等脾胃系统疾病,其从肝论治慢性萎缩性胃炎的临床疗法,疗效确切。此文主要从辨证分型及临证要点等方面总结其思想与经验,以期共同学习。

关键词：胃脘痛慢性萎缩性胃炎杨韶华肝名医经验

Effects of deformation twins on microstructure evolution,mechanical properties and corrosion behaviors in magnesium alloys-A review

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Journal of Magnesium and Alloys 2022年第9期10卷 2334-2353页

作者： lianhui li Wenhong liu Fugang Qi Di Wu Zhiqiang Zhang Key Lab of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang 110819China Engineering Research Center of Advanced Materials Preparing Technology Ministry of EducationNortheastern UniversityShenyang 110819China College of Information Science and Engineering Northeastern UniversityShenyang 110819China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Due to lattice reorientation,grain segmentation,induced recrystallization,twins play a very important role in regulating texture,refining grains,improving mechanical properties and corrosion resistance,and has received more extensive *** studies have shown that{10-12}tensile twins(TTWs)are easily activated in large quantities due to the lower critical resolve shear stresses(CRSS).Introduction of TTWs under uniaxial compression improved the strength,ductility,and formability of magnesium(Mg)***,TTWs produced by multi-directional impact forging(MDIF)can optimize the microstructure by dividing grains and promoting recrystallization,resulting in significant improvement of mechanical ***{10-11}compressive twins(CTWs)and{10-11}-{10-12}double twins(DTWs)can promote dynamic recrystallization(DRX),they are also favorable nucleation sites for *** addition,the type and volume fraction of twins can affect the corrosion resistance,and they also play different roles in the corrosion process of different Mg *** have shown great potential for improving structure and properties,but a comprehensive and critical discussion of twins in Mg alloys is still ***,based on previous studies,this article reviews the common types and variants of twins in Mg alloys,influencing factors,and their effects on the microstructure,mechanical properties and corrosion *** addition,some interesting ideas are being proposed for further research.

关键词： Twins Mg alloy Microstructure Mechanical properties Corrosion resistance

Investigation on microstructures and mechanical properties of Mg-6Zn-0.5Ce-xMn(x=0 and 1)wrought magnesium alloys

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Journal of Magnesium and Alloys 2022年第4期10卷 993-1003页

作者： Caihong Hou Hongshuai Cao Fugang Qi Qing Wang lianhui li Nie Zhao Dingfei Zhang Xiaoping Ouyang School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105PR China China Railway Eryuan Engineering Group Co.Ltd. Chengdu 610000PR China College of Materials Science and Engineering Chongqing UniversityChongqing 400045PR China

The microstructure evolution and mechanical properties of Mg–6Zn–0.5Ce–xMn(x=0 and 1 wt.%)wrought magnesium alloys were researched,and the morphologies and role of Mn element in the experimental alloys were *** research shows that all of Mn elements form theα-Mn pure phases,which do not participate in the formation of other phases,such as theτ-*** mechanical properties of Mn-containing alloys in as-extruded and aged states are superior to Mn-free *** the hot extrusion process,the dispersed fineα-Mn particle phase hinders the migration of grain boundaries and inhibits dynamic recrystallization,which mainly takes effect of grain refining and dispersion *** the aging treatments,the dispersed fineα-Mn particle phase not only hinders the growth of the solution-treated grains,but also becomes the nucleation cores ofβ1 rod-like precipitate phase,which is conducive to increasing the nucleation rate of the precipitate *** the aged alloy,the Mn addition mainly takes effect of grain refining and promoting aging strengthening.

关键词： Mg–6Zn–0.5Ce alloy Microstructure evolution Mechanical property Mn element Aging precipitation

Biological Tissue-Inspired Ultrasoft,Ultrathin,and Mechanically Enhanced Microfiber Composite Hydrogel for Flexible Bioelectronics

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Nano-Micro Letters 2023年第9期15卷 175-189页

作者： Qiang Gao Fuqin Sun Yue li lianhui li Mengyuan liu Shuqi Wang Yongfeng Wang Tie li lin liu Simin Feng Xiaowei Wang Seema Agarwal Ting Zhang i-Lab Nano-X Vacuum Interconnected WorkstationKey Laboratory of Multifunction Nanomaterials and Smart SystemsSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)Suzhou 215123JiangsuPeople’s Republic of China Department of Chemistry Bavarian Center for Battery Technology(BayBatt)Bayreuth Center for Colloids and Interfacesand Bavarian Polymer InstituteMacromolecular Chemistry IIUniversity of BayreuthUniversitätsstrasse 3095440 BayreuthGermany School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026AnhuiPeople’s Republic of China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of ScienceShanghai 200031People’s Republic of China

Hydrogels offer tissue-like softness,stretchability,fracture toughness,ionic conductivity,and compatibility with biological tissues,which make them promising candidates for fabricating flexible bioelectronics.A soft hydrogel film offers an ideal interface to directly bridge thin-film electronics with the soft ***,it remains difficult to fabricate a soft hydrogel film with an ultrathin configuration and excellent mechanical *** we report a biological tissue-inspired ultrasoft microfiber composite ultrathin(lity of tunable mechanical properties in a broad range,allowing for matching the modulus of most biological tissues and *** incorporation of glycerol and salt ions imparts the microfiber composite hydrogel with high ionic conductivity and prominent anti-dehydration *** microfiber composite hydrogels are promising for constructing attaching-type flexible bioelectronics to monitor biosignals.

关键词： Fiber Hydrogel Flexible electronics Thin film Electrospinning

An artificial neuromorphic somatosensory system with spatio-temporal tactile perception and feedback functions

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npj Flexible Electronics 2022年第1期6卷 691-698页

作者： Fuqin Sun Qifeng Lu Mingming Hao Yue Wu Yue li lin liu lianhui li Yingyi Wang Ting Zhang i-Lab Key Laboratory of Multifunctional Nanomaterials and Smart SystemsSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)398 Ruoshui RoadSuzhouJiangsu 215123People’s Republic of China School of Chips XJTLU Entrepreneur College(Taicang)Xi’an Jiaotong-Liverpool University111 Ren’ai RoadSuzhouJiangsu 215123People’s Republic of China School of Nano-Tech and Nano-Bionics University of Science and Technology of China96 Jinzhai RoadHefeiAnhui 230026People’s Republic of China Department of Health and Environmental Sciences Xi’an Jiaotong Liverpool University111 Ren’ai RoadSuzhou 215123People’s Republic of China Gusu Laboratory of Materials 388 Ruoshui RoadSuzhouJiangsu 215123People’s Republic of China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031People’s Republic of China

The advancement in flexible electronics and neuromorphic electronics has opened up opportunities to construct artificial perception systems to emulate biological functions which are of great importance for intelligent robotics and human-machine ***,artificial systems that can mimic the somatosensory feedback functions have not been demonstrated yet despite the great achievement in this *** this work,inspired by human somatosensory feedback pathways,an artificial somatosensory system with both perception and feedback functions was designed and constructed by integrating the flexible tactile sensors,synaptic transistor,artificial muscle,and the coupling ***,benefiting from the synaptic characteristics of the designed artificial synapse,the system shows spatio-temporal information-processing ability,which can further enhance the efficiency of the *** research outcome has a potential contribution to the development of sensor technology from signal sensing to perception and cognition,which can provide a special paradigm for the next generation of bionic tactile perception systems towards e-skin,neurorobotics,and advanced bio-robots.

关键词： artificial system functions

“Top-down” and “bottom-up” strategies for wafer-scaled miniaturized gas sensors design and fabrication

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Microsystems & Nanoengineering 2020年第1期6卷 1040-1049页

作者： lin liu Yingyi Wang Fuqin Sun Yanbing Dai Shuqi Wang Yuanyuan Bai lianhui li Tie li Ting Zhang Sujie Qin Department of Health and Environmental Sciences Xi’an Jiaotong-Liverpool University111 Ren’ai RoadSuzhouJiangsu 215123P.R.China Department of Environmental Science University of LiverpoolBrownlow HillLiverpool L697ZXUK i-Lab Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)398 Ruoshui RoadSuzhouJiangsu 215123P.R.China

Manufacture of large-scale patterned nanomaterials via top-down techniques,such as printing and slurry coating,have been used for fabrication of miniaturized gas ***,the reproducibility and uniformity of the sensors in wafer-scale fabrication are still a *** this work,a“top-down”and“bottom-up”combined strategy was proposed to manufacture wafer-scaled miniaturized gas sensors with high-throughput by in-situ growth of Ni(OH)2 nanowalls at specific ***,the micro-hotplate based sensor chips were fabricated on a two-inch(2″)silicon wafer by micro-electro-mechanical-system(MEMS)fabrication techniques(“top-down”strategy).Then a template-guided controllable de-wetting method was used to assemble a porous thermoplastic elastomer(TPE)thin film with uniform micro-sized holes(relative standard deviation(RSD)of the size of micro-holes300),which serves as the patterned mask for in-situ growing Ni(OH)2 nanowalls at the micro-hole areas(“bottom-up”strategy).The obtained gas microsensors based on this strategy showed great reproducibility of electric properties(RSD<0.8%,n=8)and sensing response toward real-time H _(2)S detection(RSD<3.5%,n=8).

关键词： walls sized template

Biological receptor-inspired flexible artificial synapse based on ionic dynamics

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Microsystems & Nanoengineering 2020年第1期6卷 507-516页

作者： Qifeng Lu Fuqin Sun lin liu lianhui li Yingyi Wang Mingming Hao Zihao Wang Shuqi Wang Ting Zhang i-Lab Key Laboratory of Multifunctional Nanomaterials and Smart SystemsSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)398 Ruoshui Road215123 SuzhouPR China Department of Health and Environmental Sciences Xi’an Jiaotong Liverpool University111 Ren’ai Road215123 SuzhouPR China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences200031 ShanghaiPR China

The memristor has been regarded as a promising candidate for constructing a neuromorphic computing platform that is capable of confronting the bottleneck of the traditional von Neumann ***,inspired by the working mechanism of the G-protein-linked receptor of biological cells,a novel double-layer memristive device with reduced graphene oxide(rGO)nanosheets covered by chitosan(an ionic conductive polymer)as the channel material is *** protons in chitosan and the functional groups in rGO nanosheets imitate the functions of the ligands and receptors of biological cells,*** changes in the response current depending on the historical applied voltages are observed,offering a promising pathway toward biorealistic synaptic *** memristive behavior is mainly a result of the interaction between protons provided by chitosan and the defects and functional groups in the rGO *** channel current is due to the hopping of protons through functional groups and is limited by the traps in the rGO *** transition from short-term to long-term potentiation is achieved,and learning-forgetting behaviors of the memristor mimicking those of the human brain are ***,the bioinspired memristor-type artificial synaptic device shows great potential in neuromorphic networks.

关键词： artificial offering dynamics

Superelastic alloy based electrical interconnects for highly stretchable electronics

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npj Flexible Electronics 2022年第1期6卷 91-98页

作者： Yangyong Zhao Weifan Zhou Yixiang Shi Xianqing Yang Yuanyuan Bai lianhui li Shuqi Wang Tie li Simin Feng Ting Zhang i-lab Key Laboratory of Multifunctional Nanomaterials and Smart SystemsSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)398 Ruoshui RoadSuzhou 215123P.R.China Gusu Laboratory for Materials Science 388 Ruoshui RoadSuzhou 215123P.R.China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031P.R.China

To achieve stretchable inorganic electronics,improving elastic stretchability of the electrical interconnects becomes a bottleneck needed to be ***,we propose a material of Ni-Ti superelastic alloy for the design and fabrication of deformable interconnects,whose intrinsic elastic property overcomes the low intrinsic elastic strain limit of conventional *** serpentine interconnect made by Ni-Ti alloy with an intrinsic elastic strain limit of~7.5%represents a much higher elastic stretchability than conventional Cu *** deformation behavior of the interconnect is systematically investigated through finite element analysis(FEA)simulations and *** results reveal that the interconnect exhibits an elastic stretchability up to 196%,and its resistance only changes by 0.4%with 100% ***,the potentials and challenges of other superelastic alloys as electrical interconnects are *** proposed superelastic alloys fundamentally boost the stretchable properties of electrical interconnects,which would open up opportunities for flexible and stretchable electronics.

关键词： alloy alloys deformation

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可编织柔性纤维状水伏纳米发电机

中国科学：技术科学 2022年第11期52卷 1659-1668页

作者：冯思佳李连辉刘梦愿郭昀张珽上海大学材料科学与工程学院上海200444 中国科学院苏州纳米技术与纳米仿生研究所苏州215123 材料科学姑苏实验室苏州215123

可穿戴设备在医疗健康、物联网和机器人等领域具有广泛需求,其发展具有小型化、轻量化、柔性化的趋势,然而便携式、持续稳定的能源供给方式是限制其应用的瓶颈问题.基于水伏效应的新型环境能源捕获技术为解决可穿戴设备的持续能源供给... 详细信息

可穿戴设备在医疗健康、物联网和机器人等领域具有广泛需求,其发展具有小型化、轻量化、柔性化的趋势,然而便携式、持续稳定的能源供给方式是限制其应用的瓶颈问题.基于水伏效应的新型环境能源捕获技术为解决可穿戴设备的持续能源供给问题提供了新的机遇.相关研究表明,碳纳米材料在对水能的转换与利用中展现了独特的优势.本文以导电炭黑为水伏材料,通过简易的浸涂法及材料表面浸润性调控,制备了水伏效应和原电池反应产能机制协同作用的可编织柔性纤维状水伏纳米发电机.其在纯水及多种盐溶液中均能实现持续稳定的产电,突破了目前水伏发电机对于水源中极低离子浓度要求的限制.值得一提的是,该水伏纳米发电机可以利用人体汗液直接发电,有望作为柔性可穿戴设备稳定的能源供给方式,解决柔性电子器件的持续能源供给问题.

关键词：水伏纳米发电机环境能源捕获柔性可穿戴电子汗液可编织