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Rosemary extract improves egg quality by altering gut barrier function,intestinal microbiota and oviductal gene expressions in late-phase laying hens

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Journal of Animal Science and Biotechnology 2024年第1期15卷 295-312页

作者： lianhua Zhang Junwei Ge Fei Gao Min Yang Hui Li Fei Xia Hongtong bai Xiangshu Piao Zhiying Sun Lei Shi Key Laboratory of Plant Resources Institute of BotanyChinese Academy of SciencesBeijing 100093China China National Botanical Garden Beijing 100093China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background Rosemary extract(RE)has been reported to exert antioxidant property.However,the application of RE in late-phase laying hens on egg quality,intestinal barrier and microbiota,and oviductal function has not been systematically studied.This study was investigated to detect the potential effects of RE on performance,egg quality,serum parameters,intestinal heath,cecal microbiota and metabolism,and oviductal gene expressions in late-phase laying hens.A total of 21065-week-old“Jing Tint 6”laying hens were randomly allocated into five treatments with six replicates and seven birds per replicate and fed basal diet(CON)or basal diet supplemented with chlortetracycline at 50 mg/kg(CTC)or RE at 50 mg/kg(RE50),100 mg/kg(RE100),and 200 mg/kg(RE200).Results Our results showed that RE200 improved(P<0.05)Haugh unit and n-6/n-3 of egg yolk,serum superoxide dismutase(SOD)compared with CON.No significant differences were observed for Haugh unit and n-6/n-3 of egg yolk among CTC,RE50,RE100 and RE200 groups.Compared with CTC and RE50 groups,RE200 increased serum SOD activity on d 28 and 56.Compared with CON,RE supplementation decreased(P<0.05)total cholesterol(TC)level.CTC,RE100 and RE200 decreased(P<0.05)serum interleukin-6(IL-6)content compared with CON.CTC and RE200 increased jejunal m RNA expression of ZO-1 and Occludin compared with CON.The biomarkers of cecal microbiota and metabolite induced by RE 200,including Firmicutes,Eisenbergiella,Paraprevotella,Papillibacter,and butyrate,were closely associated with Haugh unit,n-6/n-3,SOD,IL-6,and TC.PICRUSt2 analysis indicated that RE altered carbohydrate and amino acid metabolism of cecal microbiota and increased butyrate synthesizing enzymes,including 3-oxoacid Co A-transferase and butyrate-acetoacetate Co A-transferase.Moreover,transcriptomic analysis revealed that RE200 improved gene expressions and functional pathways related to immunity and albumen formation in the oviductal magnum.Conclusions Dietary supplementation with 200 mg/kg RE could increase egg quality of late-p

关键词： Intestinal health Laying hens Microbiota Oviductal function Phytochemicals Production

Factors associated with premenstrual syndrome of emergency nurse: A multicenter study in China

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Gynecology and Obstetrics Clinical Medicine 2022年第4期2卷 199-202页

作者： Yiqian Chen Xin Yang Xiaodan Li Xiaoting Wei lianhua bai Department of Obstetrics and Gynecology Peking University People's HospitalBeijingChina Peking University School of Nursing BeijingChina

Objective:To study the factors associated with premenstrual syndrome(PMS)in emergency department(ED)nurses.Methods:A multicenter cross-sectional study was conducted in female ED nurses in China.Data gathering questionnaires included the Daily Record of Severity of Problems,Chinese Nurses Stressor Scale,Social Support Rating Scale,and Self-Rating Anxiety Scale.All questionnaires were used to assess the symptoms prospectively over 2 months.Results:A total of 289 ED nurses were recruited.The incidence of PMS was 67.47%.The most common symptoms were tiredness(76.90%),anger(76.90%),restlessness(75.40%),snoring(69.20%).Univariate analysis showed that the BMI and occupational stress score was significantly higher,and the age was significantly younger in the PMS group compared with the non-PMS group.According to the multiple linear regression,the symptoms of PMS were positively associated with the occupational stress score and anxiety score,and negatively with the level of education received.Conclusions:occupational stress,anxiety,and education level may associated with the occurrence of PMS in ED nurses.

关键词： Premenstrual syndrome Emergency department Nurse

Myelin repair and functional recovery mediated by neural cell transplantation in a mouse model of multiple sclerosis

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Neuroscience Bulletin 2013年第2期29卷 239-250页

作者： lianhua bai Jordan Hecker Amber Kerstetter Robert H.Miller Department of Neurosciences Center for Translational NeuroscienceCase Western Reserve University School ofMedicine The Key Laboratory Third Military Medical University Southwest Hospital

Cellular therapies are becoming a major focus for the treatment of demyelinating diseases such as multiple sclerosis （MS）, therefore it is important to identify the most effective cell types that promote myelin repair. Several components contribute to the relative benefits of specific cell types including the overall efficacy of the cell therapy, the reproducibility of treatment, the mechanisms of action of distinct cell types and the ease of isolation and generation of therapeutic populations. A range of distinct cell populations promote functional recovery in animal models of MS including neural stem cells and mesenchymal stem cells derived from different tissues. Each of these cell populations has advantages and disadvantages and likely works through distinct mechanisms. The relevance of such mechanisms to myelin repair in the adult central nervous system is unclear since the therapeutic cells are generally derived from developing animals. Here we describe the isolation and characterization of a population of neural cells from the adult spinal cord that are characterized by the expression of the cell surface glycoprotein NG2. In functional studies, injection of adult NG2~ cells into mice with ongoing MOG3~_~5-induced experimental autoimmune encephalomyelitis （EAE） enhanced remyelination in the CNS while the number of CD3＋ T cells in areas of spinal cord demyelination was reduced approximately three-fold. In vivostudies indicated that in EAE, NG2＊ cells stimulated endogenous repair while in vitro they responded to signals in areas of induced inflammation by differentiating into oligodendrocytes. These results suggested that adult NG2~ cells represent a useful cell population for promoting neural repair in a variety of different conditions including demyelinating diseases such as MS.

关键词： NG2 glycoprotein myelin oligodendro-cytes experimental autoimmune encephalomyelitis multiple sclerosis remyelination

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城乡供水一体化建设管理研究

水利技术监督 2024年第6期 92-94,98,102页

作者：白莲花乌苏市兴源水务有限公司新疆乌苏833000

随着城镇化发展,城乡供水体系建设存在诸多问题,已成为制约社会经济发展的瓶颈,文章以乌苏市为例,研究城乡供水一体化建设管理。首先分析了乌苏市的概况及供水建设内容,然后构建评价指标体系,应用模糊层次分析法评估建设管理效果。结果... 详细信息

随着城镇化发展,城乡供水体系建设存在诸多问题,已成为制约社会经济发展的瓶颈,文章以乌苏市为例,研究城乡供水一体化建设管理。首先分析了乌苏市的概况及供水建设内容,然后构建评价指标体系,应用模糊层次分析法评估建设管理效果。结果表明,在经济效益、安全可靠性和社会效益3个方面,乌苏市的供水建设管理效果达到优秀。研究确立了评价模式,为今后供水建设管理提供借鉴,也使决策部门能够制定更科学的策略。

关键词：城乡供水一体化建设管理模糊层次分析法

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草乌致大鼠肝肾亚急性毒性的代谢组学研究

沈阳药科大学学报 2024年第1期41卷 86-95页

作者：乌日汉特日格乐娜琴敖敦格日乐莲花松林白翠兰白梅荣内蒙古医科大学蒙医药学院内蒙古呼和浩特010110 内蒙古民族大学蒙医药学院内蒙古通辽028000

目的基于代谢组学技术分析和探讨草乌致大鼠肝肾亚急性毒性的生物标志物和可能的作用机制。方法以草乌为示例药物,以大鼠为研究对象,除正常组外,给药组灌胃相应溶液,连续给予28 d。通过代谢组学技术对采集的大鼠血清、肝、肾样本进行检... 详细信息

目的基于代谢组学技术分析和探讨草乌致大鼠肝肾亚急性毒性的生物标志物和可能的作用机制。方法以草乌为示例药物,以大鼠为研究对象,除正常组外,给药组灌胃相应溶液,连续给予28 d。通过代谢组学技术对采集的大鼠血清、肝、肾样本进行检测,用主成分分析结合偏最小二乘判别分析筛选肝肾亚急性毒性敏感标志物及代谢通路。结果代谢组学分析显示,与正常组比较,草乌组血清、肝、肾样本中分别鉴定得到34、23和30个差异代谢物,主要富集于ABC转运蛋白、精氨酸和脯氨酸代谢、癌症的中心碳代谢、烟酸和烟酰胺代谢等通路。结论初步认为草乌通过影响ABC转运蛋白、精氨酸和脯氨酸代谢、癌症的中心碳代谢等对肝肾造成损伤,亚精胺、羟脯氨酸、葡萄糖、L-亮氨酸和尿素可作为潜在的肝肾毒性敏感生物标志物。

关键词：草乌肝脏肾脏亚急性毒性代谢组学

妇科护士加速康复外科理念知信行现状的调查研究

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中华护理教育 2024年第6期21卷 711-717页

作者：龚晶晶白莲花魏小停付立李晓丹刘媛媛北京大学人民医院北京市100044

目的了解妇科护士加速康复外科(enhanced recovery after surgery,ERAS)理念知信行现状。方法2023年8月,采取便利抽样法和滚雪球抽样法,选取来自20个省份的1553名妇科护士作为调查对象,采用一般资料调查表、妇科护士ERAS理念知信行问卷... 详细信息

目的了解妇科护士加速康复外科(enhanced recovery after surgery,ERAS)理念知信行现状。方法2023年8月,采取便利抽样法和滚雪球抽样法,选取来自20个省份的1553名妇科护士作为调查对象,采用一般资料调查表、妇科护士ERAS理念知信行问卷对其进行调查。结果共回收有效问卷1470份,有效问卷回收率为94.66%。1470名妇科护士ERAS理念知信行得分分别为(15.75±3.53)分、(23.57±2.62)分、(94.58±19.39)分。所在医院类别、所在科室床位数、ERAS实施时间、ERAS相关指南内容知晓情况、所在科室ERAS相关规章或流程拥有情况、成立ERAS小组情况、组织开展ERAS相关培训情况不同的妇科护士ERAS理念知信行得分比较,差异均有统计学意义(P<0.05)。结论妇科护士对ERAS的态度较为积极,但知识、行为水平仍有较大提升空间。护理管理者应注重对妇科护士ERAS理念知信行水平的评估,并基于妇科护士ERAS理念知信行水平特征对其进行针对性的干预,进而提高其ERAS理念知信行水平,保障ERAS在妇科手术围术期管理中的顺利实施,提升其实施效果。

关键词：加速康复外科护理知信行现状调查

A New Facile Route to Chlorination of Alcohols via Lewis Acid AlCl<sub>3</sub>

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International Journal of Organic Chemistry 2012年第1期2卷 21-25页

作者： Hengchang Ma Zhikang Bao lianhua bai Wei Cao Key Laboratory of Polymer Materials of Gansu Province Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou China

Halogenated aluminates AlCl3, applied as efficient chlorination reagent for hydroxyl groups of substitution alcohols is described. Primary and secondary benzylic alcohols could be transformed into corresponding aromatic halides with almost complete conversion and unique selectivity. As chlorination reagent, AlCl3 has an incomparable advantage over others, such as low material cost, commercial availability as well as convenient product isolation.

关键词： Alcohols Lewis Acid Nucleophiles Chlorination

The hippo kinases MST1/2 in cardiovascular and metabolic diseases:A promising therapeutic target option for pharmacotherapy

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Acta Pharmaceutica Sinica B 2023年第5期13卷 1956-1975页

作者： Yunfei Yin Mingyue Tan lianhua Han Lei Zhang Yue Zhang Jun Zhang Wanqian Pan Jiaxiang bai Tingbo Jiang Hongxia Li Department of Cardiology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Orthopedics the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Orthopedics the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of Chin1Hefei 230001China

Cardiovascular diseases(CVDs)and metabolic disorders are major components of noncommunicable diseases,causing an enormous health and economic burden worldwide.There are common risk factors and developmental mechanisms among them,indicating the far-reaching significance in exploring the corresponding therapeutic targets.MST1/2 kinases are well-established proapoptotic effectors that also bidirectionally regulate autophagic activity.Recent studies have demonstrated that MST1/2 influence the outcome of cardiovascular and metabolic diseases by regulating immune inflammation.In addition,drug development against them is in full swing.In this review,we mainly describe the roles and mechanisms of MST1/2 in apoptosis and autophagy in cardiovascular and metabolic events as well as emphasis on the existing evidence for their involvement in immune inflammation.Moreover,we summarize the latest progress of pharmacotherapy targeting MST1/2 and propose a new mode of drug combination therapy,which may be beneficial to seek more effective strategies to prevent and treat CVDs and metabolic disorders.

关键词： MST1/2 kinases Regulation Apoptosis Autophagy Immune Cardiovascular diseases Metabolic diseases Therapy

胰岛素抵抗和体重对子宫内膜癌患者肿瘤及妊娠结局的影响

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中国妇产科临床杂志 2024年第2期25卷 113-117页

作者：陈轶前王益勤龚晶晶白莲花刘媛媛李晓丹王建六北京大学人民医院妇产科北京100044

目的探讨胰岛素抵抗和体重对保留生育功能治疗的子宫内膜非典型增生及子宫内膜癌患者肿瘤和妊娠结局的影响。方法回顾性分析2010年1月至2022年12月就诊于北京大学人民医院行保留生育功能治疗的108例子宫内膜非典型增生及子宫内膜癌患者... 详细信息

目的探讨胰岛素抵抗和体重对保留生育功能治疗的子宫内膜非典型增生及子宫内膜癌患者肿瘤和妊娠结局的影响。方法回顾性分析2010年1月至2022年12月就诊于北京大学人民医院行保留生育功能治疗的108例子宫内膜非典型增生及子宫内膜癌患者的临床资料,对患者治疗前体重、糖脂代谢指标及治疗中体重变化进行单因素及多因素logistic回归分析。结果多因素logistic回归分析显示,胰岛素抵抗是影响保留生育功能治疗完全缓解的独立危险因素(OR=0.156,95%CI:0.032~0.756,P=0.021);治疗期间体重增加的患者未成功妊娠的风险更大(OR=0.084,95%CI:0.015~0.461,P=0.004);体重及糖脂代谢指标预测保留生育功能治疗的子宫内膜非典型增生及子宫内膜癌患者肿瘤和妊娠结局的受试者工作曲线下面积分别为0.826和0.754。结论胰岛素抵抗是影响肿瘤完全缓解的独立危险因素,治疗中体重增加是影响妊娠的独立危险因素,在保留生育治疗过程中应对患者的体重及糖脂代谢指标进行重点监测及管理,以提高疗效。

关键词：子宫内膜癌子宫内膜非典型增生保留生育治疗体重糖脂代谢