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Chinese Medical Journal 2024年第4期137卷 484-486页

作者： Jian Wu Qi Zhang xu Jia Yingting Zhu Zhidong Li Shu Tu Ling Zhao Yifan Du Wei Liu Jiaoyan Ren liangzhi xu Hanxiang Yu Fagao Luo Wenru Su Ningli Wang Yehong Zhuo State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceSun Yat-sen UniversityGuangzhouGuangdong 510060China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBeijing 100730China School of Food Sciences and Engineering South China University of TechnologyGuangzhouGuangdong 510641China Guangzhou Huazhen Biosciences GuangzhouGuangdong 510920China

To the Editor:Normal-tension glaucoma(NTG)is a progressive optic neuropathy characterized by irreversible blindness with statistically normal intraocular pressure(IOP)(≤21 mmHg),^([1,2])which makes early-stage diagnosis in the clinical practice difficult.Pathophysiological pathways underlying NTG include vascular dysregulation,toxic metabolite accumulation,and elevated translaminar cribrosa pressure difference(TLCPD).^([3])Although various small animal models have provided evidence of different pathophysiological mechanisms,the complicated clinical phenotype cannot be fully imitated by secondary disease models,and the gap between rodents and humans weakens their translational potential.Thus,the pathological changes associated with NTG remain unclear.

关键词： elevated glaucoma diagnosis

Global analysis of basic leucine zipper transcription factors in trifoliate orange and the function identification of PtbZIP49 in salt tolerance

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Horticultural Plant Journal 2024年第1期10卷 115-130页

作者： Yuanyuan xu Qiuling Hui Meng Li Hongxian Peng Yizhong He Changpin Chun liangzhi Peng Xingzheng Fu National Citrus Engineering Research Center Citrus Research InstituteSouthwest UniversityChongqing 400712China

As one of the most widely distributed and highly conserved transcription factors in eukaryotes,basic leucine zipper proteins(bZIPs)are involved in a variety of biological processes in plants,but they are largely unknown in citrus.In this study,56 bZIP family members were identified genome-wide from an important citrus rootstock,namely trifoliate orange(Poncirus trifoliata L.Raf.),and these putative bZIPs were named PtbZIP1—PtbZIP56.All PtbZIPs were classified into 13 subgroups by phylogenetic comparison with Arabidopsis thaliana bZIPs(AtbZIPs),and they were randomly distributed on nine known(50 genes)chromosomes and one unknown(6 genes)chromosome.Sequence analysis revealed the detailed characteristics of PtPZIPs,including their amino acid length,isoelectric point(pI),molecular weight(MW),predicted subcellular localization,gene structure,and conserved motifs.Prediction of promoter elements suggested the presence of drought,low-temperature,wound,and defense and stress responsive elements,as well as multiple hormone-responsive cis-acting elements.Spatiotemporal expression analysis showed the transcriptional patterns of PtbZIPs in different tissues and under dehydration,high salt,ABA,and IAA treatments.In addition,21 PtbZIPs were predicted to have direct or indirect protein—protein interactions.Among these,PtbZIP49 was experimentally proven to interact with PtbZIP1 or PtbZIP11 by using a yeast two-hybrid assay and bimolecular fluorescence complementation(BiFC).Subcellular localization analysis further revealed that PtbZIP1,PtbZIP11,and PtbZIP49 were localized in the nucleus.Moreover,PtbZIP49 was functionally identified as having an important role in salt stress via ectopic expression in A.thaliana and silenced in trifoliate orange using virus-induced gene silencing(VIGS).This study provided comprehensive information on PtbZIP transcription factors in citrus and highlights their potential functions in abiotic stress.

关键词： bZIP Citrus Trifoliate orange Abiotic stress Expression pattern

A phenology-based vegetation index for improving ratoon rice mapping using harmonized Landsat and Sentinel-2 data

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Journal of Integrative Agriculture 2024年第4期23卷 1164-1178页

作者： Yunping Chen Jie Hu Zhiwen Cai Jingya Yang Wei Zhou Qiong Hu Cong Wang liangzhi You Baodong xu Macro Agriculture Research Institute College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China College of Resources and Environment Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Agricultural Remote Sensing Ministry of Agriculture and Rural Affairs/Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory for Geographical Process Analysis&Simulation of Hubei Province/College of Urban and Environmental Sciences Central China Normal UniversityWuhan 430079China International Food Policy Research Institute NWWashingtonD.C.20005USA

Ratoon rice,which refers to a second harvest of rice obtained from the regenerated tillers originating from the stubble of the first harvested crop,plays an important role in both food security and agroecology while requiring minimal agricultural inputs.However,accurately identifying ratoon rice crops is challenging due to the similarity of its spectral features with other rice cropping systems(e.g.,double rice).Moreover,images with a high spatiotemporal resolution are essential since ratoon rice is generally cultivated in fragmented croplands within regions that frequently exhibit cloudy and rainy weather.In this study,taking Qichun County in Hubei Province,China as an example,we developed a new phenology-based ratoon rice vegetation index(PRVI)for the purpose of ratoon rice mapping at a 30 m spatial resolution using a robust time series generated from Harmonized Landsat and Sentinel-2(HLS)images.The PRVI that incorporated the red,near-infrared,and shortwave infrared 1 bands was developed based on the analysis of spectro-phenological separability and feature selection.Based on actual field samples,the performance of the PRVI for ratoon rice mapping was carefully evaluated by comparing it to several vegetation indices,including normalized difference vegetation index(NDVI),enhanced vegetation index(EVI)and land surface water index(LSWI).The results suggested that the PRVI could sufficiently capture the specific characteristics of ratoon rice,leading to a favorable separability between ratoon rice and other land cover types.Furthermore,the PRVI showed the best performance for identifying ratoon rice in the phenological phases characterized by grain filling and harvesting to tillering of the ratoon crop(GHS-TS2),indicating that only several images are required to obtain an accurate ratoon rice map.Finally,the PRVI performed better than NDVI,EVI,LSWI and their combination at the GHS-TS2 stages,with producer's accuracy and user's accuracy of 92.22 and 89.30%,respectively.These results demonstrate that the proposed PRV

关键词： ratoon rice phenology-based ratoon rice vegetation index(PRVI) phenological phase feature selection Harmonized Landsat Sentinel-2 data

基于分子干涉函数的光子-原子相干散射截面计算方法研究

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原子能科学技术 2024年第3期58卷 573-580页

作者：徐宁祖铁军曹良志吴宏春西安交通大学核科学与技术学院陕西西安710049

X射线衍射在物质结构分析和材料无损检测领域有着广泛的应用,其基本物理原理为光子与物质发生的相干散射。传统的相干散射截面计算方法基于独立原子形状因子近似方法,忽略了光子动量转移较小时与原子发生相互作用时的分子干涉效应,影响... 详细信息

X射线衍射在物质结构分析和材料无损检测领域有着广泛的应用,其基本物理原理为光子与物质发生的相干散射。传统的相干散射截面计算方法基于独立原子形状因子近似方法,忽略了光子动量转移较小时与原子发生相互作用时的分子干涉效应,影响相干散射截面的计算精度。因此,为了获得光子动量转移较小时精确的相干散射截面,本文在核数据处理程序NECP-Atlas中对基于分子干涉函数的光子-原子相干散射截面计算方法进行研究,利用分子动力学模拟方法计算分子干涉函数,对蒙特卡罗程序使用的ACE格式数据库中的原子形状因子进行修正,并给出了模拟得到的水分子和乙醇分子的分子干涉函数,对基于独立原子形状因子近似方法和考虑分子干涉效应计算得到的水和乙醇的散射成像结果进行了对比分析。数值结果显示:基于分子动力学模拟得到的分子干涉函数计算得到的水的散射成像结果与文献结果吻合较好;同时,当光子动量转移较小时,分子干涉效应对相干散射的次级光子角度分布有着显著影响。本文建立的光子-原子相干散射截面计算方法可显著提高光子动量转移较小时的相干散射次级光子角度分布计算精度,可为X射线衍射模拟提供数据基础。

关键词：核数据处理光子相干散射原子形状因子分子干涉效应 NECP-Atlas

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卵巢储备功能减退的临床处置进展

中国计划生育和妇产科 2024年第6期16卷 3-6,10页

作者：程萌许良智四川大学华西第二医院生殖内分泌科四川成都610041 四川大学华西第二医院生殖内分泌和生殖调控研究室四川成都610041 出生缺陷与相关妇儿疾病教育部重点实验室四川成都610041

卵巢储备功能减退(diminished ovarian reserve, DOR)是女性生殖能力由旺盛至衰老的一个重要转折阶段。提高对卵巢储备功能的认识,早期发现DOR,并针对性地进行临床干预,以减少由于生殖衰老所引发的生育力下降、月经异常与激素缺乏等相... 详细信息

卵巢储备功能减退(diminished ovarian reserve, DOR)是女性生殖能力由旺盛至衰老的一个重要转折阶段。提高对卵巢储备功能的认识,早期发现DOR,并针对性地进行临床干预,以减少由于生殖衰老所引发的生育力下降、月经异常与激素缺乏等相关问题,是近年来关注的热点。随着对女性生殖衰老认识的不断深入以及对各种临床检测方法的实践评估与新兴治疗措施的探索,关于DOR的临床处置也不断更新。为此,本文将紧扣生殖衰老主题,围绕DOR相关诊断与治疗进展展开综述。

关键词：卵巢储备功能减退生殖衰老女性生育力

基于MOOSE平台液态金属冷却快堆燃料性能分析程序开发

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原子能科学技术 2024年第3期58卷 539-548页

作者：邵世豪刘宙宇许晓北宗育凡曹良志吴宏春西安交通大学核科学与技术学院陕西西安710049

液态金属冷却快堆对于我国核能创新发展具有非常重要的战略意义,开发适用其的燃料性能分析程序对于快堆的设计与安全分析具有重要意义。本文基于多物理耦合平台MOOSE,开发了燃料性能分析程序LoongCALF,程序面向金属冷却快堆燃料元件。... 详细信息

液态金属冷却快堆对于我国核能创新发展具有非常重要的战略意义,开发适用其的燃料性能分析程序对于快堆的设计与安全分析具有重要意义。本文基于多物理耦合平台MOOSE,开发了燃料性能分析程序LoongCALF,程序面向金属冷却快堆燃料元件。程序采用有限元方法和JFNK方法,能够求解核反应堆燃料的热-力耦合方程,从而得到温度、应力、应变及裂变气体释放等物理量在空间上的分布及随时间的变化。程序采用模块化设计,适用于芯块材料为UO 2和MOX、包壳材料为1515Ti和HT-9的燃料元件。为验证程序的准确性,设计了两个燃料元件算例,并使用LoongCALF程序与中国原子能科学研究院Fiber-Oxide程序对算例进行对比计算。结果表明,LoongCALF程序能够准确模拟液态金属冷却快堆稳态工况条件下燃料元件内部的燃料行为与关键参数演化。

关键词：液态金属冷却快堆 MOOSE 有限元方法燃料性能分析

Ink and Brush Are the Languange of Landscape Painting

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China Book International 2024年第3期 84-87页

作者： xu Qinsong National Committee of the Chinese People's Political Consultative Conference Calligraphy and Painting Office

This book is a collection of dialogues between xu Qinsong and nine art historians and art critics,namely Shao Dazhen,Lang Shaojun,xue Yongnian,Pan Gongkai,Yi Ying,Zhu liangzhi,Yin Jinan,Yu Hui,and Wu Weishan。

关键词： dialogue collection Jinan

浮针调颈联合调神调衡针治疗心脾两虚型失眠38例

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光明中医 2024年第4期39卷 736-739页

作者：王彦璎张振营马良志张蕊徐慧颖高楠(指导) 山东中医药大学针灸推拿学院山东济南250014 山东中医药大学附属日照市中医医院针灸科山东日照276826

目的观察浮针调颈联合调神调衡针治疗心脾两虚型失眠的临床疗效。方法选取日照市中医院2021年11月—2022年6月收治的心脾两虚型失眠患者38例。治疗3周,以匹兹堡睡眠质量指数(PSQI)量表进行评估,进行自身对照研究。结果治疗后,总有效率为... 详细信息

目的观察浮针调颈联合调神调衡针治疗心脾两虚型失眠的临床疗效。方法选取日照市中医院2021年11月—2022年6月收治的心脾两虚型失眠患者38例。治疗3周,以匹兹堡睡眠质量指数(PSQI)量表进行评估,进行自身对照研究。结果治疗后,总有效率为97.37%(37/38),愈显率89.47%(34/38);随访时,总有效率为97.37%(37/38),愈显率73.68%(28/38)。结论浮针调颈联合调神调衡针可明显改善心脾两虚型失眠患者的睡眠状况,具有良好的临床疗效。

关键词：失眠心脾两虚证浮针调神调衡针

Comparison of survival prediction values of different scoring models for patients undergoing transjugular intrahepatic portal shunt:A multicenter retrospective study

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Portal Hypertension & Cirrhosis 2022年第2期1卷 107-115页

作者： Yuyi Liu Zhiyong Mu Wei Xiong Hong Hu Aimin Liu xuan An Yuqiang xu Haohong Yu Jinneng Wang Jun Wang Xiao Xiao Dongfeng Chen liangzhi Wen Department of Gastroenterology Daping HospitalArmy Medical UniversityChongqingChina Department of Gastroenterology The Third Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Interventional Radiology Nanchong Central HospitalThe Second Clinical Medical CollegeThe North Sichuan Medical College(University)NanchongSichuanChina Department of Gastroenterology Fuling Central Hospital Affiliated to Chongqing UniversityChongqingChina Department of Hepatology Chongqing University Three Gorges HospitalChongqingChina Department of Gastroenterology Leshan People's Hospital of SichuanLeshanSichuanChina Department of Gastroenterology Qianjiang Central Hospital of ChongqingChongqingChina Department of Gastroenterology The Ninth People's Hospital of ChongqingChongqingChina

Aim:The aim of this study is to compare the prognostic values of the Child–Pugh,integrated model for end‐stage liver disease(iMELD),albumin–bilirubin(ALBI),and Freiburg index of postsurvival(FIPS)scores in patients undergoing transjugular intrahepatic portosystemic shunt(TIPS).Methods:We conducted a multicenter retrospective study including patients who underwent TIPS by collecting data from several hospitals in southwest China between January 2014 and February 2021.We compared the performance of different scoring models for survival prediction in these patients.The performance of each scoring model was assessed via area under the receiver‐operating characteristic(AUROC)curve analysis.Results:The study included 378 TIPS patients(268 men,110 women;median age 52[interquartile range,45–60]years).Age;cirrhosis etiology;ascites severity;albumin levels;international normalized ratio;total bilirubin levels;sodium levels;and Child–Pugh,iMELD,ALBI,and FIPS scores were significant prognostic factors in cirrhotic patients who underwent TIPS.The Child–Pugh,iMELD,ALBI,and FIPS scores were all independent predictors of survival in TIPS patients.Survival analysis showed that all scoring models effectively stratified the prognostic risk of these patients.The Child–Pugh score was the best predictor of postoperative survival,followed by the ALBI and FIPS scores.The iMELD score was the worst predictor.The Child–Pugh,iMELD,ALBI,and FIPS scores predicted the 1‐year postoperative survival,with AUROC values of 0.832,0.677,0.761,and 0.745,respectively,and the 3‐year postoperative survival,with AUROC values of 0.710,0.668,0.721,and 0.658,respectively.The calibration curve showed that the Child–Pugh,ALBI,and FIPS models performed well in predicting 1‐and 3‐year survival,whereas the iMELD model was a poor predictor.Conclusions:The four scoring models can predict survival in cirrhotic patients after TIPS and can effectively stratify prognostic risk.The Child–Pugh score may be more suitable for predicting survival after TIPS in patients with

关键词： albumin bilirubin end‐stage liver disease liver cirrhosis portosystemic shunt transjugular intrahepatic

NECP-Atlas中屏蔽数据库制作模块的开发与验证

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核动力工程 2022年第3期43卷 15-20页

作者：祖铁军徐宁曹良志吴宏春西安交通大学核科学与技术学院西安710049

在核数据处理程序NECP-Atlas中开发了屏蔽数据库制作模块Shield_calc,该模块先利用NECPAtlas产生问题无关的MATXS格式细群中子、光子截面数据库;然后采用超细群方法、Bondarenko迭代方法进行共振自屏计算,获得有效自屏截面;最后,基于1... 详细信息

在核数据处理程序NECP-Atlas中开发了屏蔽数据库制作模块Shield_calc,该模块先利用NECPAtlas产生问题无关的MATXS格式细群中子、光子截面数据库;然后采用超细群方法、Bondarenko迭代方法进行共振自屏计算,获得有效自屏截面;最后,基于1维反应堆模型采用NECP-Hydra进行输运计算获得应用堆型的典型权重谱,将细群屏蔽数据库归并为宽群屏蔽数据库NECL-SHILED。利用Shield_calc模块,基于与BUGLE-B7相同的评价核数据库ENDF/B-Ⅶ.0,制作了47群中子、20群光子的NECL-SHILED,并与BUGLE-B7进行了对比,数值结果显示NECL-SHILD与BUGLE-B7计算结果吻合较好,验证了Shield_calc模块具有较高的精度。

关键词：屏蔽数据库核数据处理 BUGLE-B7 NECP-Atlas NECL-SHILED