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被害人教义学的理论基础、解释方法与内在逻辑

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南大法学 2024年第1期 167-182页

作者：徐前王良顺中南财经政法大学刑事司法学院

被害人教义学自其问世以来一直都存在着争议与质疑。批评者主要从三个方面否定被害人教义学的正当性:被害人教义学曲解了辅助性原则的基本内涵、目的论限缩方法逾越了刑法规范核心语义范畴、被害人教义学实质上侵占了被害人的自由空间... 详细信息

被害人教义学自其问世以来一直都存在着争议与质疑。批评者主要从三个方面否定被害人教义学的正当性:被害人教义学曲解了辅助性原则的基本内涵、目的论限缩方法逾越了刑法规范核心语义范畴、被害人教义学实质上侵占了被害人的自由空间。事实上,将辅助性原则的内涵理解为包括被害人自我保护可能性在内的扩张性概念,既是从社会契约论以及刑罚权历史演变中得出的结果,也是当前预防刑法背景下坚持自由主义立场的必然选择。目的论限缩原则的正当性源于对立法目的的忠实维护,被害人教义学作为目的论限缩方法,通过充分考虑刑法具体规范目的,并以犯罪行为的应罚性和需罚性为判断标准,能够实现对犯罪构成要件的合理限缩。被害人教义学有其特定的适用场域,家长主义并不排斥公民自我保护,因而并未侵占被害人的自由空间;被害人教义学在尊重法益主体处分自由的基础上提升了其自治能力,促进了法益主体自由的实现。

关键词：被害人教义学辅助性原则目的论限缩自由处分自治能力

AB分型联合Arima分型对食管表浅鳞状细胞癌浸润深度判定的价值

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中华消化内镜杂志 2024年第5期41卷 372-378页

作者：陆宏娜许丰张学松王瑶王耀辉邓茜郭雯莹翁烃张良舜凌亭生宁波市医疗中心李惠利医院消化内科宁波315041 江苏省中医院消化内镜中心南京230004 江苏省中医院病理科南京230004 宁波市临床病理诊断中心宁波315021

目的探讨AB分型联合Arima分型预测浅表食管鳞状细胞癌(superficial esophageal squamous cell carcinomas,SESCC)浸润深度的临床价值。方法2017年7月至2022年12月期间在宁波市医疗中心李惠利医院及江苏省中医院接受内镜黏膜下剥离术治... 详细信息

目的探讨AB分型联合Arima分型预测浅表食管鳞状细胞癌(superficial esophageal squamous cell carcinomas,SESCC)浸润深度的临床价值。方法2017年7月至2022年12月期间在宁波市医疗中心李惠利医院及江苏省中医院接受内镜黏膜下剥离术治疗且鳞状上皮乳头内毛细血管袢(intra-epithelial papillary capillary loops,IPCL)AB分型为B2型的患者(76处SESCC病变)纳入回顾性研究,根据Arima分型规则对IPCL进行二次分类,以病理判定的浸润深度为金标准,分析B2型联合Arima分型对SESCC浸润深度预测的敏感度、特异度、阳性预测值和阴性预测值。结果76处病变中,31处(40.79%)浸润黏膜肌层(T1a-MM)或黏膜下层浅层(T1b-SM1),B2型IPCL预测T1a-MM/T1b-SM1 SESCC的敏感度、特异度、阳性预测值、阴性预测值、准确率分别为70.45%(31/44)、79.64%(176/221)、40.79%(31/76)、93.12%(176/189)、78.11%(207/265)。对病变的IPCL进行Arima分型后,B2-4ML型、B2-AVA-4M型IPCL预测T1a-MM/T1b-SM1 SESCC的敏感度、特异度、阳性预测值、阴性预测值、准确率分别为61.36%(27/44)、88.24%(195/221)、50.94%(27/53)、91.98%(195/212)、83.77%(222/265)和38.64%(17/44)、94.57%(209/221)、58.62%(17/29)、88.56%(209/236)、85.28%(226/265)。结论B2型IPCL联合Arima分型可以提高对T1a-MM/T1b-SM1 SESCC的诊断准确性。

关键词：食管鳞状细胞癌放大内镜 AB分型 Arima分型 B2型黏膜肌层黏膜下浅层

Effect of processing parameters on the microstructure and mechanical properties of TiAl/Ti_(2)AlNb laminated composites

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Journal of Materials Science & Technology 2022年第14期109卷 228-244页

作者： Donghai Li Binbin Wang liangshun Luo xuewen Li Yanjin xu BinQiang Li Diween Hawezy Liang Wang Yanqing Su Jingjie Guo Hengzhi Fu National Key Laboratory for Precision Hot Processing of Metals School of Materials Science&EngineeringHarbin Institute of TechnologyHarbin 150001China Key Laboratory for Lightweight Materials Nanjing Tech UniversityNanjing 211816China AVIC Manufacturing Technology Institute Beijing 100024China Materials Research Centre College of EngineeringSwansea UniversityBay CampusSwansea SA18ENUK

In order to improve the intrinsic brittleness of TiAl alloys,Ti_(2)AlNb alloys with outstanding ductility and toughness at room temperature,and good high-temperature performance are competitive candidates in constructing the TiAl-based laminated composites.In this work,TiAl/Ti_(2)AlNb laminated composites are successfully synthesized by vacuum hot pressing combined with the foil-foil(sheet)metallurgy.Under the pressure of 65 MPa,different holding time and temperature of hot pressing are tried and the optimized fabrication parameter is acquired as 1050℃/120 min/65 MPa.Along with the changes of processing parameters,the defect,microstructure,interface,phase transformation and the corresponding mechanical properties are detailly discussed.The results show that the TiAl/Ti_(2)AlNb laminated composite fabricated at 1050℃ for 2 h achieves a good metallurgical interface bonding.The corresponding interface microstructure is composed of region I and region II.The region I consists of O,α_(2)and B2/βphase,and region II is made up ofα2.Subsequently,the tensile tests indicate that the composite synthesized at 1050℃ for 2 h possesses a maximum strength of 812 MPa and a total elongation of 1.31%at room temperature,and a strength of 539.71 MPa and the highest total elongation of 10.34%at 750℃.The well synergistic deformation ability between the interface and the two base alloys endows the composite an excellent tensile performance.Moreover,the composite processed at 1050℃ for 2 h behaves the best fracture toughness in both arrester orientation and divider orientation with the value of 32.6 MPa.m^(1/2)and 30.1 MPa.m^(1/2),respectively.The Ti_(2)AlNb alloy in the laminated structure effectively release the stress around the crack tip and plays a role in toughening.Further,crack deflection,crack bridging,crack blunting and fragmentation also make contributions to enhance the fracture toughness of the laminated composites.

关键词： TiAl/Ti_(2)AlNb laminated composite Hot pressing Processing parameters Microstructure Mechanical properties Fracture

短链脂肪酸对胰腺星状细胞氧化应激和活化的调控作用

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中华胰腺病杂志 2024年第3期24卷 210-215页

作者：陆宏娜许丰张秋波翁烃张良舜李先鹏宁波大学附属李惠利医院消化内科宁波315103 上海交通大学附属瑞金医院腹部器官移植中心上海200025

目的探讨短链脂肪酸(SCFA)对缺氧诱导的胰腺星状细胞(PSCs)氧化应激和活化的调控作用。方法常氧及缺氧培养PSCs建立常氧组和缺氧组,SCFA工作液(10 mmol/L乙酸钠、0.5 mmol/L丙酸钠及0.5 mmol/L丁酸钠)和生理盐水分别预处理PSCs后进行缺... 详细信息

目的探讨短链脂肪酸(SCFA)对缺氧诱导的胰腺星状细胞(PSCs)氧化应激和活化的调控作用。方法常氧及缺氧培养PSCs建立常氧组和缺氧组,SCFA工作液(10 mmol/L乙酸钠、0.5 mmol/L丙酸钠及0.5 mmol/L丁酸钠)和生理盐水分别预处理PSCs后进行缺氧培养建立缺氧SCFA组和缺氧对照组。采用CCK-8法检测各组PSCs生长活力,采用DCFH-DA荧光探针法检测PSCs活性氧(ROS)的相对水平,JC-1荧光探针检测线粒体膜电位的变化,蛋白质免疫印迹法检测PSCs周期相关蛋白cyclin A和cyclin D、缺氧标志蛋白HIF1α、活化标志蛋白α-SMA及抗氧化蛋白NRF2和HO-1的表达。结果缺氧组PSCs在培养48 h时的相对活力显著高于常氧组(1.23±0.05比0.99±0.04),而缺氧SCFA组在培养36 h和48 h时的相对活力均显著低于缺氧对照组(0.69±0.01比0.86±0.03,0.86±0.02比1.25±0.05)。缺氧组ROS相对水平显著高于常氧组(1.74±0.11比1.00±0.10),而缺氧SCFA组ROS相对水平显著低于缺氧对照组(1.39±0.14比1.66±0.11)。缺氧组JC-1聚合体的荧光信号明显高于常氧组(1.36±0.05比1.00±0.11),而缺氧SCFA组JC-1聚合体的荧光信号明显低于缺氧对照组(1.11±0.03比1.32±0.06)。缺氧组cyclin A、cyclin D、HIF1α、α-SMA、NRF2和HO-1表达量显著高于常氧组(1.19±0.01比0.63±0.02,0.93±0.02比0.83±0.03,1.18±0.07比0.41±0.02,1.19±0.14比0.66±0.04,1.22±0.11比0.61±0.04,1.28±0.12比0.68±0.02),而缺氧SCFA组cyclin A、cyclin D、α-SMA、NRF2和HO-1的表达量显著低于缺氧对照组(0.79±0.04比1.15±0.03,0.88±0.01比0.95±0.03,0.87±0.01比1.18±0.05,0.84±0.01比1.22±0.04,0.92±0.02比1.27±0.06)。以上差异均有统计学意义(P值均<0.05)。结论SCFA显著改善缺氧状态下PSCs的氧化应激状态,维持线粒体膜电位的稳定,抑制缺氧诱导的PSCs活化。

关键词：脂肪酸类,挥发性胰腺星形细胞低氧氧化性应激活化

The corrosion behavior of Ti-6Al-3Nb-2Zr-1Mo alloy:Effects of HCl concentration and temperature

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Journal of Materials Science & Technology 2021年第15期74卷 143-154页

作者： Baoxian Su Binbin Wang liangshun Luo Liang Wang Yanqing Su Fuxin Wang Yanjin xu Baoshuai Han Haiguang Huang Jingjie Guo Hengzhi Fu National Key Laboratory for Precision Hot Processing of Metals School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin.150001China Department of Materials Application Research AVIC Manufacturing Technology InstituteBeijing100024China School of Materials Science and Engineering.Kunming University of Science and Technology Kunming650093China Yunnan Titanium Industry Co. Ltd.Chuxiong651209China

Investigation about the corrosion behavior of Ti alloys in different ambient environment is of great significance for their practical application.Herein,we systematically investigate the corrosion behavior of a newfound Ti-6 Al-3 Nb-2 Zr-1 Mo(Ti80)alloy in hydrochloric acid(HCl)ranging from 1.37 to 7 M,and temperature ranging from 25 to 55℃,by means of electrochemical measurements,static immersion tests and surface analysis.Results manifest that increasing either HCl concentration or temperature can accelerate the corrosion of Ti80 alloy via promoting the breakdown of native protective oxide film and then further facilitating the active dissolution of Ti80 matrix.According to potentiodynamic polarization curves,Ti80 alloy displays a spontaneous passive behavior in 1.37 M HCl at 25℃,compared to a typical active-passive behavior under the other conditions.As indicated by cathodic Tafel slope,the rate determining step for cathodic hydrogen evolution reaction is likely the discharge reaction step.The apparent activation energies obtained from corrosion current density and maximum anodic current density for Ti80 alloy in 5 M HCl solution are 62.4 and 55.6 kJ mol-1,respectively,which signifies that the rate determining step in the corrosion process of Ti80 alloy is mainly determined by surface-chemical reaction rather than diffusion.Besides,the electrochemical impedance spectroscopy tests demonstrate that a stable and compact oxide film exists in 1.37 M HCl at 25℃,whereas a porous corrosion product film forms under the other conditions.Overall,the critical HCl concentration at which Ti80 alloy can maintain passivation at 25℃can be determined as a value between 1.37 and 3 M.Furthermore,the corroded surface morphology characterization reveals that equiaxedαphase is more susceptible to corrosion compared to intergranularβphase due to a lower content of Nb,Mo,and Zr in the former.

关键词： Titanium alloys Electrochemical techniques Weight loss Corrosion behavior

Numerical Simulation of the Churning Power Losses in the Automotive Hypoid Gear Reducer

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Journal of Applied Mathematics and Physics 2018年第9期6卷 1951-1956页

作者： Lin Zou Mingya Du Bing Jia Jinli xu liangshun Ren School of Mechanical and Electronic Engineering Wuhan University of Technology Wuhan China

Improving vehicle transmission efficiency and reducing vehicle fuel consumption is currently one of the main objectives in the automotive field. Reducing gear churning power losses has significant influence on the decreasing vehicle fuel consumption. Based on the two phase flow theory, a 2D two-phase model of the simplified hypoid gear is established to predict the churning losses in different conditions, the VOF method is introduced to track the volume fraction of the free surface, a standard k-ε model is also built to calculate complex turbulence. The oil distributions at the different rotational speed, the different immersion depth and the different viscosity as well as the churning losses of the hypoid gear are obtained and discussed in detail. In general, the churning power losses increase with the increase of the speed, the immersion depth and the viscosity, while the rotational speed shows the greatest influence on the churning losses. It is hoped that this investigation will be helpful in automotive industry applications.

关键词： Churning Power Loss Two Phases Flow VOF Method Hypoid Gear

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基于板簧变形的传动轴布置与复合形法优化

机械设计与研究 2016年第5期32卷 175-178,187页

作者：徐劲力万磊任良顺武汉理工大学机电工程学院武汉430070 上汽通用五菱汽车股份有限公司技术中心底盘科广西柳州545000

对变截面板簧和传动轴进行运动分析,建立了基于板簧变形的传动轴数学模型,引入复合形法作为优化算法对传动轴的空间布置进行多目标动态优化,编制程序得到传动轴更佳当量夹角的布置方案。并根据优化后的硬点坐标重构三维模型,进行了当量... 详细信息

对变截面板簧和传动轴进行运动分析,建立了基于板簧变形的传动轴数学模型,引入复合形法作为优化算法对传动轴的空间布置进行多目标动态优化,编制程序得到传动轴更佳当量夹角的布置方案。并根据优化后的硬点坐标重构三维模型,进行了当量夹角仿真模拟和万向节夹角变化规律的分析,并与传统的约束变尺度法(CVM)分析结果进行对比。结果表明,采用基于板簧变形的复合形法优化设计更为合理有效,传动轴当量夹角得到进一步优化,在空载-满载工况条件中,优化后的各万向节夹角范围平稳性得到提升,具有更优工况适应性。

关键词：传动轴板簧变形复合形法当量夹角优化布置

一类带有多重Hardy项和多重强耦合Hardy-Sobolev临界项的椭圆方程组的正解

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中南民族大学学报（自然科学版） 2017年第3期36卷 137-141页

作者：康东升李静徐良顺中南民族大学数学与统计学学院武汉430074

研究了一类带有多重Hardy项和多重强耦合Hardy-Sobolev临界项的椭圆方程组,运用集中紧性原理和山路定理,控制Hardy项系数和强耦合临界项指数,证明了在一定条件下方程组正解的存在性,首次把带有多重Hardy项的临界椭圆方程的相关方法应用... 详细信息

研究了一类带有多重Hardy项和多重强耦合Hardy-Sobolev临界项的椭圆方程组,运用集中紧性原理和山路定理,控制Hardy项系数和强耦合临界项指数,证明了在一定条件下方程组正解的存在性,首次把带有多重Hardy项的临界椭圆方程的相关方法应用到带有多重Hardy项和强耦合Hardy-Sobolev临界项的椭圆方程组.

关键词：多重Hardy项强耦合Hardy-Sobolev临界项集中紧性原理山路定理

Ti/Al固态扩散偶中初生相的选择(英文)

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稀有金属材料与工程 2011年第5期40卷 753-756页

作者：刘江平苏彦庆徐严谨骆良顺郭景杰傅恒志哈尔滨工业大学黑龙江哈尔滨150001

用热压法制备Ti/Al扩散偶,并在525,550,575,600℃进行热处理。结果表明:当Al未完全消耗时,TiAl3是Ti/Al界面处唯一的产物,TiAl3向Al箔一侧长大,Ti箔中没有检测到Al原子的存在。从固溶体的溶解度极限,Al、Ti和TiAl3的晶格失配度,以及新... 详细信息

用热压法制备Ti/Al扩散偶,并在525,550,575,600℃进行热处理。结果表明:当Al未完全消耗时,TiAl3是Ti/Al界面处唯一的产物,TiAl3向Al箔一侧长大,Ti箔中没有检测到Al原子的存在。从固溶体的溶解度极限,Al、Ti和TiAl3的晶格失配度,以及新相形成所增加的界面能3个方面解释TiAl3的首先生成。Ti在Al中的溶解度极限很小,Al(Ti)固溶体很容易生成,以及Al、Ti和TiAl3的密排面错配度很小,促使TiAl3优先形核。在所有Ti-Al化合物中,形成TiAl3所增加的界面能最少,有利于TiAl3优先形核长大。由于动力学的不稳定性,其他Ti-Al化合物的生成与长大受到抑制。

关键词： TiAl3 相选择界面能长大动力学