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Critical role of mitochondrial aldehyde dehydrogenase 2 in acrolein sequestering in rat spinal cord injury

Neural Regeneration Research 2022年第7期17卷 1505-1511页

作者： Seth A.Herr liangqin shi Thomas Gianaris Yucheng Jiao Siyuan Sun Nick Race Scott Shapiro Riyi shi Center for Paralysis Research&Department of Basic Medical Sciences College of Veterinary MedicinePurdue UniversityWest LafayetteINUSA Department of Orthopedics Ruijin HospitalSchool of MedicineShanghai Jiaotong UniversityInstitute of Trauma and OrthopedicsShanghaiChina Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA

Lipid peroxidation-derived aldehydes,such as acrolein,the most reactive aldehyde,have emerged as key culprits in sustaining post-spinal cord injury(SCI)secondary pathologies leading to functional *** evidence suggests that mitochondrial aldehyde dehydrogenase-2(ALDH2),a key oxidoreductase and powerful endogenous anti-aldehyde machinery,is likely important for protecting neurons from aldehydesmediated *** a rat model of spinal cord contusion injury and recently discovered ALDH2 activator(Alda-1),we planned to validate the aldehyde-clearing and neuroprotective role of *** an acute 2 day period post injury,we found that ALDH2 expression was significantly lowered post-SCI,but not so in rats given *** lower enzymatic expression may be linked to heightened acrolein-ALDH2 adduction,which was revealed in co-immunoprecipitation *** have also found that administration of Alda-1 to SCI rats significantly lowered acrolein in the spinal cord,and reduced cyst *** addition,Alda-1 treatment also resulted in significant improvement of motor function and attenuated post-SCI mechanical hypersensitivity up to 28 days ***,ALDH2 was found to play a critical role in in vitro protection of PC12 cells from acrolein *** is expected that the outcome of this study will broaden and enhance anti-aldehyde strategies in combating post-SCI neurodegeneration and potentially bring treatment to millions of SCI *** animal work was approved by Purdue Animal Care and Use Committee(approval No.1111000095)on January 1,2021.

关键词： acrolein acrolein-lysine adduct alda-1 enzymatic catalyst lipid peroxidation mitochondrial aldehyde dehydrogenase-2 neurotrauma oxidative stress reactive aldehydes spinal cord contusion

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Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson’s disease:implication of acrolein and TRPA1

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Translational Neurodegeneration 2021年第2期10卷 151-165页

作者： liangqin shi Yazhou Lin Yucheng Jiao Seth AHerr Jonathan Tang Edmond Rogers Zhengli Chen Riyi shi College of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 610075China Center for Paralysis Research&Department of Basic Medical Sciences College of Veterinary MedicinePurdue UniversityWest LafayetteIN 47907USA Laboratory of Animal Disease Model College of Veterinary MedicineSichuan Agricultural UniversityChengdu 625014China Department of Orthopedics Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityInstitute of Trauma and OrthopedicsShanghai 200025China Weldon School of Biomedical Engineering Purdue University West LafayetteWest LafayetteIN 47907USA

Background:The mechanisms underlying lesions of dopaminergic(DA)neurons,an essential pathology of Parkinson’s disease(PD),are largely unknown,although oxidative stress is recognized as a key *** have previously shown that the pro-oxidative aldehyde acrolein is a critical factor in PD pathology,and that acrolein scavenger hydralazine can reduce the elevated acrolein,mitigate DA neuron death,and alleviate motor deficits in a 6-hydroxydopamine(6-OHDA)rat *** such,we hypothesize that a structurally distinct acrolein scavenger,dimercaprol(DP),can also offer neuroprotection and behavioral ***:DP was used to lower the elevated levels of acrolein in the basal ganglia of 6-OHDA *** acrolein levels and related pathologies were measured by *** and behavioral effects of 6-OHDA injections and DP treatment were examined using the open field test and rotarod *** was assessed using mechanical allodynia,cold hypersensitivity,and plantar ***,the effects of DP were assessed in vitro on SK-N-SH dopaminergic cells exposed to ***:DP reduced acrolein and reversed the upregulation of pain-sensing transient receptor potential ankyrin 1(TRPA1)channels in the substantia nigra,striatum,and *** also mitigated both motor and sensory deficits typical of *** addition,DP lowered acrolein and protected DA-like cells in ***’s ability to upregulate TRPA1 was also verified in vitro using cell ***:These results further elucidated the acrolein-mediated pathogenesis and reinforced the critical role of acrolein in PD while providing strong arguments for anti-acrolein treatments as a novel and feasible strategy to combat neurodegeneration in *** the extensive involvement of acrolein in various nervous system illnesses and beyond,anti-acrolein strategies may have wide applications and broad impacts on human health.

关键词： Oxidative stress Parkinson’s disease Neuroinflammation Acrolein TRPA1 Dimercaprol

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Potassium dehydroandrographolide succinate regulates the MyD88/CDH13 signaling pathway to enhance vascular injuryinduced pathological vascular remodeling

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Chinese Journal of Natural Medicines 2024年第1期22卷 62-74页

作者： GUO Qiru LI Jiali WANG Zheng WU Xiao JIN Zhong ZHU Song LI Hongfei ZHANG Delai HU Wangming XU Huan YANG Lan shi liangqin WANG Yong College of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 610000China Chengdu University of Traditional Chinese Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610000China

Pathological vascular remodeling is a hallmark of various vascular *** research has established the significance of andrographolide in maintaining gastric vascular homeostasis and its pivotal role in modulating endothelial barrier dysfunction,which leads to pathological vascular *** dehydroandrographolide succinate(PDA),a derivative of andrographolide,has been clinically utilized in the treatment of inflammatory diseases precipitated by viral *** study investigates the potential of PDA in regulating pathological vascular *** effect of PDA on vascular remodeling was assessed through the complete ligation of the carotid artery in C57BL/6 *** approaches,including rat aortic primary smooth muscle cell culture,flow cytometry,bromodeoxyuridine(BrdU)incorporation assay,Boyden chamber cell migration assay,spheroid sprouting assay,and Matrigel-based tube formation assay,were employed to evaluate the influence of PDA on the proliferation and motility of smooth muscle cells(SMCs).Molecular docking simulations and co-immunoprecipitation assays were conducted to examine protein *** results revealed that PDA exacerbates vascular injury-induced pathological remodeling,as evidenced by enhanced neointima *** treatment significantly increased the proliferation and migration of *** mechanistic studies disclosed that PDA upregulated myeloid differentiation factor 88(MyD88)expression in SMCs and interacted with T-cadherin(CDH13).This interaction augmented proliferation,migration,and extracellular matrix deposition,culminating in pathological vascular *** findings underscore the critical role of PDA in the regulation of pathological vascular remodeling,mediated through the MyD88/CDH13 signaling pathway.

关键词： Potassium dehydroandrographolide succinate Smooth muscle cell Myeloid differentiation factor 88 T-cadherin Pathological vascular remodeling

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全三维立体解释技术在周返地区的应用

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江汉石油职工大学学报 2019年第4期32卷 1-3页

作者：石良钦中石化江汉油田分公司勘探开发研究院

周矶油田自1989年投入勘探开发以来,构造油藏发现程度高,三小微幅构造圈闭成为滚动评价的重点方向。依托周返高精度开发地震资料,以精细地层对比统层为基础,综合运用相干体、蚂蚁追踪等结合可视化全三维立体解释技术,精细解剖工区构造,... 详细信息

周矶油田自1989年投入勘探开发以来,构造油藏发现程度高,三小微幅构造圈闭成为滚动评价的重点方向。依托周返高精度开发地震资料,以精细地层对比统层为基础,综合运用相干体、蚂蚁追踪等结合可视化全三维立体解释技术,精细解剖工区构造,结构构造特征再认识有明显提升,在潜江组地层精准落实多个“三小”构造圈闭,署的圈闭井位均获得较好效果,有效指导了周返地区油气勘探生产。

关键词：周矶油田高精度全三维立体解释技术油气勘探

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Changes of anti-oxidation enzymes levels in the blood of MPTP-induced PD monkeys

Changes of anti-oxidation enzymes levels in the blood of MPT...

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中国畜牧兽医学会动物解剖及组织胚胎学分会第十九次学术研讨会

作者： Like Li liangqin shi Heng Liu Qihui Luo Chao Huang Wentao Liu Xiaolin Chen Wen Zeng Zhengli Chen Laboratory of Animal Disease Model College of Veterinary MedicineSichuan Agricultural University Key Laboratory of Animal Disease and Human Health of Sichuan Province College of Veterinary MedicineSichuan Agricultural University

Parkinson’s disease(PD) is an age-related neurodegenerative *** its pathogenic mechanism is not understand,oxidative stress is believed to play a key role in this *** order to clarify its influence on PD progress,we performed study in eight rhesus monkeys treated with 1l-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) by intramuscular injection to develop a slow evolution of *** serum superoxide dismutase(SOD),malondialdehyde(MDA),glutathione(GSH),glutathione peroxidase(GPX),and glutathione-s-transferase(GST) were detected by *** whole blood gamma-glutamyl transpeptidase(GGT),gamma-glutamylcysteine synthetase(GCS),glutathione peroxidase 1(GPX-1),and glutathione-s-transferase pi(GST-pi) were measured by *** systemic administration,monkeys gradually developed typical symptoms of PD,while the susceptibility of individual monkeys to the MPTP differed,so the toxin damages of dopaminergic neurons in brain’s substantia nigra were dissimilar,and all the monkeys showed distinct clinical behavioral symptoms which lead to the behavioral scores were big difference in the early *** all the monkeys subsequently developed the major motor symptoms of PD when receiving an additional treatment with *** prolong treated MPTP,monkeys reached a state of stable parkinsonism,and no significant variation was observed *** the contents of GSH,MDA and the expression of GCS,GST-pi kept increasing,while the activity of GPX,GST,SOD and expression of GPX-1 kept decreasing,no change was observed in GGT *** work displayed the antioxidants changes in the blood of MPTP-treated monkeys accompanied with the progresses of PD,and these data suggested a potential identification or diagnosis of PD at different time point through the blood analysis.

关键词： anti-oxidation enzymes MPTP monkey

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我国高速公路改扩建方案研究及运用AHP模糊分析法进行方案优化

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武汉理工大学学报（交通科学与工程版） 2012年第5期36卷 1005-1008,1016页

作者：石良清袁春毅吴剑锋长安大学特殊地区公路工程教育部重点实验室西安710064 交通运输部规划研究院北京100029

通过对国内外现有高速公路改扩建现状及趋势的研究,依据改扩建方案的特点,分别从宏观的路网优化层面与微观的新建、扩容方案比较层面对我国高速公路的改扩建方案进行递进分析.再通过模糊综合评价法的应用,为高速公路改扩建方案的主观决... 详细信息

通过对国内外现有高速公路改扩建现状及趋势的研究,依据改扩建方案的特点,分别从宏观的路网优化层面与微观的新建、扩容方案比较层面对我国高速公路的改扩建方案进行递进分析.再通过模糊综合评价法的应用,为高速公路改扩建方案的主观决策提供量化的客观依据.

关键词：改扩建宏观微观量化

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Joint Feature Encoding and Task Alignment Mechanism for Emotion-Cause Pair Extraction

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Computers, Materials & Continua 2025年第1期82卷 1069-1086页

作者： shi Li Didi Sun College of Computer and Control Engineering Northeast Forestry UniversityHarbin150040China

With the rapid expansion of social media,analyzing emotions and their causes in texts has gained significant ***-cause pair extraction enables the identification of causal relationships between emotions and their triggers within a text,facilitating a deeper understanding of expressed sentiments and their underlying *** comprehension is crucial for making informed strategic decisions in various business and societal ***,recent research approaches employing multi-task learning frameworks for modeling often face challenges such as the inability to simultaneouslymodel extracted features and their interactions,or inconsistencies in label prediction between emotion-cause pair extraction and independent assistant tasks like emotion and cause *** address these issues,this study proposes an emotion-cause pair extraction methodology that incorporates joint feature encoding and task alignment *** model consists of two primary components:First,joint feature encoding simultaneously generates features for emotion-cause pairs and clauses,enhancing feature interactions between emotion clauses,cause clauses,and emotion-cause ***,the task alignment technique is applied to reduce the labeling distance between emotion-cause pair extraction and the two assistant tasks,capturing deep semantic information interactions among *** proposed method is evaluated on a Chinese benchmark corpus using 10-fold cross-validation,assessing key performance metrics such as precision,recall,and F1 *** results demonstrate that the model achieves an F1 score of 76.05%,surpassing the state-of-the-art by 1.03%.The proposed model exhibits significant improvements in emotion-cause pair extraction(ECPE)and cause extraction(CE)compared to existing methods,validating its *** research introduces a novel approach based on joint feature encoding and task alignment mechanisms,contributing to advancements in emotion-c

关键词： Emotion-cause pair extraction interactive information enhancement joint feature encoding label consistency task alignment mechanisms

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Detection and Recognition of Spray Code Numbers on Can Surfaces Based on OCR

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Computers, Materials & Continua 2025年第1期82卷 1109-1128页

作者： Hailong Wang Junchao shi School of Computer Science Zhongyuan University of TechnologyZhengzhou450007China

A two-stage algorithm based on deep learning for the detection and recognition of can bottom spray codes and numbers is proposed to address the problems of small character areas and fast production line speeds in can bottom spray code number *** the coding number detection stage,Differentiable Binarization Network is used as the backbone network,combined with the Attention and Dilation Convolutions Path Aggregation Network feature fusion structure to enhance the model detection *** terms of text recognition,using the Scene Visual Text Recognition coding number recognition network for end-to-end training can alleviate the problem of coding recognition errors caused by image color distortion due to variations in lighting and background *** addition,model pruning and quantization are used to reduce the number ofmodel parameters to meet deployment requirements in resource-constrained environments.A comparative experiment was conducted using the dataset of tank bottom spray code numbers collected on-site,and a transfer experiment was conducted using the dataset of packaging box production *** experimental results show that the algorithm proposed in this study can effectively locate the coding of cans at different positions on the roller conveyor,and can accurately identify the coding numbers at high production line *** Hmean value of the coding number detection is 97.32%,and the accuracy of the coding number recognition is 98.21%.This verifies that the algorithm proposed in this paper has high accuracy in coding number detection and recognition.

关键词： Can coding recognition differentiable binarization network scene visual text recognition model pruning and quantification transport model

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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning shi Lv Qian Wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

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Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent LiCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie shi Changle Hou Jingjing Dong Dong Chen Jianzhong Li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(LIBs),properly recycling spent LIBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of LIB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to LiCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/LiCoO_(2)mass ratio of 3:1,the leaching efficiency of Li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in LiCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of LIB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

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