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Adult Neuromuscular Choristoma in the Intraconal Region of the Orbital Muscle: A Case Report

Journal of Biosciences and Medicines 2024年第11期12卷 206-212页

作者： Xuecheng Ge liangping luo Department of Radiology First Affiliated Hospital of Jinan University Guangzhou China The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation Department of Radiology The First Affiliated Hospital of Jinan University Guangzhou China Department of Radiology and Nuclear Medicine The Fifth Affiliated Hospital of Jinan University (Shenhe Peoples Hospital) Heyuan China

Background: Neuromuscular choristoma is a rare benign peripheral neuropathy composed of ectopic mature muscle fibers and nerve bundles, usually involving large nerve roots or trunks, such as brachial plexus and sciatic nerve. NMC usually occurs in childhood, and some cases are congenital. Here, we report a case of adult orbital intraconal NMC. The resected specimens were fish-like and tough. Histological pathology suggested that the specimen was composed of mature skeletal muscle tissue interspersed with peripheral nerve bundles. Histopathological examination revealed that the left orbital mass was composed of mature skeletal muscle tissue interspersed with surrounding nerve fascicles. Immunohistochemistry: S-100 protein was positive. In general, postoperative histopathological examination ultimately determined the diagnosis of NMC in the intraconal region of the orbital muscle. Case Presentation: A 51-year-old female patient was admitted to the hospital due to periocular pain for 2 weeks. Orbital CT scan showed an irregular soft tissue density in the left orbital muscle cone area, and the boundary between the local and the left lateral rectus muscle was unclear. Magnetic resonance imaging showed that there was an oval abnormal signal in the posterior lateral space of the left eyeball, with a clear edge and a size of about 22 mm × 8 mm. The boundary between the local area and the left lateral rectus muscle was unclear, and the optic nerve was compressed to the right side. The T1 WI showed low signal, T2-FS showed high and low mixed signal, and the enhanced scan showed continuous obvious enhancement. Eventually, the patient underwent surgical resection of the lesion. Conclusions: NMC is a rare benign peripheral neuropathy, especially NMC in the orbital muscle cone. There is no specificity in clinical and imaging examinations. Accurate diagnosis before surgical resection is very challenging for clinicians and radiologists. Importantly, we can differentiate orbital NMC

关键词： Neuromuscular Choristoma Desmoid-Type Fibromatosis Orbit Case Report

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Fractal description and quantitative analysis of normal brain development in infants

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Neural Regeneration Research 2011年第34期6卷 2656-2660页

作者： Hehong Li liangping luo Li Huang Department of Radiology First Affiliated Hospital Jinan University Guangzhou 510632 Guangdong Province China Guangzhou Women and Children＇s Medical Center Guangzhou 510623 Guangdong Province China

We examined the fractal pattern of cerebral computerized tomography images in 158 normal infants aged 0 3 years, based on the quantitative analysis of chaotic theory. Results showed that the fractal dimension of cerebral computerized tomography images in normal infants remained stable from 1.86-1.91. The normal distribution range in the neonatal period, 1-2 months old infants, 1-2 year old infants, and of 2-3 year old infants was 1.88 1.90 （mean： 1.891 3 ± 0.006 4）, 1.89-1.90 （mean： 1.892 7 ±0.004 5）, 1.86-1.90 （mean： 1.886 3 ± 0.008 5）, and 1.88-1.91 （mean： 1.895 8±0.008 3）, respectively. The spectrum width of the multifractal spectrum （△α） in normal infants was 1.4618. These data suggest that the spectral width parameters of the multifractal spectrum and the fractal dimension criteria in normal children may be useful as a practical specific parameter for assessing the fractal mode of brain development in normal infants.

关键词： fractal infants quantization analysis development neurobiology

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One Case of Right Posterior Mediastinum Intraneural Hemangioma Misdiagnosed as Neurilemmoma

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Journal of Biosciences and Medicines 2024年第7期12卷 30-37页

作者： Xiaoxia Tan Ruifen Zhang liangping luo Department of Medical Imaging Center The First Affiliated Hospital of Jinan University Guangzhou China

Although rare, intraneural hemangiomas should be considered in the differential diagnosis of peripheral nerve lesions. We report on a 59-year-old female patient, who was admitted to the hospital due to the discovery of bilateral breast masses for 3 months, there was no paresthesia or dyskinesia. The patient accidentally found a mass in the right upper mediastinum while completing a plain chest X-ray, initially suspected as a benign neurilemmoma on CT. Surgical resection and pathological analysis confirmed an intraneural hemangioma. Unexpectedly, the patient developed new-onset right upper limb numbness and paresthesia 3 months post-operatively, probably related to surgical nerve injury. This case underscores the importance of maintaining a broad differential for mediastinal masses, and the potential for iatrogenic neurological complications when managing these rare, yet vascular lesions.

关键词： Intraneural Hemangioma Mediastinal Tumors Spinal Nerve

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Primary Cutaneous Apocrine Carcinoma of the Neck Involving the Parotid Gland: A Case Report and Review of the Literature

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Journal of Biosciences and Medicines 2023年第12期11卷 135-141页

作者： Ruifen Zhang Lingtao Zhang liangping luo Department of Medical Imaging Center The First Affiliated Hospital of Jinan University Guangzhou China

Introduction: Primary cutaneous apocrine carcinoma (PCAC) is a rare skin malignant tumor that originates from areas with a high concentration of apocrine glands. The incidence of PCAC in the neck is relatively low. The age of onset in PCAC ranges from 5 to 70 years old. Clinically, PCAC typically shows up as painless nodules or lumps. In immunohistochemistry, positive expression of CK-7, GCDFP-15, AR, and myoepithelial markers are helpful in the diagnosis of PCAC. This case report pertains to a 59-year-old male of Asian descent. Five years ago, a painless mass was discovered behind his right ear, which grew slowly. This patient was identified as PCAC based on clinical symptoms, pathology, immunohistochemistry, and imaging characteristics. PCAC involved the parotid gland in this case;it is easy to be misdiagnosed as a primary malignant tumor of the parotid gland on imaging. Furthermore, a thorough set of clinical, imaging, pathological, and immunohistochemical examinations must be performed to make a diagnosis because it is challenging to differentiate PCAC from metastatic breast carcinoma. Conclusion: A well-developed multidisciplinary examination is essential because PCAC can be challenging to diagnose and differentiate.

关键词： Primary Cutaneous Apocrine Carcinoma Head and Neck Tumors Diagnostic Imaging

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A multifunctional nanotheranostic agent potentiates erlotinib to EGFR wild-type non-small cell lung cancer

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Bioactive Materials 2022年第7期7卷 312-323页

作者： Duo Wang Jun Zhou Weimin Fang Cuiqing Huang Zerong Chen Meng Fan Ming-Rong Zhang Zeyu Xiao Kuan Hu liangping luo Medical Imaging Center The First Affiliated Hospital of Jinan UniversityGuangzhou510632PR China The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation Jinan UniversityGuangzhou510632PR China Department of Advanced Nuclear Medicine Sciences Institute of Quantum Medical ScienceNational Institutes for Quantum and Radiological Science and TechnologyChiba263-8555Japan Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA02115USA

Epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(TKI),such as Erlotinib,have demonstrated remarkable efficacy in the treatment of non-small cell lung cancer(NSCLC)patients with mutated ***,the efficacy of EGFR-TKIs in wild-type(wt)EGFR tumours has been shown to be *** that can sensitize Erlotinib to EGFR wild-type NSCLC remain ***,we developed a multifunctional superparamagnetic nanotheranostic agent as a novel strategy to potentiate Erlotinib to EGFR-wt *** results demonstrate that the nanoparticles can co-escort Erlotinib and a vascular epithermal growth factor(VEGF)inhibitor,Bevacizumab(Bev),to EGFR-wt *** nanotheranostic agent exhibits remarkable effects as an inhibitor of EGFR-wt tumour ***,Bev normalizes the tumour embedded vessels,further promoting the therapeutic efficacy of *** addition,the tumour engagement of the nanoparticles and the vascular normalization could be tracked by magnetic resonance imaging(MRI).Collectively,our study,for the first time,demonstrated that elaborated nanoparticles could be employed as a robust tool to potentiate Erlotinib to EGFR-wt NSCLC,paving the way for imaging-guided nanotheranostics for refractory NSCLCs expressing EGFR wild-type genes.

关键词： Non-small cell lung cancer EGFR wild-Type Superparamagnetic iron oxide Erlotinib Bevacizumab Tumour vascular normalization

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Oxygen Storing Nanosystem Timely Supply of Oxygen under Near-Infrared Light to Enhance the Radiotherapy of Cancer

Oxygen Storing Nanosystem Timely Supply of Oxygen under Near...

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第十一届全国化学生物学学术会议

作者： Yuanyuan You Dong Zhang liangping luo Tianfeng Chen The Department of Chemistry Jinan University

O-delivering nanosystem can initiatively transport O into tumors to elevate the sensibility of tumor hypoxic cells to ***,oxygen was difficult to store in those nanosystem long time,which would impact the blood circulation time and the accumulation of carried oxygen in tumor result in finally poor effect of tumor ***,we designed a novel nanosystem(O-PIr@Si@PDA) that can act as an oxygen and release oxygen at specific conditions for overcoming hypoxia,which consists of PFOB core for oxygen carrier and functionalized with a novel hypoxia probe(Ir(Ⅲ) complex),subsequently wrapping with silica shell and menthol to seal oxygen,simultaneously coating the polydopamine on the surface of the nanoparticles to realize photothermal *** NIR irradiation,the nanosystem heated up quickly,so that the oxygen dissolved in PFOB released fastly and PFOB swelled with change of the temperature,resulting in the rupture of the silicon shell and the diffusion of oxygen and Ir(Ⅲ) complex.O-PIr@Si@PDA multifunctional nanosystem combined with NIR and X-ray could not only improve the inhibition effect of tumor by activating p53-mediated apoptosis in tumor tissue,and can effectively improve tumor hypoxia,but also effectively improve the safety of radiotherapy as a radiotherapy *** together,this study offers a smart strategy for designing bioinspired tumor-homing nanosystem for precise cancer therapy.

关键词： Hypoxia Oxygen Storing Nanosystem Cancer

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Diagnostic Value of Dual-Energy CT in Differentiating Malignant and Benign Thyroid Nodules: A Systematic Review and Meta-Analysis

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Journal of Biosciences and Medicines 2021年第4期9卷 54-76页

作者： Kunlin Ye Yongyao Kuang Jianye Liang Xi Xu Changzheng Shi Qingqing Cheng Zijie Jiang Ziyun Xiang liangping luo Department of Medical Imaging Center The First Affiliated Hospital of Jinan University Guangzhou China Department of Medical Imaging Longgang District People’s Hospital of Shenzhen Shenzhen China Department of Medical Imaging Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China

Objectives: To evaluate the diagnostic performance of the quantitative iodine parameters, including Iodine Concentration (IC), Normalized Iodine Concentration (NIC), and λHU, in distinguishing malignant and benign thyroid nodules. Methods: Relevant studies were searched from Web of Science, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure database and other complementary sources from inception to May 20, 2020. Study selection, data extraction, quality assessment, and data analyses were performed following the Cochrane standards and the PRISMA-DTA guideline. Results: Eight studies were included (595 patients with 737 thyroid nodules). The pooled sensitivity, specificity and summary diagnostic odds ratio of IC were 79% (95% CI: 69% - 86%), 76% (95% CI: 65% - 84%) and 11 (95% CI: 5 - 27) respectively;those of NIC were 78% (95% CI: 70% - 85%), 80% (95% CI: 74% - 85%) and 15 (95% CI: 9 - 24) respectively;those of λHU were 80% (95% CI: 71% - 87%), 77% (95% CI: 70% - 83%) and 14 (95% CI: 8 - 24) respectively. Conclusion: DECT can be a potential evaluation tool for thyroid nodules. The NIC may be the most sensitive iodine parameter and could be comparable between different DECT machines in thyroid nodule assessment.

关键词： Thyroid Nodules Differential Diagnosis Dual-Energy CT Iodine Concentration Meta-Analysis

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Magnetic resonance imaging in distinguishing malignant from benign pleural disease

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Chinese Medical Journal 2001年第6期114卷 85-89,110页

作者：罗良平陈金城黄力暨南大学医学院第一附属医院医学影像中心广州510630

Objective　To explore the role of magnetic resonance imaging (MRI) in distinguishing malignant from benign pleural ***　All 64 patients were examined with both computed tomography (CT) and MRI. The morphologic features of pleural lesions and MR signal intensity on T1-weighted, T2-weighted and contrast-enhanced T1-weighted images were ***　Mediastinal pleural involvement, circumferential pleural thickening, nodularity, irregularity of pleural contour, and infiltration of the chest wall and/or diaphragm were most suggestive of a malignant cause on CT and MR images. Contrary to what has been reported in the literature, pleural thickness greater than 1?cm either on CT or on MRI did not reveal a significant difference between malignant and benign pleural disease (P>0.05, chi-square test). Using morphologic features in combination with signal intensity features, MRI had a sensitivity of 98% and a specificity of 92% in the detection of pleural malignancy. Conclusions　Compared with those on CT, the morphologic features on MRI allowed a mostly equal and in some cases superior detection and evaluation of the spread of pleural disease. In combination with signal intensity and morphologic features, MRI is very useful in distinguishing malignant from benign pleural disease.

关键词： pleural disease · magnetic resonance imaging · computed tomography

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植物源性碱性成纤维细胞生长因子维持人胚胎干细胞的生长与分化

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中国组织工程研究 2022年第7期26卷 1032-1037页

作者：刘峰彭宇环罗良平吴本清暨南大学附属第一医院医学影像中心广东省广州市510630 中国科学院大学深圳医院(光明)内分泌科广东省深圳市518106 中国科学院大学深圳医院(光明)药学部广东省深圳市518106 中国科学院大学深圳医院(光明)新生儿科广东省深圳市518106

背景:碱性成纤维细胞生长因子是维持人胚胎干细胞长期培养的重要生长因子,提供来源可靠、无动物源性以及低成本的碱性成纤维细胞生长因子产品对维持人胚胎干细胞生长以及规模化制备至关重要。目的:为了排除动物源性或者其他细菌类的潜... 详细信息

背景:碱性成纤维细胞生长因子是维持人胚胎干细胞长期培养的重要生长因子,提供来源可靠、无动物源性以及低成本的碱性成纤维细胞生长因子产品对维持人胚胎干细胞生长以及规模化制备至关重要。目的:为了排除动物源性或者其他细菌类的潜在干扰,该研究评估植物源性碱性成纤维细胞生长因子对人胚胎干细胞生长与分化的影响。方法:以人胚胎干细胞系(H9)作为研究材料,采用免疫荧光染色、流式细胞仪检测、碱性磷酸酶染色、RT-PCR方法比较不同质量浓度植物源性碱性成纤维细胞生长因子维持干细胞特性的能力以及其向外、中、内三胚层分化和胰腺细胞分化的潜能。结果与结论:植物源性碱性成纤维细胞生长因子(4μg/L和0.4μg/L)和常规碱性成纤维细胞生长因子(4μg/L)都能很好地维持人胚胎干细胞的生长和分化能力,提示植物源性碱性成纤维细胞生长因子可以作为有效支持人胚胎干细胞生长和分化的备选产品。

关键词：干细胞人胚胎干细胞碱性成纤维细胞生长因子植物源性分化胰腺细胞

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王道与霸道——鲁迅对封建主义统治术的批判

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重庆教育学院学报 2002年第2期15卷 12-17页

作者：罗良平重庆教育学院中文系重庆400067

宽严相济,恩威并重,王道与霸道结合使用,是中国历代封建专制主义治国治民的主要手段和最大特色。它给人民造成很深的奴性,给中国民族造成根本性的毁伤,使中国人民为此遭受长期深重的苦难,延缓了历吏发展的进程。

关键词：封建专制主义思想统治 "王道" "霸道" 鲁迅封建主义统治术批判

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