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基于肠内营养耐受性评估表的早期肠内营养支持对重症监护病房患者疾病治疗的价值研究

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陕西医学杂志 2024年第5期53卷 637-640页

作者：赵海霞肖婷胡敏余建美李良鹏南通大学附属肿瘤医院江苏南通226361 南京市第一医院胸外科江苏南京210012

目的:探讨基于肠内营养耐受性评估表的早期肠内营养(EEN)支持对重症监护病房(ICU)患者疾病治疗的价值。方法:选取EEN支持治疗的ICU患者100例,根据数字表法随机分为对照组(50例)与观察组(50例)。对照组给予常规EEN治疗,观察组基于肠内营... 详细信息

目的:探讨基于肠内营养耐受性评估表的早期肠内营养(EEN)支持对重症监护病房(ICU)患者疾病治疗的价值。方法:选取EEN支持治疗的ICU患者100例,根据数字表法随机分为对照组(50例)与观察组(50例)。对照组给予常规EEN治疗,观察组基于肠内营养耐受性评估表指导EEN治疗。比较两组喂养不耐受症状发生情况、EEN治疗后第4、7天的热卡达标率、干预前和干预7 d后营养状况指标以及预后指标。结果:观察组喂养不耐受症状总发生率低于对照组(P<0.05)。观察组第7天热卡达标率高于对照组(P<0.05)。干预7 d后,两组白蛋白、总蛋白较干预前升高,且观察组高于对照组(均P<0.05);对照组血红蛋白较干预前降低,且观察组高于对照组(均P<0.05)。观察组总住院时间短于对照组(P<0.05)。结论:基于肠内营养耐受性评估表的EEN支持治疗能够减少ICU患者喂养不耐受症状的发生,改善营养状况,减少患者住院时间,有利于患者预后。

关键词：早期肠内营养肠内营养耐受性评估表重症监护病房喂养不耐受营养状况预后

Regulation of specific abnormal calcium signals in the hippocampal CA1 and primary cortex M1 alleviates the progression of temporal lobe epilepsy

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Neural Regeneration Research 2024年第2期19卷 425-433页

作者： Feng Chen Xi Dong Zhenhuan Wang Tongrui Wu liangpeng Wei Yuanyuan li Kai Zhang Zengguang Ma Chao Tian Jing li Jingyu Zhao Wei Zhang Aili liu Hui Shen Laboratory of Neurobiology School of Biomedical EngineeringTianjin Medical UniversityTianjinChina Institute for Translational Neuroscience the Second Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Institute for Translational Brain Research Fudan UniversityShanghaiChina Department of Radiology the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJiangsu ProvinceChina Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinanChina Department of Anesthesiology Tianjin Medical University General HospitalTianjinChina Department of Orthopaedics Tianjin Medical University General HospitalTianjinChina Tianjin Eye Hospital Tianjin Eye InstituteTianjin Key Lab of Ophthalmology and Visual ScienceTianjinChina Laboratory of Neurobiology School of Basic Medical SciencesTianjin Medical UniversityTianjinChina

Temporal lobe epilepsy is a multifactorial neurological dysfunction syndrome that is refractory,resistant to antiepileptic drugs,and has a high recurrence *** pathogenesis of temporal lobe epilepsy is complex and is not fully *** calcium dynamics have been implicated in temporal lobe ***,the effect of fluctuating calcium activity in CA1 pyramidal neurons on temporal lobe epilepsy is unknown,and no longitudinal studies have investigated calcium activity in pyramidal neurons in the hippocampal CA1 and primary motor cortex M1 of freely moving *** this study,we used a multichannel fiber photometry system to continuously record calcium signals in CA1 and M1 during the temporal lobe epilepsy *** found that calcium signals varied according to the grade of temporal lobe epilepsy *** particular,cortical spreading depression,which has recently been frequently used to represent the continuously and substantially increased calcium signals,was found to correspond to complex and severe behavioral characteristics of temporal lobe epilepsy ranging from gradeⅡto gradeⅤ.However,vigorous calcium oscillations and highly synchronized calcium signals in CA1 and M1 were strongly related to convulsive motor *** inhibition of pyramidal neurons in CA1 significantly attenuated the amplitudes of the calcium signals corresponding to gradeⅠ*** addition,the latency of cortical spreading depression was prolonged,and the above-mentioned abnormal calcium signals in CA1 and M1 were also significantly ***,it was possible to rescue the altered intracellular calcium *** simultaneous analysis of calcium signals and epileptic behaviors,we found that the progression of temporal lobe epilepsy was alleviated when specific calcium signals were reduced,and that the end-point behaviors of temporal lobe epilepsy were *** results indicate that the calcium dynamic between CA1 and M1 may reflect sp

关键词： Ca^(2+) calcium signals chemogenetic methods hippocampus primary motor cortex pyramidal neurons temporal lobe epilepsy

Partial aortic root remodeling for root reconstruction in patients with acute type A dissection

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The Journal of Biomedical Research 2016年第5期30卷 411-418页

作者： Fuhua Huang liangpeng li Wei Qin Cunhua Su liming Wang liqiong Xiao Xin Chen Department of Thoracic and Cardiovascular Surgery Nanjing Hospital affiliated to Nanjing Medical UniversityNanjing Cardiovascular Disease Research Institute

In the present study, we reported our experience with partial aortic root remodeling for root reconstruction in patients with acute type A dissection, which involves in non-coronary sinus and/or the right coronary sinus with just one trimmed Dacron graft. Between February 2001 and May 2010, we performed partial aortic root remodeling in 40 patients, who underwent emergency surgical intervention. The dissected sinuses were excised leaving a 3-5 mm rim of the aortic wall from the attached aortic valve cusps. A short piece （4-5 cm） of collagen coated woven polyester vascular prosthesis was trimmed with one or two ＂tongues＂ to reconstruct the non-coronary sinus and/ or the right coronary sinus, but without using separated patches. Additional procedures were including hemi-arch replacement in 11 patients, and total arch replacement plus stent-elephant trunk in 20 patients. The mean follow-up time was 36.4~3.6 months. In-hospital mortality was only 5.0% （2/40）; furthermore, 3 （8.6%） patients underwent re-operation of the aortic valve and 2 （5.7%） patients died during follow-up. At the end of follow-up, trivial or no aortic regurgitation was found in 33 patients, but mild aortic regurgitation was found in 2 patients. Our data suggest that the early and mid-term results of partial aortic root remodeling were favorable, and it restored valve durability and function. Thus, the use of technique for root reconstruction in patients with acute type A dissection should be vigorously encouraged.

关键词： aortic dissection aortic root remodeling valve function

GRK4 A486V variant contributes to ischemic injury by repressing autophagy after myocardial infarction

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中国循环杂志 2018年第S1期33卷 122-122页

作者： liangpeng li Department of Cardiology The Third Affiliated Hospital of Third Military Medical UniversityChongqingChina

Background G-protein–coupled receptor kinases (GRKs) play important roles in cardiac hypertrophy and heart failure. The role of GRK4 in hypertension has been well demonstrated, but little is known in cardiac ischemic injury. In the present study, we explore if and how GRK4 regulates cardiomyocyte autophagy and influence the prognosis of myocardial infarction (MI).

关键词： GRK4 A486V G-protein-coupled receptor kinases(GRKs) myocardial infarction(MI)

高龄患者冠状动脉旁路移植术后通气时间延长的危险因素和围术期结果分析

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中国胸心血管外科临床杂志 2023年第7期30卷 995-1001页

作者：王梧圩张航陈文李良鹏陈鑫东南大学医学院南京210009 南京医科大学附属南京医院南京市第一医院南京市心血管病医院心胸血管外科南京210006 上海交通大学医学院附属第一人民医院胸外科上海201620

目的研究高龄患者行冠状动脉旁路移植术(coronary artery bypass grafting,CABG)后通气时间延长(prolonged mechanical ventilation,PMV)的危险因素和围术期结果。方法回顾性分析2013年1月—2019年6月在南京市第一医院行CABG高龄冠心病... 详细信息

目的研究高龄患者行冠状动脉旁路移植术(coronary artery bypass grafting,CABG)后通气时间延长(prolonged mechanical ventilation,PMV)的危险因素和围术期结果。方法回顾性分析2013年1月—2019年6月在南京市第一医院行CABG高龄冠心病患者的临床资料。以呼吸机辅助时间是否≥24 h,将纳入患者分为正常拔管组和PMV组,比较两组患者围术期的临床特征,寻找PMV的危险因素。采用1∶1倾向性评分匹配分析(propensity score matching,PSM)平衡组间基线资料差异,分析两组患者围术期结果。结果最终纳入患者956例,其中男586例、女370例,年龄70~94(74.3±3.5)岁。PMV组187例、正常拔管组769例。与正常拔管组相比,PMV组吸烟史、术前合并肾功能损伤、术中输血、主动脉内球囊反搏(intra-aortic balloon pump,IABP)置入患者比例更高,心功能更差,肾小球滤过率和射血分数更低,左心房内径更大,体外循环时间和升主动脉阻断时间更长(P均0.05)。二元多因素logistic回归分析示:女性、吸烟史、慢性阻塞性肺疾病、左心室射血分数≤56.0%、体外循环时间>106.0 min、IABP置入和术中输血是高龄患者PMV的独立危险因素。PSM后正常拔管组和PMV组各146例,PMV组患者的住ICU时间和住院时间更长,胸腔引流量更多(P均0.05)。结论影响高龄患者CABG术后PMV的危险因素众多,临床医师可在此研究基础上,进一步对术前、术中相关因素做精细评估,以期建立更加完整、规范的PMV预测模型,改善此类患者围术期结果。

关键词：高龄患者冠状动脉旁路移植术机械通气拔管危险因素

Surgical stent-graft implantation by open procedure for type B aortic dissection without optimal landing zone

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The Journal of Biomedical Research 2019年第5期33卷 357-362页

作者： Wei Qin Reinard Iskandar liangpeng li Fuhua Huang Xin Chen Department of Thoracic and Cardiovascular Surgery Nanjing First Hospital Nanjing Medical University

Thoracic endovascular aortic repair(TEVAR)has been considered as a first-choice treatment for type B aortic dissection(TBAD).However,some patients that is lack of optimal landing zones(lized a surgical stent-graft implantation in the descending aorta combined with supra-aortic vessels transposition through median sternotomy for these special TBAD *** short-and mid-term results showed that our procedure is a good and alternative therapy for such kind patients.

关键词： Type B aortic dissection open surgery

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新疆下坂地水库运行12年来效益分析

水利规划与设计 2024年第7期 1-5,33页

作者：李江洪良鹏新疆塔里木河流域管理局新疆库尔勒841000

下坂地水利枢纽工程是塔里木河流域近期综合治理规划中唯一的山区水利枢纽工程。为分析下坂地水库建成后运行效益,文章基于水库2010—2022年运行过程,总结了下坂地水库在灌溉、发电、生态、防洪、节水、社会等方面效益。结果表明工程建... 详细信息

下坂地水利枢纽工程是塔里木河流域近期综合治理规划中唯一的山区水利枢纽工程。为分析下坂地水库建成后运行效益,文章基于水库2010—2022年运行过程,总结了下坂地水库在灌溉、发电、生态、防洪、节水、社会等方面效益。结果表明工程建成后效益显著,年均节水4.17亿m^(3),超额完成多年平均向塔里木河补充生态水1.84亿m^(3)(喀群断面)及年均补充2.33亿m^(3)春灌供水任务,灌区灌溉保证率从12.8%提高到76.6%;实现多年平均发电量4.644亿kW·h目标;显著提高了塔什库尔干河的防洪能力,年均拦蓄洪水3.86亿m^(3);为流域全面打赢脱贫攻坚战提供强有力的水利保障。研究成果对于科学运行水库,实现水资源高效利用具有重要的借鉴意义。

关键词：运行效益防洪发电生态下坂地水库

FXR up-regulates fibroblast growth factor 21 expression in C57/BL6 liver

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FXR up-regulates fibroblast growth factor 21 expression in C...

第11届全国脂质与脂蛋白学术会议

作者： Yongchao Wang Jiahe Peng liangpeng li Yan Zhang Jinyu Dong Xiaohua liu Yu Jiang Department of Biochemistry and Molecular Biolog College of Basic Medical SciencesThird Military Medical University

Objective:Obesity is becoming an important risk factor to human health,and always accompanied with hypercholesteremia、hypertension、hyperlipemia and diabetes and so *** growth factor 21(FGF21) is an new metabolic rugulation *** of researches demonstrated that FGF21 has potent functions on modulating glucose and lipid metabolism,and the ability of resisting diet-induced obesity and lowering the obse animal weight *** X receptor(FXR),

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降雨天气下人机混驾交通流跟驰特性研究

重庆交通大学学报（自然科学版） 2024年第5期43卷 70-77页

作者：傅成红李高伟高良鹏福建理工大学交通运输学院福建福州350118

为揭示降雨天气下人机混驾交通流跟驰规律,从分析降雨对行车的影响入手,引入路面附着系数、驾驶能见度等参数,改进Gipps安全距离和行车加速度限制,针对不同跟驰模式建立元胞自动机模型,探寻降雨强度、渗透率双重影响的人机混驾交通流跟... 详细信息

为揭示降雨天气下人机混驾交通流跟驰规律,从分析降雨对行车的影响入手,引入路面附着系数、驾驶能见度等参数,改进Gipps安全距离和行车加速度限制,针对不同跟驰模式建立元胞自动机模型,探寻降雨强度、渗透率双重影响的人机混驾交通流跟驰特性。数值仿真结果表明:雨天渗透率与通行能力呈正相关,但当渗透率低于0.25时,智能网联车对混合交通流平均速度、临界密度及通行能力的影响有限;当降雨强度高于0.3 mm/min时,随雨强度增大会加剧智能网联车跟驰退化,显著降低混合交通流的自由速度、临界速度及通行能力;小雨情况下,约0.1的渗透率可弥补降雨造成的通行能力损失;在中雨至大雨的降雨强度区间内,降雨强度每增加0.1 mm/min,相应提高渗透率0.1,路段通行能力可恢复到与晴天纯人工驾驶交通流相当的水平。

关键词：交通运输工程人机混驾交通流跟驰特性降雨强度元胞自动机