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Beneficial effect of arginine vasopressin on hemorrhagic shock through improving the vascular reactivity

Frontiers of Medicine 2008年第3期2卷 248-254页

作者： Tao LI Guangming YANG Jing XU Jiancang liu liangming liu State Key Laboratory of Trauma Burns and Combined Injurythe 2nd Department of Research Institute of SurgeryDaping HospitalThird Military Medical UniversityChongqing 400042China

The vascular reactivity and calcium sensitivity were decreased following hemorrhagic *** vasopressin(AVP)was beneficial to endotoxic,infec-tious/septic and hemorrhagic *** previous studies found that Rho kinase played an important role in the occurrence of calcium desensitization following *** was reported that AVP was with stimulation effect of Rho *** we hypothesized that AVP might have bene-ficial effect on shock via activation of Rho kinase to regu-late the calcium sensitivity and vascular *** shock(40 mmHg for 2 h)Wistar rats in vivo were adopted to observe the effects of small dose of AVP on hemodynamics,24-h survival rate,the pressor effect of norepinephrine(NE)and the contractility of superior mesenteric artery(SMA).Isolated SMAs from hemorrha-gic shock rats were adopted to observe the effects of AVP on vascular reactivity and calcium sensitivity and its rela-tionship to Rho kinase with an isolated organ perfusion *** results show that AVP at the concentration of 0.1 U/kg and 0.4 U/kg significantly improved the hemo-dynamic parameters and the 24-h survival rate of hemor-rhagic shock ***,these dosages of AVP significantly increased the pressor effect of NE and the contractile response of SMA to NE.Y-27632(3 mg/kg),a Rho kinase specific inhibitor,abolished the beneficial effects of *** vitro,the calcium sensitivity and vas-cular reactivity of SMA to calcium and NE were signifi-cantly decreased following hemorrhagic *** at the concentration of 0.5 nmol/L and 5 nmol/L signifi-cantly increased the calcium sensitivity and vascular *** effects of AVP were abolished by Y-27632(10 mmol/L).Taken together,the results suggest that AVP at 0.1 U/kg and 0.4 U/kg is beneficial to hemorrha-gic shock by improving the vascular reactivity,which involves activation of Rho kinase.

关键词： hemorrhagic shock vascular reactivity cal-cium sensitivity Rho kinase arginine vasopressin

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A framework design for the Chinese National Disaster Reduction System of Systems(CNDRSS)

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International Journal of Digital Earth 2014年第1期7卷 68-87页

作者： Deren Li Linglin Zeng Nengcheng Chen Jie Shan liangming liu Yida Fan Wei Li State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanChina School of Remote Sensing and Information Engineering Wuhan UniversityWuhanChina School of Civil Engineering Purdue UniversityWest LafayetteINUSA National Commission for Disaster Reduction BeijingChina

China is one of the most disaster-prone countries in the ***,the disaster prevention and relief mechanism in China is mainly based on single disaster types and is implemented by different ministries and divisions in single administrative ***,the available resources,including data,services,materials,and human resources,cannot be shared and used *** on the idea of an observation system of systems and a business system of systems,this paper presents an integrated framework for a Chinese National Disaster Reduction System of Systems(CNDRSS)to address this *** CNDRSS framework aims to achieve data sharing and collaboration among different disaster-related ministries/institutions by providing one-stop services for all phases of disaster management and linking together existing and planned disaster-related business systems and observation *** key technologies use federated databases and a web service to integrate multiple disaster management systems among different ministries/institutions and a sensor web to integrate airborne,space-borne,and in-situ observations through the web *** event-driven focused-services connecting the various observations,processing,and mapping processes can meet the requirements for complex disasterchain systems.

关键词： federated database sensor web information sharing collaboration focusing service

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AUTO-IDENTIFICATION OF FOREST FIRE-POINTS IN NOAA IMAGES BASED ON NEURAL NETWORK

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Geo-Spatial Information Science 2001年第3期4卷 68-72页

作者： LIANG Yitong HU Jianglin liu liangming XIE Ping Wuhan Central Meteorological Observatory of Hubei Province

Identification of forest fire-points in NOAA images in the basis of monitoring forest fire using NOAA satellite data. Traditional visual interpretation is difficult to settle for auto identification with computer. The artificial neural network technique provides a new means for solving this problem. In this paper, the principles and method of using neural network technique to automatically identify fire-points in NOAA images are discussed and the test in the range of Hubei province is presented. The result of the test shows that the disciplined neural network has collected the character of fire-points and has ability to identify fire-points in NOAA images. Comparing neural network with visual interpretation, the conclusion is drawn that by using neural network the purpose of auto-identification of forest fire-points in NOAA images can be realized with the almost same precision.

关键词： forest fire-point auto-identification neural network NOAA images

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NUMERICAL GEODYNAMIC MODELLING OF COUPLED MECHANO-THERMO-HYDROLOGICAL PROCESSES AND ITS APPLICATION IN PREDICTIVE EXPLORATION IN THE FENGHUANGSHAN ORE FIELD, TONGLING

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Geotectonica et Metallogenia 2005年第2期29卷 164-173页

作者： liu liangming PENG Shenglin ZHANG Yanhua Departinent of Geology Central South University Changsha HN 410083 China CSIRO Division of Exploration and Mining PO Box 1130 Bentley WA 6102 Australia

Mineralisation is the result of the coupled multi-geodynamic processes in the crust. The coupled mechano-thermo-hydrological （MTH） processes are the basic physical processes that govern the location of the hydrothermal mineralization, which can be simulated in the computer by using of the numerical codes, such as FLAC. The numerical modeling results can be used not only to explain the features of existing ore deposits, but also to predict the fhvorable mineralization locations. This paper has summarized the basic equations describing coupled MHT processes in the water-saturated porous rocks, the principles of FLAC, and its application to the MHT processes related to copper mineralization in the Fenghuangshan ore field. We used the FLAC to simulate the syn-deformation cooling and fluid flowing evolution after the intrusion was emplaced and solidified. The modeling results suggest a most prospective exploration area where the subsequent exploration supported the prediction and the test bore hole disclosed the high quality copper ore bodies in the target, demonstrating a positive role of the numerical MTH modeling in facilitating predictive ore discovery.

关键词： mechano-thermo-hydrological coupling, geodynamics numerical modeling, mineral prediction Fenghuangshan

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“十三五”期间国内外创伤急救医学研究的亮点与进展

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中华创伤杂志 2021年第4期37卷 193-198页

作者：刘良明陆军军医大学大坪医院野战外科研究部创伤、烧伤与复合伤国家重点实验室重庆400042

创伤是现代社会的一大公害,全球每年有350万~580万人死于各类创伤。各国政府对创伤的预防、救治高度重视,纷纷成立了相应的应急救援机构和救援队伍,提出了应急救援模式和针对性的防治措施。中国在创伤救治研究方面也取得了显著成绩。笔... 详细信息

创伤是现代社会的一大公害,全球每年有350万~580万人死于各类创伤。各国政府对创伤的预防、救治高度重视,纷纷成立了相应的应急救援机构和救援队伍,提出了应急救援模式和针对性的防治措施。中国在创伤救治研究方面也取得了显著成绩。笔者对“十三五”期间国内外在创伤伤情评估、现场急救、早期救治以及创伤并发症的预警和干预研究方面的进步进行总结,为创伤救治提供参考。

关键词：创伤急救创伤救治伤情评估早期救治现场急救救援队伍应急救援干预研究

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铜官山矿田深部构造的三维计算模拟及其找矿意义

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大地构造与成矿学 2016年第5期40卷 928-938页

作者：刘亮明曹伟中南大学计算地球科学研究中心教育部有色金属成矿预测重点实验室湖南长沙410083

计算模拟已成为研究矿田深部三维构造重要可行手段,对深部找矿具有重要意义。基于铜官山矿田地质背景及所获勘查数据特征,我们采用知识驱动下多级约束和多源数据融合建模方法模拟矿田范围内–2000 m以上主要地质界面。以逆冲推覆导致断... 详细信息

计算模拟已成为研究矿田深部三维构造重要可行手段,对深部找矿具有重要意义。基于铜官山矿田地质背景及所获勘查数据特征,我们采用知识驱动下多级约束和多源数据融合建模方法模拟矿田范围内–2000 m以上主要地质界面。以逆冲推覆导致断展–断弯褶皱理论模式解释大地测深的电阻率数据,推断地质界面位置,在Micromine-GOCAD耦合平台上在多级约束下融合多源的界面位置数据,以离散光滑插值算法和Delaunay三角网剖分法重构主要地质界面,在计算机虚拟空间再现矿田三维构造格架。结果显示:铜官山岩体和天鹅抱蛋岩体三维形态变化复杂,总体上向西倾,向深部岩体规模快速变小。位于铜官山岩体东接触带的铜官山铜矿田深部无找矿潜力,原因是接触带产状变陡,并且是岩体直接与上泥盆统砂岩接触;矿田深部主要构造为走向NE并沿倾向弯曲的逆冲推覆断层;铜官山背斜东翼含矿的中–上石炭统层位向深部倒转后又在–1200 m至–1500 m深度返转成向东南缓倾的正常层位,其底部与逆冲推覆断层重合,是深部找矿的有利靶区。

关键词：深部构造三维模型计算模拟铜官山矿田

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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui liu Xingxing Fang liangming Zhang Bin liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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战创伤休克早期救治研究进展与思考

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陆军军医大学学报 2022年第20期44卷 2025-2029页

作者：刘良明陆军特色医学中心战伤休克与输血研究室创伤、烧伤与复合伤国家重点实验室重庆400042

战创伤休克是战创伤患者早期死亡的重要原因。近年来针对战创伤休克早期救治,国际上提出了很多新的理念和技术,如限制性液体复苏、允许性低压复苏和延长黄金救治时间窗等。基于我军卫勤保障和战伤救治任务,本文重点分析高原高寒和海战... 详细信息

战创伤休克是战创伤患者早期死亡的重要原因。近年来针对战创伤休克早期救治,国际上提出了很多新的理念和技术,如限制性液体复苏、允许性低压复苏和延长黄金救治时间窗等。基于我军卫勤保障和战伤救治任务,本文重点分析高原高寒和海战伤休克的特点,并从线粒体功能保护角度提出的抗休克新措施;探讨脓毒症后肠道和血管屏障功能发生机制及新的保护措施,以及苹果酸新型复苏液体;同时,从新型复苏液体研究、新的救治靶点寻找讨论了战创伤休克救治研究趋势和方向。

关键词：战创伤休克早期救治液体复苏器官功能

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成矿理论的预测能力及其改善途径

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地学前缘 2007年第5期14卷 82-91页

作者：刘亮明中南大学计算地学研究中心湖南长沙410083

成矿理论预测能力决定了成矿理论的价值及其对找矿勘查的贡献。通过分析成矿理论预测能力的历史和现状,探讨了制约成矿理论预测能力的因素,并针对这些因素提出促使成矿理论预测能力提高的途径。成矿系统的复杂性和研究方法上的不足,使... 详细信息

成矿理论预测能力决定了成矿理论的价值及其对找矿勘查的贡献。通过分析成矿理论预测能力的历史和现状,探讨了制约成矿理论预测能力的因素,并针对这些因素提出促使成矿理论预测能力提高的途径。成矿系统的复杂性和研究方法上的不足,使得应用成矿理论进行成矿预测时,既没有能完全把握成矿的本质过程及控制矿体定位的关键因素,也没能弄清勘查区域的地质特征与地质过程,还进行了条件并不充分的不严格推理,从而使得当前成矿理论的预测能力并不高。从历史的变化规律来看,任何一种成矿理论经过一段时间应用后,其预测能力是逐渐下降的;针对某一特定矿床建立的成矿模式的预测能力要比根据某一类矿床的共同特征而建立的成矿理论低得多,区域成矿的理论预测远比矿床(体)预测容易。针对创造和应用成矿理论的不足,提高成矿预测能力的途径主要有:(1)不盲目追求高新技术和新奇理论,扎扎实实做好基础地质工作;(2)发展地球信息探测技术,在更大的范围更准确地探测地球信息;(3)创新地壳构造理论,更加准确推测地壳构造时空演化特征;(4)以整体论方法研究成矿理论系统,揭示成矿作用的复杂性规律;(5)去掉多余假设,使理论的内核尽可能简单化;(6)发展地质动力学计算模拟,通过计算模拟更深入了解成矿及相关地质系统;(7)发展多源信息三维空间集成技术,实现推理计算化。

关键词：成矿理论预测能力成矿动力学计算模拟

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战伤休克早期液体复苏新方法与新策略

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中国实用外科杂志 2006年第12期26卷 913-915页

作者：刘良明第三军医大学大坪医院野战外科研究所第二研究室

随着休克病理生理、发病机制研究的不断深入,以及休克防治上的不断探索,世界各国包括军队针对战伤休克的早期液体复苏,从复苏时机、复苏方法与原则、复苏终点与标准选择上都提出了许多新的观点和概念。本文重点对这方面的进展做一概述。... 详细信息

随着休克病理生理、发病机制研究的不断深入,以及休克防治上的不断探索,世界各国包括军队针对战伤休克的早期液体复苏,从复苏时机、复苏方法与原则、复苏终点与标准选择上都提出了许多新的观点和概念。本文重点对这方面的进展做一概述。[第一段]

关键词：早期液体复苏休克战伤病理生理发病机制复苏方法标准选择复苏终点

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