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Study on frictional behavior of SiC_(f)/SiC composite clad tube clamping condition under nuclear irradiation

Friction 2024年第5期12卷 919-938页

作者： Chenglong XIAO liangliang shen Tianqi ZHU Jianbo TANG Ximing XIE Xinyu FAN Jian XU Zhiying REN School of Mechanical Engineering Zhejiang University of TechnologyHangzhou310023China Engineering Laboratory of Advanced Energy Materials Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China State Key Laboratory of Fine Chemicals Liaoning High-Performance Polymer Engineering Research CenterSchool of Chemical EngineeringDalian University of TechnologyDalian116024China School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou350116China School of Computer Science and Technology Shandong UniversityQingdao266237China Aviation Industry Corporation of China Ltd.Beijing100028China

Silicon carbide fiber reinforced silicon carbide matrix(SiC_(f)/SiC)composite is the key cladding material of nuclear fuel,which determines the safety and reliability of nuclear fuel storage and transportation.The replacement of its storage and transportation scenario needs to be completed by the manipulator,but the application of SiC_(f)/SiC wear,fracture,and nuclear leakage in the snatching process of brittle-flexible-rigid contact in the irradiation environment has been seriously restricted due to unclear understanding of the damage mechanism.Therefore,the effects of irradiation dose and clamping load on the friction characteristics of the contact interface between SiC_(f)/SiC clad tube are studied in this paper,and the effects of irradiation parameters and clamping force on the static friction coefficient of the contact interface between the clad tube and flexible nitrile are obtained.Based on the Greenwood-Williamson tribological model,a numerical model of the shape and structure of the contact micro-convex at the micro-scale of the clamping interface is constructed by introducing the multi-surface integral,and finally verified by experiments.The research results show that there is a unique“Irradiation suppression zone”under the clamping condition of SiC_(f)/SiC cladding tube under the nuclear irradiation environment,and the growth of static friction coefficient slows down until stagnates after irradiation reaches a certain extent(600 kGy),and there will be a decline when the irradiation dose continues to increase,among which the clamping force of 15.2 N within the irradiation interval of 1,000 kGy can meet the safety of nuclear environment operation.The results of this paper can provide an important theoretical basis and application guidance for the safe operation of SiC_(f)/SiC cladding tubes in the storage and transportation clamping process.

关键词： SiC_(f)/SiC Clad tube nuclear irradiation conditions Greenwood-Williamson tribological model multi-surface integral

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Regulation and application of supramolecular gel with circularly polarized luminescence

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Science China Chemistry 2024年第6期67卷 1865-1880页

作者： shen Song Yulong Shi liangliang Zhu Bingbing Yue School of Materials and Chemistry&Institute of Bismuth and Rhenium University of Shanghai for Science and TechnologyShanghai200093China State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai200438China

Supermolecular gel is a three-dimensional network structure assembled by small molecules or polymers in solvents through noncovalent interaction.The emergence of system complexity occurs spontaneously during the molecular self-assembly process.A multitude of chiral molecular self-assembly systems have been engineered,facilitating the achievement of circularly polarized luminescence(CPL)through the amalgamation of chiral entities with fluorophores.Hydrogen bonding,π-πstacking,and noncovalent forces,such as host-guest interactions and Van der Waals'forces,confer upon supramolecular gels the capacity to react to diverse stimuli.Due to the flexibility of supramolecular assembly,the CPL properties of supramolecular gels have rich controllability and can be used in various applications.In this review,we summarized the examples of CPL-active supramolecular gel assembly,and further summarized the assembly environment factors and external stimuli.Furthermore,the versatility of CPL applications in supramolecular gels is demonstrated,ranging from optical devices,information encryption,biosensing and chemical sensing,and other practical applications.In conclusion,the study provides insights into the multicultural factors influencing CPL in supramolecular gels,describes their applications in various domains,and presents future perspectives in the field.

关键词： supramolecular gels circularly polarized luminescence self-assembly chirality stimuli-response

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Preparation of baicalin colon-targeted granules and its intervention effect on ulcerative colitis in rats

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Particuology 2024年第2期85卷 13-21页

作者： Yongqing Huang Yuxin Zhou Yao shen Jin Wang liangliang Zhou Zhenhua Chen Jiangxi Provincial Key Laboratory of Drug Design and Evaluation School of PharmacyJiangxi Science and Technology Normal UniversityNanchang330013China

Baicalin(BA)is a flavonoid extracted from the dried root of Scutellaria baicalensis Georgi with excellent antioxidant and anti-inflammatory biological activities.In this study,Eudragit S100 was used as the colonic target material to prepare BA colonic targeting granules(EBCGs)based on plasticizer dry powder coating technology to improve the targeting transportation performance of BA.In vitro studies showed that EBCGs with pH-sensitive properties were successfully prepared by plasticizer dry powder coating,and in vivo animal imaging studies showed that EBCGs could deliver BA to the colon and inhibit the release of BA in the upper gastrointestinal tract(GIT).In vivo studies showed that EBCGs had good therapeutic effects in colitis,which reduced expression levels of tumor necrosis factor alpha(TNF-α)and interleukin-1β(IL-1β)and increased superoxide dismutase(SOD)activities in the colonic tissues of rats with colitis.In conclusion,Eudragit S100 could be used for the preparation of multi-unit oral colon-targeted formulations by plasticizer dry powder coating technology,and our prepared EBCGs had good colon-targeting properties,which could improve the therapeutic effect and provide a potential application for ulcerative colitis(UC).

关键词： Plasticizer dry powder coating Colon-targeted granulesIn vivo imaging Ulcerative colitis

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Shared mooring systems for offshore floating wind farms: A review

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Energy Reviews 2024年第1期3卷 76-89页

作者： Hang Xu shengjie Rui Kanmin shen liangliang Jiang Haojie Zhang Long Teng Zhejiang Key Laboratory of Offshore Geotechnics and Material College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou310058China Norwegian Geotechnical Institute Sandakerveien 140Oslo0484Norway PowerChina Huadong Engineering Corporation Limited Hangzhou311122China Department of Chemical and Petroleum Engineering The University of CalgaryCalgaryAlbertaCanada

Offshore wind energy,as a form of renewable power,has seen rapid development in recent years.While fixedbottom wind turbines are typically used in water depths less than 50 m,the utilization of floating offshore wind turbines(FOWTs)becomes essential for deeper waters.Secure and effective mooring systems play a crucial role in making FOWTs commercially viable.The concept of a shared mooring system offers an innovative solution for deploying floating wind farms in clusters or arrays,which can reduce overall construction costs for large-scale floating wind farms.It is imperative to optimize the shared mooring arrangement for maximum cost-effectiveness and wind farm stability.However,implementing a shared mooring system introduces complexity to the dynamics of FOWTs,requiring the development of advanced simulation tools to meet modelling requirements.Under the shared mooring arrangement,mooring lines and anchors face more significant challenges,such as chain-seabed interactions,soil cyclic weakening,and anchor out-of-plane loading,which underscore the need for innovative,reliable,and efficient shared anchor designs.This article offers an overview of the current research status on shared mooring systems for floating wind farms,which might serve as a valuable reference for the construction of large-scale floating wind farms worldwide.

关键词： Floating offshore wind turbines Wind farm Shared mooring Shared anchor Renewable energy

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Dry friction damping mechanism of flexible microporous metal rubber based on cell group energy dissipation mechanism

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Friction 2023年第2期11卷 259-279页

作者： liangliang shen Zhiying REN Jian XU Lin PAN Youxi LIN Hongbai BAI School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou 350116China Engineering Research Center for Metal Rubber Fuzhou UniversityFuzhou 350116China State Key Laboratory of Fine Chemicals Liaoning High Performance Polymer Engineering Research CenterSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China Fuzhou Friction and Lubrication Industry Technology Innovation Center Fuzhou 350108China

Flexible microporous metal rubber (FMP-MR) is a high-damping material that dissipates energy by dry friction through internal spiral metal wires in contact with each other. However, the FMP-MR energy dissipation mechanism is not fully understood owing to its disordered grid interpenetrating structure. In this work, computer-aided preparation technology is used to accurately reconstruct the complex spiral network structure of FMP-MR multipoint random contact, and a cell group model with an energy dissipation mechanism is proposed to obtain the dynamic energy distribution of the contact friction in both space and time dimensions. By judging the effective contact point, a global displacement ablation phenomenon of hooked staggered porous materials is induced. The macro- and micro-equivalent frictions are introduced to effectively explain the characteristics of the strong energy dissipation in FMP-MR under fretting excitation. A real and effective damping hysteresis constitutive model is then constructed to dynamically capture the mapping relationship between the complex nonlinear topological structure effect of the materials and spatial random contact dry friction in real time. The results indicate that the contact behavior between turns of the FMP-MR wire follows a clear quasi-Gaussian distribution under an external load, forcing the topological results to change. The energy dissipation of the materials revealed peak energy consumption lagging behind the loading limit for a certain distance, which can be determined by the effective contact point and contact dry friction slip. The consistency between the quasi-static compression tests and constitutive curves of the model was quantitatively verified through residual analysis. The data demonstrated the differential behavior of the FMP-MR meso-structure to follow a phased growth law during loading with different action mechanisms in the guiding, main growth, and relaxation stages of the energy consumption displacement curve. In summary, these findings provide an accept

关键词： flexible microporous metal rubber(FMP-MR) effective contact energy dissipation dry friction damping hysteresis

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Augmented cellular uptake and homologous targeting of exosome-based drug loaded IOL for posterior capsular opacification prevention and biosafety improvement

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Bioactive Materials 2022年第9期7卷 469-481页

作者： Siqing Zhu Huiying Huang Dong Liu Shimin Wen liangliang shen Quankui Lin Department of Biomaterials School of Ophthalmology&OptometryEye HospitalWenzhou Medical UniversityWenzhou325027PR China

Posterior capsular opacification(PCO),the most common complication after cataract surgery,is caused by the proliferation,migration and differentiation of residual lens epithelial cells(LECs)on the surface of the intraocular lens(IOL).Although drug-loaded IOLs have been successfully developed,the PCO prevention efficacy is still limited due to the lack of targeting and low bioavailability.In this investigation,an exosome-functionalized drug-loaded IOL was successfully developed for effective PCO prevention utilizing the homologous targeting and high biocompatibility of exosome.The exosomes derived from LECs were collected to load the anti-proliferative drug doxorubicin(Dox)through electroporation and then immobilized on the aminated IOLs surface through electrostatic interaction.In vitro experiments showed that significantly improved cellular uptake of Dox@Exos by LECs was achieved due to the targeting ability of exosome,compared with free Dox,thus resulting in superior anti-proliferation effect.In vivo animal investigations indicated that Dox@Exos-IOLs effectively inhibited the development of PCO and showed excellent intraocular biocompatibility.We believe that this work will provide a targeting strategy for PCO prevention through exosome-functionalized IOL.

关键词： Exosome Intraocular lens Surface modification Targeted therapy Posterior capsular opacification

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Regenerative cerium oxide nanozymes alleviate oxidative stress for efficient dry eye disease treatment

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Regenerative Biomaterials 2022年第1期9卷 942-954页

作者： Haoyu Zou Haiting Wang Baoqi Xu Lin Liang liangliang shen Quankui Lin Department of Biomaterials School of Ophthalmology&OptometryEye HospitalWenzhou Medical UniversityWenzhou 325027P.R.China

Dry eye disease(DED)is the most common eye disease in ophthalmic consultation except for refractive errors.Therefore,an exploration of valid and alternative therapeutic interventions is essential to feed the urgent medical need.It has been demonstrated that oxidative stress causes multiple adverse effects in the pathogenesis of DED,thence alleviating oxidative stress is an effective therapeutic strategy for the DED treatment.Herein,we developed a cerium oxide nanozyme combined with branched poly(ethylene imine)-graftpoly(ethylene glycol)(bPEI-g-PEG).Owing to its stable hydrophilic chains on the surface reducing the cytotoxicity and loads of amines groups that be combined with cerium ions through coordination bonds,the modified nanozymes(referred to as CNP@bPEI-g-PEG)are water soluble and highly biocompatible.Meanwhile,due to its excellent antioxidant activity,CNP@bPEI-g-PEG nanozymes can mimic the activity of superoxide dismutase and catalase to scavenge intracellular reactive oxygen species(ROS).Experimental studies firmly demonstrated that the modified nanozymes were auto-regenerative and more active in scavenging excessive ROS and alleviating oxidative stress by cerium-element valence state recycling,recovering the morphology of corneal,conjunctival epithelium and the number of goblet cells.The advanced combination may offer a superior therapeutic strategy to deal with oxidative stress for effective treatment of DED.

关键词： cerium oxide nanozymes dry eye reactive oxygen species oxidative stress

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Complex micelles with the bioactive function of reversible oxygen transfer

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Nano Research 2015年第2期8卷 491-501页

作者： liangliang shen Lizhi Zhao Rui Qu Fan Huang Hongjun Gao Yingli An Linqi Shi State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Institute of Polymer Chemistry Nankai University Tianjin 300071 China State Key Laboratory of Hollow Fiber Membrane Materials and Processes School of Materials Science and Engineering Tianjin Polytechnic University Tianjin 300387 China

复杂 micelle 作为血红素，有可逆的氧转移的 biaoactive 函数的功能的模型 poly 通过 diblock 共聚物的层次汇编被构造了(乙烯乙二醇)-blockpoly(4-vinylpyridine-co-N-heptyl-4-vinylpyridine)( PEG-b-P ( 4VP-co-4VPHep ))， tetrakis ( 4-sulfonatophenyl ) porphinato 铁( II )( Fe ( II ) TPPS )和 -cyclodextrin (-CD)。含氧 Fe (II ) TPPS 更暗淡因为 Fe (II ) TPPS 通过主人客人被包括进 CD 的洞，成功地被禁止相互作用。与 pyridine 组一起协调的 Fe (II ) TPPS 作为活跃地点工作 reversibly 绑 dioxygen。在 adition，主人客人包括(-CD/Fe(II)TPPS) 在复杂 micelle 的恐水病的核心被包含并且紧由 P4VP 链修理了。在水的答案拉长组成稳定复杂 micelle 的结构象一样的壳的吸水的木钉块赋予复杂 micelle 以足够的血发行量时间。Dioxygen 能被绑在位于限制空间和 dioxygen 的有约束力版本的过程的优秀可逆性的 Fe (II ) TPPS 能被完成。第四级的胺 N-heptyl-4-vinylpyridine 能强制丰富的 S 2 O 4 进复杂 micelle 的核心的 2 个离子处理便于自我减小。Dioxygen 使内收(Fe (II ) TPPS (O 2 )) 被由 cyclodextrin 和提高能力抵抗亲核的分子的复杂 micelle 的核心的洞构造的双恐水病的障碍有效地保护。因此，讲道理地设计的 amphiphilic 结构能作为有希望的人工的 O 工作 2 搬运人。潜在地，复杂 micelle 能被期望改进与组织缺氧连接的疾病的治疗。

关键词：胶束结构氧转移复合物可逆性生物活性 4-乙烯基吡啶主客体相互作用二嵌段共聚物

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Development and application of high-precision multifunction astronomical plate digitizers in China

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Astronomical Techniques and Instruments 2024年第1期1卷 71-75页

作者： Meiting Yang Yong Yu liangliang Wang Zhengjun Shang Changshun Liu Lixin Zheng Zhendong Chen Jing Yang Dongmei Da Shan Dong Shiyin shen Zhenghong Tang Jianhai Zhao Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China University of Chinese Academy of Sciences Beijing 100049China

Before charge-coupled device detectors became widely employed in observational astronomy,for more than a hundred years,the main detection method was photography on astronomical glass plates.Recently,in order to preserve these historical data and maintain their usability,the International Astronomical Union has appealed to all countries for global digitization of astronomical plates by developing or adopting advanced digitization technology.Specialized digitizers with high precision and high measuring speed represent key equipment for this task.The Shanghai Astronomical Observatory and the Nishimura Co.,Ltd in Japan cooperated between 2013 and 2016 to develop the first Chinese high-precision astronomical plate digitizer,which was then used for complete digitization of all nighttime-observation astronomical plates in China.Then,in 2019–2021,the Shanghai Astronomical Observatory independently developed new models of plate digitizers that enabled countries such as Uzbekistan and Italy to digitize their astronomical plates.Additionally,a new high-precision and multifunction digitizer was also used to digitize valuable microscope slides from the Shanghai Natural History Museum,providing a successful example of cross-domain application of high-precision digitization technology.

关键词： Astrometry-instrumentation Detectors-methods Data analysis-techniques Image processing

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A unique photosystem I reaction center from a chlorophyll d-containing cyanobacterium Acaryochloris marina

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Journal of Integrative Plant Biology 2021年第10期63卷 1740-1752页

作者： Caihuang Xu Qingjun Zhu Jing-Hua Chen liangliang shen Xiaohan Yi Zihui Huang Wenda Wang Min Chen Tingyun Kuang Jian-Ren shen Xing Zhang Guangye Han Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310058China Photosynthesis Research Center Key Laboratory of PhotobiologyInstitute of BotanyThe Chinese Academy of SciencesBeijing 100093China College of Life Sciences University of Chinese Academy of ScienceBeijing 100049China Center of Cryo-Electron Microscopy Zhejiang University School of MedicineHangzhou 310058China School of Life and Environmental Science Faculty of ScienceUniversity of SydneySydney NSW2006Australia Division of Photosynthesis and Structural Biology Institute for Interdisciplinary Scienceand Graduate School of Natural Science and TechnologyOkayama UniversityOkayama 700-8530Japan

Photosystem I(PSI)is a large protein supercomplex that catalyzes the light-dependent oxidation of plastocyanin(or cytochrome c6)and the reduction of ferredoxin.This catalytic reaction is realized by a transmembrane electron transfer chain consisting of primary electron donor(a special chlorophyll(Chl)pair)and electron acceptors A_(0),A_(1),and three Fe_(4)S_(4) clusters,F_(X),F_(A),and F_(B).Here we report the PSI structure from a Chl d-dominated cyanobacterium Acaryochloris marina at 3.3Åresolution obtained by single-particle cryo-electron microscopy.The A.marina PSI exists as a trimer with three identical monomers.Surprisingly,the structure reveals a unique composition of electron transfer chain in which the primary electron acceptor A_(0) is composed of two pheophytin a rather than Chl a found in any other well-known PSI structures.A novel subunit Psa27 is observed in the A.marina PSI structure.In addition,77 Chls,13α-carotenes,two phylloquinones,three Fe-S clusters,two phosphatidyl glycerols,and one monogalactosyl-diglyceride were identified in each PSI monomer.Our results provide a structural basis for deciphering the mechanism of photosynthesis in a PSI complex with Chl d as the dominating pigments and absorbing far-red light.

关键词： A.marina chlorophyll d cryoelectron microscopy pheophytin a photosynthesis photosystem I reaction center

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