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Dechloranes exhibit binding potency and activity to thyroid hormone receptors

Journal of Environmental Sciences 2022年第2期34卷 16-24页

作者： Jianqiao Zhu Lixia Zhao lianghong guo State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Institute of Environmental and Health Sciences China Jiliang UniversityHangzhou 310018China Institute of Environment and Health Jianghan UniversityWuhan 430056China

Dechloranes are a group of halogenated flame retardants with a basic bicyclo[2.2.1]heptene,including Dechlorane Plus(DP),Dechlorane 602(Dec 602),Dechlorane 603(Dec 603)and Dechlorane 604(Dec 604).A few epidemiological investigations and animal experiments have shown that DP exhibited thyroid-interfering *** the present study,we investigated whether DP and three other dechloranes could interfere the thyroid function through thyroid hormone receptors(TRs,TRαand TRβ)signaling *** binding affinities of the four dechloranes to the two TRs were determined by fluorescence competitive binding *** was found that all the four dechloranes could bind with the two *** relative potency(RP)values ranged from nd(not detectable)to *** the two TRs,dechloranes were more inclined to bind with TRβ,which implies that the thyroid interference effect of dechloranes may have selectivity in different tissues and ***-mediated luciferase reporter gene assay and T-screen assay showed that all the four dechloranes exhibited antagonistic activity to TRs in the *** together,our results demonstrated that dechloranes might interfere with thyroid function by binding with TRs and acting as TR *** health risk of highly exposed human populations should be of serious concern because of the high hazard quotient calculated from our cell assay results.

关键词： Antagonists Dechloranes Health risk Thyroid hormone receptors

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Exposure to perfluorooctane sulfonate reduced cell viability and insulin release capacity of β cells

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Journal of Environmental Sciences 2022年第5期34卷 162-172页

作者： Weiping Qin Xiaomin Ren Lixia Zhao lianghong guo State Key Laboratory of Environmental Chemistry and Eco-toxicology Research Center for Eco-environmental SciencesChinese Academy of SciencesBeijing 100085China Institute of Environmental and Health Sciences China Jiliang UniversityHangzhou 310018China

Per-and polyfluoroalkyl substances(PFAS)are found to have multiple adverse outcomes on human ***,epidemiological and toxicological studies showed that exposure to PFAS had adverse impacts on pancreas and showed association with insulin *** explore how PFAS may contribute to diabetes,we studied impacts of perfluorooctane sul-fonate(PFOS)on cell viability and insulin release capacity of pancreatic β cells by using in vivo and in vitro *** found that 28-day administration with PFOS(10 mg/(kg body weight·day))caused reductions of pancreas weight and islet size in male *** admin-istration also led to lower serum insulin level both in fasting state and after glucose infusion among male *** cell-based in vitro bioassay,we used mouse β-TC-6 cancer cells and found 48-hr exposure to PFOS decreased the cell viability at 50 μmol/*** measuring insulin content in supernatant,48-hr pretreatment of PFOS(100 μmol/L)decreased the insulin re-lease capacity of β-TC-6 cells after glucose *** these concentrations were higher than the environmental concentration of PFOS,it might be reasonable for high con-centration of PFOS to exert observable toxic effects in mice considering mice had a faster removal efficiency of PFOS than *** exposure(50 μmol/L)to β-TC-6 cells induced intracellular accumulation of reactive oxidative specie(ROS).Excessive ROS induced the re-active toxicity of cells,which eventually invoke apoptosis and *** in this study provide evidence for the possible causal link of exposure to PFOS and diabetes risk.

关键词： Perfluorooctane sulfonate Insulin secretion Pancreaticβcells Apoptosis Reactive oxidative species

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In vitro assessment of thyroid hormone receptor activity of four organophosphate esters

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Journal of Environmental Sciences 2016年第7期28卷 185-190页

作者： Xiaomin Ren Linying Cao Yu Yang Bin Wan Sufang Wang lianghong guo State Key Laboratory of Environmental Chemistry and Eco-toxicology Research Centre for Eco-environmental Sciences Chinese Academy of Sciences Institute of Environment and Health Jianghan University

Previous animal experiments have implied that organophosphate esters（OPEs） have a disruption effect on the thyroid endocrine system. However, knowledge of the toxicological mechanism remains limited. In this study, the activities of four OPEs have been characterized against the thyroid hormone（TH） nuclear receptor（TR） using two in vitro models, with the aim of evaluating their toxicity mechanisms towards the TR. The results of a TH-dependent cell proliferation assay showed that tris（2-chloro-1-（chloromethyl）ethyl）phosphate（TDCPP） could induce cell growth, while the other three OPEs had no effect. The results of a luciferase reporter gene assay revealed that all four of the OPEs tested in the current study showed agonistic activity towards TRβ, with TDCPP being the most potent one. Moreover, molecular docking revealed that all the tested OPEs could fit into the ligand binding pocket of TRβ, with TDCPP binding more effectively than the other three OPEs. Taken together, these data suggest that OPEs might disrupt the thyroid endocrine system via a mechanism involving the activation of TR.

关键词： organophosphate esters disruption effect TDCPP TR pathway agonistic activity

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全氟和多氟烷基物质在人体生物样本中的检测方法与暴露水平研究进展

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环境化学 2024年第9期43卷 2881-2896页

作者：江建明李敏杰叶铖罗海威洪文俊郭良宏中国计量大学质量与安全工程学院杭州310018 中国计量大学环境与健康科学研究院杭州310018 浙江交科环境科技有限公司杭州311305 上海安谱实验科技股份有限公司上海210609

全氟和多氟烷基物质(PFASs)是一类人工合成的化学物质,在环境介质和人体生物样本中被广泛检出.本文针对人体血液、尿液、母乳、头发和指甲等5种人体生物样本,总结了PFASs的前处理方法和仪器分析方法,介绍了国内外关于人体生物样本中PFAS... 详细信息

全氟和多氟烷基物质(PFASs)是一类人工合成的化学物质,在环境介质和人体生物样本中被广泛检出.本文针对人体血液、尿液、母乳、头发和指甲等5种人体生物样本,总结了PFASs的前处理方法和仪器分析方法,介绍了国内外关于人体生物样本中PFASs暴露水平的最新研究进展,展望了这一领域的发展方向.通过研究结果显示,PFASs在普通人群5种样本中的检出情况为血液>母乳>尿液>头发和指甲,人群的饮食特征、饮用水来源、研究区域工业化水平等均为影响PFASs暴露水平的重要因素,且研究发现从事相关行业的职业人群或相关行业周边居住居民其体内PFASs暴露水平比普通人群普遍高1—2个数量级.在5种人体生物样本中,PFOA和PFOS均为检出浓度较高的物质.本文旨在为今后关于PFASs的人体暴露和检测分析提供参考,为国家和地区人体生物监测提供技术支撑.

关键词：全氟和多氟烷基物质人体生物样本检测方法暴露水平.

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Rapid assessment of DNA damage induced by polystyrene nanosphere suspension using a photoelectrochemical DNA sensor

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Science China Chemistry 2011年第8期54卷 1260-1265页

作者： ZHANG BinTian DU Xin JIA SuPing HE JunHui guo lianghong State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Functional Nanomaterials Laboratory and Key Laboratory of Organic Optoelectronic Functional Materials and Molecular Engineering Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beifing 100080 China

Nanomaterials have been used increasingly in a wide variety of applications, and some of them have shown toxic effects on experimental animals and cells. In this study, a previously established photoelectrochemical DNA sensor was employed to rapidly detect DNA damage induced by polystyrene nanosphere （PSNS） suspensions. In the sensor, a double-stranded DNA film was assembled on a semiconductor electrode, and a DNA intercalator, Ru（bpy）2（dppz）2＋（bpy = 2,2＇-bipyridine, dppz = dipyrido[3,2-a：2＇,3＇-c]phenazine） was used as the photoelectrochemical signal indicator. After the DNA-modified electrode was exposed to 2.0 mg/mL PSNS suspension, photocurrent of DNA-bound Ru（bpy）2（dppz）2＋ decreased by about 20%. The decrease is attributed to the chemical damage of DNA and consequently less binding of Ru（bpy）2（dppz）2＋ molecules to the electrode. Gel electrophoresis of DNA samples incubated with PSNS suspension confirmed DNA damage after the chemical exposure. However, in both photoelectrochemical and gel electrophoresis experiments, extensively washed PSNS did not induce any DNA damage, and the supernatant of PSNS suspension exhibited comparable DNA damage as the unwashed PSNS suspension. Furthermore, UV-visible absorption spectrum of the supematant displayed a pattern very similar to that of styrene oxide （SO）, a compound which has been shown to induce DNA damage by forming covalent DNA adducts. It is therefore suggested that styrene oxide and other residual chemicals in the PSNS may be responsible for the observed DNA damage. The results highlight the importance of full characterization of nanomaterials before their toxicity study, and demonstrate the utility of photoelectrochemical DNA sensors in the rapid assessment of DNA damage induced by chemicals and nanomaterials.

关键词： nanomaterial toxicity DNA damage sensor

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PHOTOELECTROCHEMICAL DETECTION OF CHEMICALLY DAMAGED DNA ON RU(BPY)3-MODIFIED TIN OXIDE NANOPARTICLE ELECTRODE

PHOTOELECTROCHEMICAL DETECTION OF CHEMICALLY DAMAGED DNA ON ...

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第十一届北京分析测试学术报告会暨展览会(BCEIA 2005)

作者： Minmin LIANG lianghong guo State Key Laboratory of Environmental Chemistry and Eco-toxicology Research Centre for Eco-environmental SciencesChinese Academy of Sciences

It is vital to detect DNA damage sensitively and selectively,because damage to DNA has been associated with alterations in DNA sequence,aberrant gene expression,increased mutation rates,cell transformation,and

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PHOTOELECTROCHEMICAL SENSOR FOR THE RAPID SCREENING OF DNA-DAMAGING CHEMICALS

PHOTOELECTROCHEMICAL SENSOR FOR THE RAPID SCREENING OF DNA-D...

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第十二届北京分析测试学术报告会暨展览会(BCEIA 2007)

作者： lianghong guo Minmin LIANG State Key Laboratory of Environmental Chemistry and Eco-toxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

Rapid and sensitive detection methods are in urgent demand for the screening of an overwhelming number of existing and new chemicals as potential DNAdamaging *** this presentation,a photoelectrochemical sensor was proposed and tested for the detection of DNA damage caused by Fe and styrene,each representing the heavy metal and organic class of environmental *** sensor surface is an assembly of a multi-layer film composed of

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氟调醇的环境污染与毒理学研究

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化学进展 2016年第7期28卷 993-1005页

作者：李忠民郭良宏中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室北京100085 江汉大学环境与健康研究院武汉430056

多氟和全氟烷基化合物(PFASs)由于其独特的稳定性、疏水性和疏油性被广泛用于生产和生活中。PFASs的生产方式有两种:电化学氟化法(ECF)和调聚反应。由于持久性、毒性和生物富集性,ECF生产过程中产生的全氟辛烷磺酸(PFOS)及其盐和全氟辛... 详细信息

多氟和全氟烷基化合物(PFASs)由于其独特的稳定性、疏水性和疏油性被广泛用于生产和生活中。PFASs的生产方式有两种:电化学氟化法(ECF)和调聚反应。由于持久性、毒性和生物富集性,ECF生产过程中产生的全氟辛烷磺酸(PFOS)及其盐和全氟辛基磺酰胺(POSF)于2009年被正式列入《斯德哥尔摩公约》的POPs名单,发达国家也开始逐渐停止用ECF方法生产PFASs。因此,调聚反应产生的PFASs前驱体氟调醇(FTOHs)的产量不断增加。研究表明,FTOHs经生物或非生物转化能够生成全氟烷基羧酸(PFCAs),可能是PFCAs污染的间接来源。此外,FTOHs的一些中间代谢产物能够与多种生物分子共价结合,引起严重的毒性效应,而代谢终产物又能引起肝毒性和肾毒性等。近年来,FTOHs的环境问题已成为环境科学、毒理学和流行病学领域的研究热点。本文综述了FTOHs的生产状况、环境污染水平和相关代谢产物的毒性。最后讨论了目前存在的问题,并对未来的研究进行了展望。

关键词：氟调醇多氟和全氟化合物环境污染生物转化毒性效应

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多溴联苯醚的环境毒理学研究进展

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环境化学 2011年第1期30卷 143-152页

作者：万斌郭良宏中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室北京100085

多溴联苯醚(PBDEs)是一类广泛使用的溴代阻燃剂,其大量生产和使用导致了越来越严重的环境污染.由于PBDEs具有较高的亲脂性,化学性质比较稳定,它们可远距离传输到地球各种环境介质中,并通过食物链累积放大,在生物体内蓄积产生毒性效应.... 详细信息

多溴联苯醚(PBDEs)是一类广泛使用的溴代阻燃剂,其大量生产和使用导致了越来越严重的环境污染.由于PBDEs具有较高的亲脂性,化学性质比较稳定,它们可远距离传输到地球各种环境介质中,并通过食物链累积放大,在生物体内蓄积产生毒性效应.本文针对近年来PBDEs毒性效应和致毒机制的研究进展,从PBDEs的内分泌干扰毒性、发育神经毒性和免疫毒性三个方面进行总结,并分析了当前研究需要解决的问题,展望了PBDEs毒理学的研究方向.

关键词：多溴联苯醚内分泌干扰发育神经毒性免疫毒性致毒机制

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组合串联运算压制多次波的应用效果

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中国煤炭地质 2008年第B9期20卷 63-66页

作者：郭良红中国煤炭地质总局第一勘探局物测队河北邢台054000

扼要介绍了多次反射波的基本理论及其处理方法的应用,在对多次波的时距曲线及数据作详细分析后,可以提出有针对性的压制多次波的多种方案;对多种方法进行测试和效果分析后,提取其中效果显著的方法进行处理;压制多次波的手段往往不能单... 详细信息

扼要介绍了多次反射波的基本理论及其处理方法的应用,在对多次波的时距曲线及数据作详细分析后,可以提出有针对性的压制多次波的多种方案;对多种方法进行测试和效果分析后,提取其中效果显著的方法进行处理;压制多次波的手段往往不能单独仅用一种方法,而应该用多种方法串联运算,才能达到最佳效果。

关键词：多次反射波时距曲线压制方法反褶积组合串联运算应用

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