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脑震荡:从“一刀切”到精准靶向治疗

中华脑科疾病与康复杂志（电子版） 2024年第2期14卷 127-128页

作者：周良辅复旦大学附属华山医院神经外科上海200040

脑震荡,又称轻度颅脑外伤(traumaticbrain injury,TBI),是由外力直接或间接作用于头部引起的大脑复杂的病理生理改变,具有以下临床特点:(1)患者意识丧失的时长通常小于30s,甚至无意识丧失;(2)患者伤后30s内GCS评分为13~15分;(3)患者伤... 详细信息

脑震荡,又称轻度颅脑外伤(traumaticbrain injury,TBI),是由外力直接或间接作用于头部引起的大脑复杂的病理生理改变,具有以下临床特点:(1)患者意识丧失的时长通常小于30s,甚至无意识丧失;(2)患者伤后30s内GCS评分为13~15分;(3)患者伤后出现顺行或逆行性遗忘;(4)其他神经功能短暂异常,不超过24h。脑震荡的年发生率高于6/1000人,约占整个TBI的70%~90%,男性多于女性,好发年龄段为≤5岁、15~24岁、≥75岁。

关键词：脑震荡诊断靶向治疗

A thermodynamic model showing that information recording can drive active ion transport

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2058-2060页

作者： Xiang Zou Kun Song Minbiao Ji Lingzhao Min liangfu zhou Ying Mao Liang Chen Department of Neurosurgery Neurosurgical Institute of Fudan UniversityNational Center for Neurological DisordersHuashan HospitalFudan UniversityShanghai200040China Department of Physics Fudan UniversityShanghai200433China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science School of Basic Medical Sciences and Institutes of Brain ScienceFudan UniversityShanghai200040China

Dear Editor,Ion gradients are characteristic features of a living cell that do not represent thermodynamic *** unequilibrium status are maintained by various ion pumps such as Na-K-ATPase,which are known as the P-type *** mechanism of Na-K-ATPase is described as Post-Albers cycle1(Fig.1a).However,the reaction scheme is non-Michaelis-Menten kinetics assembled from transient-state results,which can hardly be used to rebuild the real reaction cycle.

关键词： recording maintained showing

Microsurgical treatment of posterior inferior cerebellar aneurysms based on angioarchitecture supplemented by high-resolution vessel wall MRI:a case series report

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Stroke & Vascular Neurology 2022年第4期7卷 337-344,I0046-I0050页

作者： Zixiao Yang Jianping Song Kai Quan Peiliang Li Qingzhu An Yuan Shi Peixi Liu Guo Yu Yanlong Tian liangfu zhou Wei Zhu Department of Neurosurgery Huashan Hospital Fudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Neurosurgical Institute of Fudan University ShanghaiChina Shanghai Clinical Medical Center of Neurosurgery ShanghaiChina

Background Surgical treatment of posterior inferior cerebellar artery(PICA)aneurysms is challenging because many are nonsaccular and *** report our tailored approach to PICA aneurysms,which is based on angioarchitecture supplemented by high-resolution vessel wall MRI(HR-VW MRI)*** From March 2010 to September 2020,27 patients with 29 PICA aneurysms underwent surgical treatment in our *** October 2016,HR-VW MRI has been used for aneurysmal wall *** characteristics,radiological data and surgical outcomes were *** Nineteen proximal PICA aneurysms(vertebral artery(VA),P1,P2 and P3)were treated using the far-lateral *** distal PICA aneurysms(P4,P5)were treated using the suboccipital midline *** clipping or clip reconstruction was achieved in 19 *** were trapped in conjunction with extracranial-intracranial or intracranial-intracranial bypass,including three occipital artery-PICA reimplantations,three PICA-VA reimplantations,two PICA-PICA side-to side anastomoses,one PICA-PICA reimplantation and one PICA-PICA *** aneurysms were eventually completely obliterated and all bypasses remained *** the last follow-up,26 patients(96.2%)achieved a good outcome(modified Rankin Scale score<3).Eight patients underwent HR-VW *** these,the six aneurysms with focal wall enhancement required bypass and the two with negative enhancement were successfully *** PICA aneurysms have a higher frequency of complex features such as large or giant size and fusiform or dissecting *** outcomes were achieved with individualised microsurgical strategies based on ***-VW MRI may be used as a promising technique to predict aneurysmal atherosclerosis.

关键词： aneurysm treatment implantation

Optimization and test for structural parameters of UAV spraying rotary cup atomizer

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International Journal of Agricultural and Biological Engineering 2017年第3期10卷 78-86页

作者： zhou Qingqing Xue Xinyu Qin Weicai Cai Chen zhou liangfu Nanjing Research Institute for Agriculture Mechanization Ministry of AgricultureNanjing 210014China

Small unmanned aerial vehicle(UAV)pesticide application technology is developing rapidly in ***,the spray efficiency of UAV sprayer is not stable,one important reason is that the lack of specialized aviation *** cup atomizer is not easily to be blocked and has broad application foreground in UAV *** order to obtain good spraying quality and narrow droplet spectrum aviation spraying centrifugal nozzle,the impacts of rotary cup atomizer structural parameters on atomization property were *** this research,a centrifugal atomization test device was designed,on which a frequency converter was used to adjust the rotary speed,and a return valve was used to stabilize the flow rate and pressure of spray *** droplet volume medium diameter(VMD)and droplet spectrum relative width(SRW)were tested by using laser particle analyzer and particle analysis *** analysis results of variance and quadratic regression orthogonal test were used to optimize the structural parameters of rotary cup *** influences of rotary cup atomizer structural parameters on atomization property,such as groove shape,diameter,teeth number,cone angle and height were evaluated and analyzed by conducting single-factor *** results showed that:the best optimized rotary groove shape was square,diameter and teeth number had significant effects on droplet VMD and SRW,while cone angle had no effect on the droplet VMD and SRW,height affected droplet VMDbut did not affect droplet ***,diameter and teeth number were selected as the variables of quadratic regression orthogonal test,droplet VMD and SRW regression model was established by using response surface analysis *** optimized structural parameters respectively were:groove shape square,cone angle 60°,height 20 mm,diameter 61.5 mm and teeth number *** VMD and SRW simulation value respectively were 200μm and *** differences between simulation value and test value were 0.68%and 9.90

关键词： rotary cup atomizer atomization droplet VMD droplet SRW optimization mathematical model response surface

Prolonged propagation of rat neural stem cells relies on inhibiting autocrine/paracrine bone morphogenetic protein and platelet derived growth factor signals

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Neural Regeneration Research 2011年第13期6卷 965-971页

作者： Yirui Sun liangfu zhou Xing Wu Hua Liu Qiang Yuan Ying Mao Jin Hu Department of Neurosurgery Shanghai Huashan Hospital Fudan University Shanghai 200040 China Shanghai No. 6 People's Hospital Shanghai Jiao Tong University Shanghai 200233 China

Continuous expansion of rat neural stem cell lines has not been achieved due to proliferation arrest and spontaneous differentiation in vitro. In the current study, neural precursor cells derived from the subventricular zone of adult rats spontaneously underwent astroglial and oligodendroglial differentiation after limited propagation. This differentiation was largely induced by autocrine or paracrine bone morphogenetic protein and platelet derived growth factor signals. The results showed that, by inhibiting bone morphogenetic protein and platelet derived growth factor signals, adult rat neural precursor cells could be extensively cultured in vitro as tripotent stem cell lines. In addition to adult rat neural stem cells, we found that bone morphogenetic protein antagonists can promote the proliferation of human neural stem cells. Therefore, the present findings illustrated the role of autocrine or paracrine bone morphogenetic protein and platelet derived growth factor signaling in determining neural stem cell self-renewal and differentiation. By antagonizing both signals, the long-term propagation of rat neural stem cell lines can be achieved.

关键词： neural stem cells cell dormancy proliferation arrest stem cell lines bone morphogenetic protein platelet derived growth factor

Application of CUSA Excel ultrasonic aspiration system in resection of skull base meningiomas

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Chinese Journal of Cancer Research 2014年第6期26卷 653-657页

作者： Hailiang Tang Haishi Zhang Qing Xie Ye Gong Mingzhe Zheng Daijun Wang Hongda Zhu Xiancheng Chen liangfu zhou Department of Neurosurgery Huashan Hospital Fudan University

Background： Effective methods for managing patients with solitary pulmonary nodules（SPNs） depend critically on the predictive probability of ***： Between July 2009 and June 2011, data on gender, age, cancer history, tumor familial history, smoking status, tumor location, nodule size, spiculation, calcification, the tumor border, and the final pathological diagnosis were collected retrospectively from 154 surgical patients with an SPN measuring 3-30 mm. Each final diagnosis was compared with the probability calculated by three predicted models—the Mayo, VA, and Peking University（PU） models. The accuracy of each model was assessed using area under the receiver operating characteristics（ROC） and calibration ***： The area under the ROC curve of the PU model [0.800; 95% confidence interval（CI）： 0.708-0.891] was higher than that of the Mayo model（0.753; 95% CI： 0.650-0.857） or VA model（0.728; 95% CI： 0.623-0.833）; however, this finding was not statistically significant. To varying degrees, calibration curves showed that all three models overestimated ***： The three predicted models have similar accuracy for prediction of SPN malignancy, although the accuracy is not sufficient. For Chinese patients, the PU model may has greater predictive ***： Here, we introduced our short experience on the application of a new CUSA Excel ultrasonic aspiration system, which was provided by Integra Lifesciences corporation, in skull base meningiomas ***： Ten patients with anterior, middle skull base and sphenoid ridge meningioma were operated using the CUSA Excel ultrasonic aspiration system at the Neurosurgery Department of Shanghai Huashan Hospital from August 2014 to October 2014. There were six male and four female patients, aged from 38 to 61 years old（the mean age was 48.5 years old）. Five cases with tumor located at anterior skull base, three cases with tumor on middle skull base, and two cases with tumor on sphe

关键词： CUSA Excel skull base meningiomas

Disseminated intravascular coagulation scores as predictors for progressive hemorrhage and neurological prognosis following traumatic brain injury

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Neural Regeneration Research 2011年第2期6卷 136-142页

作者： Yirui Sun Caihua Xi Ersong Wang Jianqing Wang Yong Liu Hua Liu Qiang Yuan Haijun Yao liangfu zhou Jin Hu Department of Neurosurgery Huashan Hospital Fudan University Shanghai 200040 China Shanghai Sixth Hospital Shanghai Jiao Tong University Shanghai 200233 China Department of Neurosurgery Ruijin Minhang District Central Hospital Shanghai 201100 China Nanjing Brain Hospital Nanjing Medical University Nanjing 100027 Jiangsu Province China

Coagulation abnormalities, such as disseminated intravascular coagulation （DIC）, are associated with progressive hemcrrhagic injury （PHI） following head trauma. However, the exact relationship between coagulopathy and PHI remains unclear. The present study utilized a scoring system defined by the International Society of Thrombosis and Haemostasis to investigate whether a high DIC score is predictive for PHI. This study was a multicenter prospective design involving four hospitals, a 6-month observation, and follow-up. Of 352 traumatic brain injury （TBI） patients, serial CT scan indicated approximately one third of patients developed progressive hemorrhage, which was most frequently observed in the frontal, temporal, and orbitofrontal lobes of patients with brain contusion. PHI-positive patients exhibited poor prognosis, as indicated by prolonged length of hospital/intensive care unit stay and high mortality. More importantly, a DIC score after TBI, as well as patient age and sex, could serve as predictors for PHI. In addition, DIC scores were closely associated with injury severity. Therefore, the DIC scoring system facilitated early PHI diagnosis in TBI patients, and DIC scores might serve as a valuable predictor for TBI patients with PHI.

关键词： coagulopathy disseminated intravascular coagulation disseminated intravascular coagulation scoring intracranial hemorrhage progressive hemorrhagic injury traumatic brain injury

Effects of vascular endothelial growth factor on angiogenesis of the endothelial cells isolated from cavernous malformations

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Chinese Science Bulletin 2008年第3期53卷 370-376页

作者： TAN YuZhen ZHAO Yao WANG HaiJie zhou liangfu MAO Ying LIU Rui SHU Jia WANG YongFei Department of Anatomy and Histology and Embryology Shanghai Medical School of Fudan University Shanghai 200032 China Department of Neurosurgery Huashan Hospital Fudan University Shanghai 200040 China

Human cerebral cavernous malformation(CM)is a common vascular malformation of the central nervous *** have investigated the biological characteristics of CM endothelial cells and the cellular and molecular mechanisms of CM angiogenesis to offer new insights into exploring effective measures for treatment of this *** endothelial cells were isolated from CM tissue masses dissected during operation and expanded in *** of VEGFR-1 and VEGFR-2 was examined with immunocytochemical ***,migration and tube formation of CM endothelial cells were determined using MTT,wounding and transmigration assays,and three-dimensional collagen type I gel *** endothelial cells were successfully isolated from the tissue specimens of 25 CMs dissected without dipolar *** cells show the general characteristics of the vascular endothelial *** of VEGFR-1 and VEGFR-2 on the cells is higher than that on the normal cerebral microvascular endothelial *** treatment with VEGF,numbers of the proliferated and migrated cells,the maximal distance of cell migration and the length and area of capillary-like struc-tures formed in the three-dimensional collagen gel increase *** results demonstrate that expression of VEGFR-1 and VEGFR-2 on CM endothelial cells is *** binding to re-ceptors,VEGF may activate the downstream signaling pathways and promote proliferation,migration and tube formation of CM endothelial ***/VEGFR signaling pathways play important regulating roles in CM angiogenesis.

关键词：血管内皮生长因子内皮细胞血管畸形生物特征

Cloud Top Pressure Retrieval Using Polarized and Oxygen A-band Measurements from GF5 and PARASOL Satellites

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Advances in Atmospheric Sciences 2024年第4期41卷 680-700页

作者： Lesi WEI Huazhe SHANG Jian XU Chong SHI Gegen TANA Kefu CHAO Shanhu BAO liangfu CHEN Husi LETU State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 101407China College of Physics and Electronic Information Inner Mongolia Normal UniversityHohhot 010022China College of Geographical Science Inner Mongolia Normal UniversityHohhot 010022China University of Chinese Academy of Sciences Beijing 100101China

Cloud top pressure(CTP)is one of the critical cloud properties that significantly affects the radiative effect of ***-angle polarized sensors can employ polarized bands(490 nm)or O_(2)A-bands(763 and 765 nm)to retrieve the ***,the CTP retrieved by the two methods shows inconsistent results in certain cases,and large uncertainties in low and thin cloud retrievals,which may lead to challenges in subsequent *** study proposes a synergistic algorithm that considers both O_(2)A-bands and polarized bands using a random forest(RF)*** CTP data are used as the true values and the polarized and non-polarized measurements are concatenated to train the RF model to determine ***,through analysis,we proposed that the polarized signal becomes saturated as the cloud optical thickness(COT)increases,necessitating a particular treatment for cases where COT<10 to improve the algorithm's *** synergistic method was then applied to the directional polarized camera(DPC)and Polarized and Directionality of the Earth’s Reflectance(POLDER)measurements for evaluation,and the resulting retrieval accuracy of the POLDER-based measurements(RMSEPOLDER=205.176 hPa,RMSEDPC=171.141 hPa,R^(2)POLDER=0.636,R^(2)DPC=0.663,respectively)were higher than that of the MODIS and POLDER Rayleigh pressure *** synergistic algorithm also showed good performance with the application of DPC *** algorithm is expected to provide data support for atmosphere-related fields as an atmospheric remote sensing algorithm within the Cloud Application for Remote Sensing,Atmospheric Radiation,and Updating Energy(CARE)platform.

关键词： atmospheric remote sensing cloud top pressure multi-angle polarized O_(2)A-band GF-5/DPC PARASOL/POLDER-3