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Recent Progress in Capturing and Neutralizing Inflammatory Cytokines

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CCS Chemistry 2020年第3期2卷 376-389页

作者： Qiangzhe zhang Hua Gong Weiwei Gao liangfang zhang Departments of NanoEngineering Chemical Engineering Programand Moores Cancer CenterUniversity of California San DiegoLa JollaCA 92093

Inflammatory cytokines are key players in modulating immune responses to mount effective host ***,excessive production of inflammatory cytokines contributes to the destructive components responsible for various inflammatory *** a result,treatment strategies have been developed to lower the cytokine levels or block their *** particular,therapeutic agents that directly capture and neutralize cytokines have gained significant attention as they bypass the interactions with the host cells,and therefore,are less likely to induce immunogenic response and *** them,“monoplex”platforms such as cytokine-neutralizing antibodies(CNAs)are commonly designed to target a specific cytokine for ***,to address the multiplexity of the cytokine targets in diseases,multiplex platforms such as glycosaminoglycan-containing biomaterials and cell-membrane-coated nanoparticles are ***,we have reviewed the recent progress of these cytokine-neutralizing platforms(CNPs)and discussed their applications in treating inflammatory ***,understanding the structure–function relationships underlying these CNPs would lead to the design of novel therapeutics toward effective management of inflammatory diseases.

关键词： inflammatory disorder cytokine neutralization anticytokine monoplex multiplex

Design Strategies for Cellular Nanosponges as Medical Countermeasures

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Biomedical Engineering Frontiers 2023年第1期4卷 144-157页

作者： Shuyan Wang Dan Wang Mingxuan Kai Wei-Ting Shen Lei Sun Weiwei Gao liangfang zhang Department of NanoEngineering Chemical Engineering Programand Moores Cancer CenterUniversity of California San DiegoLa JollaCA 92093USA

The interest in using therapeutic nanoparticles to bind with harmful molecules or pathogens and subsequently neutralize their bioactivity has grown *** various nanomedicine platforms,cell membrane-coated nanoparticles,namely,“cellular nanosponges,”stand out for their broadspectrum neutralization capability challenging to achieve in traditional countermeasure *** ability is attributable to their cellular function-based rather than target structure-based working *** cellular nanosponges with various synthetic substrates further makes their applications exceptionally versatile and *** review discusses the latest cellular nanosponge technology focusing on how the structure–function relationship in different designs has led to versatile and potent medical *** design strategies are discussed,including harnessing native cell membrane functions for biological neutralization,functionalizing cell membrane coatings to enhance neutralization capabilities,combining cell membranes and functional cores for multimodal neutralization,and integrating cellular nanosponges with hydrogels for localized *** in each design strategy are selected,and the discussion is to highlight their structure–function relationships in complex disease *** review may inspire additional design strategies for cellular nanosponges and fulfill even broader medical applications.

关键词： sponge versatile integrating

A genetically engineered neuronal membrane-based nanotoxoid elicits protective immunity against neurotoxins

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Bioactive Materials 2024年第8期38卷 321-330页

作者： Zhongyuan Guo Audrey T.Zhu Xiaoli Wei Yao Jiang Yiyan Yu Ilkoo Noh Weiwei Gao Ronnie H.Fang liangfang zhang Department of NanoEngineering Chemical Engineering ProgramShu and K.C.Chien and Peter Farrell CollaboratoryUniversity of California San DiegoLa JollaCA92093USA Division of Host-Microbe Systems and Therapeutics Department of PediatricsUniversity of California San DiegoLa JollaCA92093USA

Given their dangerous effects on the nervous system,neurotoxins represent a significant threat to public *** therapeutic approaches,including chelating agents,receptor decoys,and toxin-neutralizing antibodies,have been *** prophylactic vaccines are desirable,it is oftentimes difficult to effectively balance their safety and efficacy given the highly dangerous nature of *** address this,we report here on a nanovaccine against neurotoxins that leverages the detoxifying properties of cell membrane-coated nanoparticles.A genetically modified cell line with constitutive overexpression of theα7 nicotinic acetylcholine receptor is developed as a membrane source to generate biomimetic nanoparticles that can effectively and irreversibly bind toα-bungarotoxin,a model *** abrogates the biological activity of the toxin,enabling the resulting nanotoxoid to be safely delivered into the body and processed by the immune *** co-administered with an immunological adjuvant,a strong humoral response againstα-bungarotoxin is generated that protects vaccinated mice against a lethal dose of the ***,this work highlights the potential of using genetic modification strategies to develop nanotoxoid formulations against various biological threats.

关键词： Antivirulence vaccine Cell membrane-coated nanoparticle Genetic engineering α-bungarotoxin Nanotoxoid

Engineered Biomimetic Platelet Membrane-Coated Nanoparticles Block Staphylococcus aureus Cytotoxicity and Protect Against Lethal Systemic Infection

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Engineering 2021年第8期7卷 1149-1156页

作者： Jwa-Kyung Kim Satoshi Uchiyama Hua Gong Alexandra Stream liangfang zhang Victor Nizet Division of Nephrology Department of Internal Medicine&Kidney Research InstituteHallym University Sacred Heart HospitalAnyang 14068Republic of Korea Department of Clinical Immunology Hallym University Sacred Heart HospitalAnyang 14068Republic of Korea Division of Host-Microbe Systems and Therapeutics Department of PediatricsUniversity of California San DiegoLa JollaCA 92093USA Department of NanoEngineering University of California San DiegoLa JollaCA 92093USA Moores Cancer Center University of California San Diego HealthLa JollaCA 92037USA Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San DiegoLa JollaCA 92093USA

Staphylococcus aureus(***)is a leading human pathogen capable of producing severe invasive infections such as bacteremia,sepsis,and endocarditis with high morbidity and mortality,exacerbated by the increasingly widespread antibiotic resistance exemplified by methicillin-resistant strains(MRSA).*** pathogenesis is fueled by the secretion of toxins—such as the membrane-damaging pore-forming atoxin,which have diverse cellular targets including the epithelium,endothelium,leukocytes,and ***,we examine the use of human platelet membrane-coated nanoparticles(PNPs)as a biomimetic decoy strategy to neutralize *** toxins and preserve host cell defense *** PNPs blocked platelet damage induced by *** secreted toxins,thereby supporting platelet activation and bactericidal ***,the PNPs blocked macrophage damage induced by *** secreted toxins,thus supporting macrophage oxidative burst,nitric oxide production,and bactericidal activity,and diminishing MRSA-induced neutrophil extracellular trap *** a mouse model of MRSA systemic infection,PNP administration reduced bacterial counts in the blood and protected against *** together,the results from the present work provide a proof of principle of the therapeutic benefit of PNPs in toxin neutralization,cytoprotection,and increased host resistance to invasive *** infection.

关键词： Nanoparticle Nanosponge Platelet Staphylococcus aureus Bacterial toxins Sepsis

结合对DNA分子结构的分析谈激光育种的一些设想

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光电子.激光 1985年第2期 46-48页

作者：张亮芳陕西省粮食作物研究所

本文根据我国激光育种工作情况从三个方面谈了笔者对该工作的设想,根据DNA分子结构的特点谈选择适宜激光条件问题、利用计算机统计规律及育种选材。

关键词：激光育种 DNA 统计规律条件问题激光波长激光作用激光光子碱基对变异率实验数据

266nm波长及其它波长激光照射麦类的诱变效应

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光电子.激光 1987年第6期 13-14页

作者：张亮芳华中工学院

在理论上若激光光子能量与DNA分子键能相同,二者作用时应产生共振,后者的键易被打断。若选激光波长与DNA分子最大吸收波长(265nm)相同,则前者应与后者的键共振最强,易改变遗传结构,引起显著变异。然而极少有人用此波长激光进行系统的生... 详细信息

在理论上若激光光子能量与DNA分子键能相同,二者作用时应产生共振,后者的键易被打断。若选激光波长与DNA分子最大吸收波长(265nm)相同,则前者应与后者的键共振最强,易改变遗传结构,引起显著变异。然而极少有人用此波长激光进行系统的生物诱变实验研究。

关键词：波长 DNA 激光器光激射器电子器件激光处理激光照射麦类 nm

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南水北调山东段某泄洪闸无线传输方案研究

水利技术监督 2021年第12期29卷 28-31,61页

作者：赵琳张亮方山东省水利勘测设计院山东济南250013 南水北调东线山东干线有限责任公司山东济南250013

南水北调东线山东段工程在枣庄市利旧一座泄洪闸,要实现泄洪闸与主体工程的统一调度,需要对泄洪闸机电工程进行自动化改造,将泄洪闸的运行信息可靠地传输至最近的干线泵站枢纽工程,达到实时监控的目标,自动控制系统的通信传输十分重要,... 详细信息

南水北调东线山东段工程在枣庄市利旧一座泄洪闸,要实现泄洪闸与主体工程的统一调度,需要对泄洪闸机电工程进行自动化改造,将泄洪闸的运行信息可靠地传输至最近的干线泵站枢纽工程,达到实时监控的目标,自动控制系统的通信传输十分重要,经综合考虑宜采用无线传输技术,对该泄洪闸无线传输技术方案进行分析和研究。

关键词：无线传输通信链路分析传输设备南水北调

具有核壳结构特征的相包容粒子设计及其对POM树脂的增韧条件

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太原科技 2006年第8期 3-6页

作者：于建张良方郭朝霞清华大学高分子研究所北京100084

以POM/TPU/CaCO3复合体系为基础,采用界面诱导技术使TPU被诱导并包覆在CaCO3表面上,自动地形成以CaCO3为核,以TPU为壳的相包容粒子,并实现了对POM树脂的有效增韧,改性材料不仅制备方法简单,而且在性能上完全达到了目前POM/TPU合金的水... 详细信息

以POM/TPU/CaCO3复合体系为基础,采用界面诱导技术使TPU被诱导并包覆在CaCO3表面上,自动地形成以CaCO3为核,以TPU为壳的相包容粒子,并实现了对POM树脂的有效增韧,改性材料不仅制备方法简单,而且在性能上完全达到了目前POM/TPU合金的水准。首次证明了利用具有包覆层的无机刚性粒子对高分子基体进行增韧时,其脆—韧转变不仅和增韧粒子的粒间距有关,而且和粒子包覆层厚度有关。对POM树脂而言,只有体系的粒间距达到临界值Tc≤0.18μm,且包覆层厚度达到临界值Lc≥0.7μm时,材料才有可能发生脆—韧转变,此时材料的冲击强度可比POM基体树脂增大数10倍,而且拉伸强度可达30MPa左右。

关键词：聚甲醛相包容粒子粒间距包覆层增韧

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基于ASON技术的电力通信网优化及应用

电子测试 2013年第6S期24卷 258-259,245页

作者：潘基明张亮方赵琳中国电子科技集团公司第34研究所广西桂林541004 南水北调东线山东干线有限责任公司 250013

智能电网建设需要新一代智能通信技术做基石和保证,通过研究ASON技术特征及应用,并结合传统电力SDH/MSTP通信网的不足,指出了ASON必然成为电力通信系统发展的主流方向,在现有SDH/MSTP通信网的基础上引进ASON控制平面,承载ASON业务,完善... 详细信息

智能电网建设需要新一代智能通信技术做基石和保证,通过研究ASON技术特征及应用,并结合传统电力SDH/MSTP通信网的不足,指出了ASON必然成为电力通信系统发展的主流方向,在现有SDH/MSTP通信网的基础上引进ASON控制平面,承载ASON业务,完善网络拓扑结构,提升带宽利用率,提高核心业务的可靠性和安全性。

关键词： ASON 电力通信网络优化可靠性