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Effect of antidepressants on body weight, ethology and tumor growth of human pancreatic carcinoma xenografts in nude mice

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World Journal of Gastroenterology 2008年第27期14卷 4377-4382页

作者： Lin jia yuan-yuan Shang Yu-yuan Li Department of Digestive Diseases Guangzhou Municipal First People's Hospital Guangzhou Medical College Guangzhou 510180 Guangdong Province China

AIM: To investigate the effects of mirtazapine and fluoxetine, representatives of the noradrenergic and specific serotonergic antidepressant (NaSSA) and se- lective serotonin reuptake inhibitor (SSRI) antidepres- sant respectively, on body weight, ingestive behavior, locomotor activity and tumor growth of human pancre- atic carcinoma xenografts in nude mice. METHODS: A subcutaneous xenograft model of hu- man pancreatic cancer cell line SW1990 was estab- lished in nude mice. The tumor-bearing mice were ran- domly divided into mirtazapine group [10 mg/(kg·d)], fluoxetine group [10 mg/(kg·d)] and control group (an equivalent normal saline solution) (7 mice in each group). Doses of all drugs were administered orally, once a day for 42 d. Tumor volume and body weight were measured biweekly. Food intake was recorded once a week. Locomotor activity was detected weekly using an open field test (OFT). RESULTS: Compared to the fluoxetine, mirtazapine significantly increased food intake from d 14 to 42 and attenuated the rate of weight loss from d 28 to 42 (t = 4.38, P < 0.05). Compared to the control group, food intake was significantly suppressed from d 21 to 42 and weight loss was promoted from d 35 to 42 in the fluoxetine group (t = 2.52, P < 0.05). There was a significant difference in body weight of the mice after removal of tumors among the three groups. The body weight of mice was the heaviest (13.66 ± 1.55 g) in the mirtazapine group and the lightest (11.39 ± 1.45 g) in the fluoxetine group (F(2,12) = 11.43, P < 0.01). The behavioral test on d 7 showed that the horizontal and vertical activities were significantly increased in the mirtazapine group compared with the fluoxetine and control groups (F(2,18) = 10.89, P < 0.01). These effects disappeared in the mirtazapine and fluoxetine groups during 2-6 wk. The grooming activity was higher in the mirtazapine group than in the fluoxetine group (10.1 ± 2.1 vs 7.1 ± 1.9 ) (t = 2.40, P < 0.05) in the second week. There was n

关键词： Pancreatic carcinoma Mirtazapine Fluoxetine Body weight Nude mice Locomotor activity Ethology

Nano-micrometer surface roughness gradients reveal topographical influences on differentiating responses of vascular cells on biodegradable magnesium

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Bioactive Materials 2021年第1期6卷 262-272页

作者： Ke Zhou Yutong Li Lei Zhang liang Jin Feng yuan Jinyun Tan Guangyin yuan jia Pei National Engineering Research Center of Light Alloy Net Forming&State Key Laboratory of Metal Matrix Composite School of Materials Science&EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai200240China Department of Biomedical Engineering University of Texas at AustinTX78712USA Department of Vascular Surgery Huashan HospitalFudan UniversityShanghai200040China

Distinctively directing endothelial cells(ECs)and smooth muscle cells(SMCs),potentially by surface topography cue,is of central importance for enhancing bioefficacy of vascular *** the first time,surface gradients with a broad range of nano-micrometer roughness are developed on Mg,a promising next-generation biodegradable metal,to carry out a systematic study on the response of ECs and *** adhesion,spreading,and proliferation are quantified along gradients by high-throughput imaging,illustrating drastic divergence between ECs and SMCs,especially in highly rough *** profound role of surface topography overcoming the biochemical cue of released Mg2+is unraveled at different roughness ranges for ECs and *** insights into the underlying regulatory mechanism are gained at subcellular and gene *** work enables highefficient exploration of optimized surface morphology for modulating favored cell selectivity of promoting ECs and suppressing SMCs,providing a potential strategy to achieve rapid endothelialization for Mg.

关键词： Surface roughness gradients Topography cue Vascular cells Cell adhesion and proliferation Cell selectivity

Big Theta Equals Small Theta Generically

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Acta Mathematica Sinica,English Series 2024年第3期40卷 717-730页

作者： Rui CHEN jia liang ZOU Institute for Advanced Study in Mathmatics Zhejiang UniversityHangzhou 310058P.R.China Department of Mathematics University of Michigan530 Church StAnn ArborMI 48109USA

In this paper we consider the theta correspondence over a non-Archimedean local *** the homological method and the theory of derivatives,we show that under a mild condition the bigtheta lift is irreducible.

关键词： Theta correspondence derivatives

Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期 46-95页

作者： Zhong-liang Gong Hong-Jie Zhang Yan Cheng jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong Yong Chen Chang-jiang Yao yuan-yuan Zhu liang-Jin Xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

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Solitary wave for a nonintegrable discrete nonlinear Schr?dinger equation in nonlinear optical waveguide arrays

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Chinese Physics B 2018年第3期27卷 108-119页

作者： Li-yuan Ma jia-liang Ji Zong-Wei Xu Zuo-Nong Zhu Department of Applied Mathematics Zhejiang University of TechnologyHangzhou 310023China School of Mathematics Physics and StatisticsShanghai University of Engineering ScienceShanghai 201620China School of Mathematical Sciences Shanghai Jiao Tong UniversityShanghai 200240China

We study a nonintegrable discrete nonlinear SchriSdinger （dNLS） equation with the term of nonlinear nearest-neighbor interaction occurred in nonlinear optical waveguide arrays. By using discrete Fourier transformation, we obtain numerical approximations of stationary and travelling solitary wave solutions of the nonintegrable dNLS equation. The analysis of stability of stationary solitary waves is performed. It is shown that the nonlinear nearest-neighbor interaction term has great influence on the form of solitary wave. The shape of solitary wave is important in the electric field propagating. If we neglect the nonlinear nearest-neighbor interaction term, much important information in the electric field propagating may be missed. Our numerical simulation also demonstrates the difference of chaos phenomenon between the nonintegrable dNLS equation with nonlinear nearest-neighbor interaction and another nonintegrable dNLS equation without the term.

关键词： nonintegrable dNLS equation solitary waves chaos nonlinear nearest-neighbor interaction

Dynamic soil-tunnel interaction in layered half-space for incident plane SH waves

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Earthquake Engineering and Engineering Vibration 2016年第4期15卷 715-727页

作者： Fu jia liang jianwen Qin Lin State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin University Department of Civil Engineering Tianjin University

The dynamic soil-tunnel interaction is studied by indirect boundary element method （IBEM）, using the model of a rigid tunnel in layered half-space, which is simplified to a single soil layer on elastic bedrock, subjected to incident plane SH waves. The accuracy of the results is verified through comparison with the analytical solution. It is shown that soil-tunnel interaction in layered half-space is larger than that in homogeneous half-space and this interaction mechanism is essentially different from that of soil-foundation-superstructure interaction.

关键词： underground tunnel layered half-space plane SH wave indirect boundary element method soil-tunnel interaction site dynamic characteristics

Dual-Voltage Single-Rail Dynamic DPA-Resistant Logic Based on Charge Sharing Mechanism

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Chinese Journal of Electronics 2017年第5期26卷 899-904页

作者： TANG Wenyi jia Song WANG yuan Institution of Microelectronics Peking University

Differential power analysis(DPA) has become a ma jor system security *** achieve high levels of security with low power and die area costs,a novel Dual-voltage single-rail dynamic logic(DSDL) design is *** proposed scheme can reduce power dissipation and obtain extremely well-balanced power *** charge sharing mechanism is used for voltage transfer in the internal nodes during the evaluation of the *** power supply voltages are used with positive feedback to speed up the evaluation process.A 4-bit micro Substitution box(SBOX) of the Advanced encryption standard(AES) algorithm has been implemented to verify the security of the proposed logic *** experimental results proved the security and the efficiency of the proposed DSDL,which can reduce power dissipation by up to 20% and occupies at most 83% of the silicon area when compared with previous state-of-the-art countermeasures.

关键词： DPA Charge sharing Three-phase logic family Side-channel attacks

Assemblies of covalent organic framework microcrystals:multiple-dimensional manipulation for enhanced applications

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Science China Chemistry 2018年第2期61卷 143-152页

作者： Fuyu yuan Jing Tan jia Guo State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science Fudan University

Covalent organic frameworks (COFs) are well known as the next generation of shape-persistent zeolite analogues, which have brought new impetus to the development of porous organic materials as well as two-dimensional polymers. Since the advent of COFs in 2005, many striking findings have definitely proven their great potentials expanding applications across energy,environment and healthcare fields. With thorough exploration over a decade, research interest has been drawn on the scientific challenges on chemistry, while making full play of COF values has remained far from satisfactory yet. Thus opening an avenue to modulating COF assemblies on the multi-scale is no longer just an option, but a necessity for matching the application requirements with enhanced performances. In this mini-review, we summarize the recent progress on design of nanoscale COFs with varying forms. Detailed description is concentrated on the synthetic strategies of COF assemblies such as spheres, fibers,tubes, coatings and films, thereby shedding light on the flexible manipulation over dimensions, compositions and ***, the advanced applications of nanoscale COFs have been discussed here with comparison of their bulky counterparts.

关键词： covalent organic frameworks controllable synthesis porous materials nanoscale

Traditional Chinese medicine for prevention and treatment of hepatocellular carcinoma: A focus on epithelial-mesenchymal transition

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Journal of Integrative Medicine 2021年第6期19卷 469-477页

作者： jia-jia Li Qing liang Guang-chun Sun Department of Pharmacy Shanghai Fifth People’s HospitalFudan UniversityShanghai 200240China

Hepatocellular carcinoma(HCC)is one of the most prevalent malignant cancers *** transition(EMT),which endows epithelial cells with mesenchymal properties,plays an important role in the early stages of *** cancer therapies have promising effects,but issues remain,such as high rates of metastasis and drug ***,exploring and evaluating new therapies is an urgent *** Chinese medicines(TCMs)have been acknowledged for their multi-target and coordinated intervention effects against *** evidence indicates that TCM can inhibit the malignancy of cells and the progression of EMT in ***,studies on the effects of TCM on EMT in HCC are *** this review,we summarized recent developments in anti-EMT TCMs and formulae,focusing on their underlying pharmacological mechanisms,to provide a foundation for further research on the exact mechanisms through which TCM affects EMT in HCC.

关键词： Traditional Chinese medicine Chinese medicine formulae Hepatocellular carcinoma Epithelial-mesenchymal transition Metastasis Cancer therapy