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计算机工程与应用 2001年第3期37卷 69-70,87页

作者：朱福喜余亮黄干平武汉大学数学与计算机科学学院武汉430072

文章提出了一种新的求解智力难题──假币与天平问题的方法，该方法利用了ＡＩ的搜索技术，将智力问题用一个适当的问题空间表达出来，然后将要求解的问题转化为与／或图中的搜索。研究表明ＡＯ非常适合求解这个智力难题。

关键词：人工智能 AO^*算法智力问题假币-天平问题

Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients

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World Journal of Clinical Cases 2025年第4期13卷 18-27页

作者： Cheng-Cheng Wei yu-Qing huang Cheng-Hong yu Department of Cardiology Tongxiang First People's HospitalTongxiang 314500Zhejiang ProvinceChina Department of Cardiology Guangdong Cardiovascular InstituteGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained *** To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive *** Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of *** changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal *** examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%*** The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the *** the course of a mean follow-up of 4.8 years,143 ischemic strokes *** normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal Wei CC et *** changed and ischemic stroke WJCC https://*** 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;P<0.001)and 1.448(95%CI:1.002-2.298;P=0.047)(P for trend was 0.233),*** In individuals with hypertension,longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.

关键词： Longitudinal change Hypertension Dyslipidemia Lipid profile Ischemic stroke

Integration of Electrical Properties and Polarization Loss Modulation on Atomic Fe–N‑RGO for Boosting Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 517-532页

作者： Kaili Zhang yuefeng Yan Zhen Wang Guansheng Ma Dechang Jia Xiaoxiao huang yu Zhou State Key Laboratory of Precision Welding&Joining of Materials and Structures Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China MIIT Key Laboratory of Advanced Structural‑Functional Integration Materials&Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

Developing effective strategies to regulate graphene’s conduction loss and polarization has become a key to expanding its application in the electromagnetic wave absorption(EMWA)*** on the unique energy band structure of graphene,regulating its bandgap and electrical properties by introducing heteroatoms is considered a feasible ***,metal-nitrogen doping reduced graphene oxide(M–N-RGO)was prepared by embedding a series of single metal atoms M–N_(4) sites(M=Mn,Fe,Co,Ni,Cu,Zn,Nb,Cd,and Sn)in RGO using an N-coordination atom-assisted *** composites had adjustable conductivity and polarization to optimize dielectric loss and impedance matching for efficient EMWA *** results showed that the minimum reflection loss(RL_(min))of Fe–N-RGO reaches−74.05 dB(2.0 mm)and the maximum effective absorption bandwidth(EAB_(max))is 7.05 GHz(1.89 mm)even with a low filler loading of only 1 wt%.Combined with X-ray absorption spectra(XAFS),atomic force microscopy,and density functional theory calculation analysis,the Fe–N_(4) can be used as the polarization center to increase dipole polarization,interface polarization and defect-induced polarization due to d-p orbital hybridization and structural ***,electron migration within the Fe further leads to conduction loss,thereby synergistically promoting energy *** study demonstrates the effectiveness of metal-nitrogen doping in regulating the graphene′s dielectric properties,which provides an important basis for further investigation of the loss mechanism.

关键词： Electromagnetic wave absorption Fe-N-RGO Dipole polarization Conduction loss Impedance matching

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao liang Xingping Quan Xiaorui Geng yujing huang Yonghua Zhao Lei Xi Zhen yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava:A retrospective cohort study

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World Journal of Gastroenterology 2025年第1期31卷 42-57页

作者： Kun huang Zhu Chen Heng Xiao Hai-Yang Hu Xing-yu Chen Cheng-You Du Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of General Surgery Mianyang Hospital of Traditional Chinese MedicineMianyang 621000Sichuan ProvinceChina

BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under *** the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ *** To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional *** The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively *** novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the ***,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a ***,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic *** short-term postoperative outcomes and oncological results of the two approaches were evaluated and *** A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel *** novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)comp

关键词： Laparoscopic liver resection Inferior vena cava Retrohepatic tunnel Short hepatic veins Complex liver tumors Intraoperative bleeding control

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu yu Wang Hanlin huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Quickly obtaining densely dispersed coherent particles in steel matrix and its related mechanical property

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao Wang Qingsong huang School of Chemical Engineering Sichuan UniversityChengdu 610065China

Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compression test work hardening

传统皮瓣与穿支皮瓣在面颌缺损整形手术中的应用效果比较

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上海医药 2017年第21期38卷 50-52,58页

作者：梁向新余晓波黄媖江西省九江学院附属口腔医院口腔颌面外科九江332000 江西省九江学院护理学院九江332000 江西省九江学院附属口腔医院医学影像中心九江332000

目的 :比较分析传统皮瓣与穿支皮瓣在面颌缺损整形手术中的应用效果。方法 :选取2016年1月—2017年1月我院口腔颌面外科收治的行面颌缺损整形手术患者100例,按照随机、对照、双盲试验原则分为两组,行传统皮瓣手术的50例患者作为对照组,... 详细信息

目的 :比较分析传统皮瓣与穿支皮瓣在面颌缺损整形手术中的应用效果。方法 :选取2016年1月—2017年1月我院口腔颌面外科收治的行面颌缺损整形手术患者100例,按照随机、对照、双盲试验原则分为两组,行传统皮瓣手术的50例患者作为对照组,行穿支皮瓣手术的50例患者作为观察组。结果 :观察组患者皮瓣成活率98.00%,显著高于对照组的96.00%(P0.05;两组患者术后外形、语言、吞咽功能良好恢复率比较P>0.05。结论:在面颌缺损整形手术中,传统皮瓣与穿支皮瓣在手术风险、皮瓣存活率、术后功能等方面存在一定的共性和差异,临床应根据实际情况选择皮瓣类型。

关键词：穿支皮瓣传统皮瓣面颌缺损整形手术

超声引导下腘静脉穿刺治疗下肢静脉血栓的临床效果

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中国当代医药 2017年第6期24卷 41-43页

作者：黄友清廖斌李梁瑜黄智勇广东省茂名市人民医院超声诊断科广东茂名525100

目的探讨超声引导下腘静脉穿刺治疗下肢静脉血栓的临床效果。方法选取我院2014年6月~2016年3月收治的88例下肢静脉血栓患者,采用双色球分组法分为对照组和观察组。对照组患者采用经外周静脉滴注尿激酶治疗,观察组患者在超声引导下经腘... 详细信息

目的探讨超声引导下腘静脉穿刺治疗下肢静脉血栓的临床效果。方法选取我院2014年6月~2016年3月收治的88例下肢静脉血栓患者,采用双色球分组法分为对照组和观察组。对照组患者采用经外周静脉滴注尿激酶治疗,观察组患者在超声引导下经腘静脉穿刺,置入溶栓导管,经导管持续灌注尿激酶溶栓治疗。比较两组患者的肿胀消退时间与住院时间、临床效果与并发症发生率。结果观察组患者的肿胀消退时间为(6.33±2.14)d,住院时间为(8.04±2.37)d,对照组患者肿胀消退时间为(9.18±2.62)d,住院时间为(12.55±3.16)d,两组比较,差异有统计学意义(P0.05)。结论超声引导下腘静脉穿刺治疗下肢静脉血栓的临床效果较好,可缩短患者肿胀消退时间与住院时间,并发症发生率较低,值得临床推广应用。

关键词：超声引导腘静脉穿刺下肢静脉血栓

DNA双链断裂修复蛋白在乳腺癌和乳腺纤维腺瘤中的表达

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华中科技大学学报（医学版） 2008年第3期37卷 332-335页

作者：庄亮于世英黄晓园熊慧华曹阳李伟华中科技大学同济医学院附属同济医院肿瘤中心武汉430030

目的研究DNA双链断裂修复蛋白(Ku80、DNA-PKcs和ATM)在乳腺癌和乳腺纤维腺瘤组织中的表达,探讨3种蛋白在乳腺癌发生发展中的作用及相互关系。方法应用免疫组化SP法检测55例乳腺癌和14例乳腺纤维腺瘤组织中Ku80、DNA-PKcs和ATM蛋白的表... 详细信息

目的研究DNA双链断裂修复蛋白(Ku80、DNA-PKcs和ATM)在乳腺癌和乳腺纤维腺瘤组织中的表达,探讨3种蛋白在乳腺癌发生发展中的作用及相互关系。方法应用免疫组化SP法检测55例乳腺癌和14例乳腺纤维腺瘤组织中Ku80、DNA-PKcs和ATM蛋白的表达情况。结果Ku80、DNA-PKcs和ATM蛋白在乳腺癌患者中的阳性率分别为74.5%、54.5%和52.7%,在乳腺纤维腺瘤患者中的阳性率分别为92.9%、92.9%和71.4%;DNA-PKcs蛋白在乳腺癌组织中的表达显著低于乳腺纤维腺瘤组织(χ2=6.975,P=0.008),而Ku80和ATM的表达虽在乳腺癌组织中的表达亦低于乳腺纤维腺瘤组织,但差异无显著性意义(均P>0.05)。ATM和DNA-PKcs蛋白的表达在不同病理类型、肿块大小、临床分期和淋巴结转移状态的乳腺癌患者中差异无统计学意义(P>0.05);但Ku80的表达与患者的肿块大小和临床分期相关(P<0.01)。Spearman等级相关分析提示:在55例乳腺癌患者中,Ku80与DNA-PKcs的表达呈正相关(r=0.355,P=0.008);Ku80与ATM的表达亦呈正相关(r=0.325,P=0.015)。结论DNA-PKcs蛋白可能在乳腺癌的发生发展中起重要作用;Ku80可以促进乳腺癌细胞生长;Ku80与DNA-PKcs及ATM存在密切关系。

关键词： Ku80 DNA-PKcs ATM 乳腺癌乳腺纤维腺瘤