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Safety, pharmacokinetics, and biomarkers of F-652, a recombinant human interleukin-22 dimer, in healthy subjects

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Cellular & Molecular Immunology 2019年第5期16卷 473-482页

作者： Kai-Yang Tang Jason Lickliter Zhi-Hua huang Zong-Shu Xian Han-Yang Chen Cheng huang Chong Xiao yu-Peng Wang Ying Tan Lin-Feng Xu yu-liang huang Xiao-Qiang Yan Generon(Shanghai)Corporation Ltd. Zhangjiang Hi-Tech ParkShanghaiChina Nucleus Network MelbourneVICAustralia

F-652 is a recombinant fusion protein consisting of two human interleukin-22(IL-22)molecules linked to an immunoglobulin constant region(IgG 2-Fc).IL-22 plays critical roles in promoting tissue repair and suppressing bacterial *** safety,pharmacokinetics(PK),tolerability,and biomarkers of F-652 were evaluated following a single dose in healthy male volunteers in a randomized,double-blind,placebo-controlled *** single-dose subcutaneous(SC)injection of F-652 at 2.0µg/kg into healthy subjects,six out of six subjects experienced delayed injection site reactions,which presented as erythematous and/or discoid eczematous lesions 10 to 17 days post-dosing.F-652 was then administered to the healthy subjects via an intravenous(IV)infusion at 2.0,10,30,and 45µg/*** severe adverse event(SAE)was observed during the *** the IV-dosed cohorts,eye and skin treatment emergent adverse events(TEAEs)were observed in the 30 and 45µg/kg cohorts.F-652 IV dosing resulted in linear increases in C max and AUC(0–t),and the T 1/2 ranged from 39.4 to 206h in the *** IV injection of F-652 induced dose-dependent increases in serum marker serum amyloid A,C-reactive protein,and FIB,and decreased serum *** serum levels of 36 common pro-inflammatory cytokines/chemokines were not altered by the treatment of F-652 at 45μg/*** conclusion,IV administration of F-652 to healthy male volunteers is safe and well-tolerated and demonstrates favorable PK and pharmacodynamic *** results warrant further clinical development of F-652 to treat inflammatory diseases.

关键词： Interleukin-22 F-652 Pharmacokinetics Pharmacodynamics Safety

Recognizing and monitoring infectious sources of schistosomiasis by developing deep learning models with high-resolution remote sensing images

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Infectious Diseases of Poverty 2023年第1期12卷 24-35页

作者： Jing-Bo Xue Shang Xia Xin-Yi Wang Lu-Lu huang liang-yu huang yu-Wan Hao Li-Juan Zhang Shi-Zhu Li National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research On Tropical DiseasesShanghai 200025China School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghai 200025China

Background China is progressing towards the goal of schistosomiasis elimination,but there are still some problems,such as difficult management of infection source and snail *** study aimed to develop deep learning models with high-resolution remote sensing images for recognizing and monitoring livestock bovine,which is an intermediate source of Schistosoma japonicum infection,and to evaluate the effectiveness of the models for real-world *** The dataset of livestock bovine’s spatial distribution was collected from the Chinese National Platform for Common Geospatial Information *** high-resolution remote sensing images were further divided into training data,test data,and validation data for model *** recognition models based on deep learning methods(ENVINet5 and Mask R-CNN)were developed with reference to the training *** performance of the developed models was evaluated by the performance metrics of precision,recall,and *** A total of 50 typical image areas were selected,1125 bovine objectives were labeled by the ENVINet5 model and 1277 bovine objectives were labeled by the Mask R-CNN *** the ENVINet5 model,a total of 1598 records of bovine distribution were *** model precision and recall were 81.9%and 80.2%,*** F1 score was *** the Mask R-CNN mode,1679 records of bovine objectives were *** model precision and recall were 87.3%and 85.2%,*** F1 score was *** applying the developed models to real-world schistosomiasis-endemic regions,there were 63 bovine objectives in the original image,53 records were extracted using the ENVINet5 model,and 57 records were extracted using the Mask R-CNN *** successful recognition ratios were 84.1%and 90.5%for the respectively developed *** The ENVINet5 model is very feasible when the bovine distribution is low in structure with few *** Mask R-CNN model has a good framework de

关键词： Deep learning High-resolution remote sensing Recognizing Monitoring Infectious source Schistosomiasis

Effects of topiramate and carbamazepine on thyroid hormone level in adults with epilepsy

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Neural Regeneration Research 2006年第8期1卷 706-709页

作者： liang yu, yulan huang, Hongbin Sun, Jie Liu, Fei Xu, Xiaoping Wang Sichuan Academy of Medical Sciences Department of Neurology, Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, China Sichuan Academy of Medical Sciences Department of Neurology Sichuan Provincial People's Hospital Chengdu 610072 Sichuan Province China

BACKGROUND: It has been demonstrated that traditional antiepileptics, such as phenytoin, carbamazepine (CBZ), phenobarbital, etc., can result in the decrease of thyroid hormone of epileptic patients. However, there is still no sufficient evidence for the studies about the effect of new-type antiepileptics, such as topiramate (TPM), on thyroid hormones. OBJECTIVE: To observe the effects of TPM and CBZ on the level of thyroid hormones in serum of adults with epilepsy. DESIGN: A comparative observation. SETTING: Department of Neurology, Sichuan Provincial People's Hospital. PARTICIPANTS: Totally 100 outpatients or inpatients newly diagnosed to have epilepsy were selected from the Department of Neurology, Sichuan Provincial People's Hospital from July 2003 to August 2005, including 60 males and 40 females, aged 18-70 years. All the patients were accorded with the standard for the classification of epilepsy set by International League Against Epilepsy (ILAE) in 1981; Had been Informed and agreed with the detection; Had no history of thyroid gland disease; Had not taken any drugs could affect the thyroid function. Meanwhile, 40 adult healthy examinees were selected from our hospital as the control group, including 24 males and 16 females, aged 18-65 years. METHODS: ① The 100 epileptic patients were randomly divided into TPM group (n =50) and CBZ group (n =50), and they were treated with TPM (Xian-Janssen Pharmaceutical, Ltd.; Batch number: 03AS032, Norm: 25 mg/tablet) and CBZ (Shanghai Sunve Pharmaceutical Co., Ltd.; Batch number: 030201, Norm: 100 mg/tablet) respectively. The initial dosage of TPM was 25 mg per day, increased by 25 mg every week, the objective dosage of 100-200 mg per day was maintained when the symptoms were satisfactorily controlled. The dosage of CBZ was 6-8 mg/kg per day. All the patients were administrated for 1 year. ② The serum levels of total thyroxine (TT4), free thyroxine (FT4), total triiodothyronine (TT3), free triiodothyronine (FT3) and thyr

关键词： CBZ Effects of topiramate and carbamazepine on thyroid hormone level in adults with epilepsy

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang yu-Wen Alvin huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Inflammation-induced ER stress and ARMET expression in antigen-induced arthritis

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Inflammation-induced ER stress and ARMET expression in antig...

High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

第十届全国抗炎免疫药理学学术会议

作者： Li-Jie Feng,Chang-liang yu,Xue-Gui huang,Fa-Cai Wang,yu-Jun Shen,Yong-Qiang yu,Hai-Ping Wang,yu-Xian Shen,Jun Li

Introduction:Rheumatoid arthritis(RA) is an inflammatory,progressive,destructive autoimmune disease with synovial hyperplasia followed by impairment of quality of ***,its exact mechanism(s) is not fully *** reticulum(ER) stress has been shown to be involved in the pathogenesis of several diseases,including autoimmune ***-rich,mutated

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Journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng Xinyi huang Mingwei Zhao Shuling Liao Quanhong Yang Nianjun Yang Siyu yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Flexible supercapacitors High-temperature tolerance Gel polymer electrolytes Electrode materials

圆环病毒2型感染对猪瘟疫苗免疫效果的抑制作用

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养猪 2013年第6期 3-4页

作者：杜根成胡群山 yu-liang huang 普莱柯生物工程股份有限公司

猪瘟菲律宾毒株兔化弱毒(LPC)疫苗是预防和控制猪瘟感染的一种重要工具,在包括中国台湾在内大多数猪瘟流行地区被广泛应用。本研究的目的是调查PCV2感染是否影响LPC疫苗免疫效果。选择18头6周龄剖腹生产、未吃初乳的仔猪(CDCD),随机分为... 详细信息

猪瘟菲律宾毒株兔化弱毒(LPC)疫苗是预防和控制猪瘟感染的一种重要工具,在包括中国台湾在内大多数猪瘟流行地区被广泛应用。本研究的目的是调查PCV2感染是否影响LPC疫苗免疫效果。选择18头6周龄剖腹生产、未吃初乳的仔猪(CDCD),随机分为4组。组1和2的猪,在出生当天鼻内

关键词：猪瘟猪霍乱病毒病 LPC

大学生的人生意义与社会支持:自尊的中介作用

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安康学院学报 2018年第3期30卷 114-117页

作者：余亮黄龙皖南医学院团委安徽芜湖241000

目的探讨自尊、社会支持与大学生人生意义的关系。方法采用人生意义量表、自尊量表和社会支持量表对安徽省某地区三所大学的650名学生匿名施测。结果 (1)在控制性别和专业的基础上,社会支持对大学生人生意义有正向预测作用。(2)自尊在... 详细信息

目的探讨自尊、社会支持与大学生人生意义的关系。方法采用人生意义量表、自尊量表和社会支持量表对安徽省某地区三所大学的650名学生匿名施测。结果 (1)在控制性别和专业的基础上,社会支持对大学生人生意义有正向预测作用。(2)自尊在主观支持、支持利用度和人生意义之间起完全中介作用;自尊在客观支持和人生意义之间起部分中介作用。结论主观支持、客观支持和支持利用度对大学生人生意义具有直接和间接作用,自尊起中介作用。

关键词：大学生人生意义社会支持自尊中介作用

Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： Ke Jiang Zhi Chen Ji yu Chen Zheng Shan huang Ming Wang Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing