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Comparisons of Supine Roll Test and Alternative Positional Tests in HC-BPPV Lateralization

Current Medical Science 2022年第3期42卷 613-619页

作者： Geeta KOJU Dan BING liang-qiang zhou Zhong-yao MAO Yan-ling TAO Qing-guo CHEN Jin CHEN Yun LIU Ting TONG Han-qi CHU Department of Otolaryngology-Head and Neck Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective The purpose of the study was to evaluate the efficiency of the supine roll test(SRT)and alternative positional tests(APTs)including the bow and lean test(BLT),pseudo-spontaneous nystagmus(PSN),and lying down nystagmus(LDN)to identify the affected side in horizontal canal benign paroxysmal positional vertigo(HC-BPPV).Methods In our prospective study,we performed a testing profile(PSN,BLT,LDN,SRT)on 59 HC-BPPV patients using videonystagmography.We compared the accuracy and sensitivity of these tests in HC-BPPV lateralization.Data from 30 healthy patients were collected as the control group.Results When performing positional tests,the elicited nystagmus coinciding with Ewald’s second law was defined as a“positive response”.In 44 patients with geotropic nystagmus,the rates of positive response in LDN,PSN,and BLT were 22/44(50%),19/44(43%),and 18/44(41%),respectively,while in 15 patients with apogeotropic nystagmus,the positive response rates of these three tests were 10/15(66.7%),9/15(60%),and 4/15(27.00%),respectively.The sensitivity of LDN(54.38%)was higher than that of PSN(47.37%)and BLT(38.60%)but lower than that of SRT(89.47%).Notably,the accuracy rate of PSN(71.8%)was higher than that of the other APTs.In 6 patients with symmetrical nysgtamus during the roll test,5 patients showed a positive response in both LDN and BLT(83.34%),whereas 4 patients showed a positive response in PSN(66.67%).Conclusion All positional tests are helpful for determining the affected side of HC-BPPV,but SRT carries the highest accuracy of lateralization followed by PSN.

关键词： horizontal canal benign paroxysmal positional vertigo pseudo spontaneous nystagmus bow and lean test lying down nystagmus supine roll test

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Expression ofα2-Na/K-ATPase in C57BL/6J Mice Inner Ear and Its Relationship with Age-related Hearing Loss

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Current Medical Science 2021年第1期41卷 153-157页

作者： Yun LIU Han-qi CHU Yan-bo SUN Dan BING liang-qiang zhou Jin CHEN Qing-guo CHEN Zhi-hui DU Department of Otolaryngology-Head and Neck Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Otolaryngology-Head and Neck Surgery the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

K^(+)cycling in the cochlea is critical to maintain hearing.Many sodium-potassium pumps are proved to participate in K^(+)cycling,such as Na/K-ATPase.Theα2-Na/K-ATPase is an important isoform of Na/K-ATPase.The expression ofα2-Na/K-ATPase in the cochlea is not clear.In this study,we used C57BL/6 mice as a model of presbycusis and implemented immunohistochemistry staining and quantitative real time-PCR,and theα2-Na/K-ATPase expression pattern was confirmed in the inner ear.It was foundα2-Na/K-ATPase was expressed widely in cochlea and its mRNA and protein expression was gradually reduced with aging(4-,14-,26-and 48-weeks old mice).We suspected that,the down-regulation ofα2-Na/K-ATPase expression might be associated with the remodeling of K^(+)cycling,degeneration of morphological structure and decrease of hearing function in aging C57 mice.In conclusion,we speculated that the reduction ofα2-Na/K-ATPase might play an important role in the pathogenesis of age-related hearing loss.

关键词： α2-Na/K-ATPase C57BL/6J mouse inner ear age-related hearing loss K^(+)cycling

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Molecular characterization and gene functional analysis of Dicer-2 gene from Nilaparvata lugens （Hemiptera： Geometroidea）

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Insect Science 2013年第1期20卷 61-68页

作者： Xiao-Yi Zhang Kai Lu Jia-liang zhou qiang zhou State Key Laboratory of Biological Control and Institute of Entomology Sun Yat-sen University Guangzhou China

Nilaparvata lugens （St^il）（Hemiptera： Geometroidea）, a serious rice pest in many countries of Asia, causes a great loss in rice production every year. RNA interference （RNAi） is a powerful technology for gene fimction study in insects and a potential tool for pest control. As a core component of RNAi pathway, Dicer-2 （Dcr-2） protein determines the production of small interfering RNA （siRNA） and is crucial for the efficiency of RNAi. In this study, the full-length complementary DNA （cDNA） ofN. lugens Dcr-2 （NlDcr-2） was first cloned and analyzed, and then the RNAi experiment was conducted to explore the function ofNlDcr-2 gene. The complete Dcv-2 cDNA ofN. lugens was 4 971 bp in length with an open reading frame （ORF） of 1,656 amino acids. Phylogenetic and protein domain analysis showed that the predicted N1Dcr-2 protein was similar to Tribolium castaneum. In the RNAi experiment, the messenger RNA level of NlDcr-2 was significantly reduced by NlDcr-2 double-stranded RNA （dsRNA）（dsDcr-2）. Fifty-five per cent decrease of N1Dcr-2 was found after 4 days of unremitting feeding. No significant effect was observed on the development ofN. lugens after dsRNA ingestion.

关键词： clone Dicer-2 Nilaparvata lugens RNAi qRT-PCR

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PABP-driven secondary condensed phase within RSV inclusion bodies activates viral mRNAs for ribosomal recruitment

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Virologica Sinica 2024年第2期39卷 235-250页

作者： qiang Zhang Hanzhe Ye Cong Liu Haiwu zhou Mingbin He Xiaodong liang Yu zhou Kun Wang Yali Qin Zhifei Li Mingzhou Chen State Key Laboratory of Virology and Modern Virology Research Center College of Life SciencesWuhan UniversityWuhan430072China Taikang Center for Life and Medical Sciences Wuhan UniversityWuhan430072China Hubei Jiangxia Laboratory Wuhan430200China

Inclusion bodies(IBs)of respiratory syncytial virus(RSV)are formed by liquid-liquid phase separation(LLPS)and contain internal structures termed“IB-associated granules”(IBAGs),where anti-termination factor M2-1 and viral mRNAs are concentrated.However,the mechanism of IBAG formation and the physiological function of IBAGs are unclear.Here,we found that the internal structures of RSV IBs are actual M2-1-free viral messenger ribonucleoprotein(mRNP)condensates formed by secondary LLPS.Mechanistically,the RSV nucleoprotein(N)and M2-1 interact with and recruit PABP to IBs,promoting PABP to bind viral mRNAs transcribed in IBs by RNArecognition motif and drive secondary phase separation.Furthermore,PABP-eIF4G1 interaction regulates viral mRNP condensate composition,thereby recruiting specific translation initiation factors(eIF4G1,eIF4E,eIF4A,eIF4B and eIF4H)into the secondary condensed phase to activate viral mRNAs for ribosomal recruitment.Our study proposes a novel LLPS-regulated translation mechanism during viral infection and a novel antiviral strategy via targeting on secondary condensed phase.

关键词： Respiratory syncytial virus(RSV) Inclusion bodies(IBs) Biomolecular condensates Liquid-liquid phase separation(LLPS) Secondary condensed phase mRNA activation

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Clinical review and literature analysis of hepatic epithelioid angiomyolipoma in alcoholic cirrhosis: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2382-2388页

作者： Jing-qiang Guo Jia-Hui zhou Kun Zhang Xin-liang Lv Chao-Yong Tu Department of Hepatobiliary and Pancreatic Surgery Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina Department of Pathology Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina Department of General Surgery The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Hepatic epithelioid angiomyolipoma(HEA)has a low incidence and both clinical manifestations and imaging lack specificity.Thus,it is easy to misdiagnose HEA as other tumors of the liver,especially in the presence of liver diseases such as hepatitis cirrhosis.This article reviewed the diagnosis and treatment of a patient with HEA and alcoholic cirrhosis,and analyzed the literature,in order to improve the understanding of this disease.CASE SUMMARY A 67-year-old male patient with a history of alcoholic cirrhosis was admitted due to the discovery of a space-occupying lesion in the liver.Based on the patient’s history,laboratory examinations,and imaging examinations,a malignant liver tumor was considered and laparoscopic partial hepatectomy was performed.Postoperative pathology showed HEA.During outpatient follow-up,the patient showed no sign of recurrence.CONCLUSION HEA is difficult to make a definite diagnosis before surgery.HEA has the poten-tial for malignant degeneration.If conditions permit,surgical treatment is recom-mended.

关键词： Hepatic epithelioid angiomyolipoma Alcoholic cirrhosis Magnetic resonance imaging Computed tomography Immunohistochemistry Misdiagnose analysis Case report

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Remote sensing image encryption algorithm utilizing 2D Logistic memristive hyperchaotic map and SHA-512

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Science China(Technological Sciences) 2024年第5期67卷 1553-1566页

作者： LAI qiang LIU Yuan YANG liang School of Electrical and Automation Engineering East China Jiaotong UniversityNanchang330013China

The two-dimensional Logistic memristive hyperchaotic map(2D-LMHM)and the secure hash SHA-512 are the foundations of the unique remote sensing image encryption algorithm(RS-IEA)suggested in this research.The proposed map is formed from the improved Logistic map and the memristor,which has wide phase space and hyperchaotic range and is exceptionally excellent to be utilized in specific applications.The proposed image algorithm uses the permutation-assignment-diffusion structure.Permutation generates two position matrices in a progressive manner to achieve an efficient random exchange of pixel positions,assignment is carried through on the image pixels of the permutated image to entirely remove the original image information,strengthening the relationship between permutation and diffusion,and loop diffusion in two different directions can use subtle changes of pixels to affect the whole plane.The random key and plain-image SHA-512 hash values are used to produce an additional key,which is then utilized to figure out the permutation parameters and the initial value of a chaotic map.The experimental results with the average NPCR=99.6094%(NPCR:number of pixels change rate),average UACI=33.4638%(UACI:unified average changing intensity),100%pass rate of the targets in the test set,the average correlation coefficient is 0.00075,and the local information entropy is 7.9025,which shows that the algorithm is able to defend against a variety of illegal attacks and provide more trustworthy protection than some of the existing state-of-the-art algorithms.

关键词： chaos memristive hyperchaotic map remote sensing SHA-512 image encryption RS-IEA

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A Plasma Membrane Polarity Sensor Harnessing Conjoined Twisted Intramolecular Charge Transfer Modulation and Charge Number Control Strategy

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CCS Chemistry 2024年第3期6卷 733-748页

作者： Yu-qiang Zhao Le Yu Liping Zhu Jinsong liang Ying zhou Jong Seung Kim College of Chemical Science and Technology Yunnan UniversityKunming 650091 Department of Chemistry Korea UniversitySeoul 02841 TheranoChem Incorporation Seoul 02856

Polarity is a critical microenvironmental factor of the plasma membrane,which can offer valuable insights into various biological processes.Herein,we proposed a novel strategy for the construction of fluorescent agents to measure plasma membrane polarity by conjoining twisted intramolecular charge transfer(TICT)modulation and charge number control.It is shown that compounds with a stronger TICT tendency are more sensitive to polarity shifts due to the number of dialkylated amino groups present(from 1 to 3),and the molecules with two or more charged centers remain in the plasma membrane.Therefore,we developed two fluorescent agents with high polarity sensitivity,excellent turn-on ratios,and superior ability,to target the plasma membrane.In the wash-free fluorescence imaging and fluorescence lifetime tests,our designed agent could detect plasma membrane polarity with high precision,allowing effective distinction between cancer cells and normal cells based on their differences in plasma membrane polarity.Moreover,both fluorescence and fluorescence lifetime changes of the plasma membrane in the ferroptosis model established by Sorafenib confirmed an increase in plasma membrane polarity during cell ferroptosis.

关键词： membrane polarity fluorescence agents fluorescence imaging fluorescence lifetime imaging

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Optimizing magnetoelastic properties by machine learning and high-throughput micromagnetic simulation

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Rare Metals 2024年第5期43卷 2251-2262页

作者： Jian-Hu Gong Zheng-Ming Zhang Cheng-liang Zhang Peng-qiang Hu Chao zhou Dun-Hui Wang Sen Yang Division of Microelectronic Materials and Devices Hangzhou Dianzi University School of Physics MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter and State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University National Laboratory of Solid State Microstructures Nanjing University

Magnetoelastic couplings in giant magnetostrictive materials （GMMs） attract significant interests due to their extensive applications in the fields of spintronics and energy harvesting devices.Understanding the role of the selection of materials and the response to external fields is essential for attaining desired functionality of a GMM.Herein,machine learning （ML） models are conducted to predict saturation magnetostrictions （λs） in RFe2-type （R=rare earth） GMMs with different compositions.According to ML-predicted composition–λsrelations,it is discovered that the values ofλshigher than1100×10–6are almost situated in the composition space surrounded by 0.26≤x≤0.60 and 1.90≤y≤2.00 for the ternary compounds of TbxDy1-xFey.Assisted by ML predictions,the compositions are further narrowed down to the space surrounded by 0.26≤x≤0.32 and 1.92≤y≤1.97 for the excellent piezomagnetic （PM） performance in the TbxDy1-xFey-based PM device through our developed high-throughput （HTP） micromagnetic simulation（MMS） algorithm.Accordingly,high sensitivities up to10.22–13.61 m T·MPa–1are observed in the optimized range within which the available experimental data fall well.This work not only provides valuable insights toward understanding the mechanism of magnetoelastic couplings,but also paves the way for designing and optimizing highperformance magnetostrictive materials and PM sensing devices.

关键词： Magnetostriction Piezomagnetic effect Machine learning Micromagnetic simulation

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Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2024年第10期30卷 1393-1404页

作者： Ming-Hui Zeng Qi-Yu Shi liang Xu Yu-qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Gastroenterology Cangzhou People’s HospitalCangzhou 061000Hebei ProvinceChina Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Tianjin Research Institute of Liver Diseases Tianjin 300192China

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease worldwide,affecting about 1/4th of the global population and causing a huge global economic burden.To date,no drugs have been approved for the treatment of NAFLD,making the correction of unhealthy lifestyles the principle method of treatment.Identifying patients with poor adherence to lifestyle correction and attempting to improve their adherence are therefore very important.AIM To develop and validate a scale that can rapidly assess the adherence of patients with NAFLD to lifestyle interventions.METHODS The Exercise and Diet Adherence Scale(EDAS)was designed based on com-pilation using the Delphi method,and its reliability was subsequently evaluated.Demographic and laboratory indicators were measured,and patients completed the EDAS questionnaire at baseline and after 6 months.The efficacy of the EDAS was evaluated in the initial cohort.Subsequently,the efficacy of the EDAS was internally verified in a validation cohort.RESULTS The EDAS consisted of 33 items in six dimensions,with a total of 165 points.Total EDAS score correlated significantly with daily number of exercise and daily reduction in calorie intake(P500 kacl/d),(sensitivity/specificity was 100.0%/75.8%),while patients score below 97 could nearly rule out the possibility of daily exercise(sensitivity/specificity was 89.5%/44.4%).Total EDAS scores≥116,97-115,and<97 points were indicative of good,average,and poor adherence,respectively,to diet and exercise recommendations.CONCLUSION The EDAS can reliably assess the adherence of patients with NAFLD to lifestyle interventions and have clinical application in this population.

关键词： Fatty liver Lifestyle intervention Behavioral change Patient adherence Compliance

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Ternary-phase layered cathodes toward ultra-stable and highrate sodium ion storage

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Rare Metals 2024年第4期43卷 1589-1598页

作者： Wen-Ji Yin Pei-Dan Su Qi Lu Xiao-Qiong Li Ji-Ming Peng Teng-Fei zhou Ge-Meng liang Yu-liang Cao Hong-qiang Wang Qing-Yu Li Si-Jiang Hu Guangxi Key Laboratory of Low Carbon Energy Materials School of Chemistry and Pharmaceutical SciencesGuangxi Normal University Institutes of Physical Science and Information Technology Anhui University Department of Chemistry and Pharmaceutical Sciences Guilin Normal College College of Chemistry and Chemical Engineering Huanggang Normal University School of Chemical Engineering and Advanced Materials The University of Adelaide Engineering Research Center of Organosilicon Compounds and Materials of Ministry of Education College of Chemistry and Molecular SciencesWuhan University

With the shortage of lithium resources,sodiumion batteries（SIBs） are considered one of the most promising candidates for lithium-ion batteries.P2-type and O3-type layered oxides are one of the few cathodes that can access high energy density.However,they usually exhibit structural change,capacity decay,and slow Na ion kinetic.Herein,we present layered ternary-phase cathodes with P2,P3 and O3 phases by a lattice doping strategy,which is demonstrated by X-ray diffraction（XRD） refinement.Combining the characteristics of P2,P3 and O3 phases,the layered composites show performance improvement during long-term battery cycling.In particular,Na0.7Li0.1Co0.3-Fe0.3Mn0.3O2（NLCFM） delivers a reversible capacity of120.1 mAh·g-1at 0.1C(1.0C=175 mA·g-1) with a superior capacity retention of 72.5% after 1000 cycles at10.0C.This work offers insights into the development of advanced cathode materials for SIBs.

关键词： Sodium-ion battery Cathode material Layered oxides Lattice doping Mixed phase

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