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Fine-grained grid computing model for Wi-Fi indoor localization in complex environments

Journal of Electronic Science and Technology 2024年第1期22卷 42-52页

作者： Yan liang Song Chen Xin Dong tu Liu School of Computer Engineering Chengdu Technological UniversityChengdu611730China HAN Networks Corporation Limited Beijing100094China

The fingerprinting-based approach using the wireless local area network(WLAN)is widely used for indoor ***,the construction of the fingerprint database is quite *** when the position of the access point(AP)or wall changes,updating the fingerprint database in real-time is *** appropriate indoor localization approach,which has a low implementation cost,excellent real-time performance,and high localization accuracy and fully considers complex indoor environment factors,is preferred in location-based services(LBSs)*** this paper,we proposed a fine-grained grid computing(FGGC)model to achieve decimeter-level localization *** points(RPs)are generated in the grid by the FGGC ***,the received signal strength(RSS)values at each RP are calculated with the attenuation factors,such as the frequency band,three-dimensional propagation distance,and walls in complex *** a result,the fingerprint database can be established automatically without manual measurement,and the efficiency and cost that the FGGC model takes for the fingerprint database are superior to previous *** proposed indoor localization approach,which estimates the position step by step from the approximate grid location to the fine-grained location,can achieve higher real-time performance and localization accuracy *** mean error of the proposed model is 0.36 m,far lower than that of previous ***,the proposed model is feasible to improve the efficiency and accuracy of Wi-Fi indoor *** also shows high-accuracy performance with a fast running speed even under a large-size *** results indicate that the proposed method can also be suitable for precise marketing,indoor navigation,and emergency rescue.

关键词： Fine-grained grid computing (FGGC) Indoor localization Path loss Random forest Reference points(RPs)

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An integrated MINLP model for multi-party coordination in downstream oil supply chain

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Petroleum Science 2024年第3期21卷 2066-2079页

作者： Rui Qiu Bo Zhang Wei Zhao Ren-Fu tu Man-Qiu He Qi Liao Yong-tu liang National Engineering Laboratory for Pipeline Safety/Beijing Key Laboratory of Urban Oil and Gas Distribution Technology China University of Petroleum-BeijingFuxue Road No.18Changping DistrictBeijing102249PR China Strategy&Implementation Department PipeChinaDongtucheng Road No.5Chaoyang DistrictBeijing100013PR China

Cooperation among enterprises can bring overall and individual performance improvement,and a smooth coordination method is ***,due to the lack of customized coordination methods,cooperation in the downstream oil supply chain cannot be carried out *** paper intends to propose a multi-party coordination method to promote cooperation between oil shippers and pipeline operator by optimizing oil transportation,oil substitution and pipeline pricing *** integrated game-theoretic modeling and analysis approach is developed to characterize the operation behaviors of all stakeholders in the downstream oil supply *** proposed mixed integer nonlinear programming model constrains supply and demand capacity,transportation routes,oil substitution rules and pipeline freight *** transformation and price discretization are introduced for model linear *** experiments are carried out in the oil distribution system in South *** results show that compared to the business-as-usual scheme,the new scheme saves transportation cost by 3.48%,increases pipeline turnover by 5.7%,and reduces energy consumption and emissions by 7.66%and 6.77%.It is proved that the proposed method improves the revenue of the whole system,achieves fair revenue distribution,and also improves the energy and environmental benefits of the oil supply chain.

关键词： Downstreamoil supplychain Multi-partycoordination Cooperative game Mixed integernonlinear programming model Pipeline transportation Revenue distribution

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NIR-IIb-triggered photodynamic therapy combined with chemotherapy platform based on rare-earth-doped nanoparticles

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Rare Metals 2024年第7期43卷 3220-3231页

作者： Zhuo tu Yong Wan Juan Ge Chen-Chen Li Tao liang Zhen Li College of Health Science and Engineering College of Chemistry and Chemical EngineeringHubei University

Photodynamic therapy（PDT）,with high spatiotemporal selectivity,minimal side effects and less drug resistance,has emerged as a promising approach for the treatment of ***,inadequate penetration depth and poor efficacy seriously restrict its practical *** address these challenges,we developed a combined therapy platform（RENP@C/D-FA） based on rare-earth-doped nanoparticles（RENPs） with a structure of NaErF4:Tm（0.5%）@NaYF4,on which photosensitizer Ce6（chlorin e6） and chemo-therapeutic drug（DOX）(doxorubicin) were loaded by encapsulating with an amphiphilic polymer distearoyl phosphatidylethanolamine-polyethylene glycol-folic acid（DSPE-PEG-FA）.RENPs with NaErF4as the matrix possess multiple excitation/emission peaks,enabling activation of PDT under near-infrared-Ⅱb（NIR-Ⅱb,1500-1700 nm） excitation and luminescence imaging in NIR-Ⅱb region by absorbing 808 nm near-infrared ***,DOX can be selectively released in the acidic microenvironment of *** from the tumor targeting capability of folic acid,this platform can successfully ablate tumor cells and inhibit tumor growth by combining PDT and *** innovative approach holds great promise as a powerful tool for cancer treatment,showing the potential to revolutionize PDT.

关键词： Photodynamic therapy Rare-earth-doped nanoparticles NIR-IIb Chemotherapy Combined therapy

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New supernova candidates from the SDSS-DR7 spectral survey

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Research in Astronomy and Astrophysics 2009年第6期9卷 635-640页

作者： liang-ping tu A-Li Luo Fu-Chao Wu Chao Wu Yong-Heng Zhao Institute of Automation Chinese Academy of Sciences Beijing 100190 China National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China School of Science University of Science and Technology Liaoning Anshan 114051 China

This letter presents 25 supernova candidates discovered from SDSS-DR7 by using our dedicated method, called Sample Decrease. Ten of them have been confirmed by other research groups, while the remaining 15, including 14 Type la and one Type Ⅱ, are first discovered based on Supernova Identification analysis. The results demonstrate that our method is reliable. The description of the method and some detailed spectral analysis procedures are also presented.

关键词： techniques spectroscopic -- supernovae method -- data analysis

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Responses of plant diversity and soil microorganism diversity to nitrogen addition in the desert steppe,China

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Journal of Arid Land 2024年第3期16卷 447-459页

作者： YE He HONG Mei XU Xuehui liang Zhiwei JIANG Na tu Nare WU Zhendan College of Grassland Resources and EnvironmentInner Mongolia Agricultural UniversityInner Mongolia Key Laboratory of Soil Quality and Nutrient ResourcesHohhot 010018China Key Laboratory of Agricultural Ecological Security and Green Development at University of Inner Mongolia Hohhot 010018China

Nitrogen(N)deposition is a significant aspect of global change and poses a threat to terrestrial *** impact of plant-soil microbe relationships to N deposition has recently attracted considerable *** microorganisms have been proven to provide nutrients for specific plant growth,especially in nutrient-poor desert steppe ***,the effects of N deposition on plant-soil microbial community interactions in such ecosystems remain poorly *** investigate these effects,we conducted a 6-year N-addition field experiment in a Stipa breviflora *** steppe in Inner Mongolia Autonomous Region,*** N treatment levels(N0,N30,N50,and N100,corresponding to 0,30,50,and 100 kg N/(hm2•a),respectively)were applied to simulate atmospheric N *** results showed that N deposition did not significantly affect the aboveground biomass of desert steppe plants.N deposition did not significantly reduce the alfa-diversity of plant and microbial communities in the desert steppe,and low and mediate N additions(N30 and N50)had a promoting effect on *** variation pattern of plant Shannon index was consistent with that of the soil bacterial Chao1 index.N deposition significantly affected the beta-diversity of plants and soil bacteria,but did not significantly affect fungal *** conclusion,N deposition led to co-evolution between desert steppe plants and soil bacterial communities,while fungal communities exhibited strong stability and did not undergo significant *** findings help clarify atmospheric N deposition effects on the ecological health and function of the desert steppe.

关键词： soil microorganisms plant-microbial community interaction plant diversity nitrogen deposition desert steppe

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Large animal models for Huntington's disease research

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Zoological Research 2024年第2期45卷 275-283页

作者： Bofeng Han Weien liang Xiao-Jiang Li Shihua Li Sen Yan Zhuchi tu Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan University Key Laboratory of CNS Regeneration(Jinan University)-Ministry of EducationGuangdong Key Laboratory of Non-Human Primate ResearchGuangzhouGuangdong 510632China Department of Pathophysiology School of MedicineJinan UniversityGuangzhouGuangdong 510632China

Huntington'sdisease(HD)isahereditary neurodegenerative disorder for which there is currently no ***,the development of appropriate disease models is critical to thoroughly investigate disease *** genetic basis of HD involves the abnormal expansion of CAG repeats in the huntingtin(HTT)gene,leading to the expansion of a polyglutamine repeat in the HTT *** HTT carrying the expanded polyglutamine repeat undergoes misfolding and forms aggregates in the brain,which precipitate selective neuronal loss in specific brain *** models play an important role in elucidating the pathogenesis of neurodegenerative disorders such as HD and in identifying potential therapeutic *** to the marked species differences between rodents and larger animals,substantial efforts have been directed toward establishing large animal models for HD *** models are pivotal for advancing the discovery of novel therapeutic targets,enhancing effective drug delivery methods,and improving treatment *** have explored the advantages of utilizing large animal models,particularly pigs,in previous *** then,however,significant progress has been made in developing more sophisticated animal models that faithfully replicate the typical pathology of *** the current review,we provide a comprehensive overview of large animal models of HD,incorporating recent findings regarding the establishment of HD knock-in(KI)pigs and their genetic *** also explore the utilization of large animal models in HD research,with a focus on sheep,non-human primates(NHPs),and *** objective is to provide valuable insights into the application of these large animal models for the investigation and treatment of neurodegenerative disorders.

关键词： Huntington's disease Large animal models Sheep Non-human primates Transgenic pigs

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A novel marine-derived anti-acute kidney injury agent targeting peroxiredoxin 1 and its nanodelivery strategy based on ADME optimization

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3232-3250页

作者： ping Yu Tanwei Gu Yueyang Rao Weimin liang Xi Zhang Huanguo Jiang Jindi Lu Jianglian She Jianmin Guo Wei Yang Yonghong Liu Yingfeng tu Lan Tang Xuefeng Zhou Guangdong Provincial Key Laboratory of New Drug Screening Guangdong-Hong Kong-Macao Joint Laboratory for New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaSouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China NMPA Key Laboratory for Research and Evaluation of Drug Metabolism School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Lewwin Pharmaceutical Research Institute Co. Ltd.Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and ResearchGuangdong Engineering Research Center for Innovative Drug Evaluation and ResearchGuangzhou 510990China

Insufficient therapeutic strategies for acute kidney injury(AKI)necessitate precision therapy targeting its *** study reveals the new mechanism of the marine-derived anti-AKI agent,piericidin glycoside S14,targeting peroxiredoxin 1(PRDX1).By binding to Cys83 of PRDX1 and augmenting its peroxidase activity,S14 alleviates kidney injury efficiently in Prdx1-overexpression(Prdx1-OE)***,S14 also increases PRDX1 nuclear translocation and directly activates the Nrf2/HO-1/NQO1 pathway to inhibit ROS *** to the limited druggability of S14 with low bioavailability(2.6%)and poor renal distribution,a pH-sensitive kidney-targeting dodecanaminechitosan nanoparticle system is constructed to load S14 for precise treatment of AKI.L-Serine conjugation to chitosan imparts specificity to kidney injury molecule-1(Kim-1)-overexpressed *** developed S14-nanodrug exhibits higher therapeutic efficiency by improving the in vivo behavior of S14 *** encapsulation with micelles,the AUC_(0-t),half-life time,and renal distribution of S14 increase 2.5-,1.8-,and 3.1-fold,*** main factors contributing to the improved druggability of S14 nanodrugs include the lower metabolic elimination rate and UDPglycosyltransferase(UGT)-mediated *** summary,this study identifies a new therapeutic target for the marine-derived anti-AKI agent while enhancing its ADME properties and druggability through nanotechnology,thereby driving advancements in marine drug development for AKI.

关键词： Acute kidney injury Piericidin glycoside Peroxiredoxin 1 Nanodrug Kim-1 targeted ADME Marine drug Druggability

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Charge Accumulation Characteristics of SF6-Epoxy Interface Under Negative Repetitive Nanosecond Pulses

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1808-1815页

作者： Shaocong Wu Geng Chen Yuming Shao Hao Xu Xuanning Zhang Yanyu liang Youping tu State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources and the Beijing Key Laboratory of High Voltage and EMC North China Electric Power UniversityBeijing 102206China

Repetitve nanosecond impulses in gas-insulated metal-enclosed switchgear (GIS) are likely to trigger inside flashover. Interface charges on the spacer in GIS are considered one of the main factors damaging insulation performance and may be induced by overvoltage. For good understanding of insulation failures, accumulation characteristics of charges between SF6 and epoxy spacers under repetitive nanosecond impulses are investigated. It can be found under nanosecond impulses, the charge source in gas volume contributes to interface charge accumulation predominantly. Interface charges will be promoted by impulse number and amplitude. Accumulation processes are analyzed based on runaway electrons mechanism. When impulse amplitude exceeds a threshold value, discharge in the gas volume turns to a runaway mode. A runaway electron leads to the interface charge accumulation. Affected by motion of the runaway electrons, the potential peak gradually moves close to the grounded electrode when impulse amplitude is raised. Meanwhile, increasing impulse number can enhance surface potential. Surface potential will reach saturation eventually. However, memory effect of the repetitive impulse discharge makes the half-peak width of the surface potential at the interface change little. Design of GIS gas-solid insulations can refer to this research.

关键词： GIS interface charge repetitive nano-second pulse SF6

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Different mechanisms underlie similar species-area relationships in two tropical archipelagoes

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Plant Diversity 2024年第2期46卷 238-246页

作者： Shengchun Li Tieyao tu Shaopeng Li Xian Yang Yong Zheng liang-Dong Guo Dianxiang Zhang Lin Jiang Key Laboratory of Plant Resources Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China ECNU-Alberta Joint Lab for Biodiversity Study Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China School of Biological Sciences Georgia Institute of TechnologyAtlantaGA 30332USA Jiangxi Academy of Forestry Nanchang 330032China Institute of Eco-Chongming(IEC) Shanghai 202162China State Key Laboratory of Biocontrol School of EcologySun Yat-sen UniversityGuangzhou 510275China School of Geographical Sciences Fujian Normal UniversityFuzhou 350007China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Despite much research in the field of island biogeography,mechanisms regulating insular diversity remain ***,we aim to explore mechanisms underlying plant species-area relationships in two tropical archipelagoes in the South China *** found positive plant species-area relationships for both coral and continental ***,our results showed that different mechanisms contributed to similar plant species-area relationships between the two *** coral islands,soil nutrients and spatial distance among communities played major roles in shaping plant community structure and species *** contrast,the direct effect of island area,and to a lesser extent,soil nutrients determined plant species richness on continental ***,increasing soil nutrients availability(N,P,K)had opposite effects on plant diversity between the two *** summary,the habitat quality effect and dispersal limitation are important for regulating plant diversity on coral islands,whereas the passive sampling effect,and to a lesser extent,the habitat quality effect are important for regulating plant diversity on continental *** generally,our findings indicate that island plant species-area relationships are outcomes of the interplay of both niche and neutral processes,but the driving mechanisms behind these relationships depends on the type of islands.

关键词： Coral and continental islands Plant diversity Soil nutrients Species-area relationships The sampling effect

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Stark splitting of intense red emission for Er^(3+)in O_(h) symmetry sites realizing optical temperature sensing in biological applications

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Rare Metals 2024年第3期43卷 1263-1274页

作者： Yue Guo Lin-Jun Qin Jing Xu Xiao-ping Jiang Xiao-Yu Yue Yi Hou Hao Shi Li-Xi Wang Qi-tu Zhang Collage of Materials Science and Engineering Nanjing Tech UniversityNanjing211816China Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites Nanjing211816China

Optical temperature sensing based on the fluorescence intensity ratio(FIR)of red emission for lanthanide ions holds significant relevance in non-contact temperature measurement for biological *** this study,the perovskite-structured KZnF_(3)is utilized as a host material for Er^(3+)to achieve a high-purity upconversion(UC)red *** observed Stark splitting of the red emission peak provides evidence of the energy level splitting of Er^(3+).Group theory is employed to decompose the spectral branching of Er^(3+)under the point group symmetry of KZnF_(3),allowing for the derivation of Stark splitting energy levels induced by the crystal field *** optical temperature-sensing behavior of the red UC luminescence was investigated,specifically examining the FIR of the splitting sub-peaks,which exhibited an exponential relationship with *** KZnF_(3):Yb^(3+),Er^(3+)demonstrated a relative sensitivity(S_(r))of 0.00182%·K^(-1)at 298 K,highlighting its excellent response to *** vivo bio-thermometry experiments conducted on chicken breast validated the material's ability to penetrate biological tissues and showed its significant sensitivity of the FIR to *** results establish KZnF_(3):Yb^(3+),Er^(3+)as a promising material for optical thermometry in various biological applications.

关键词： KZnF_(3) Er^(3+) Upconversion luminescence Stark splitting Temperature sensing

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