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Synthesis and structures of malonate derivative-calix [4] arene conjugates

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Chinese Chemical Letters 2015年第7期26卷 914-917页

作者： Wen-Jing Hu ming-liang ma Yahu A.Liu Jiu-Sheng Li Biao Jiang Ke Wen Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development East China Normal University Medicinal Chemistry Chem Bridge Research Laboratories Inc. San Diego CA 92127 USA School of Physical Science and Technology Shanghai Tech University

A series of malonate derivatives-calix[4]arene conjugates were synthesized through Knoevenagel condensation reaction between formyl-tetrapropoxycalix[4]arene and malonate derivatives. The structures of the resulting malonate derivative functionalized calix[4]arenes were characterized by NMR spectroscopy, mass spectrometry and even single crystal X-ray diffraction analysis.

关键词： Calixarene malonate derivatives Knoevenagel condensation reaction

Xylyl derived oxacalixcrowns:Synthesis and crystal structure

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Chinese Chemical Letters 2013年第4期24卷 279-282页

作者： Xiao-Yan Li Chun Hu ming-liang ma Yahu A.Liu Xian-Qiang Mi Biao Jiang Ke Wen Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development East China Normal University Medicinal Chemistry ChemBridge Research Laboratories Inc. Sustainable Technology Research Center Shanghai Advanced Research InstituteChinese Academy of Science

Oxacalixcrowns 1, 2 and 3 were synthesized via reactions of dihydroxyoxacalix[2]arene[2]pyrazine S with ortho-, meta- and para-bis（bromomethyl）benzenes in a 1：1 fashion. The structures and conformations of 1, 2 and... 详细信息

关键词： OxacalixareneOxacalixcrownCrown ethermacrocycle

Anti-BCma CAR-T Cell Therapy in Relapsed or Refractory Multiple Myeloma Patients with Impaired Renal Function

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Current Medical Science 2021年第3期41卷 474-481页

作者： Shao-long HE Yu-hang CHENG Di WANG Meng-lei XU Yi-mei QUE Yan-jie XU liang-ming ma Chun-rui LI Jian-feng ZHOU Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Third Hospital of Shanxi Medical University Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTongji Medical CollegeHuazhong University of Science and TechnologyTaiyuan 030032China

Anti-B cell maturation antigen(BCma)chimeric antigen receptor(CAR)T-cell therapyis effective and well-tolerated for refractory or relapsed multiple myeloma(RRMM).The purposcof the present study was to analyze efficacy in RRMM patients with renal impairment treated byanti-BCma CAR-T cell therapy.A total of 59 RRMM patients were selected,and divided intoimpaired renal function(lRF)group[basclinc cstimated giomerular filtration rate(eSFR)mal renal function(NRF)group(baseline eGFR≥90 mL/min/1.73 m,n=41).For patients with IRF,eGFR at the 6th month post-CAR-T cells infusion was significantlyhigher than the baseline(P<0.05).The multivariate analysis showed that light chain type and beta-2 micro-globulin(bcta-2M)were associated factors with the decrease of serum ***-free survival(PFS)in the NRF group and IRF group was 266 days and 181 *** survival(OS)in the NRF group and lRF group was 877 days and 238 *** was no significant difference in the objective response rate(ORR)between thelRF group and the NRF *** is suggested that CAR-T cells therapy could improve the renalfunction during the treatment of *** renal function could be more significantly improvedin RRMM patients with light chain type than with other types.

关键词： relapsed or refractory multiple myeloma chimeric antigen receptor T-cell therapy impaired renal function B cell maturation antigen

Systematic profiling of SARS-CoV-2-specific IgG epitopes at amino acid resolution

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Cellular & Molecular Immunology 2021年第4期18卷 1067-1069页

作者： Huan Qi ming-liang ma He-wei Jiang Jian-ya Ling Ling-yun Chen Hai-nan Zhang Dan-yun Lai Yang Li Zi-wen Guo Chuan-sheng Hu Shu-juan Guo Qing-feng Meng Yan Ren Xiao Yang Wei Wang Jie Zhou Xiao-dong Zhao Hua Li Sheng-ce Tao Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Shanghai Jiao Tong UniversityShanghaiChina State Key Laboratory of Microbial Technology Shandong UniversityQingdaoShandongChina BGI Education Center University of Chinese Academy of SciencesShenzhenGuangdongChina State Key laboratory for Oncogenes and Bio-ID Center School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina BGI-Shenzhen ShenzhenGuangdongChina Foshan Fourth People's Hospital FoshanGuangdongChina Institute of Biophysics Chinese Academy of SciencesBeijingChina

There is a worldwide pandemic of COVID-19 caused by SARS-CoV-2.1 By January 28,2021,more than 100 million cases had been diagnosed,and more than 2 million deaths had been reported(https://***/***).The comprehensive and in-depth elucidation of SARS-CoV-2-specific IgG responses will help us to better understand COVID-19 immunity and facilitate the precise development of neutralizing antibodies and vaccines.

关键词： map. precise neutral

Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

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International Journal of Minerals,Metallurgy and materials 2025年第2期32卷 498-503页

作者： liang Chu Haoyu Shen Hudie Wei Hongyu Chen Guoqiang ma Wensheng Yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector

MoS_(2)Lubricate‑Toughened MXene/ANF Composites for Multifunctional Electromagnetic Interference Shielding

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Nano-Micro Letters 2025年第2期17卷 358-371页

作者： Jiaen Wang Wei ming Longfu Chen Tianliang Song Moxi Yele Hao Zhang Long Yang Gegen Sarula Benliang liang Luting Yan Guangsheng Wang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

The design and fabrication of high toughness electromagnetic interference(EMI)shielding composite films with diminished reflection are an imperative task to solve electromagnetic pollution *** MXene/ANF(aramid nanofibers)–MoS_(2)composite films with nacre-like layered structure here are fabricated after the introduction of MoS_(2)into binary MXene/ANF composite *** introduction of MoS_(2)fulfills an impressive“kill three birds with one stone”improvement effect:lubrication toughening mechanical performance,reduction in secondary reflection pollution of electromagnetic wave,and improvement in the performance of photothermal *** the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 50:50),the strain to failure and tensile strength increase from 22.1±1.7%and 105.7±6.4 MPa and to 25.8±0.7%and 167.3±9.1 MPa,*** toughness elevates from 13.0±4.1 to 26.3±0.8 MJ m^(−3)(~102.3%)*** the reflection shielding effectiveness(SE_(R))of MXene/ANF(mass ratio of 50:50)decreases~10.8%.EMI shielding effectiveness(EMI SE)elevates to 41.0 dB(8.2–12.4 GHz);After the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 60:40),the strain to failure increases from 18.3±1.9%to 28.1±0.7%(~53.5%),the SE_(R)decreases~22.2%,and the corresponding EMI SE is 43.9 *** MoS_(2)also leads to a more efficient photothermal conversion performance(~45 to~55℃).Additionally,MXene/ANF–MoS_(2)composite films exhibit excellent electric heating performance,quick temperature elevation(15 s),excellent cycle stability(2,2.5,and 3 V),and long-term stability(2520 s).Combining with excellent mechanical performance with high MXene content,electric heating performance,and photothermal conversion performance,EMI shielding ternary MXene/ANF–MoS_(2)composite films could be applied in many industrial *** work broadens how to achieve a balance between mechanical properties and versatility of composites in the case of high-function fillers.

关键词： MXene-MoS_(2) Lubrication toughening EMI shielding Photothermal conversion Electric heating performance

COVID-ONE-hi:The One-stop Database for COVID-19-specific Humoral Immunity and Clinical Parameters

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Genomics, Proteomics & Bioinformatics 2021年第5期19卷 669-678页

作者： Zhaowei Xu Yang Li Qing Lei Likun Huang Dan-yun Lai Shu-juan Guo He-wei Jiang Hongyan Hou Yun-xiao Zheng Xue-ning Wang Jiaoxiang Wu ming-liang ma Bo Zhang Hong Chen Caizheng Yu Jun-biao Xue Hai-nan Zhang Huan Qi Siqi Yu mingxi Lin Yandi Zhang Xiaosong Lin Zongjie Yao Huiming Sheng Ziyong Sun Feng Wang Xionglin Fan Sheng-ce Tao Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Gastrointestinal Cancer(Fujian Medical University) Ministry of EducationSchool of Basic Medical SciencesFujian Medical UniversityFuzhou 350122China Department of Pathogen Biology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Fujian Key Laboratory of Crop Breeding by Design Key Laboratory of GeneticsBreeding and Multiple Utilization of CropsMinistry of EducationFujian Agriculture and Forestry UniversityFuzhou 350028China Department of Clinical Laboratory Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Public Health Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China

Coronavirus disease 2019(COVID-19),which is caused by SARS-CoV-2,varies with regard to symptoms and mortality rates among *** immunity plays critical roles in SARS-CoV-2 infection and recovery from ***,differences in immune responses and clinical features among COVID-19 patients remain largely ***,we report a database for COVID-19-specific IgG/IgM immune responses and clinical parameters(named COVID-ONE-hi).COVID-ONE-hi is based on the data that contain the IgG/IgM responses to 24 full-length/truncated proteins corresponding to 20 of 28 known SARS-CoV-2 proteins and 199 spike protein peptides against 2360 serum samples collected from 783 COVID-19 *** addition,96 clinical parameters for the 2360 serum samples and basic information for the 783 patients are integrated into the ***,COVID-ONE-hi provides a dashboard for defining samples and a one-click analysis pipeline for a single group or paired groups.A set of samples of interest is easily defined by adjusting the scale bars of a variety of *** the“START”button is clicked,one can readily obtain a comprehensive analysis report for further ***-ONE-hi is freely available at ***.

关键词： SARS-CoV-2 Protein microarray Humoral immunity One-stop tool Shiny

Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： Jin-Hui Chen Zuo-Tang liang Yu-Gang ma Xin-Li Sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

一种在欧氏空间设计多项式时间近似方案的新技术

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山东大学学报（理学版） 2003年第2期38卷 58-63页

作者：张洪良朱大铭马绍汉山东大学计算机科学与技术学院济南250100

提出了一种在欧氏平面上设计多项式时间近似方案的新技术 .应用该技术设计多项式近似方案分为两步 :( 1)对欧氏平面进行随机分割 ;( 2 )对随机分割的结果利用动态规划技术计算近似最优解 .近年来Arora利用该技术获得了TSP ,Steiner树 ,K... 详细信息

提出了一种在欧氏平面上设计多项式时间近似方案的新技术 .应用该技术设计多项式近似方案分为两步 :( 1)对欧氏平面进行随机分割 ;( 2 )对随机分割的结果利用动态规划技术计算近似最优解 .近年来Arora利用该技术获得了TSP ,Steiner树 ,K median三个著名NP hard问题的多项式近似方案 .经验表明 ,该技术适用于欧氏平面上对“距离和”优化的NP hard问题 ,并可十分容易地推广到多维欧氏空间 .

关键词：算法多项式时间近似方案复杂度