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Research on Site Planning of Mobile Communication Network

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Computers, Materials & Continua 2024年第8期80卷 3243-3261页

作者： Jiahan he Guangjun liang Meng Li KefanYao Bixia Wang Lu Li Department of Computer Information and Cyber Security Jiangsu Police InstituteNanjing210000China Engineering Research Center of Electronic Data Forensics Analysis Nanjing210000China Key Laboratory of Digital Forensics Department of Public Security of Jiangsu ProvinceNanjing210000China Basic Course Teaching and Research Department Jiangsu Police InstituteNanjing210000China Communication and Signal College Nanjing Railway Vocational and TechnicalNanjing210000China

In this paper,considering the cost of base station,coverage,call quality,and other practical factors,a multi-objective optimal site planning scheme is ***,based on practical needs,mathematical modeling methods were used to establish mathematical expressions for the three sub-objectives of cost objectives,coverage objectives,and quality ***,a multi-objective optimization model was established by combining threshold and traffic volume *** order to reduce the time complexity of optimization,a non-dominated sorting genetic algorithm(NSGA)is used to solve the multi-objective optimization problem of site ***,a strategy for clustering and optimizing weak coverage areas was *** order to avoid redundant neighborhood retrieval during cluster expansion,the Fast Density-Based Spatial Clustering of Applications with Noise(FDBSCAN)clustering method was *** different sub-objectives as the main objectives,this paper obtained the distribution map of weak coverage areas before and after the establishment of new base stations,as well as relevant site planning maps,and provided three planning schemes for different main *** simulation results show that the traffic coverage of the three station planning schemes is above 90%.The change in the main optimization objective will result in a significant difference between the cost of the three solutions and the coverage of weak coverage points.

关键词： Siting of station multi-objective optimization genetic algorithm NSGA general greed FDBSCAN cluster

Mechanism of high-preload support based on the NPR anchor cable in layered soft rock tunnels

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Journal of Mountain Science 2024年第4期21卷 1403-1418页

作者： SUI Qiru he Manchao shi Mengfan TAO Zhigang ZHAO Feifei ZHANG Xiaoyu State Key Laboratory for Tunnel Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China

The control of large deformation problems in layered soft rock tunnels needs to solve *** roof problem is particularly severe among the deformation issues in *** study first analyzes the asymmetric deformation modes in layered soft rock tunnels with large ***,we construct a mechanical model under ideal conditions for controlling the roof of layered soft rock tunnels through high preload with the support of NPR anchor *** prominent roles of long and short NPR anchor cables in the support system are also *** results indicate the significance of high preload in controlling the roof of layered soft rock *** short NPR anchor cables effectively improve the integrity of the stratified soft rock layers,while the long NPR anchor cables effectively mobilize the self-bearing capacity of deep-stable rock ***,the high-preload support method with NPR anchor cables is validated to have a good effect on controlling large deformations in layered soft rock tunnels through field monitoring data.

关键词： Tunnel engineering Soft rock High-preload support NPR anchor cables

AAV for Gene Therapy in Ocular Diseases:Progress and Prospects

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Research 2024年第3期2023卷 651-670页

作者： Xiaoyu he Yidian Fu liang Ma Yizheng Yao Shengfang Ge Zhi Yang Xianqun Fan Department of Ophthalmology Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghaiChina Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology ShanghaiChina Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience Soochow UniversityClinical Research Center of Neurological DiseaseThe Second Affiliated Hospital of Soochow UniversitySuzhouChina

Owing to the promising therapeutic effect and one-time treatment advantage, gene therapy may completely change the management of eye diseases, especially retinal diseases. Adeno-associated virus (AAV) is considered one of the most promising viral gene delivery tools because it can infect various types of tissues and is considered as a relatively safe gene delivery vector. The eye is one of the most popular organs for gene therapy, since its limited volume is suitable for small doses of AAV stably transduction. Recently, an increasing number of clinical trials of AAV-mediated gene therapy are underway. This review summarizes the biological functions of AAV and its application in the treatment of various ocular diseases, as well as the characteristics of different AAV delivery routes in clinical applications. here, the latest research progresses in AAV-mediated gene editing and silencing strategies to modify that the genetic ocular diseases are systematically outlined, especially by base editing and prime editing. We discuss the progress of AAV in ocular optogenetic therapy. We also summarize the application of AAV-mediated gene therapy in animal models and the difficulties in its clinical transformation.

关键词： AAV organs treatment

Ionic liquid-trimetallic electrocatalytic system for C–O bond cleavage in lignin model compounds and lignin under ambient conditions

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Nano Research 2024年第4期17卷 2420-2428页

作者： Guangyong Liu Yumiao Lu JunFeng Lu Yanlei Wang shijing liang Hongyan he Lilong Jiang National Engineering Research Center of Chemical Fertilizer Catalyst Fuzhou UniversityFuzhou 350002China CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Multiphase Complex SystemsBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Longzihu New Energy Laboratory Zhengzhou Institute of Emerging Industrial TechnologyZhengzhou 450000China

Electrocatalytic depolymerization of lignin into value-added chemicals offers a promising technique to make biorefining ***,we report a robust trimetallic PdNiBi electrocatalyst for reductive C–O bond cleavage of different lignin model dimers and oxidized lignin under mild *** reduction reaction proceeds with complete substrate conversion and excellent yields toward monomers of phenols(80%–99%)and acetophenones(75%–96%)in the presence of an ionic liquid electrolyte with operational *** experimental investigations together with density functional theory(DFT)calculations reveal that the outstanding performance of the catalyst results from the synergistic effect of the metal elements,which facilitates the easier formation of a key Cαradical intermediate and the facile desorption of the as-formed products at the *** results open up new opportunities for lignin valorization through the green electrocatalytic approach.

关键词： electrocatalytic depolymerization lignin Ionic liquids density functional theory(DFT)calculation

Protective effect of retaining wall on rock avalanche:A case study of Nayong rock avalanche in China

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Journal of Mountain Science 2024年第4期21卷 1215-1230页

作者： WANG Zhongfu shi Fengge he Siming ZHANG Xusheng WANG Jingying LIU Enlong North China University of Water Resources and Electric Power Zhengzhou 450046China Hunan Provincial key Laboratory of key Technology on Hydropower Development Changsha 410014China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China College of Water Resource and Hydropower Sichuan UniversityChengdu 610065China

Rock avalanches are generally difficult to prevent and control due to their high velocities and the extensive destruction they ***,barrier structures constructed along the path of a rock avalanche can partially mitigate the magnitudes and consequences of such catastrophic *** selected a rock avalanche in Nayong County,Guizhou Province,China as a case to study the effect of the location and height of a retaining wall on the dynamic characteristics of rock avalanche by using both actual terrain-based laboratory-model tests and coupled PFC3D-FLAC3D numerical *** findings demonstrate that a retaining wall can largely block a rock avalanche and its protective efficacy is significantly influenced by the integrity of the retaining *** numerical simulation can serve as a powerful tool for analyzing the interaction between a rock avalanche and a retaining wall,facilitating precise observations of its deformation and *** impact-curve characteristics of the retaining wall depend upon whether or not the rock avalanche-induced destruction is taken into *** location of the retaining wall exerts a greater influence on the outcome compared to the height and materials of the retaining wall,while implementing a stepped retaining-wall pattern in accordance with the terrain demonstrates optimal efficacy in controlling rock avalanche.

关键词： Rock avalanche Laboratory model test Retaining wall PFC^(3D) FLAC^(3D) Impact force

heptamethine cyanines in bioorthogonal chemistry

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Chinese Chemical Letters 2024年第2期35卷 131-137页

作者： Yuanyuan Liao Yuting liang Yurou Huang Xiaoyan Zeng Tian he Jun Yin National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China

Due to their excellent fluorescence properties and biological function,cyanine dyes have been widely applied in biological *** cyanine(Cy7)dyes,as a type of classic near-infrared(NIR)fluorescent dyes,are considered as one of the effective fluorescent tools in the living organisms due to their good biocompatibility and very low background *** reactions performed in living cells and tissues have developed by leaps and bounds in recent *** NIR fluorescent labeling technique involving cyanine has attracted widespread *** review summarizes their recent application in the field of bioorthogonal imaging,mainly concluding Cy7-type dyes,labeling strategy,bioimaging application,*** expect this work can provide some helps for the studies of NIR bioorthogonal reaction in vivo.

关键词： Fluorescent probes heptamethine cyanines Bioorthogonal reaction Imaging Cell

The effect of glutathione on glucosinolate biosynthesis through the sulfur assimilation pathway in pakchoi associated with the growth conditions

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Horticultural Plant Journal 2024年第2期10卷 473-487页

作者： Biao Zhu Zhile liang Dan Wang Chaochao he Zhujun Zhu Jing Yang Key Laboratory of Quality and Safety Control for Subtropical Fruit and Vegetable Ministry of Agriculture and Rural AffairsCollaborative Innovation Center for Efficient and Green Production of Agriculture in Mountainous Areas of Zhejiang ProvinceCollege of Horticulture ScienceZhejiang A&F UniversityHangzhouZhejiang 311300China

Glucosinolates(GSLs) are a group of nitrogen-and sulfur-containing secondary metabolites, synthesized primarily in members of the Brassicaceae family, that play an important role in food flavor, plant antimicrobial activity, resistance to insect attack, stress tolerance, and human anti-cancer effects. As a sulfur-containing compound, glutathione has a strong connection with GSLs biosynthesis as a sulfur donor or redox system, and exists in reduced(glutathione;GSH) and oxidized(glutathione disulfide;GSSG) forms. However, the mechanism of GSH regulating GSLs biosynthesis remainds unclear. hence, the exogenous therapy to pakchoi under normal growth condition and sulfur deficiency condition were conducted in this work to explore the relevant mechanism. The results showed that exogenous application of buthionine sulfoximine, an inhibitor of GSH synthesis, decreased the transcript levels of GSLs synthesis-related genes and transcription factors, as well as sulfur assimilation-related genes under the normal growth condition. Application of exogenous GSH inhibited the expression of GSLs synthesis-and sulfur assimilation-related genes under the normal condition, while the GSLs biosynthesis and the sulfur assimilation pathway were activated by exogenous application of GSH when the content of GSH in vivo of plants decreased owing to sulfur deficiency. Moreover,exogenous application of GSSG increased the transcript levels of GSLs synthesis-and sulfur assimilation-related genes under the normal growth condition and under sulfur deficiency. The present work provides new insights into the molecular mechanisms of GSLs biosynthesis underlying glutathione regulation.

关键词： Pakchoi Glucosinolates Reduced glutathione Oxidized glutathione Sulfur assimilation

Data-driven Wasserstein distributionally robust chance-constrained optimization for crude oil scheduling under uncertainty

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Chinese Journal of Chemical Engineering 2024年第5期69卷 152-166页

作者： Xin Dai liang Zhao Renchu he Wenli Du Weimin Zhong Zhi Li Feng Qian Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237China Engineering Research Center of Process System Engineering Ministry of EducationEast China University of Science and TechnologyShanghai 200237China

Crude oil scheduling optimization is an effective method to enhance the economic benefits of oil *** uncertainties,including uncertain demands of crude distillation units(CDUs),might make the production plans made by the traditional deterministic optimization models infeasible.A data-driven Wasserstein distributionally robust chance-constrained(WDRCC)optimization approach is proposed in this paper to deal with demand uncertainty in crude oil ***,a new deterministic crude oil scheduling optimization model is developed as the basis of this *** Wasserstein distance is then used to build ambiguity sets from historical data to describe the possible realizations of probability distributions of uncertain demands.A cross-validation method is advanced to choose suitable radii for these ambiguity *** deterministic model is reformulated as a WDRCC optimization model for crude oil scheduling to guarantee the demand constraints hold with a desired high probability even in the worst situation in ambiguity *** proposed WDRCC model is transferred into an equivalent conditional value-at-risk representation and further derived as a mixed-integer nonlinear programming *** case studies from a real-world refinery are conducted to show the effectiveness of the proposed ***-of-sample tests demonstrate that the solution of the WDRCC model is more robust than those of the deterministic model and the chance-constrained model.

关键词： Distributions Model Optimization Crude oil scheduling Wasserstein distance Distributionally robust chance constraints

Relaxor antiferroelectric-relaxor ferroelectric crossover in NaNbO_(3)-based lead-free ceramics for high-efficiency large-capacitive energy storage

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Chinese Chemical Letters 2024年第7期35卷 465-469页

作者： Shuangliang Xie Yuyue Chen Qing he liang Chen Jikun Yang shiqing Deng Yimei Zhu he Qi School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Advanced Innovation Center for Materials Genome Engineering Department of Physical ChemistryUniversity of Science and Technology BeijingBeijing 100083China School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China Department of Condensed Matter Physics and Materials Science Brookhaven National LaboratoryUptonNew York 11973United States

Relaxor ferroic dielectrics have garnered increasing attention in the past decade as promising materials for energy *** them,relaxor antiferroelectrics(AFEs)and relaxor ferroelectrics(FEs)have shown great promise in term of high energy storage density and efficiency,*** this study,a unique phase transition from relaxor AFE to relaxor FE was achieved for the first time by introducing strong-ferroelectricity BaTiO_(3)into NaNbO_(3)-BiFeO_(3)system,leading to an evolution from AFE R hierarchical nanodomains to FE polar nanoregions.A novel medium state,consisting of relaxor AFE and relaxor FE,was identified in the crossover of 0.88NaNbO_(3)–0.07BiFeO_(3)–0.05BaTiO_(3)ceramic,exhibiting a distinctive core-shell grain structure due to the composition *** harnessing the advantages of high energy storage density from relaxor AFE and large efficiency from relaxor FE,the ceramic showcased excellent overall energy storage *** achieved a substantial recoverable energy storage density W_(rec)~13.1 J/cm^(3)and an ultrahigh efficiencyη~88.9%.These remarkable values shattered the trade-off relationship typically observed in most dielectric capacitors between W_(rec)andη.The findings of this study provide valuable insights for the design of ceramic capacitors with enhanced performance,specifically targeting the development of next generation pulse power devices.

关键词： Relaxor ferroelectric Antiferroelectric Core-shell Energy storage High efficiency