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细银质针治疗围绝经期膝骨性关节炎临床观察

中国中医药现代远程教育 2024年第11期22卷 95-98页

作者：侯冯彬黄少莹邱世明贺昀梁粤珠海市斗门区侨立中医院传统疗法科广东珠海519100 珠海市斗门区侨立中医院针灸康复科广东珠海519100

目的观察细银质针治疗不同中医证型围绝经期膝骨性关节炎患者的效果,及其对炎性因子和雌二醇(E2)表达水平的影响。方法选取2018年1月—2022年4月广东省珠海市斗门区侨立中医院收治的153例围绝经期女性膝骨性关节炎患者为研究对象,根据... 详细信息

目的观察细银质针治疗不同中医证型围绝经期膝骨性关节炎患者的效果,及其对炎性因子和雌二醇(E2)表达水平的影响。方法选取2018年1月—2022年4月广东省珠海市斗门区侨立中医院收治的153例围绝经期女性膝骨性关节炎患者为研究对象,根据所用针法的不同分为细银质针组和温针组。比较两组治疗前后视觉模拟量表(VAS)、西安大略和麦克马斯特大学骨性关节炎指数(WOMAC)评分及炎症因子、E2水平。结果细银质针组总有效率为82.79%(101/122),显著高于温针组的61.29%(19/31)(P<0.05);且细银质针组总有效率寒湿阻滞型为90.91%(30/33)、肝肾亏虚型为86.67%(26/30),明显高于瘀血阻滞型的67.86%(19/28)、湿热阻滞型的64.52%(20/31)(P<0.05)。治疗后,两组患者VAS、WOMAC评分和炎症因子、E2水平均优于治疗前,且细银质针组优于温针组(P<0.05)。结论细银质针治疗围绝经期膝骨性关节炎效果显著,且对寒湿阻滞型、肝肾亏虚型的效果优于湿热阻滞型、瘀血阻滞型,且能改善患者炎症因子和E2水平,值得临床推广应用。

关键词：痹证膝骨性关节炎细银质针疗法寒湿阻滞证肝肾亏虚证

piggyBac-mediated germline transformation of the malaria mosquito Anopheles sinensis (Diptera:Culicidae)

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Insect Science 2021年第4期28卷 1202-1206页

作者： Jin-Gang Liu liang Qiao Jia-Jun Zhang Bin Chen Zheng-Bo he Chongqing Key Laboratory of Vector Insects Institute of Entomology and Molecular BiologyCollege of Life SciencesChongqing Normal UniversityChongqingChina

Dear Editor,Anopheles sinensis is the primary vector of vivax malaria in *** the risks posed by ***,many methods have been used to control this vector,most commonly chemical ***,the extensive use of insecticides has subjected mosquitoes to intense selection pressure,resulting in the development of resistance,variations in mosquito behavior.

关键词： malaria behavior. China.

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何洪阳教授治疗腰椎间盘突出症的临床经验

四川中医 2024年第9期42卷 21-24页

作者：薛亮何洪阳刘青松罗勇罗详飞四川省医学科学院·四川省人民医院(电子科技大学附属医院)中医科四川成都610072 成都中医药大学附属医院四川成都610072 成都中医药大学针灸推拿学院四川成都611137 成都市新都区中医医院四川成都610100

四川杜氏骨伤科第四代传承人何洪阳教授,治疗腰椎间盘突出症特点突出、疗效显著。本文分别从发病机制、辨证分型、中药内治、推拿要点、腰部练功等方面详细阐述何教授的治疗经验,以供同行分享。

关键词：名医经验何洪阳腰椎间盘突出症临床经验

三聚氰胺固化单宁微球的制备及其吸附性能研究

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西部皮革 2024年第6期46卷 12-15页

作者：梁力丽代玉兰于婷婷何花刘琦四川幼儿师范高等专科学校鄂尔多斯市农畜产品质量安全中心

为解决核能发展所带来的含铀废水问题，以皮革鞣制剂单宁为主要原料，利用曼尼希反应将杨梅单宁交联固化在三聚氰胺上形成不溶于水的三聚氰胺固化单宁微球（MA-T）；通过批量吸附实验探讨了MA-T微球对铀酰离子的吸附性能，并对其吸附热... 详细信息

为解决核能发展所带来的含铀废水问题，以皮革鞣制剂单宁为主要原料，利用曼尼希反应将杨梅单宁交联固化在三聚氰胺上形成不溶于水的三聚氰胺固化单宁微球（MA-T）；通过批量吸附实验探讨了MA-T微球对铀酰离子的吸附性能，并对其吸附热力学和动力学模型进行拟合研究，结合SEM、FT-IR、粒度分析和比表面积分析其吸附机理。结果表明，在p H值5.8、投料量0.01 g、吸附时间480 min、初始浓度200 mg/L的条件下，微球吸附容量可达401 mg/g。MA-T微球对铀酰离子的吸附机理为微球表面-OH等活性基团与铀酰离子的配位。

关键词：杨梅单宁三聚氰胺曼尼希反应吸附铀酰离子

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遵义某钼镍矿矿渣自燃机理及防治方法探讨

贵州地质 2024年第2期41卷 178-184页

作者：唐广江攀和陈磊张明思杨再良梁劲松闫文清贵州省地矿局102地质大队贵州遵义563000

为对自燃钼镍矿矿渣开展综合治理,通过遵义某钼镍金属矿矿渣现场调查及样品采集分析,查明了钼镍矿矿渣的矿物成分、元素含量及主要自燃气体成分,初步确定钼镍矿矿渣自燃的引燃物为黄铁矿,提供可持续燃烧的可燃物主要为炭质,当矿渣自身... 详细信息

为对自燃钼镍矿矿渣开展综合治理,通过遵义某钼镍金属矿矿渣现场调查及样品采集分析,查明了钼镍矿矿渣的矿物成分、元素含量及主要自燃气体成分,初步确定钼镍矿矿渣自燃的引燃物为黄铁矿,提供可持续燃烧的可燃物主要为炭质,当矿渣自身属性满足要求,供氧及聚热条件达到某一平衡时,便会发生自燃;提出了“降温+切断供氧通道”,“注浆+覆盖”综合治理措施以及尚未自燃矿渣的预防建议。工程验证治理取得了良好的效果,研究成果为同类型工程问题提供了一定的解决经验和思路。

关键词：钼镍矿矿渣自燃机理黄铁矿防治方法预防措施

Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis

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Nano Research 2018年第11期11卷 6086-6101页

作者： Yuwei he Ruixiang Li Jianming liang Ying Zhu Shuya Zhang Zicong Zheng Jing Qin Zhiqing Pang Jianxin Wang Department of Pharmaceutics School of Pharmacy Fudan University & Key Laboratory of Smart Drug Delivery Ministry of Education Shanghai 201203 China Institute of Clinical Pharmacology Guangzhou University of Traditional Chinese Medicine Guangzhou 510006 China

The effective drug treatment of rheumatoid arthritis (RA) is hindered by poor delivery efficiency to the diseased site and the serious side effects caused by wide-spread drug distribution. Traditional drug-targeting strategies, such as ligand modification, are complex, laborious, and inefficient. Inspired by the intrinsic relationship between platelets and RA, platelet-mimetic nanoparticles (PNPs) were developed for targeted drug delivery in RA. Through platelet receptor-mediated adhesion, an intact platelet membrane was coated onto poly (lactic-co-glycolic acid) nanoparticles, endowing the resulting PNPs with various functional receptors. By coating with platelet membranes, the nanoparticles were stabilized and had a better circulation profile, providing a benefit for passive targeting. In vitro binding of PNPs to inflamed endothelium, and in vivo accumulation in joints of a collagen-induced arthritis (CIA) mouse model of RA were significantly improved via P-selectin and GVPI recognition, indicating that the PNPs could effectively target to RA tissues through multiple mechanisms, similar to natural platelets. Moreover, FK506, a model drug, was loaded into the PNPs and used to treat RA. Pharmacodynamic studies demonstrated that the FK506-PNPs had a notable anti-arthritic effect in CIA mice. This study provides a new biomimetic targeting strategy with great potential for the treatment of RA.

关键词： biomimetic nanoparticles platelet membrane rheumatoid arthritis targeted drug delivery

若尔盖湿地土壤及水体重金属分布特征及健康风险评价

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西南民族大学学报（自然科学版） 2024年第3期50卷 247-258页

作者：唐亮施天宇景连东杨胜韬刘佳青藏高原污染控制化学与环境功能材料国家民委重点实验室四川成都610041 西南民族大学化学与环境学院四川成都610041

若尔盖湿地属典型的高寒湿地生态系统,是我国青藏高原生态屏障的重要组成部分.青藏高原地区重金属监测多集中在青藏高原西南部,针对若尔盖湿地重金属分布特征、污染来源及潜在人体健康风险尚未完全清楚.于2022年7月采集湿地土壤(退化湿... 详细信息

若尔盖湿地属典型的高寒湿地生态系统,是我国青藏高原生态屏障的重要组成部分.青藏高原地区重金属监测多集中在青藏高原西南部,针对若尔盖湿地重金属分布特征、污染来源及潜在人体健康风险尚未完全清楚.于2022年7月采集湿地土壤(退化湿地和未退化湿地)及地表水水样,分别对4种重金属(Cr、As、Cd和Pd)进行分析,阐述其浓度分布特征,并进行人体健康风险评估.结果表明:Cr、As、Cd和Pd在未退化湿地和退化湿地的浓度(mg􀅰kg-1)分别为6.23~26.19、2.06~45.00、0.01~0.63和1.32~10.87,7.56~23.56、5.10~21.87、0.01~0.43和2.16~11.13.参照《土壤环境质量——农用地土壤污染风险管控标准》,Cr、Pd、Cd和As达标率为100%、88%、94.4%、80%;地表水中Cd未检出,Cr、As和Pd浓度(μg·L-1)分别为0.04~1.14、0.15~23.77和0.01~0.94,符合国家地表水质量Ⅰ类标准.参照美国环保署(USEPA)和国际辐射防护委员(ICRP)标准,若尔盖湿地土壤总非致癌风险指数(HI)均小于1;总致癌风险(TCR)范围为2.53×10^(-6)~1.20×10^(-4),均在可接受致癌健康风险水平10-6~10-4数量级范围内;地表水中总健康风险指数(R)为1.97×10^(-6)~2.01×10^(-4),人体最大可接受风险水平为5.0×10^(-5),其中,21.4%地表水样品超过健康风险水平.As是导致健康风险的主导因子.研究结果可补充若尔盖地区环境背景值的基础数据库,为该地污染防治及环境质量改善提供一定的数据支撑.

关键词：若尔盖湿地重金属污染人体健康风险评价

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Effects of chloride on electrochemical and stress corrosion cracking behavior of 9Cr ferritic-martensitic steel

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Journal of Iron and Steel Research International 2020年第6期27卷 719-731页

作者： Zhen Zhang Zheng-fei Hu liang he Xiao-bo Zhang Xin-xian Fang Bao-sen Zhang Zhi-xin Ba Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing 211167JiangsuChina School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing 211167JiangsuChina School of Materials Science and Engineering Tongji UniversityShanghai 201804China School of Materials Science and Engineering Georgia Institute of TechnologyAtlanta 30332-0620USA

The electrochemical and stress corrosion cracking behavior of 9Cr ferritic-martensitic steel is investigated in the chloride environment by using the traditional electrochemical method, the scanning vibrating electrode technique and the slow strain rate test (SSRT). Results of the static corrosion tests and corrosion morphology show that the prior austenite grain boundaries and martensite lath boundaries are the preferred sites for pit nucleation and growth in chloride environment. Results of SSRT coupled with insitu electrochemical test show that the transition from pitting corrosion to uniform corrosion, as well as the nucleation of stress corrosion crack, is the synergistic effects of the chloride and applied load. Stress corrosion cracking of the steel in the chloride environment can be divided into three different regions as follows: fast and uniform corrosion activ-ity, microcrack nucleation and propagation, and active crack growth regions.

关键词： 9Cr ferritic-martensitic steel Chloride In situ electrochemical test Scanning vibrating electrode technique Stress corrosion cracking

Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota

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Neural Regeneration Research 2022年第2期17卷 409-417页

作者： Yi-Tong Lin Qing-Qing shi Lei Zhang Cai-Ping Yue Zhi-Jun he Xue-Xia Li Qian-Jun he Qiong Liu Xiu-Bo Du College of Life Sciences and Oceanography Guangdong Provincial Key Laboratory for Plant EpigeneticsShenzhen UniversityShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringHealth Science CenterShenzhen UniversityShenzhenGuangdong ProvinceChina Shenzhen Bay Laboratory ShenzhenGuangdong ProvinceChina

Hydrogen exhibits the potential to treat Alzheimer's disease. Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice. In this study, triple transgenic(3×Tg) Alzheimer's disease mice were treated with hydrogen-rich water for 7 months. The results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×Tg Alzheimer's disease mice. In addition, hydrogen-rich water improved brain energy metabolism disorders and intestinal flora imbalances and reduced inflammatory reactions. These findings suggest that hydrogen-rich water is an effective hydrogen donor that can treat Alzheimer's disease. This study was approved by the Animal Ethics and Welfare Committee of Shenzhen University, China(approval No. AEWC-20140615-002) on June 15, 2014.

关键词： Alzheimer's disease amyloid-β anti-inflammation bioenergetics gut microbiota hydrogen therapy neurodegenerative disease neurofibrillary tangles