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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang Gang Li Xing cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen Jiang Fei Long Liyuan Han Qifeng Han Yi‑bing cheng Yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

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Designing novel adaptive dynamic event-triggered protocols for uncertain multi-agent systems

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Science China(Information Sciences) 2024年第1期67卷 310-311页

作者： bin cheng bin HE College of Electronics and Information Engineering Tongji University Frontiers Science Center for Intelligent Autonomous Systems

Multi-agent systems (MASs) have garnered widespread attention and have been investigated by numerous researchers in recent years, primarily due to their broad applications in industry, transportation, agriculture, and astronomy. While studying the cooperative control of MASs, numerous researchers place emphasis on reducing the frequency of communication among neighboring agents.

关键词： Directed graphs

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Radiomics and molecular analysis:Bridging the gap for predicting hepatocellular carcinoma prognosis

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World Journal of Clinical Cases 2025年第4期13卷 56-60页

作者： Chun-Han cheng Wen-Rui Hao Tzu-Hurng cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305TaiwanChina Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404333TaiwanChina

This editorial examines a recent study that used radiomics based on computed tomography(CT)to predict the expression of the fibroblast-related gene enhancer of zeste homolog 2(EZH2)and its correlation with the survival of patients with hepatocellular carcinoma(HCC).By integrating radiomics with molecular analysis,the study presented a strategy for accurately predicting the expression of EZH2 from CT *** findings demonstrated a strong link between the radiomics model,EZH2 expression,and patient *** noninvasive approach provides valuable insights into the therapeutic management of HCC.

关键词： Hepatocellular carcinoma Computed tomography Radiomics Enhancer of zeste homologue 2 expression Non-invasive imaging

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市域(郊)铁路CBTC与CTCS-2双制式信号系统切换方案研究

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铁道通信信号 2025年第1期61卷 31-41页

作者：程梁刘雅祯中铁工程设计咨询集团有限公司北京100055 北京城建设计发展集团股份有限公司北京100032

为满足市域(郊)铁路列车跨线运行需求,研究市域(郊)铁路CBTC与CTCS-2双制式信号系统的兼容性方案。分析衔接线路接驳方式、两种制式列控系统切换对应的运营场景;从车载、轨旁设备层面,介绍采用双套车载设备进行信号制式切换的方法,并对... 详细信息

为满足市域(郊)铁路列车跨线运行需求,研究市域(郊)铁路CBTC与CTCS-2双制式信号系统的兼容性方案。分析衔接线路接驳方式、两种制式列控系统切换对应的运营场景;从车载、轨旁设备层面,介绍采用双套车载设备进行信号制式切换的方法,并对制式切换过程进行描述;探讨停车切换、不停车切换方式的设备管界,系统结构及信息交互、轨旁设备配置、地面信号显示方案等;讨论跨线运行列车的追踪间隔控制要求,以及调度系统配置、临时限速设置方案;研究不同切换方式对列控系统控车模式的要求,分析切换瞬间不同制式列控系统列车限制速度曲线不一致的风险,讨论车载设备之间,以及车载设备与车辆、司机、外围设备的接口配置;最后提出工程设计、施工、运营方面的相关建议,展望市域(郊)铁路信号系统互联互通应用前景,为市域(郊)铁路工程设计、信号设备研发等提供思路和借鉴。

关键词：市域(郊)铁路四网融合信号系统列控系统制式切换场景分析设备配置

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Influences of Alloying Elements on Oxidation Behavior of Steels and Microstructure of Oxide Scales

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Journal of Iron and Steel Research International 2016年第3期23卷 231-237页

作者： Hui-bin WU Di WANG Peng-cheng ZHANG Jin-ming liang Sheng LIU Di TANG National Engineering Research Center for Advanced Rolling Technology University of Science and Technology Beijing

In order to figure out the oxidation behavior of steels during heating,five micro-alloyed steels were subjected to continuous and isothermal oxidation using the thermo gravimetric analyzer and the Gleeble-3500thermo-mechanical *** microstructure of oxide scales,especially the thickness fractions of Fe2O3,Fe3O4 and FeO layers,was analyzed using the scanning electron microscope（SEM）,electron probe microanalyzer（EPMA）and electron backscattered diffraction（EBSD）*** micro-alloyed steels containing alloying elements（Si,Cr,Ni and Cu）show a higher oxidation resistance compared with the low carbon *** is found that alloying elements accumulated at scale/substrate interface during high temperature *** elements function in two ways in the oxidation of steels：one is enhancing the scale/substrate interface and consequently suppressing the blister of scales;and the other is impeding the outward diffusion of iron cations from substrate to scales,resulting in the decrease of oxidation *** the diffusion of iron cations is impeded,the thickness fractions of Fe2O3 and Fe3O4of micro-alloyed steels are more than those of low carbon steels.

关键词： micro-alloyed steel high temperature oxidation oxidation kinetics microstructure oxide scale

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Simultaneous Stabilization of Port-Hamiltonian Systems Subject to Actuation Saturation and Input Delay

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International Journal of Automation and computing 2021年第5期18卷 849-854页

作者： liang-cheng Cai Department of Electrical Engineering Southwest Jiaotong UniversityEmei 614202China

This paper investigates the simultaneous stabilization of Port-Hamiltonian(PH) systems subject to actuation saturation(AS) and input delay. Firstly, two parallel connecting PH systems subject to the AS and input delay are proposed. Secondly, a simultaneous stabilization control law is designed by a difference between the two feedback control laws containing the input ***, computing a Lyapunov-Krasovskii function assures the simultaneous stabilization of the above systems. Finally, simulation is given to show the correctness of the proposed contents.

关键词： Port-Hamiltonian system(PH) simultaneous stabilization actuator saturation input delay Lyapunov-Krasovskii function

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Broadband Acoustic Transmission Enhancement through a Structured Stiff Plate with Locally Resonant Elements

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Chinese Physics Letters 2012年第11期29卷 123-126页

作者： LI Yong liang bin ZOU Xin-Ye cheng Jian-Chun Key Laboratory of Modern Acoustics MOEInstitute of AcousticsDepartment of PhysicsNanjing UniversityNanjing 210093 State Key Laboratory of Acoustics Chinese Academy of SciencesBeijing 100190

Broadband acoustic transmission enhancement(ATE)is realized for a periodically structured stiff plate without any opening that is conventionally thought to be only capable of supporting narrowband ATE,by introducing locally resonant(LR)*** exotic phenomenon is interpreted by analyzing the vibration pattern of the structure-induced LR modes,and is well modeled by a simple"spring-mass"system which reveals the contribution of the LR effect to the important broadband *** findings should help to better understand the physical mechanism of ATE and may have potential impact on ultrasonic applications such as broadband acoustic filters or compact acoustic devices in subwavelength scale.

关键词： Locally resonant stiff

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Viscosity and surface tension of CaF_(2)-CaO-Al_(2)O_(3)-based slag with varying SiO_(2) and B_(2)O_(3) contents for ESR of rotor steel

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Journal of Iron and Steel Research International 2023年第1期30卷 74-81页

作者： Yi Huang cheng-bin Shi Xiu-xiu Wan Yu-jing liang Jing Li Shu-jie Liu State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Xingtai Shuzhi Metallurgy Technology Co. Ltd.Xingtai 054027HebeiChina

The effect of SiO_(2) and B_(2)O_(3) on viscosity and surface tension of CaF_(2)-CaO-Al_(2)O_(3)-MgO-SiO_(2)-B_(2)O_(3) slag designed for electroslag remelting of rotor steel was *** viscosity of the slag melts increases with increasing the SiO_(2) content from 0.37 to 8.03 mass%,and the viscous activation energy increases from 54.21 to 58.49 kJ/*** B_(2)O_(3) content of the slag from 0 to 3.62 mass%exhibits a similar effect on the viscosity,and the activation energy increases from 47.30 to 55.71 kJ/*** increase in the viscosity and activation energy for viscous flow of slag is attributed to the enhanced polymerization degree of slag melts network with increasing either SiO_(2) or B_(2)O_(3) *** surface tension of slag melts decreases with increasing *** surface tension of slag melts decreases with increasing either SiO_(2) or B_(2)O_(3) content,which is originated from the increase in the polymerization degree and the decrease in the CaO content of the slag.

关键词： High-fluoride slag Structure Viscosity Surface tension Activation energy

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Experimental investigation of the flow characteristics of jet pumps for zero flow-ratio conditions

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Journal of Hydrodynamics 2023年第6期35卷 1146-1156页

作者： Yun-zhi liang Jiong Wang Zu-ti Zhang bin Ji Huai-yu cheng Xin-ping Long Key Lab of Jet Theory and New Technology of Hubei Province Wuhan UniversityWuhan430072China School of Power and Mechanical Engineering Wuhan UniversityWuhan430072China State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan430072China

Experimental research was conducted on the performance curves and the cavity evolution for different flow and geometric parameters in jet pumps for zero flow ratio(ZFR)*** pressure ratio,Pr,flow ratio,qr,were used in place of the conventional performance parameters h,q,to characterize the jet pump flow performance.A super cavitation cavity in the jet pump was observed to fill most of the flow channel,which hindered further increases of the flow rate and increased qr to one,thus,created a critical point on the new P_(r)-q_(r)^(2)*** the critical point,P_(r)was proportional to q_(r)^(2)with a coefficient that was much more sensitive to the area ratio than the relative throat length and the diffusion *** the critical point,the flow rate reached its maximum,the limiting flow rate,which only depended on the total inlet pressure and the area *** total inlet pressure was proportional to the square of the limiting flow rate with a flow coefficient that was only a quadratic function of the area ratio.

关键词： Jet pump performance curve zero flow-ratio super-cavitation

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