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Co-infection of SENV-D among chronic hepatitis C patients treated with combination therapy with high-dose interferon-alfa and ribavirin

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World Journal of Gastroenterology 2005年第27期11卷 4241-4245页

作者： Chia-yen Dai Wan-Long Chuang Wen-Yu Chang Shinn-Chemg Chen Li-Po Lee Ming-yen Hsieh Nei-Jen Hou Zu-Yau Un Ming-Yuh Hsieh liang-yen wang Ming-Lung Yu Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University Hospital Kaohsiung Taiwan China Department of Internal Medicine Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung TaiwanChina Department of Occupational Medicine Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung Taiwan China

AIM： The clinical significance of co-infection of SENV-D among patients with chronic hepatitis C （CHC） and response of both viruses to combination therapy with high-dose interferon-alfa （IFN） plus ribavirin remain uncertain and are being ***： Total 164 （97 males and 67 females, the mean age 48.1＋11.4 years, range： 20-73 years, 128 histologically proved） naive CHC patients were enrolled in this study. SENV-D DNA was tested by PCR *** of serum HCV RNA was performed using a standardized automated qualitative RT-PCR assay （COBAS AMPLICOR HCV Test, version 2.0）. HCV genotypes la,lb, 2a, 2b, and 3a were determined by using genotypespecific primers. Pretreatment HCV RNA levels were determined by using the branched DNA assay （Quantiplex HCV RNA 3.0）. There are 156 patients receiving combination therapy with IFN 6 MU plus ribavirin for 24 wk and the response to therapy is ***： Sixty-one （37.2%） patients were positive for SENV-D DNA and had higher mean age than those who were negative （50.7＋ 10.6 years vs 46.6＋ 11.6 years,P = 0.026）. The rate of sustained viral response （SVR） for HCV and SENV-D were 67.3% （105/156） and 56.3% （27/48）, respectively. By univariate analysis, the higher rate of SVR was significantly related to HCV genotype non-1b （P〈0.001）, younger ages （P = 0.014）, lower pretreatment levels of HCV RNA （P = 0.019） and higher histological activity index （HAI） score for intralobular regeneration and focal necrosis （P= 0.037）. By multivariate analyses, HCV genotype non-lb, younger age and lower pretreatment HCV RNA levels were significantly associated with HCV SVR （odds ratio （OR）/95% confidence interval （CI）： 12.098/0.02-0.19, 0.936/0.890-0.998, and 3.131/1.080-9.077, respectively）. The SVR of SENV-D was higher among patients clearing SENV-D than those who had viremia at the end of therapy （P = 0.04）.CONCLUSION： Coexistent SENV-D infection, apparently associated with higher ages, is found in more than onethird Taiwan Resi

关键词： Chronic hepatitis C Combination therapy Interferon Ribavirin SENV-D

Dynamics modeling and optimal control for multi-information diffusion in Social Internet of Things

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Digital Communications and Networks 2024年第3期10卷 655-665页

作者： Yaguang Lin Xiaoming wang liang wang Pengfei Wan School of Computer Science Shaanxi Normal UniversityXi'an710119China

As an ingenious convergence between the Internet of Things and social networks,the Social Internet of Things(SIoT)can provide effective and intelligent information services and has become one of the main platforms for people to spread and share ***,SIoT is characterized by high openness and autonomy,multiple kinds of information can spread rapidly,freely and cooperatively in SIoT,which makes it challenging to accurately reveal the characteristics of the information diffusion process and effectively control its *** this end,with the aim of exploring multi-information cooperative diffusion processes in SIoT,we first develop a dynamics model for multi-information cooperative diffusion based on the system dynamics theory in this ***,the characteristics and laws of the dynamical evolution process of multi-information cooperative diffusion are theoretically investigated,and the diffusion trend is *** this basis,to further control the multi-information cooperative diffusion process efficiently,we propose two control strategies for information diffusion with control objectives,develop an optimal control system for the multi-information cooperative diffusion process,and propose the corresponding optimal control *** optimal solution distribution of the control strategy satisfying the control system constraints and the control budget constraints is solved using the optimal control ***,extensive simulation experiments based on real dataset from Twitter validate the correctness and effectiveness of the proposed model,strategy and method.

关键词： Social Internet of Things Information diffusion Dynamics modeling Trend prediction Optimal control

Underwater Pulse Waveform Recognition Based on Hash Aggregate Discriminant Network

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Journal of Ocean University of China 2024年第3期23卷 654-660页

作者： wang Fangchen ZHONG Guoqiang wang liang College of Computer Science and Technology Ocean University of ChinaQingdao 266100China College of Marine Technology Ocean University of ChinaQingdao 266100China

Underwater pulse waveform recognition is an important method for underwater object *** existing works focus on the application of traditional pattern recognition methods,which ignore the time-and space-varying characteristics in sound propagation channels and cannot easily extract valuable waveform *** propagation channels in seawater are time-and space-varying convolutional *** the extraction of the waveform features of underwater acoustic signals,the effect of high-accuracy underwater acoustic signal recognition is identified by eliminating the influence of time-and space-varying convolutional channels to the greatest extent *** propose a hash aggregate discriminative network(HADN),which combines hash learning and deep learning to minimize the time-and space-varying effects on convolutional channels and adaptively learns effective underwater waveform features to achieve high-accuracy underwater pulse waveform *** the extraction of the hash features of acoustic signals,a discrete constraint between clusters within a hash feature class is *** constraint can ensure that the influence of convolutional channels on hash features is *** addition,we design a new loss function called aggregate discriminative loss(AD-loss).The use of AD-loss and softmax-loss can increase the discriminativeness of the learned hash *** results show that on pool and ocean datasets,which were collected in pools and oceans,respectively,by using acoustic collectors,the proposed HADN performs better than other comparative models in terms of accuracy and mAP.

关键词： convolutional channel hash aggregate discriminative network aggregate discriminant loss waveform recognition

Geometrical transition properties of vortex cavitation and associated flow-choking characteristics in poppet valves

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第6期25卷 455-469页

作者： liang LU Zhongdong liang Yuming LIU Zhipeng wang Shohei RYU School of Mechanical Engineering Tongji UniversityShanghai 201804China Frontiers Science Center for Intelligent Autonomous Systems Tongji UniversityShanghai 201210China Technical Research Laboratory Hitachi Construction Machinery Co.Ltd.Tsuchiura 300-0013Japan

Poppet valves have become increasingly significant in ensuring precise digital flow rate and pressure control in hydraulic systems,necessitating a more profound understanding of the geometrical properties of cavitation in them,as well as associated flow-choking *** a comparative analysis with experimentally observed cavity images,we found that large eddy simulation(LES)turbulence modeling effectively replicates the geometrical properties of cavitation in these *** analysis demonstrated that cavitation is generated from vortices that result from the interaction between the notch contracta flow and the surrounding fluid *** in the internal or external vena contracta conditions result in fixed or discrete cavities,and the length-to-diameter ratio serves as a measure of the transition between internal and external vena contracta flow *** study establishes a threshold length-to-diameter ratio of approximately 2 for the tested poppet *** specifically,in notch structures with a smaller valve opening,longer sealing length,and smaller throttling angle(corresponding to a larger length-to-diameter ratio),the liquid-to-vapor transfer process is more evident than that in the reverse direction.A long-standing vapor cavity becomes fixed inside the notch,leading to a more pronounced flow-choking *** contrast,for structures with a smaller length-to-diameter ratio,the cavitation process for discrete vapor cavities is more complete,ensuring fluid flow continuity and significantly reducing the occurrence of the flow-choking phenomenon.

关键词： Poppet valves Vena contracta Vortex flow Vapor cavity Flow-choking

The Boundary Element Method for Ordinary State-Based Peridynamics

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2807-2834页

作者： Xue liang Linjuan wang State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceCollege of EngineeringPeking UniversityBeijing100871China CAPT-HEDPS and IFSA Collaborative Innovation Center of MoECollege of EngineeringPeking UniversityBeijing100871China School of Astronautics Beihang UniversityBeijing100191China

The peridynamics(PD),as a promising nonlocal continuum mechanics theory,shines in solving discontinuous *** to now,various numerical methods,such as the peridynamic mesh-free particlemethod(PD-MPM),peridynamic finite element method(PD-FEM),and peridynamic boundary element method(PD-BEM),have been ***-BEM,in particular,outperforms other methods by eliminating spurious boundary softening,efficiently handling infinite problems,and ensuring high computational ***,the existing PD-BEM is constructed exclusively for bond-based peridynamics(BBPD)with fixed Poisson’s ratio,limiting its applicability to crack propagation problems and scenarios involving infinite or semi-infinite *** this paper,we address these limitations by introducing the boundary element method(BEM)for ordinary state-based peridynamics(OSPD-BEM).Additionally,we present a crack propagationmodel embeddedwithin the framework ofOSPD-BEM to simulate crack *** validate the effectiveness of OSPD-BEM,we conduct four numerical examples:deformation under uniaxial loading,crack initiation in a double-notched specimen,wedge-splitting test,and threepoint bending *** results demonstrate the accuracy and efficiency of OSPD-BEM,highlighting its capability to successfully eliminate spurious boundary softening phenomena under varying Poisson’s ***,OSPDBEMsignificantly reduces computational time and exhibits greater consistencywith experimental results compared to PD-MPM.

关键词： Ordinary state-based peridynamics boundary element method crack propagation fracture toughness

Pan Shuh:the founding figure of modern Chinese psychology

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Protein & Cell 2024年第4期15卷 235-238页

作者： Ligang wang Tongqi Wei liang wang Institute of Psychology Chinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Mental Health Institute of PsychologyBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 101408China

Entering the lobby of the Institute of Psychology,Chinese Academy of Sciences,the first thing that catches the eye is the Pan Shuh *** the library,Pan Shuh’s six decades of life are displayed in the form of a life photo exhibition,representing 10 years of determination,10 years of wandering,10 years of exploration,10 years of following the path,10 years of self-improvement,and 10 years of *** six decades not only reflect the life journey of Pan Shuh,the pioneer of Chinese psychology but also serve as a microcosm of the historical development of modern Chinese psychology(Qicheng Jing,Xiaolan Fu,2011).

关键词： founding representing Shu

The higher-order topological pumping explored in the 2D acoustic crystal

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 127-133页

作者： Yanqiu wang Bin liang Jianchun Cheng Key Laboratory of Modern Acoustics Ministry of EducationInstitute of AcousticsDepartment of PhysicsNanjing UniversityNanjing 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

The topological pumping has been instrumental in advancing our understanding of topological phase transitions in various physical systems,which can be extended to uncover intriguing higher-order topological phases in the lower-dimensional ***,we propose a theoretical exploration of topological dipole pumping on an acoustic square superlattice by cyclically modulating intracell couplings,which shares the topological nature of an extended three-dimensional system with chiral hinge *** the multipole chiral numbers,we characterize the higher-order topological phases that arise during the *** evolution of topological phase transitions is verified by numerical simulations and shows corner states are transferred across the *** findings can inspire the construction of chiral hinge states in artificial crystals,opening up new possibilities for the design of devices allowing the unidirectional propagation of sound.

关键词： topological phases of matter Thouless pumping acoustic metamaterial

Galerkin-based quasi-smooth manifold element(QSME)method for anisotropic heat conduction problems in composites with complex geometry

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 137-154页

作者： Pan wang Xiangcheng HAN Weibin WEN Baolin wang Jun liang School of Civil Engineering Central South UniversityChangsha 410083China Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China School of Science Harbin Institute of TechnologyShenzhen 518055Guangdong ProvinceChina

The accurate and efficient analysis of anisotropic heat conduction problems in complex composites is crucial for structural design and performance evaluation. Traditional numerical methods, such as the finite element method(FEM), often face a trade-off between calculation accuracy and efficiency. In this paper, we propose a quasi-smooth manifold element(QSME) method to address this challenge, and provide the accurate and efficient analysis of two-dimensional(2D) anisotropic heat conduction problems in composites with complex geometry. The QSME approach achieves high calculation precision by a high-order local approximation that ensures the first-order derivative *** results demonstrate that the QSME method is robust and stable, offering both high accuracy and efficiency in the heat conduction analysis. With the same degrees of freedom(DOFs), the QSME method can achieve at least an order of magnitude higher calculation accuracy than the traditional FEM. Additionally, under the same level of calculation error, the QSME method requires 10 times fewer DOFs than the traditional FEM. The versatility of the proposed QSME method extends beyond anisotropic heat conduction problems in complex composites. The proposed QSME method can also be applied to other problems, including fluid flows, mechanical analyses, and other multi-field coupled problems, providing accurate and efficient numerical simulations.

关键词： anisotropic heat conduction quasi-smooth manifold element(QSME) composite with complex geometry numerical simulation finite element method(FEM)

Revealing the Role of Defect in 3D Graphene-Based Photocatalytic Composite for Efficient Elimination of Antibiotic and Heavy Metal Combined Pollution

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Energy & Environmental Materials 2024年第3期7卷 168-178页

作者： Xin wang Jingzhe Zhang Hui wang Mengjun liang Qiang wang Fuming Chen Research Institute of Frontier Science Southwest Jiaotong University Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials School of Electronics and Information EngineeringSouth China Normal University School of Aeronautics Northwestern Polytechnical University Hubei Key Laboratory for High-Efficiency Utilization of Solar Energy and Operation Control of Energy Storage System Hubei University of Technology MOE Key Laboratory of Thermo-Fluid Science and Engineering School of Energy and Power EngineeringXi'an Jiaotong University

Defect engineering can give birth to novel properties for adsorption and photocatalysis in the control of antibiotics and heavy metal combined pollution with photocatalytic ***,the role of defects and the process mechanism are complicated and ***,TiO2/CN/3DC was fabricated and defects were introduced into the tripartite structure with separate O2plasma treatment for the single *** find that defect engineering can improve the photocatalytic activity,attributing to the increase of the contribution from h+and *** contrast to TiO2/CN/3DC with a photocatalytic tetracycline removal rate of 75.2%,the removal rate of TC with D-TiO2/CN/3DC has increased to 88.5%.Moreover,the reactive sites of tetracycline can be increased by adsorbing on the defective *** defect construction on TiO2shows the advantages in tetracycline degradation and Cu2+adsorption,but also suffers significant inhibition for the tetracycline degradation in a tetracycline/Cu2+combined *** contrast,the defect construction on graphene can achieve the cooperative removal of tetracycline and Cu2+.These findings can provide new insights into water treatment strategies with defect engineering.

关键词： 3D graphene Cu defect photocatalytic composite tetracycline