检索结果-南通市图书馆

Five-year sequential changes in secondary antibiotic resistance of Helicobacter pylori in Taiwan

World Journal of Gastroenterology 2015年第37期21卷 10669-10674页

作者： I-Ting Wu Seng-Kee Chuah Chen-Hsiang Lee Chih-Ming liang Lung-Sheng Lu Yuan-Hung Kuo Yi-Hao Yen Ming-Luen Hu Yeh-Pin chou Shih-Cheng Yang Chung-Mou Kuo Chung-Huang Kuo Chun-Chih Chien Yu-Shao Chiang Shue-Shian Chiou Tsung-Hui Hu Wei-Chen Tai Division of Hepatogastroenterology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Division of Infectious Diseases Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Department of Laboratory Medicine Kaohsiung Chang Gung Memorial Hospital

AIM: To determine changes in the antibiotic resistance of Helicobacter pylori(H. pylori) in southern Taiwan after failure of first-line standard triple ***: We analyzed 137 H. pylori-infected isolates from patients who experienced eradication failure after standard first-line triple therapy from January2010 to December 2014. The H. pylori strains were tested for susceptibility to amoxicillin, clarithromycin,levofloxacin, metronidazole and tetracycline using the E-test method. The minimal inhibitory concentration(MIC) was determined by the agar dilution *** values of ≥ 0.5, ≥ 1, ≥ 1, ≥ 4 and ≥ 8 mg/L were considered to be the resistance breakpoints for amoxicillin, clarithromycin, levofloxacin, tetracycline and metronidazole, ***: A high resistance rate was found for clarithromycin(65%-75%) and metronidazole(30%-40%)among patients who failed first-line standard *** resistance levels to amoxicillin and tetracycline remained very low; however, levofloxacin resistance was as high as 37.5% in 2010 but did not increase any further during the past 5 years. The rates of resistance to these antibiotics did not show a statistically significant upward or downward ***: Antibiotic resistance of H. pylori remains a problem for the effective eradication of this pathogen and its associated diseases in Taiwan. High clarithromycin resistance indicated that this antibiotic should not be prescribed as a second-line H. pylori eradication therapy. Moreover, levofloxacin-based second-line therapy should be used cautiously, and the local resistance rates should be carefully monitored.

关键词： Helicobacter pylori Antibiotic resistance Five-yea

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

传统年画概况及清末民初改良年画的出现

引用

北京理工大学学报（社会科学版） 2005年第2期7卷 6-9页

作者：梁绸北京理工大学艺术设计学院北京100081

民间艺术中的非物质文化也是文化遗产中的一个重要组成部分。物质形态的文化和非物质形态的文化只有在一个统一体中,才能构成一种真正的文化。中国丰富的民间美术资源和悠久的传统,存在于民间。其中,传统年画是民间美术里最为精彩的一... 详细信息

民间艺术中的非物质文化也是文化遗产中的一个重要组成部分。物质形态的文化和非物质形态的文化只有在一个统一体中,才能构成一种真正的文化。中国丰富的民间美术资源和悠久的传统,存在于民间。其中,传统年画是民间美术里最为精彩的一部分。清末民初,社会发生了大的变革,民间年画发生了自身的改良。对中国传统民间年画以及清末民初改良年画的分析研究,以期对中国文化遗产的相关研究课题能有所助益。

关键词：传统年画年年画的概念年画题材改良年画

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

裸花紫珠的化学成分研究

引用

中草药 2023年第1期54卷 15-28页

作者：陈倩倩邹献亮侴桂新上海中医药大学中药研究所上海201203 上海中药标准化研究中心上海201203 萍乡卫生职业学院江西萍乡337000

目的研究裸花紫珠Callicarpa nudiflora叶的化学成分。方法采用多种现代分离色谱技术进行分离纯化,通过波谱数据和理化性质进行结构鉴定,以及ECD确定新化合物的绝对构型;采用CCK-8法对新化合物的细胞毒活性进行筛选。结果从裸花紫珠... 详细信息

目的研究裸花紫珠Callicarpa nudiflora叶的化学成分。方法采用多种现代分离色谱技术进行分离纯化,通过波谱数据和理化性质进行结构鉴定,以及ECD确定新化合物的绝对构型;采用CCK-8法对新化合物的细胞毒活性进行筛选。结果从裸花紫珠叶70%乙醇提取物中分离鉴定出34个化合物,其中化合物1~5为裸花紫珠烷A1(1)、(4S,6S)-4,6-二羟基-α-松油醇(2)、(1R)-2,2-二甲基-3-羟甲基-3-环己烯-1-甲酸(3)、(1R,4R)-2,2-二甲基-3-亚甲基-4-羟基环己烷-1-甲酸(4)、(1R)-2,2-二甲基-4-羟甲基-3-环己烯-1-甲酸(5);化合物6~34为2,6-二甲氧基-对-苯醌(6)、对薄荷-8-烯-1,2-二醇(7)、天目地黄素B(8)、北玄参素G(9)、黄牡丹醇B(10)、香桂酮(11)、8-羟基-2,6-二甲基-(2E,6E)-辛二烯酸(12)、8-羟基-2,6-二甲基-(2E)-辛烯酸(13)、裸花紫珠烷A(14)、丁子香烷-2β,9α-二醇(15)、丁香烷-1,9β-二醇(16)、(8R,9R)-异丁香烷-8,9-二醇(17)、(S)-(+)-去氢催吐萝芙叶醇(18)、(3S,5R,6S,7E)-5,6-环氧-3-羟基-7-大柱香波龙烯-9-酮(19)、脱落酸(20)、紫珠醌B(21)、12-羟基茉莉酸(22)、(-)-12-羟基茉莉酸甲酯(23)、齐墩果酸(24)、熊果酸(25)、蔷薇酸(26)、5,4’-二羟基-3,7,3’-三甲氧基黄酮(27)、毡毛美洲茶素(28)、5,7,4′-三羟基-3′-甲氧基黄酮(29)、柳叶柴胡酚(30)、九里香亭(31)、芥子醛(32)、香草醛(33)和丁香酸(34)。结论化合物1~5为新化合物,分别命名为裸花紫珠烷A1~E1,化合物6~13、17~18和31均为首次从马鞭草科中分离鉴定,化合物30、32~33均为首次在紫珠属植物中发现,化合物15、21和28均为首次从裸花紫珠中分离得到。体外细胞毒活性筛选结果表明,化合物4对人肝癌Hep G2细胞具有细胞毒活性,其半数抑制浓度(half inhibition concentration,IC50)值为24.0μmol/L。

关键词：马鞭草科裸花紫珠裸花紫珠烷A1 (1R,4R)-2,2-二甲基-3-亚甲基-4-羟基环己烷-1-甲酸丁子香烷-2β,9α-二醇紫珠醌B 毡毛美洲茶素柳叶柴胡酚

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synaptic Mechanisms for Bandwidth Tuning in Mouse Primary Auditory Cortex

Synaptic Mechanisms for Bandwidth Tuning in Mouse Primary Au...

引用

中国神经科学学会第十二届全国学术会议

作者： Feixue liang Haifu Li Lucas Mesik Xiao-lin chou Huizhong Whit Tao Zhongju Xiao Li I.Zhang Department of Physiology School of Basic Medical Sciences Southern Medical University

Band-passed noise（BPN） stimuli are prevalent in communication sounds. Tuning of auditory neurons for bandwidth of BPN may be functionally important for the perception of these sounds. In awake mouse primary auditory cortex（A1）, we found that excitatory neurons exhibit decreasing, increasing or flat bandwidth tuning, and there is an enhancement of tuning strength from layer 4 to layer 2/3. On the other hand, parvalbumin（PV） positive inhibitory neurons had flat tuning. Sequential cell-attached and whole-cell voltage clamp recordings from the same cells revealed that the tuning properties of excitatory neurons were inherited from excitation they received, whereas in all neurons inhibition had flat tuning. Importantly, tuning strength of spike response was enhanced as compared with excitation. Our neuron modeling work demonstrate an important role of flat（untuned） inhibition in enhancing bandwidth tuning of spike responses. Our study, for the first time, elucidated synaptic mechanisms underlying bandwidth tuning of auditory cortical neurons.

关键词： auditory cortex bandwidth tuning synaptic mechanisms Band-passed noise

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

体育院系研究生教育成本分担改革研究

引用

广州体育学院学报 2008年第2期28卷 118-121页

作者：隗金水邹亮畴广州体育学院研究生部广东广州510500

研究生教育成本分担改革直接影响到研究生教育的质量。主要以文献资料法对研究生教育成本分担的理论和意义进行了探讨,在分析体育院系研究生教育成本分担改革面临问题的基础上,提出了相应对策,以图为进一步深化我国体育院系研究生教育... 详细信息

研究生教育成本分担改革直接影响到研究生教育的质量。主要以文献资料法对研究生教育成本分担的理论和意义进行了探讨,在分析体育院系研究生教育成本分担改革面临问题的基础上,提出了相应对策,以图为进一步深化我国体育院系研究生教育成本分担改革提供参考。

关键词：研究生教育成本分担体育院系

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Upper gastrointestinal carcinoid tumors incidentally found by endoscopic examinations

引用

World Journal of Gastroenterology 2005年第44期11卷 7028-7032页

作者： Tsung-Hui Hu Chung-Mou Kuo King-Wah Chiu Chung-Huang Kuo Keng-liang Wu Yeh-Pin chou Sheng-Nan Lu Shue-Shian Chiou Chi-Sin Changchien Hock-Liew Eng Department of Hepato-Gastroenterology Chang Gung Memorial Hospital 123 Ta-Pei Road Niao-sung Hsiang Kaohsiung HsienTaiwan China Department of Pathology Chang Gung Memorial Hospital 123 Ta-Pei Road Niao-sung Hsiang Kaohsiung HsienTaiwan China

AIM: This study shares Asian clinical experiences of carcinoid tumors that originated in the upper gastrointestinal ***: From May 1987 to June 2002, we had found only 13 cases of histologically confirmed carcinoid tumors in the upper gastrointestinal tract by endoscopic examinations. There were eight males and five *** mean age was 53.16±20.51 years that ranged from 26 to 82 years. Each of their clinical presentations,locations, tumor morphology, and size and the treatment outcome were analyzed and ***: One patient had a polypoid lesion at the lower esophagus, nine were stomach lesions and three located at the duodenum. All patients with polypoid and submucosal tumor types were of small size (＜1.7 cm) and all patients survived after simple excision or *** of the five patients in tumor mass forms died and the tumors were more than 2.0 cm in ***: Carcinoid tumors rarely originated from the upper gastrointestinal tract and are usually found accidentally after endoscopic study. Bigger size (more than 2 cm) tumor masses may indicate a more severe disease and poor prognosis.

关键词： Upper gastrointestinal carcinoid tumors Tumor morphology Sizes Treatment courses Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

女子曲棍球运动员膝关节屈伸肌群等速测试与分析

引用

中国组织工程研究与临床康复 2011年第37期15卷 6891-6894页

作者：曹峰锐邹亮畴彭森太原理工大学体育学院山西省太原市030024 广州体育学院研究生部广东省广州市510500 湖南体育职业学院湖南省长沙市410014

背景：等速测试系统已广泛应用来评价不同项目运动员关节肌群的力量特征。目的：测试广东省女子曲棍球运动员的膝关节进行等速向心,观察曲棍球项目运动员膝关节屈伸肌群的等速向心测试力量特征。方法：运用CON-TREX等速测试系统对广东... 详细信息

背景：等速测试系统已广泛应用来评价不同项目运动员关节肌群的力量特征。目的：测试广东省女子曲棍球运动员的膝关节进行等速向心,观察曲棍球项目运动员膝关节屈伸肌群的等速向心测试力量特征。方法：运用CON-TREX等速测试系统对广东省14名现役女子曲棍球运动员的膝关节进行等速向心测试。检测指标为相对峰力矩、关节肌群屈伸肌峰力矩比值、平均功率、总功和疲劳指数。结果与结论：在60（°/s）慢速测试时,女子曲棍球队员的两侧膝关节肌群相对峰力矩值表现为伸肌大于屈肌（P〈0.01）;左膝关节屈伸肌峰力矩比值在3种不同测试速度下的范围为66%~77%,右膝关节屈伸肌峰力矩比值为82%~88%;左膝关节伸肌平均功率值均大于屈肌（P〈0.01）;左右膝关节伸肌的总功值均大于屈肌（P〈0.01）;膝关节屈伸肌疲劳指数范围在0.24~0.48之间。膝关节伸肌的最大力量大于屈肌,屈伸肌峰力矩比值在240（°/s）快速测试时略微偏低,而右膝关节屈伸肌峰力矩比值在慢速测试时偏高,说明女子曲棍球队员左膝关节屈肌快速力量偏低,右膝关节伸肌最大力量比较低,伸肌的快速力量大于屈肌,伸肌的工作能力强于屈肌,屈伸肌的力量耐力水平比较低。

关键词：曲棍球运动员膝关节伸肌屈肌肌肉力量等速测试组织工程

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Vegetation Landscape,Ecological Characteristics and Soil Fixation for Riverbank in Taiwan,China

引用

Wuhan University Journal of Natural Sciences 2007年第4期12卷 677-683页

作者： CHANG Chunpin LIN Farching liang Taching CHEN Yichang Department of Landscape Architecture Chung-Chou Institute of Technology Zhanghua 150 Taiwan China Department of Forestry and Resource Conservation Taiwan University Taipei 106 Taiwan China Department of Landscape Design and Management Chin Yi University of Technology Taichung 411 Taiwan China

This study is aimed to investigate and analyze the vegetation landscape around Rivers of Hou-lung, Fa-tz, Da-li, Ching-shuei and Gau- ping, and to select the suitable plant species that could be applied for the area of riverbank ecological engineering in Taiwan. Studying the vegetation established the key point and procedure of ecological engineering in the riverside and revetment, to compile and edit the dominant plants＇ types, life form, propagating method, root systems＇ characteristics and functions for soil conservation. This research choses three dominant plants for roots strength test. The fitting models of plants pulling resistance（Rp, kg） between plant height （H, cm）, diameter near ground （Dn, mm）, diameter above ground 100 mm （Da, mm）, The research finished the relative abundant, types and cluster analysis of riverbank dominant plants that generalize vegetative distribution and ecological restoration for different river types to apply and manage in Taiwan.

关键词： vegetation landscape ecological restoration dominant plants pulling resistance

来源：

维普期刊数据库

同方期刊数据库评论