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Automatic pectoral muscle boundary detection in mammograms based on Markov chain and active contour model

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第2期11卷 111-118页

作者： Lei WANG Miao-liang ZHU li-ping DENG Xin YUAN School of Computer Science and Technology Zhejiang University Hangzhou 310027 China

Automatic pectoral muscle removal on medio-lateral oblique (MLO) view of mammogram is an essential step for many mammographic processing algorithms. However,it is still a very difficult task since the sizes,the shapes and the intensity contrasts of pectoral muscles change greatly from one MLO view to another. In this paper,we propose a novel method based on a discrete time Markov chain (DTMC) and an active contour model to automatically detect the pectoral muscle boundary. DTMC is used to model two important characteristics of the pectoral muscle edge,i.e.,continuity and uncertainty. After obtaining a rough boundary,an active contour model is applied to refine the detection results. The experimental results on images from the Digital Database for Screening Mammography (DDSM) showed that our method can overcome many limitations of existing algorithms. The false positive (FP) and false negative (FN) pixel percentages are less than 5% in 77.5% mammograms. The detection precision of 91% meets the clinical requirement.

关键词： Pectoral muscle Markov chain Active contour Mammogram

Rainbow Pancyclicity in a Collection of Graphs Under the Dirac-type Condition

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 269-274页

作者： Lu-yi li ping li Xue-liang li Center for Combinatorics and LPMC Nankai UniversityTianjin 300071China School of Mathematics and Statistics Shaanxi Normal UniversityXi’an 710062China

Let G={Gi:i∈[n]} be a collection of not necessarily distinct n-vertex graphs with the same vertex set V,where G can be seen as an edge-colored(multi)graph and each Gi is the set of edges with color i.A graph F on V is called rainbow if any two edges of F come from different Gis’.We say that G is rainbow pancyclic if there is a rainbow cycle Cℓof lengthℓin G for each integerℓ2[3,n].In 2020,Joos and Kim proved a rainbow version of Dirac’s theorem:Ifδ(Gi)≥2/n for each i∈[n],then there is a rainbow Hamiltonian cycle in *** this paper,under the same condition,we show that G is rainbow pancyclic except that n is even and G consists of n copies of Kn/2,n/*** result supports the famous meta-conjecture posed by Bondy.

关键词： rainbow Hamiltonian cycle rainbow pancyclic meta-conjecture

2011—2022年武威市人间布鲁氏菌病流行特征分析

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疾病预防控制通报 2024年第3期39卷 33-35,43页

作者：李盛李之果李普郭庆王金玉梁莉萍兰州市肺科医院兰州730046 甘肃中医药大学兰州730000 甘肃省白银市第二人民医院甘肃白银730900 兰州市第一人民医院兰州730050 兰州大学基础医学院兰州730000 甘肃省武威市疾病预防控制中心甘肃武威733000

目的了解2011—2022年甘肃省武威市人间布鲁氏菌病流行病学特征,为制定针对性防控措施提供科学依据。方法从中国疾病预防控制信息系统中导出2011—2022年武威市人间布鲁氏菌病报告病例资料,对其流行特征进行统计分析。结果2011—2022年... 详细信息

目的了解2011—2022年甘肃省武威市人间布鲁氏菌病流行病学特征,为制定针对性防控措施提供科学依据。方法从中国疾病预防控制信息系统中导出2011—2022年武威市人间布鲁氏菌病报告病例资料,对其流行特征进行统计分析。结果2011—2022年武威市共报告人间布鲁氏菌病病例3115例,报告发病率呈先增后降再增的趋势,不同年度布鲁氏菌病发病率差异有统计学意义(χ^(2)=3255.692,P<0.05)。报告病例主要集中在5—9月和11—12月,共报告2185例、占总病例数的70.14%;凉州区报告病例数最多、占37.78%,天祝藏族自治县最少、占12.46%;男女性别比为2.55∶1,年均发病率男性(22.77/10万)高于女性(9.27/10万),差异有统计学意义(χ^(2)=529.233,P<0.05),发病年龄主要集中在30~69岁组、占86.61%;职业分布以农民为主、占82.86%。结论2011—2022年武威市人间布鲁氏菌病疫情呈上升趋势,并呈明显的人群和季节性分布特点;应继续开展健康教育和布鲁氏菌病相关知识宣传,加强监测和早期诊断,及时治疗患者,有效控制布鲁氏菌病疫情。

关键词：人间布鲁氏菌病发病率流行病学特征

Expression of BC047440 protein in hepatocellular carcinoma and its relationship to prognosis

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Chinese Journal of Cancer 2010年第11期29卷 931-936页

作者： Lu Zheng ping liang Jing li Xiao-Bing Huang Wei-Wei Wang liang Wang Huan Feng Department of Hepatobiliary Surgery Second Affiliated Hospital of Third Military Medical University Chongqing 400037 P. R. China

Background and Objective: BC047440 is a new gene related to cancer growth and proliferation. Due to the lack of specific antibodies, how BC047440 protein influences the liver cancer growth is unclear. This study aimed to determine the relationship between BC047440 protein expression and clinicopathologic parameters of hepatocellular carcinoma (HCC), and to evaluate the prognostic value of BC047440 for HCC patients. Methods: We prepared the polyclonal antibodies of BC047440, and used Western blot and immunohistochemical staining to detect BC047440 expression in 68 specimens of HCC. The correlations of BC047440 expression to clinicopathologic features and prognosis of HCC patients were analyzed. Results: The polyclonal antibodies could effectively recognize endogenous BC047440 in HCC tissues. The positive rate of BC047440 protein was significantly higher in HCCs than in adjacent tissues (44.1% vs. 23.5%, P < 0.05); the rate was significantly higher in patients with larger tumor (P < 0.05) and portal vein invasion (P <0.01). The HCC patients with high BC047440 expression showed a significantly poorer prognosis than those with low BC047440 expression (P < 0.05). Conclusion: BC047440 can promote the growth and invasion of HCC.

关键词：蛋白质肝癌预后免疫组织化学染色多克隆抗体生长影响临床病理蛋白表达

床边肺超声在低出生体质量早产儿呼吸窘迫综合征中的诊断价值及影响因素分析

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中国妇幼保健 2024年第11期39卷 2102-2105页

作者：梁丽萍郑艳芬任海波包头医学院第二附属医院超声科内蒙古包头014030

目的探讨床边肺超声在低出生体质量早产儿呼吸窘迫综合征(neonatal respiratory distress syndrome,NRDS)中的诊断价值及影响因素分析。方法选取2021年1月—2022年6月在包头医学院第二附属医院出生24 h内有呼吸窘迫症状及胸部X线确诊为N... 详细信息

目的探讨床边肺超声在低出生体质量早产儿呼吸窘迫综合征(neonatal respiratory distress syndrome,NRDS)中的诊断价值及影响因素分析。方法选取2021年1月—2022年6月在包头医学院第二附属医院出生24 h内有呼吸窘迫症状及胸部X线确诊为NRDS的60例低出生体质量早产儿作为观察组,同期在该院出生24 h内的60例正常足月新生儿作为对照组。两组均进行双肺12分区超声评分,运用非参数秩和检验比较两组间超声评分的差异;利用ROC曲线分析观察组患儿肺脏超声评分截断值、曲线下面积(AUC)、灵敏度及特异度;根据Spearman相关性分析观察组患儿肺超声评分与胎龄、体质量的相关性;运用非参数秩和检验比较观察组不同生产方式间的超声评分差异。结果观察组双肺超声评分中位数落在28.5分,对照组双肺超声评分中位数落在48分,观察组患儿双肺超声评分显著低于对照组,差异有统计学意义(Z=-8.338,P<0.001);ROC曲线分析观察组患儿肺脏超声评分截断点为37分,AUC为0.937,灵敏度76%,特异度100%。观察组患儿胎龄与双肺12分区超声评分呈正相关(r=0.786,P<0.001);观察组患儿出生体质量与双肺12分区超声评分呈正相关(r=0.833,P<0.001);观察组患儿不同生产方式双肺12分区超声评分比较,差异有统计学意义(Z=-2.565,P<0.05)。结论床边肺脏超声检查可以作为NRDS患儿的一种无创影像学诊断方法;肺脏超声评分作为半定量化判断NRDS患儿病情严重程度的指标,诊断NRDS诊断效果较好;早产儿自身因素(如胎龄、出生体质量、生产方式)与肺脏超声评分密切相关。

关键词：早产儿低出生体质量呼吸窘迫综合征超声检查

2011一2022年武威市丙型病毒性肝炎流行特征分析

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疾病预防控制通报 2024年第2期39卷 35-38,65页

作者：李盛李之果李普郑艳妮王金玉梁莉萍兰州市肺科医院兰州730046 甘肃中医药大学兰州730000 白银市第二人民医院甘肃白银730900 兰州市第一人民医院兰州730050 兰州大学基础医学院兰州730000 武威市疾病预防控制中心甘肃武威733000

目的了解2011一2022年甘肃省武威市丙型病毒性肝炎(简称丙肝)流行特征,为丙肝的有效预防和控制提供参考依据。方法从中国疾病预防控制信息系统中导出2011一2022年武威市丙肝发病资料,采用描述流行病学方法统计和分析相关数据。结果2011... 详细信息

目的了解2011一2022年甘肃省武威市丙型病毒性肝炎(简称丙肝)流行特征,为丙肝的有效预防和控制提供参考依据。方法从中国疾病预防控制信息系统中导出2011一2022年武威市丙肝发病资料,采用描述流行病学方法统计和分析相关数据。结果2011一2022年武威市累计报告丙肝病例22595例,其中死亡1例,年平均报告发病率为107.48/10万。各年度报告发病率差异有统计学意义(χ^(2)=911.184,P<0.05);第一季度报告病例最多6345例,第三季度报告病例最少5226例,各季度构成差异有统计学意义(χ^(2)=239.492,P<0.05);凉州区病例数最多18444例、占81.63%,年均发病率156.77/10万。其次为古浪县2155例、占9.54%,天祝藏族自治县最少963例、占4.26%。各县(区)报告发病率差异有统计学意义(χ^(2)=478.746,P<0.05);发病率女性115.51/10万高于男性99.85/10万,差异有统计学意义(χ^(2)=143.121,P<0.05)。病例以40~69岁为主,各年度不同年龄组间构成差异有统计学意义(χ^(2)=1560.284,P<0.05);以农民为主16161例、占71.52%,家务及待业人员1808例、占8.00%,离退休人员1496例、占6.62%。结论2011一2022年武威市丙肝报告发病率呈逐年下降趋势,应继续加强高风险人群的预防干预,减少丙肝的传播和疾病负担。

关键词：丙型病毒性肝炎流行病学特征发病率

Ensemble projections of climate and streamflow in a typical basin of semi-arid steppes in Mongolian Plateau of 2021-2100

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Advances in Climate Change Research 2024年第2期15卷 230-243页

作者： Hang PAN Jian-ping TANG liang CHENG Man-Chun li Jiangsu Provincial Key Laboratory of Geographic Information Science and Technology Nanjing UniversityNanjing 210023China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Key Laboratory of Mesoscale Severe Weather/Ministry of Education Nanjing UniversityNanjing 210023China School of Atmospheric Sciences Nanjing UniversityNanjing 210023China

The Kherlen River is the main water source for Hulun Lake,the largest lake in northern *** to reduced inflow from the Kherlen River,Hulun Lake experienced rapid shrinkage at the beginning of the 21st century,posing a serious threat to the ecological security of northern ***,there is still a significant lack of projections regarding future climate change and its hydrological response in the Kherlen River *** study analyzed the projected climate and streamflow changes in the Kherlen River basin,a vital yet vulnerable international semi-arid steppes type basin.A combination of multi-model ensemble projection techniques,and the soil and water assessment tool(SWAT)model was employed to examine the spatio-temporal changes in precipitation,temperature,streamflow,and the associated uncertainties in the *** temperature(an increase of 1.84-6.42℃)and the precipitation(an increase of 15.0-46.0 mm)of Kherlen River basin are projected to increase by 2100,leading to a rise in streamflow(1.08-4.78 m^(3) s^(-1)).The upstream of the Kherlen River exhibits remarkable increasing trends in precipitation,which has a dominant influence on streamflow of Kherlen *** increases in streamflow are observed in April,August,September,and October compared to the reference period(1971-2000).These findings suggest a partial alleviation of water scarcity in the Kherlen River,but also an increased likelihood of hydrological extreme *** projected temperature increase in the Kherlen River basin exhibits the smallest uncertainty,while more pronounced uncertainties are found in precipitation and *** spread among the results of CMIP6 models is greater than that of CMIP5 models,with lower signal-to-noise ratio(SNR)values for temperature,precipitation,and streamflow.

关键词： Climate change Flow projection Uncertainty SWAT Mongolian Plateau

Review Article li-current collector interface in lithium metal batteries

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Nano Research 2024年第10期17卷 8706-8728页

作者： Tian-Yu Wang Dingyi Zhao Keyue liang Yuzhang li Department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesLos AngelesCalifornia 90095USA

Interfaces within batteries,such as the widely studied solid electrolyte interface(SEI),profoundly influence battery *** these interfaces,the solid-solid interface between electrode materials and current collectors is crucial to battery performance but has received less discussion and *** review highlights the latest research advancements on the solid-solid interface between lithium metal(the next-generation anode)and current collectors(typically copper),focusing on factors affecting the li-current collector interface and improvement strategies from perspectives of current collector substrate(lithiophilicity,crystal facets,mechanical properties,and topological structure),electrolyte chemistry,current density,stacking pressure,SEI,electric field and temperature,and provides a future directions and opportunities on this topic.

关键词： lithium metal anode current collectors li-current collector interface solid-solid interface improvement strategies

Microdeletion on Xq27.1 in a Chinese VACTERL-like Family with Kidney and Anal Anomalies

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Biomedical and Environmental Sciences 2024年第5期37卷 503-510页

作者： li Min ZHANG Yu Lan ZHANG Kai li li ping ping LYU Yu Han liang Ya Xin YU Yue Department of Gynecology and Obstetrics Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing HospitalBeijing 100730China The Key Laboratory of Geriatrics Beijing Institute of GeriatricsBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective VATER/VACTERL-like association is associated with adverse pregnancy *** evidence of this disorder is *** this study,we aimed to provide genetic insights to improve the diagnosis of *** We have described a Chinese family in which four members were affected by renal defects or agenesis,anal atresia,and anovaginal fistula,which is consistent with the diagnosis of a VACTERL-like *** and genetic analyses were conducted using genome and exome *** Segregation analysis revealed the presence of a recessive X-linked microdeletion in two living affected individuals,harboring a 196–380 kb microdeletion on Xq27.1,which was identified by familial exome *** sequencing was performed on the affected male,confirming a-196 kb microdeletion in Xq27.1,which included a 28%loss of the CDR-1 *** family members were included in the co-segregation analysis,and only VACTERL-like cases with microdeletions were reported in *** These results suggest that the 196–380 kb microdeletion in Xq27.1 could be a possible cause of the VATER/VACTERL-like ***,further genetic and functional analyses are required to confirm or rule out genetic background as the definitive cause of the VACTERL association.

关键词： Prenatal diagnosis VACTERL whole-genome sequencing whole-exome sequencing X-linked