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Reprogramming the tumor immune microenvironment via nanomaterial-mediated dynamic therapy

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Nano Research 2023年第12期16卷 13100-13112页

作者： Wangbo Jiao Yao Feng Chen liang Qiaoyi Lu Haiming Fan Xing-Jie liang Xiaoli liu Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi’an 710069China Laboratory of Controllable Nanopharmaceuticals Chinese Academy of Sciences(CAS)Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and TechnologyBeijing 100190China Institute of Regenerative and Reconstructive Medicine Med-X InstituteFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710049China

Our improved knowledge of tumor immunology laid a solid foundation for the clinical use of tumor immunotherapies such as immune checkpoint blockers,and the efficacy of these drugs increased our confidence that immunomodulation was a viable way of treating *** basis of immunotherapy is to break the immune escape of the tumor and resolve the immune suppressive microenvironment of ***-mediated dynamic therapy(NDT)is an emerging immuno-regulatable type for tumor therapy,whose effects are mediated by increased cellular levels of reactive oxygen species(ROS).ROS is a potent trigger of immunogenic cell death,and this process initiates antitumor *** for use in NDT can be engineered to interact with almost all cell types in the tumor microenvironment to remodel this *** this review,we systematically examined the effects of NDT on four major cell types in the tumor microenvironment,namely tumor cells,lymphocytes,myeloid cells,and tumor stromal *** believe that this review will improve researchers’understanding of the anti-tumor immunity triggered by NDT,and provide ideas and inspiration for how optimally designed NDT schemes can be used to target the cells in the tumor microenvironment.

关键词： tumor immunotherapy tumor immune microenvironment nanomaterials reactive oxygen species immune cells

Assessing the relative role of climate and human activities on vegetation cover changes in the up-down stream of Danjiangkou,China

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Journal of Plant Ecology 2022年第1期15卷 180-195页

作者： Hai liu Feng liu Hongmeng Yuan liang Zheng Yuan Zhang Faculty of Resources and Environmental Science Hubei UniversityWuhan 430062China Key Laboratory of Regional Development and Environmental Response Hubei UniversityWuhan 430062China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430079China Ecological Research Laboratory Environmental Monitoring Center Station of Hubei ProvinceWuhan 430071China

Danjiangkou Reservoir is water source of Middle Route Project of the South-to-North Water Diversion(SNWD)Project,research on the dynamic changes in vegetation cover and its influencing factors is of great significance for understanding the ecological environment of the water diversion area and formulating protection *** this study,the normalized difference in vegetation index(NDVI)was used to analyze the dynamic changes and influencing factors of vegetation in the upstream and downstream of Danjiangkou Dam from 1982 to *** results showed that the NDVI exhibited an upward trend of 0.017 year−1(P<0.05),and that the significantly increased area was located near the valley upstream of the dam,while the significantly decreased area was mainly distributed in the basin downstream of the dam and around the central *** comprehensive contributions of climate and human activity factors to NDVI changes were 92.03%and 7.97%,*** human activities in the upstream of the dam were mainly reflected in the ecological measures such as returning farmland to forest;the human activities at the downstream of the dam were mainly reflected in urban expansion,occupation of cultivated land and forest land by construction land.

关键词： remote sensing monitoring NDVI climate change urban expansion returning farmland to forest

2022 Multiple-country Monkeypox Outbreak and Its Importation Risk into China:An Assessment Based on the Risk Matrix Method

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Biomedical and Environmental Sciences 2022年第10期35卷 878-887页

作者： DU min ZHANG Shi Mo SHANG Wei Jing YAN Wen Xin liu Qiao QIN Chen Yuan liu min liu Jue Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Institute for Global Health and Development Peking UniversityBeijing 100871China Global Center for Infectious Disease and Policy Research&Global Health and Infectious Diseases Group Peking UniversityBeijing 100191China

Objective To analyze the 2022 multiple-country monkeypox outbreak and assess its importation risk into *** Data was from United States Centers for Disease Control and *** described the global epidemic and calculated concentration index to measure economic-related *** risk into China was evaluated and ranked by using risk matrix method and Borda count method,*** As of July 29,2022,of 79 countries or territories,39(49.37%,39/79),17(21.52%,17/79),6(7.59%,6/79),12(15.19%,12/79),and 5(6.33%,5/79)country or territories identified cases1,*** were economic-related health disparities exist in the distribution of cases(the concentration index=0.42,P=0.027),and the inequality disadvantageous to the rich(pro-poor).There were 12(15.38%,12/78),15(19.23%,15/78),6(7.69%,6/78),and 45(57.69%,45/78)countries or territories with extremely high,high,moderate,and low importation *** States and France ranked first with the highest Borda points of 156,and counts of *** Of 78 countries or territories,the key attention need be paid to the United States and France,*** the epidemic progresses,preparing prevention and control measures to further reduce importation risk was crucial.

关键词： Monkeypox Importation risk China Risk matrix method

交通碳排放研究综述::核算方法、影响因素及作用机理

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交通运输工程与信息学报 2024年第1期22卷 111-127页

作者：左大杰赵亮熊巧刘志鹏王梦涛池俞良西南交通大学交通运输与物流学院成都611756 综合交通大数据应用技术国家工程实验室成都611756 综合交通运输智能化国家地方联合工程实验室成都611756 温江区规划和自然资源局成都611130 包头铁道职业技术学院规划审计处包头014060

交通运输业是碳减排的重要行业,关于交通碳排放核算方法、影响因素及作用机理的研究一直是交通碳排放研究领域的一个热点。本文从交通碳排放量核算方法、交通碳排放影响因素辨识、交通碳排放作用机理分析三个方面来进行综述。在交通碳... 详细信息

交通运输业是碳减排的重要行业,关于交通碳排放核算方法、影响因素及作用机理的研究一直是交通碳排放研究领域的一个热点。本文从交通碳排放量核算方法、交通碳排放影响因素辨识、交通碳排放作用机理分析三个方面来进行综述。在交通碳排放量核算方法部分按照直接获取、“自上而下”法、“自下而上”法、机动车排放模型四种方法进行分类。在交通碳排放影响因素辨识部分从IPAT模型、Kaya恒等式、直接选取三点进行综述,并对近年学者们选取的影响因素进行了总结。在交通碳排放作用机理分析部分综述了脱钩模型、因素分解法、计量经济学方法、系统动力学方法,进而对用不同方法分析的交通碳排放作用机理进行了总结,其中Tapio脱钩模型和对数平均迪氏指数分解法是应用较为广泛的方法。最后,探讨了交通碳排放核算方法、影响因素及作用机理研究中的关键问题,指出本领域的研究难点主要集中于交通碳排放核算方法的优化及统一、影响因素选取体系的形成上。

关键词：综合运输碳排放量核算影响因素作用机理文献综述

不确定性跨期决策视角下绿色行为的心理机制及干预

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心理科学进展 2024年第7期32卷 1048-1056页

作者：周蕾林浇敏陈艺琦梁泳超古晨妍孙祺章广东工业大学管理学院广州510520 北京理工大学设计与艺术学院北京100081

公众的绿色行为普遍要求将可持续原则纳入日常的跨期决策,选择对环境友好的长远利益。然而,绿色行为通常“知易行难”,其重要原因可能在于人们对行为的结果和效用等存在不确定性感知。在绿色行为的跨期决策研究中,不确定性感知如何影响... 详细信息

公众的绿色行为普遍要求将可持续原则纳入日常的跨期决策,选择对环境友好的长远利益。然而,绿色行为通常“知易行难”,其重要原因可能在于人们对行为的结果和效用等存在不确定性感知。在绿色行为的跨期决策研究中,不确定性感知如何影响决策偏好尚缺少证据。因此,本研究拟基于整合的不确定性跨期决策新理论框架,综合运用行为实验、眼动追踪、现场实验,辅以计算建模、眼动操纵等技术,揭示在不确定性条件下,人们践行绿色跨期行为的规律和心理机制,并探索基于心理机制助推和助力绿色行为的有效途径。本研究将加深对绿色行为心理机制的理解,并为有效促进绿色行为提供方案,为相关公共政策的制定与发布提供依据。

关键词：跨期决策绿色行为不确定性可持续性助推

A disaggregation approach for estimating high spatial resolution broadband emissivity for bare soils from Landsat surface reflectance

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International Journal of Digital Earth 2018年第7期11卷 691-702页

作者： Jie Cheng Shunlin liang Hao liu Aixiu Nie Qiang liu State Key Laboratory of Remote Sensing Science Faculty of GeographyBeijing Normal UniversityBeijingPeople’s Republic of China Department of Geographical Sciences University of MarylandCollege ParkMDUSA State Key Laboratory of Remote Sensing Science College of Global Change and Earth System ScienceBeijing Normal UniversityBeijingPeople’s Republic of China

High spatial resolution land surface broadband emissivity(BBE)is not only useful for surface energy balance studies at local scales,but also can bridge the gap between existing coarser resolution BBE products and point-based field *** study proposes a disaggregation approach that utilizes the established BBE–reflectance relationship for estimating high spatial resolution BBE for bare soils from Landsat surface reflectance *** disaggregated BBE is compared to the BBE calculated from spatial–temporal matched Advanced Spaceborne Thermal Emission and Reflectance Radiometer emissivity *** results show that better agreement is achieved over relative homogeneous areas,but deteriorated over heterogeneous and cloud-contaminated *** addition,field-measured emissivity data over large homogeneous desert were also used to validate the disaggregated BBE,and the bias is *** comparison and validation results indicated that the disaggregation approach can obtain high spatial resolution BBE with better accuracy for homogeneous area.

关键词： Broadband emissivity ASTER TM bare soil disaggregation

基于ERK/p38 MAPK信号通路探讨芍药苷对顺铂诱导大鼠心功能障碍及心肌细胞损伤的影响

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中国现代应用药学 2024年第11期41卷 1476-1483页

作者：张诗捷田瑞琦丁银川武琦王沂然刘磊孙红薛敏徐州医科大学基础医学院生理学教研室江苏徐州221004 徐州医科大学基础医学国家级实验教学示范中心江苏徐州221004

目的探究芍药苷(paeoniflorin,PF)对顺铂(cisplatin,CDDP)诱导大鼠心功能障碍及心肌细胞损伤的保护作用。方法SD雄性大鼠随机分为对照组、CDDP组、CDDP+PF低剂量组及CDDP+PF高剂量组,PowerLab多功能记录仪进行左心室插管检测心功能相关... 详细信息

目的探究芍药苷(paeoniflorin,PF)对顺铂(cisplatin,CDDP)诱导大鼠心功能障碍及心肌细胞损伤的保护作用。方法SD雄性大鼠随机分为对照组、CDDP组、CDDP+PF低剂量组及CDDP+PF高剂量组,PowerLab多功能记录仪进行左心室插管检测心功能相关指标[左室内压峰值(left ventricular peak pressure,LVSP)、左室舒张末压(left ventricular enddiastolic pressure,LVEDP)、左室内压变化速率(±dp/dt)]的数值变化;取各组大鼠血清,检测炎性因子TNF-α、IL-1β和IL-6水平;取心肌组织染色,观察组织结构变化。H9c2心肌细胞分为对照组、CDDP组、PF组及CDDP+PF组,CCK-8法测各组细胞活性;流式细胞术检测各组心肌细胞凋亡情况;Western blotting检测心肌细胞中MAPK信号通路相关蛋白p38、ERK、JNK及其磷酸化蛋白表达和凋亡相关蛋白Bax、Bcl-2、Casp3、Cl-casp3的表达情况。结果与对照组相比,CDDP组LVSP、±dp/dt明显下降(P<0.01),LVEDP明显升高(P<0.01);与CDDP组比较,PF低、高剂量预处理均可升高LVSP及±dp/dt水平(P<0.05或P<0.01),降低LVEDP水平(P<0.01),降低大鼠血清中炎性因子TNF-α、IL-1β和IL-6含量(P<0.01)。细胞水平结果显示,与对照组相比,CDDP组细胞活性下降,凋亡相关蛋白Bax、Cl-casp3表达增加(P<0.01),抗凋亡蛋白Bcl-2表达降低(P<0.01),MAPK通路p38及ERK磷酸化表达升高(P<0.01);与CDDP组相比,PF可恢复细胞活性,下调凋亡相关蛋白Bax、Cl-casp3表达(P<0.05或P<0.01),增加抗凋亡蛋白Bcl-2表达(P<0.01),抑制MAPK通路p38及ERK磷酸化表达(P<0.01)。结论PF可恢复CDDP诱导大鼠心功能障碍及心肌细胞损伤,其作用可能通过调控ERK/p38 MAPK信号抑制炎症反应和细胞凋亡。

关键词：心功能障碍芍药苷炎症凋亡 ERK/p38 MAPK

不同纬度植物群落系统发育与功能性状结构研究

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生态学报 2024年第1期44卷 317-329页

作者：苗乐乐刘旻霞肖音迪杨春亮王千月王敏西北师范大学地理与环境科学学院兰州730070

研究植物群落系统发育和功能性状结构有助于了解植物多样性维持机制及物种间的亲缘关系。甘肃省地理环境复杂,显著而多变的气候梯度形成了区域植被和环境差异,丰富了栖息地类型,具有显著的纵向连通性和纬度隔离性,以甘肃省典型纬度梯度... 详细信息

研究植物群落系统发育和功能性状结构有助于了解植物多样性维持机制及物种间的亲缘关系。甘肃省地理环境复杂,显著而多变的气候梯度形成了区域植被和环境差异,丰富了栖息地类型,具有显著的纵向连通性和纬度隔离性,以甘肃省典型纬度梯度植物群落为研究对象,通过对其进行群落学调查和功能性状测定,计算净亲缘关系指数(Net relatedness index, NRI)和平均成对性状距离(Mean pairwise trait distance, PW)来分析植物群落系统发育结构和功能性状格局对不同纬度的响应。结果表明:(1) Shannon-Weiner多样性指数,物种丰富度,谱系α多样性指数表现出随纬度增加而显著降低的变化趋势(P0)的谱系结构,表明种间竞争作用减弱,环境过滤作用逐渐增强,随纬度继续升高相似性限制作用在物种聚集过程中占优势;而群落的功能性状结构随着纬度增加表现出与谱系结构相反的状态,因此植物群落的系统发育和功能性状结构不一致;(3)植物高度表现出微弱的系统发育信号(P<0.05),其他性状均未表现出显著的系统发育信号,表明植物功能性状受环境因素影响大,与系统发育关系不大。总体而言,甘肃省典型纬度梯度植物群落物种多样性维持机制由确定性过程主导,支持生态位理论,其中环境过滤和竞争排斥作用在大多数群落物种聚集过程中占优势地位。土壤含水量、土壤酸碱度和年平均气温等环境因子对植物性状格局影响较大,本研究有助于了解不同气候带植物多样性的地理分布格局和潜在的生态维持机制。

关键词：纬度梯度系统发育结构功能性状环境因子系统发育信号

改良式尾侧下颌骨节段性切除术治疗猫颞下颌关节强直效果的回顾性分析

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中国兽医杂志 2024年第8期60卷 142-148页

作者：郑栋强袁占奎庞茉刘玥朱军辛良曲艺中国农业大学教学动物医院北京海淀100193 中国农业大学动物医学院北京海淀100193

为了探讨猫颞下颌关节强直的临床发病特点、手术方法、并发症和手术效果,本文回顾性分析了在中国农业大学教学动物医院就诊的8只颞下颌关节强直患猫的病历,结合电话回访评估手术并发症和手术效果。结果显示,8只患猫均进行了电子计算机... 详细信息

为了探讨猫颞下颌关节强直的临床发病特点、手术方法、并发症和手术效果,本文回顾性分析了在中国农业大学教学动物医院就诊的8只颞下颌关节强直患猫的病历,结合电话回访评估手术并发症和手术效果。结果显示,8只患猫均进行了电子计算机断层扫描(CT)检查,其中4只(3只单侧和1只双侧)诊断为假性强直,另外4只(2只单侧和2只双侧)诊断为真性强直;5只(3只单侧和2只双侧)进行了改良式尾侧下颌骨节段性切除术,3只(2只单侧和1只双侧)放弃治疗;进行手术的5只患猫术后口腔打开角度均良好,其中1只(单侧)因苏醒质量较差选择了安乐死。长期随访(随访时间7个月~5年,平均约25个月)结果显示,单侧强直的2只患猫手术效果良好,双侧强直的2只患猫手术效果较差,未手术的3只患猫因无法进食而安乐死。结果表明,颞下颌关节强直患猫应该进行手术治疗。改良式尾侧下颌骨节段性切除术可以替代关节成形术、关节外骨切除术和尾侧下颌骨节段性切除术,达到相似的手术效果,并可以降低关节周围医源性神经和血管损伤或牙齿损伤的风险;改良式尾侧下颌骨节段性切除术对于单侧颞下颌关节强直的患猫治疗效果较好,而对于双侧颞下颌关节强直的患猫治疗效果不理想。

关键词：猫颞下颌关节强直改良式尾侧下颌骨节段性切除术回顾性分析