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dAIS: a method for identifying spatial domains based on density clustering of spatial omics data

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Journal of Genetics and Genomics 2024年第8期51卷 884-887页

作者： Qichao Yu Ru Tian Xin Jin liang Wu College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China BGI Research ShenzhenGuangdong 518083China BGI ResearchChongqing 401329China BGI Research ShenzhenGuangdong 518083China BGI Research Chongqing 401329China

In multicellular organisms,the spatial arrangement of cells profoundly influences the biological functions of tissues,underscoring the importance of identifying spatial domains in *** advancements in spatial omics,particularly spatial transcriptomics(ST)(Bressan et al.,2023),have enhanced our understand.ng of tissue spatial organization(Zhang et al.,2022;Tian et al.,2023).

关键词： arrangement identifying domains

A Multi-Strategy-Improved Northern Goshawk Optimization Algorithm for Global Optimization and Engineering design

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Computers, Materials & Continua 2024年第7期80卷 1677-1709页

作者： liang Zeng Mai Hu Chenning Zhang Quan Yuan Shanshan Wang School of Electrical and Electronic Engineering Hubei University of TechnologyWuhan430068China Hubei Key Laboratory for High-Efficiency Utilization of Solar Energy and Operation Control of Energy Storage System Hubei University of TechnologyWuhan430068China

Optimization algorithms play a pivotal role in enhancing the performance and efficiency of systems across various scientific and engineering *** enhance the performance and alleviate the limitations of the Northern Goshawk Optimization(ngO)algorithm,particularly its tendency towards premature convergence and entrapment in local optima during function optimization processes,this study introduces an advanced Improved Northern Goshawk Optimization(IngO)*** algorithm incorporates a multifaceted enhancement strategy to boost operational ***,a tent chaotic map is employed in the initialization phase to generate a diverse initial population,provid.ng high-quality feasible ***,after the first phase of the ngO’s iterative process,a whale fall strategy is introduced to prevent premature convergence into local *** is followed by the integration of T-distributionmutation strategies and the State Transition Algorithm(STA)after the second phase of the ngO,achieving a balanced synergy between the algorithm’s exploitation and *** research evaluates the performance of IngO using 23 benchmark functions alongside the IEEE CEC 2017 benchmark functions,accompanied by a statistical analysis of the *** experimental outcomes demonstrate IngO’s superior achievements in function optimization ***,its applicability in solving engineering design problems was verified through simulations on Unmanned Aerial Vehicle(UAV)trajectory planning issues,establishing IngO’s capability in addressing complex optimization challenges.

关键词： Northern Goshawk Optimization tent chaotic map T-distribution disturbance state transition algorithm UAV path planning

An improved GNSS ambiguity best integer equivariant estimation method with Laplacian distribution for urban low-cost RTK positioning

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Satellite Navigation 2024年第1期5卷 109-124页

作者： Ying Liu Wanke Liu Xiaohong Zhang Yantao liang Xianlu Tao Liye Ma School of Geodesy and Geomatics Hubei Luojia LaboratoryWuhan University129 Luoyu RoadWuhan430079HubeiChina Chinese Antarctic Center of Surveying and Mapping Wuhan University129 Luoyu RoadWuhan430079HubeiChina School of Instrument Science and Engineering Southeast UniversityNanjingJiangsuChina The 54 Research Institute of China Electronics Technology Group CorporationShijiazhuang050081HebeiChina State Key Laboratory of Satellite Navigation System and Equipment Technology Shijiazhuang050081HebeiChina

The integer least squares(ILS)estimation is commonly used for carrier phase ambiguity resolution(AR).More recently,the best integer equivariant(BIE)estimation has also attracted an attention for complex application scenarios,which exhibits higher reliability by a weighted fusion of integer ***,traditional BIE estimation with Gaussian distribution(GBIE)faces challenges in fully utilizing the advantages of BIE for urban low-cost positioning,mainly due to the presence of outliers and unmodeled *** this end,an improved BIE estimation method with Laplacian distribution(LBIE)is proposed,and several key issues are discussed,includ.ng the weight function of LBIE,determination of the candidates included based on the OIA test,and derivation of the variance of LBIE solutions for reliability *** results show that the proposed LBIE method has the positioning accuracy similar to the BIE using multivariate t-distribution(TBIE),and significantly outperforms the ILS-PAR and GBIE *** an urban expressway test with a Huawei Mate40 smartphone,the LBIE method has positioning errors of less than 0.5 m in three directions and obtains over 50%improvements compared to the ILS-PAR and GBIE *** an urban canyon test with a low-cost receiver STA8100 produced by STMicroelectronics,the positioning accuracy of LBIE in three directions is 0.112 m,0.107 m,and 0.252 m,respectively,with improvements of 17.6%,27.2%,and 26.1%compared to GBIE,and 23.3%,28.2%,and 30.6%compared to ***,its computational time increases by 30–40%compared to ILS-PAR and is approximately half of that using TBIE.

关键词： Ambiguity resolution Best integer equivariant estimation Laplacian distribution Urban environments Low-cost GNSS receivers Real-time kinematic

Safety monitoring method for powerline corridors based on single‐stage detector and visual matching

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High Voltage 2024年第4期9卷 805-815页

作者： Jinheng Li Hanbo Zheng Peng Liu Yanshen liang Feng Shuang Junjie Huang Guangxi Key Laboratory of Power System Optimization and Energy Technology Guangxi UniversityNanningChina China Southern Power Grid Guangxi Power Grid Company Ltd. NanningChina State Grid Hubei Electric Power Research Institute WuhanChina

Effective monitoring and early warning of overhead power lines are critical for ensuring power supply stability and personnel ***,existing methods that rely solely on single vision or light detection and ranging(LidAR)have limitations such as numerous invalid alarms,hardware equipment constraints,and lack of real-time monitoring *** article proposes an intelligent monitoring method for safety distance of the powerline corridor based on heterogeneous sensor ***,an optimised single-stage detector is designed to detect safety hazard *** the detector,the backbone network and the sample matching strategy are improved;in addition,the learning strategy is ***,the pose transformation relationship is obtained through the visual matching of prior LidAR information and *** back projection transformation of 2d–3d is achieved accord.ng to the ***,a monocular camera-based end-to-end distance measurement scheme is proposed by combining 2d object information with coordinate transformation *** scheme is applied to the distance measurements from hazard objects to *** experimental results show that the optimisation method improves the detection accuracy and reduces the computational complexity of the ***,case experiments with continuous frame data verify the effectiveness of the safety distance monitoring scheme.

关键词： visual hardware matching

Highly selective and eco-friendly dihydroisoquinoline synthesis via Cu/Co synergistic catalysis in Cu NPs@MOFs catalyst under mild conditions

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Science China Chemistry 2024年第5期67卷 1561-1568页

作者： Peng-Fei Guo Ze-Long liang Yue-E Jiao Hang Xu Bin Zhao Key Laboratory of Advanced Energy Material Chemistry Renewable Energy Conversion and Storage CenterDepartment of ChemistryNankai UniversityTianjin 300071China

3,4-dihydroisoquinoline(dHIQ)is an important precursor used in the production of drugs for treating cancer,HIV,Alzheimer's disease,*** studies on dHIQ synthesis show low catalytic selectivity due to the susceptible over-oxidation feedstock of1,2,3,4-tetrahydroisoquinoline(THIQ),which often requires alkali ***,it is desirable yet challenging to explore a highly selective and efficient oxydehydrogenation capacity for dHIQ synthesis under eco-friendly reaction ***,a novel framework 1 was synthesized,exhibiting 1d channels with the size of 4.6 A×9.6 A and high solvent/p H/thermal stability.A stable framework allows it to encapsulate Cu nanoparticles(NPs)to form Cu NPs@1-x(x=1,2,3,and 4)with varying load.ng amounts of Cu NPs at 2.0 wt%,3.0 wt%,4.0 wt%,and 6.0 wt%,*** NPs@1-3 could selectively catalyze the reaction from THIQ to dHIQ with a high selectivity of 98%and a recorded turnover frequency(TOF)of 22.1 h-1under eco-friendly mild *** correspond.ng catalytic activity can maintain at least five recyclings and can be further applied to gram-scale ***,the efficient preparation of dHIQ catalyzed by Cu NPs@1-3 could be realized even under air ***,the anticancer molecule precursor synthesis of 6,7-dimethoxy-3,4-dihydroisoquinoline was also selectively catalyzed by Cu NPs@*** investigations revealed that high catalytic performance can be attributed to the stable framework and the synergistic catalytic effect of the loaded Cu NPs and Co metal *** importantly,this work represents the first example of MOF catalysts for selectively thermo-catalytic dHIQ synthesis and demonstrates a simple approach to obtain efficient catalysts for selective oxydehydrogenation in the production of unsaturated compounds.

关键词： metal-organic frameworks Cu NPs@MOFs 3 4-dihydroisoquinoline selective oxydehydrogenation synergistic catalysis

Preparation of Chemically Recyclable Poly(ether-alt-ester) by the Ring Opening Polymerization of Cyclic Monomers Synthesized by Coupling Glycolide and Epoxides

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Chinese Journal of Polymer Science 2024年第2期42卷 168-175,I0006页

作者： Feng Ren Zhuang-Zhuang liang Ming-Xin Niu Chen-Yang Hu Xuan Pang Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China

Polyester and polyether are two key oxygenated polymers, and completely alternative sequence of poly(ester-alt-ether) could efficiently combine the advantages(includ.ng flexibility, degradability, etc.) of both segments. Currently, despite their copolymers could be synthesized from one-pot mixture of cyclic esters and epoxides, perfectly alternative microstructure is very challenging to realize and typically restricted to certain monomer pairs. Moving forward, synthesizing poly(ester-alt-ether) from commercially available and largescale monomers would be a significant advance. For example, successfully commercialized poly(glycolic acid)(PGA), which is not easily soluble in polymers due to its high crystallinity and is brittle and difficult to control the degradation cycle, would encounter a new paradigm if engineered into poly(ester-altether). In this work, starting from the design of monomer with hybrid structures, we successfully synthesized a series of 1,4-dioxan-2-one containing different substituents based on glycolide(GA) and epoxides using commercially available Salen-Cr(III) and PPNCl catalytic *** new monomers underwent ring-opening polymerization(ROP) to form a series of poly(ester-alt-ether) with perfectly alternating glycolic acid and propylene glycol repeat units under catalytic system of thiourea/base. The poly(ester-alt-ether) have significantly lower glass-transition temperature than PGA. Additionally, the poly(ester-alt-ether) can be chemically recovered to monomer using Sn(Oct)2 or 1,8-diazabicyclo[5.4.0]undecane-7-ene(dBU) as a catalyst in solution, thus establishing a closed-loop life cycle. From monomers derived from GA and epoxides, this work furnishes a novel strategy for the synthesis of poly(ester-alt-ether) with chemical recyclability.

关键词： Polyester Polyether Alternative copolymer Ring-opening polymerization

Regulated polarization degree of upconversion luminescence and multiple anti-counterfeit applications

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Rare Metals 2024年第5期43卷 2172-2183页

作者： d.ng-Ping Wen Ping Chen Yi liang Xiao-Ming Mo Cao-Feng Pan Center On Nanoenergy Research Guangxi Key Laboratory for Relativistic AstrophysicsSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004China Key Laboratory of Micronano Energy and Sensor CAS Center for Excellence in NanoscienceBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100140China

Polarization upconversion luminescence(PUCL)of lanthanide ions(Ln^(3+))has been widely used in single particle tracking,microfluidics detection,three-dimensional displays,and so ***,no effective strategy has been developed for modulating *** we report a strategy to regulate PUCL in Ho^(3+)-doped NaYF4single nanorods based on the number of upconversion *** constructing a multiphoton upconversion system for Ho^(3+),we regulate the degree of polarization(dOP)of PUCL from 0.590 for two-photon luminescence to 0.929 for three-photon upconversion luminescence(UCL).Furthermore,our strategy is verified from cross-relaxation between Ho^(3+)and Yb^(3+),excitation wavelength,excitation power density,and local site *** this regulation strategy of PUCL has also been achieved in Tm^(3+),with the dOP ranging from 0.233 for two-photon luminescence to 0.925 for four-photon UCL Besides,multi-dimensional anti-counterfeiting display has been explored with *** work provides an effective strategy for regulating PUCL and also provides more opportunities for the development of polarization display optical encod.ng,anti-counterfeiting,and integrated optical devices.

关键词： Polarization upconversion luminescence degree of polarization Population density of excited state Number of upconversion photons Polarization anti-counterfeitingdisplay

NIR-IIb-triggered photodynamic therapy combined with chemotherapy platform based on rare-earth-doped nanoparticles

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Rare Metals 2024年第7期43卷 3220-3231页

作者： Zhuo Tu Yong Wan Juan Ge Chen-Chen Li Tao liang Zhen Li Chemistry and Chemical Engineering Hubei UniversityWuhan 430062China

Photodynamic therapy(PdT),with high spatiotemporal selectivity,minimal side effects and less drug resistance,has emerged as a promising approach for the treatment of ***,inadequate penetration depth and poor efficacy seriously restrict its practical *** address these challenges,we developed a combined therapy platform(RENP@C/d-FA)based on rare-earth-doped nanoparticles(RENPs)with a structure of NaErF_(4):Tm(0.5%)@NaYF_(4),on which photosensitizer Ce6(chlorin e6)and chemo-therapeutic drug(dOX)(doxorubicin)were loaded by encapsulating with an amphiphilic polymer distearoyl phosphatidylethanolamine-polyethylene glycol-folic acid(dSPE-PEG-FA).RENPs with NaErF_(4) as the matrix possess multiple excitation/emission peaks,enabling activation of PdT under near-infrared-Ⅱb(NIR-Ⅱb,1500-1700 nm)excitation and luminescence imaging in NIR-Ⅱb region by absorbing 808 nm near-infrared ***,dOX can be selectively released in the acidic microenvironment of *** from the tumor targeting capability of folic acid,this platform can successfully ablate tumor cells and inhibit tumor growth by combining PdT and *** innovative approach holds great promise as a powerful tool for cancer treatment,showing the potential to revolutionize PdT.

关键词： Photodynamic therapy Rare-earth-doped nanoparticles NIR-IIb Chemotherapy Combined therapy

Studying the co-evolution of information diffusion,vaccination behavior and disease transmission in multilayer networks with local and global effects

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Chinese Physics B 2024年第3期33卷 677-689页

作者：霍良安武兵杰 Business School University of Shanghai for Science and TechnologyShanghai 200093China School of Intelligent Emergency Management University of Shanghai for Science and TechnologyShanghai 200093China

Today,with the rapid development of the internet,a large amount of information often accompanies the rapid transmission of disease outbreaks,and increasing numbers of scholars are studying the relationship between information and the disease transmission process using complex *** fact,the disease transmission process is very *** this information,there will often be individual behavioral measures and other factors to *** of the previous research has aimed to establish a two-layer network model to consider the impact of information on the transmission process of disease,rarely divided into information and behavior,*** carry out a more in-depth analysis of the disease transmission process and the intrinsic influencing mechanism,this paper divides information and behavior into two layers and proposes the establishment of a complex network to study the dynamic co-evolution of information diffusion,vaccination behavior,and disease *** is achieved by considering four influential relationships between adjacent layers in multilayer *** the information layer,the diffusion process of negative information is described,and the feedback effects of local and global vaccination are *** the behavioral layer,an individual's vaccination behavior is described,and the probability of an individual receiving a vaccination is influenced by two factors:the influence of negative information,and the influence of local and global disease *** the disease layer,individual susceptibility is considered to be influenced by vaccination *** state transition equations are derived using the micro Markov chain approach(MMCA),and disease prevalence thresholds are *** is demonstrated through simulation experiments that the negative information diffusion is less influenced by local vaccination behavior,and is mainly influenced by global vaccination behavior;vaccination behavior is mainly influenced by local d

关键词： information diffusion vaccination behavior disease transmission multilayer networks local and global effect