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Genetic diversity of Plasmodium vivax revealed by the merozoite surface protein-1 icb5-6 fragment

Infectious Diseases of Poverty 2017年第1期6卷 801-809页

作者： Wei Ruan Ling-ling Zhang Yan Feng Xuan Zhang hua-liang chen Qiao-yi Lu Li-nong Yao Wei Hu Department of Communicable Diseases of Control and Prevention Zhejiang Provincial Centre for Disease Control and PreventionHangzhouChina School of Life Sciences FuDan UniversityShanghaiChina

Background:Plasmodium vivax remains a potential cause of morbidity and mortality for people living in its endemic *** the genetic diversity of *** from different regions is valuable for studying population dynamics and tracing the origins of *** PvMSP-1 gene is highly polymorphic and has been used as a marker in many *** population *** aim of this study was to investigate the genetic diversity of the PvMSP-1 gene icb5-6 fragment and to provide more genetic polymorphism data for further studies on *** population structure and tracking of the origin of clinical ***:Nested PCR and sequencing of the PvMSP-1 icb5-6 marker were performed to obtain the nucleotide sequences of 95 *** isolates collected from Zhejiang province,*** investigate the genetic diversity of PvMSP-1,the 95 nucleotide sequences of the PvMSP-1 icb5-6 fragment were genotyped and analyzed using DnaSP v5,MEGA ***:The 95 *** isolates collected from Zhejiang province were either indigenous cases or imported cases from different regions around the world.A total of 95 sequences ranging from 390 to 460 bp were *** 95 sequences were genotyped into four allele-types(Sal I,Belem,R-III and R-IV)and 17 unique haplotypes.R-III and Sal I were the predominant *** haplotype diversity(Hd)and nucleotide diversity(Pi)were estimated to be 0.729 and 0.062,indicating that the PvMSP-1 icb5-6 fragment had the highest level of polymorphism due to frequent recombination processes and single nucleotide *** values of dN/dS and Tajima’s D both suggested neutral selection for the PvMSP-1icb5-6 *** addition,a rare recombinant style of R-IV type was ***:This study presented high genetic diversity in the PvMSP-1 marker among *** strains from around the *** genetic data is valuable for expanding the polymorphism information on ***,which could be helpful for further study on populat

关键词： Plasmodium vivax PvMSP-1 Genetic diversity Malaria

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Optimal Model Average Prediction in Orthogonal Kriging Models

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Journal of Systems Science & Complexity 2024年第3期37卷 1080-1099页

作者： WANG Jun HE Jiabei liang hua LI Xinmin School of Mathematics and Statistics Qingdao UniversityQingdao 266071China Department of Statistics George Washington UniversityWashington DC 20052USA

The main objective of this paper is to consider model averaging methods for kriging *** paper proposes a Mallows model averaging procedure for the orthogonal kriging model and demonstrate the asymptotic optimality of the model averaging estimators in terms of mean square *** studies are conducted to evaluate the performance of the proposed method and compare it with the competitors to demonstrate its *** authors also analyse a real dataset for an illustration.

关键词： Asymptotic optimality Mallows criterion optimal model averaging orthogonal kriging model

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Adsorption behavior of CO2/H2S mixtures in calcite slit nanopores for CO2 storage:An insight from molecular perspective

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Petroleum Science 2024年第4期21卷 2444-2456页

作者： cheng Qian Zhen-hua Rui Yue-liang Liu Kai Du chen Liu Yang Zhao Xiao-Min Ma State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum College of Petroleum Engineering China University of Petroleum College of Carbon Neutrality Future Technology China University of Petroleum College of Petroleum China University of Petroleum-Beijing at Karamay College of Mining Engineering Taiyuan University of Technology

It is acknowledged that injecting CO2into oil reservoirs and saline aquifers for storage is a practical and affordable method for *** CO2produced from industrial exhaust contains impurity gases such as H2S that might impact CO2sequestration due to competitive *** study makes a commendable effort to explore the adsorption behavior of CO2/H2S mixtures in calcite slit *** Canonical Monte Carlo（GCMC） simulation is employed to reveal the adsorption of CO2,H2S as well as their binary mixtures in calcite *** show that the increase in pressure and temperature can promote and inhibit the adsorption capacity of CO2and H2S in calcite nanopores,***2exhibits stronger adsorption on calcite surface than *** energy plays the dominating role in the adsorption *** energy accounts for 97.11% of the CO2-calcite interaction energy and 56.33% of the H2S-calcite interaction energy at 10 MPa and 323.15 *** presence of H2S inhibits the CO2adsorption in calcite nanopores due to competitive adsorption,and a higher mole fraction of H2S leads to less *** quantity of CO2adsorbed is lessened by approximately 33% when the mole fraction of H2S reaches ***2molecules preferentially occupy the regions near the po re wall and H2S molecules tend to reside at the center of nanopore even when the molar ratio of CO2is low,indicating that CO2has an adsorption priority on the calcite surface over *** addition,moisture can weaken the adsorption of both CO2and H2S,while CO2is more *** interestingly,we find that pure CO2is more suitable to be sequestrated in the shallower formations,i.e.,500-1500 m,whereas CO2with H2S impurity should be settled in the deeper reservoirs.

关键词： Adsorption behavior CO 2 /H 2 S binary mixtures Molecular perspective Calcite slit nanopores CO 2 sequestration

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Evaluation of frictional pressure drop correlations for air-water and air-oil two-phase flow in pipeline-riser system

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Petroleum Science 2024年第2期21卷 1305-1319页

作者： Nai-liang Li Bin chen School of Low-carbon Energy and Power Engineering China University of Mining and TechnologyXuzhou221116JiangsuChina State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049ShaanxiChina

Accurate prediction of the frictional pressure drop is important for the design and operation of subsea oil and gas transporting system considering the length of the pipeline. The applicability of the correlations to pipeline-riser flow needs evaluation since the flow condition in pipeline-riser is quite different from the original data where they were derived from. In the present study, a comprehensive evaluation of 24prevailing correlation in predicting frictional pressure drop is carried out based on experimentally measured data of air-water and air-oil two-phase flows in pipeline-riser. Experiments are performed in a system having different configuration of pipeline-riser with the inclination of the downcomer varied from-2°to-5°to investigated the effect of the elbow on the frictional pressure drop in the riser. The inlet gas velocity ranges from 0.03 to 6.2 m/s, and liquid velocity varies from 0.02 to 1.3 m/s. A total of885 experimental data points including 782 on air-water flows and 103 on air-oil flows are obtained and used to access the prediction ability of the correlations. Comparison of the predicted results with the measured data indicate that a majority of the investigated correlations under-predict the pressure drop on severe slugging. The result of this study highlights the requirement of new method considering the effect of pipe layout on the frictional pressure drop.

关键词： Frictional pressure drop Pipeline-riser Gas-liquid two-phase flow Severe slugging Correlation

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Enhanced thermoelectric performance enabled by compositing ZrO_(2)in n-type SiGe alloy with low thermal conductivity

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Rare Metals 2024年第3期43卷 1167-1176页

作者： Meng-Fei Wang hua-Jun Lai Ji-Sheng liang Jun-liang chen Wang-Yang Ding Qi Zhou Ying Peng cheng-Yan Liu Lei Miao Guangxi Key Laboratory for Relativity Astrophysics State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite StructuresSchool of Physical Science and TechnologyGuangxi UniversityNanning530004China Guangxi Academy of Sciences Nanning530007China Key Laboratory of Information Material Engineering Research Center of Electronic Information Materials and DevicesGuilin University of Electronic TechnologyMinistry of EducationGuilin541004China Guangxi Key Laboratory of Precision Navigation Technology and Application School of Information and CommunicationGuilin University of Electronic TechnologyGuilin541004China

SiGe-based thermoelectric(TE)materials have gained increasing interests due to their low maintenance costs,environmental friendliness and long ***,the intrinsically high thermal conductivity of Si-based materials also results in poor TE *** this investigation,a zirconia(ZrO_(2))composite strategy was applied to an n-type SiGe alloy,tremendously elevating its TE *** mechanical alloying and spark plasma sintering(SPS)processes,the ZrO_(2)induced the formation of nanopores in the SiGe matrix via phosphorus ***,such increase in porosity enhanced the phonon scattering and dramatically suppressed lattice thermal conductivity,from 2.83 to 1.59 W·m^(-1)·K^(-1)at 873 ***,reduced phosphorus doping led to an increase in Seebeck coefficients and a relatively minor decrease in electrical conductivity,The power factor didn't deteriorate significantly,either,as its maximum of~3.43 mW·m^(-1-)K^(-2)was achieved at 873 K with(Si_(0.8)Ge_(0.2))_(0.097)P_(0.03)(ZrO_(2))_(0.003).In short,a peak figure of merit(ZT)of~1.27 at 873 K and an average ZT~0.7 from 323 to 873 K were *** study demonstrates that the electrical and thermal transportation of SiGe material can be synergistically tuned by compositing ZrO_(2),illustrating a novel strategy to optimize the TE properties of bulk materials.

关键词： Thermoelectric SiGe alloy ZrO2 composting P element adsorption nanopores

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Glibenclamide pretreatment attenuates early hematoma expansion of warfarin-associated intracerebral hemorrhage in rats by alleviating perihematomal blood-brain barrier dysfunction

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Chinese Neurosurgical Journal 2024年第1期10卷 8-19页

作者： Zongwei Zeng liang liang Zhou Feng Peiwen Guo Xiaoke Hao Jishu Xian hua Feng Yujie chen Zhi chen Department of Neurosurgery and State Key Laboratory of Trauma Burn and Combined InjurySouthwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Neurosurgery The 945Th Hospital of PLAYaanSichuan Province 625099China Department of Rehabilitation Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Chongqing Key Laboratory of Precision Neuromedicine and Neuroregeneration Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Chongqing Clinical Research Center for Neurosurgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China

Background Hematoma expansion is a determinant of poor outcome of intracerebral hemorrhage but occurs frequently,especially in warfarin-associated intracerebral hemorrhage(W-ICH).In the present study,we employ the warfarin-associated intracerebral hemorrhage(W-ICH)rat model,to explore the efficacy and potential mechanism of glibenclamide pretreatment on hematoma expansion after intracerebral hemorrhage,hoping to provide proof of concept that glibenclamide in stroke primary and secondary prevention is also potentially beneficial for intracerebral hemorrhage patients at early *** In the present study,we tested whether glibenclamide,a common hypoglycemic drug,could attenuate hematoma expansion in a rat model of *** expansion was evaluated using magnetic resonance imaging;brain injury was evaluated by brain edema and neuronal death;and functional outcome was evaluated by neurological *** blood-brain barrier integrity was assessed using Evans blue extravasation and tight junction-related *** The data indicated that glibenclamide pretreatment significantly attenuated hematoma expansion at 24 h after W-ICH,thus mitigating brain edema and neuronal death and promoting neurological function recovery,which may benefit from alleviating blood-brain barrier disruption by suppressing matrix *** The results indicate that glibenclamide pretreatment in stroke primary and secondary prevention might be a promising therapy for hematoma expansion at the early stage of W-ICH.

关键词： Intracerebral hemorrhage Warfarin Glibenclamide Hematoma expansion Blood-brain barrier Matrix metallopeptidase-9

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Laser powder bed fusion of NiTiFe shape memory alloy via premixed powder:microstructural evolution,mechanical and functional properties

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Rare Metals 2024年第5期43卷 2300-2316页

作者： Bo Yuan Jin-Guo Ge liang Zhang Hong-Jun chen Long-Sha Wei Yu-Duo Zhou Run-hua Song Institute of Intelligent Manufacturing Technology Shenzhen PolytechnicShenzhen 518055China School of Mechanical and Electrical Engineering Guilin University of Electronic TechnologyGuilin 541004China Guangdong Advanced Polymer Composite Engineering Technology Research Center Shenzhen Academy of Aerospace TechnologyShenzhen 518057China Jihua Laboratory Testing Center Jihua LaboratoryFoshan 528000China

High-cost pre-alloyed powder is the bottleneck problem that limits the widespread application of additivemanufactured shape memory *** this work,the lowcost ternary NiTiFe shape memory alloy is fabricated by laser powder bed fusion(LPBF)technique via mechanically mixed pre-alloy NiTi powder and varying contents pure Fe powder(1,2,3 wt%).All NiTiFe alloys show a relative density of up to 99.8%by optimizing the LPBF processing *** to the heterogeneous nucleation effect of micron-sized Fe particles,both grain refinement and texture weakening are generated in the NiTiFe alloys,accompanied by the reduction of dislocation *** the room-temperature mechanical properties,the NiTi-3Fe alloy shows the highest microhardness of HV370,but the fracture strength and elongation reduce to1701 MPa and 23%*** evolution of mechanical properties is attributed to the high internal defects,low dislocation density and the incoherent ***,the NiTi-3Fe alloy shows the quasi-linear superelasticity behavior;the superelastic recoverable strain of NiTi-1Fe and NiTi-2Fe decreased with the increase in Fe *** study provided a new-fangled insight for the development of multi-component NiTi-based shape memory alloys by additive manufacturing.

关键词： Additive manufacturing Shape memory alloy Metal matrix composite Microstructure Mechanical properties

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AFM probe for measuring~10^(−5)ultra-low friction coefficient:Design and application

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Friction 2024年第1期12卷 64-73页

作者： Yushan chen liang JIANG Linmao QIAN Tribology Research Institute State Key Laboratory of Traction PowerSouthwest Jiaotong UniversityChengdu 610031China

Superlubricity provides a novel approach to addressing friction and wear issues in mechanical ***,little is known regarding improving the atomic force microscope(AFM)friction coefficient measurement ***,this study established the theoretical formula for the AFM friction coefficient measurement and deduced the measurement ***,the formula was applied to the AFM probe with a rectangular cross-section *** measurement resolution is associated with the dimensional properties of the AFM probe,the mechanical properties of the cantilever material,the properties of the position-sensitive detector(PSD),and probably the anti-vibration performance of the *** is feasible to make the cantilever as short as possible and the tip as high as possible to improve the measurement *** AFM probe for measuring an ultra-low friction coefficient was designed and *** cantilever’s length,width,and thickness are 50,35,and 0.6μm,*** tip height is 23μ*** measurement resolution can reach 7.1×10^(−6) under the maximum normal ***,the AFM probe was applied to measure the superlubricity between graphene *** friction coefficient is 0.00139 under 853.08 *** work provides a promising method for measuring a~10^(−5) friction coefficient of superlubricity.

关键词： atomic force microscope(AFM) superlubricity friction coefficientμ probe

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Stereoselective synthesis of substituted 1,3-dienes from propargylic esters: electrophilic-metal or redox catalysis?

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Science China Chemistry 2024年第5期67卷 1384-1396页

作者： Mengfu Dai liangliang Song liang-An chen Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of New Power BatteriesSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China

1,3-Diene architectures are not only widely present in natural products, pharmaceuticals, and functional organic materials but also serve as versatile building blocks to furnish important functionalized molecules in synthetic chemistry due to conjugated repeating C=C units. Accordingly, various strategies to access substituted 1,3-dienes in a stereoselective manner have been developed. However, chemo-, regio-and stereoselective synthesis of highly substituted 1,3-dienes still remains elusive and challenging. Readily available propargylic esters have emerged as an appealing class of synthetic intermediates for accessing functionalized 1,3-dienes, especially challenging tri-or tetrasubstituted variants, via transition-metal catalysis, including electrophilic metal and redox neutral catalysis. This review, for the first time, systematically highlights recent advances in transitionmetal catalyzed synthesis of substituted 1,3-dienes from propargylic esters, discusses the mechanisms and synthetic utilities, and gives the remaining challenges and potential opportunities in this field.

关键词： 1 3-diene propargylic ester Lewis acid redox catalysis transition metal

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Preparation of PVA/GO/h-BN Janus Film with High Thermal Conductivity and Excellent Flexibility via a Density Deposition Self-assembly Method

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Chinese Journal of Polymer Science 2024年第8期42卷 1217-1226页

作者： Fang-hua Luo Zhi-Tao Dong Guo-hua chen chen Ma huai-Yuan Wang College of Chemistry and Chemical Engineering Northeast Petroleum UniversityDaqing 163318China College of Materials Science and Engineering Huaqiao UniversityXiamen 361000China School of Chemical Engineering and Technology and State Key Laboratory for Chemical Engineering Tianjin UniversityTianjin 300350China

Janus films with asymmetric physical/chemical properties have attracted con siderable attention due to their promising applications in personal thermal management,electronic skin s,sensors,actuators,***,traditional methods for fabricating Janus films conventionally need the assistance of an interface or auxiliary equipment,which are usually complex and ***,flexible poly(vinyl alcohol)(PVA)/graphene oxide(GO)/h-BN(recorded as PVA/GO/h-BN)Janus films with thermally,optically,and electrically anisotropic properties are fabricated by a simple density deposition self-assem bly method,which just utilizes the density difference between GO and h-BN during water *** results show that the two sides of the acquired Janus films have obvious asymmetric *** the original state of the PVA/GO/h-BN Janus films,the thermal conductivity of the GO side(10.06 W·m^(-1)·K^(-1))is generally lower than that of the h-BN side(10.48W·m^(-1)·K^(-1)).But after GO is reduced,the thermal conductivity of the rGO side reaches 12.17 W·m^(-1)·K^(-1),surpassing that of the h-BN *** addition,the relative reflectance of the h-BN side of Janus film is also significantly higher than that of the rGO side,and the su rface resistance difference between the two sides is about 4 orders of *** prepared PVA/GO/h-BN Janus films show great application potential in human thermal management,light conversion switches,and electronic *** study provides a simple and versatile strategy for fabricating Janus films with multifunctional(such as thermal,optical,and electrical)anisotropies.

关键词： Janus films PVA/GO/h-BN Density deposition self-assembly method

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