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Prognostic factors and predictors of postoperative adjuvant transcatheter arterial chemoembolization benefit in patients with resected hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第10期26卷 1042-1055页

作者： Ming-Yu Chen Sarun Juengpanich Jia-hao Hu Win Topatana Jia-Sheng Cao Chen-hao Tong Jian lin Xiu-Jun Cai Department of General Surgery Sir Run-Run Shaw HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina School of Medicine Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Engineering Research Center of Cognitive Healthcare of Zhejiang Province Hangzhou 310000Zhejiang ProvinceChina Department of General Surgery Shaoxing People’s HospitalZhejiang UniversityShaoxing 312000Zhejiang ProvinceChina Department of General Surgery Longyou People’s HospitalQuzhou 314400Zhejiang ProvinceChina

BACKGROUND Postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) has improved overall survival (OS) in patients with hepatocellular carcinoma (HCC).However,the prognostic and predictive factors remain *** To assess the prognostic factors and the predictors of PA-TACE benefit for OS in patients with resected *** Univariate and multivariate analyses were performed to identify the potential prognostic factors for *** order to assess the predictive factors of PA-TACE benefit,the interaction variables between treatments for each subgroup were evaluated using the Cox proportional hazards regression *** A total of 378 patients (PA-TACE vs surgery alone,189:189) from three centerswere included after a propensity-score 1:1 matching *** to the group receiving surgery alone,PA-TACE prolonged the OS rate in patients with resected HCC (P linic Liver Cancer system and ferritinto-hemoglobin ratio (FHR) were used as the prognostic factors for OS in both *** (P=0.023) and microscopic vascular invasion (MVI)(P=0.002) were also identified in the PA-TACE group,while gender (P=0.027),hepatitis B virus(P=0.034) and albumin-bilirubin grade (P=0.027) were also selected in the surgery alone *** addition,PA-TACE resulted in longer OS than surgery alone across subgroups [all hazard ratios (PA-TACE-to-surgery alone)linic Liver Cancer stages were regarded as prognostic factors for ***,high FHR and the absence of MVI were important predictive factors,which can be used to assist clinicians in selecting which patients could achieve a better OS with PA-TACE.

关键词： Postoperative adjuvant transcatheter arterial chemoembolization Hepatocellular carcinoma Prognostic factors Predictive factors Overall survival

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交联型自修复水性聚氨酯的合成与性能

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工程塑料应用 2024年第8期52卷 39-45页

作者：党海春武美君边祥成林先鸿梁晋帆李杰赵剑波张子梁太原工业学院材料工程系太原030008

水性聚氨酯膜容易被划伤,利用双硫键引发的动态交换反应可赋予水性聚氨酯自修复能力。但动态共价键键合强度较弱,导致水性聚氨酯的自修复和力学性能难以兼得。采用聚环氧丙烷醚三醇和含双硫键的2-羟乙基二硫化物,在水性聚氨酯分子中同... 详细信息

水性聚氨酯膜容易被划伤,利用双硫键引发的动态交换反应可赋予水性聚氨酯自修复能力。但动态共价键键合强度较弱,导致水性聚氨酯的自修复和力学性能难以兼得。采用聚环氧丙烷醚三醇和含双硫键的2-羟乙基二硫化物,在水性聚氨酯分子中同时引入双硫键和支化结构,制得高强度、交联型的自修复水性聚氨酯。以异氟尔酮二异氰酸酯(IPDI)、聚四氢呋喃醚二醇、聚环氧丙烷醚三醇、2-双(羟甲基)丙酸(DMPA)以及2-羟乙基二硫化物(HEDS)等为主要原料,经预聚物法合成不同DMPA/HEDS物质的量比的IPDI型交联型自修复水性聚氨酯,研究DMPA与HEDS物质的量比对水性聚氨酯乳液稳定性、水性聚氨酯胶膜力学性能和自修复性能的影响。采用傅里叶变换红外光谱(FTIR)仪和拉曼光谱对其进行结构表征,验证了含双硫键的自修复水性聚氨酯的成功合成。双硫键和支化结构的同时引入显著提高了水性聚氨酯胶膜的拉伸强度和自修复性能,当DMPA与HEDS物质的量比为1∶1时,拉伸强度从不含双硫键聚氨酯胶膜的13.1 MPa提高到24.2 MPa,自修复后强度达19.4 MPa,自修复率达80.1%。

关键词：水性聚氨酯双硫键交联自修复胶膜

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Non-ultrawide bandgap CsPbBr_(3) nanosheet for sensitive deep ultraviolet photodetection

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Journal of Materials Science & Technology 2023年第28期159卷 251-257页

作者： Chun-Yan Wu Yu-Xuan Le Li-Yan liang Jing-Yue Li Feng-Xia liang Shi-Rong Chen Xiao-Ping Yang Yu-Xue Zhou lin-Bao Luo School of Microelectronics Hefei University of TechnologyHefei 230009China College of Physical Science and Technology Yangzhou UniversityYangzhou 225002China

In this study,we report the fabrication of a sensitive deep ultraviolet(DUV)photodetector by using CsPbBr_(3) nanosheets synthesized through confined-space growth at room *** peak pho-toresponse of the device upon illumination blueshifts with decreasing thickness and a 68 nm CsPbBr_(3) nanosheet based device displays a peak response to 265 nm illumination,showing responsivity and spe-cific detectivity of 85 mA/W and 4.05×1011 Jones at 3 V bias,*** simulation re-veals that the blueshift is associated with the wavelength-dependent absorption coefficient of CsPbBr_(3) nanosheet:incident light with shorter wavelengths can be absorbed on the superficial surface,while long-wavelength light has a larger penetration depth,leading to dominant DUV absorption in thinner CsPbBr_(3) *** work will shed light on the facile and cost-effective fabrication of DUV photode-tectors from non-ultrawide bandgap(UWBG)all-inorganic perovskite materials.

关键词： Non-ultrawide bandgap semiconductors CsPbBr_(3)nanosheet Wavelength-dependent absorption coefficient Sensitive DUV photodetector

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瑞马唑仑在老年患者无痛胃肠镜检查中的应用

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中国新药与临床杂志 2024年第6期43卷 442-445页

作者：苏丹梁涛陈超然季中华张微姚秀秀王颖林同济大学附属东方医院麻醉科上海200120

目的评价瑞马唑仑用于老年患者无痛胃肠镜检查的效果。方法选择拟行无痛胃肠镜检查的老年患者,随机分为2组。对照组麻醉诱导方案为舒芬太尼0.1μg·kg^(-1)+丙泊酚1.5 mg·kg^(-1),检查过程中丙泊酚追加剂量为每次0.5 mg·kg^(-1);试验... 详细信息

目的评价瑞马唑仑用于老年患者无痛胃肠镜检查的效果。方法选择拟行无痛胃肠镜检查的老年患者,随机分为2组。对照组麻醉诱导方案为舒芬太尼0.1μg·kg^(-1)+丙泊酚1.5 mg·kg^(-1),检查过程中丙泊酚追加剂量为每次0.5 mg·kg^(-1);试验组的给药方案为舒芬太尼0.1μg·kg^(-1)+瑞马唑仑0.15 mg·kg^(-1)诱导,检查过程中瑞马唑仑每次追加剂量为首剂的1/3。记录麻醉过程中患者心率、呼吸频率、平均动脉压、血氧饱和度,以及诱导、苏醒、出室时间,观察注射痛、低氧血症、低血压等不良反应的发生情况。结果最终441例患者纳入分析,对照组225例,试验组116例。给药后5、10 min,试验组平均动脉压高于对照组,差异有显著意义(P<0.05)。试验组诱导、苏醒和出室时间分别为(41.8±4.3)s、(5.7±4.4)和(10.2±6.5)min,对照组分别为(32.6±2.7)s、(6.6±3.9)和(12.9±7.4)min,试验组诱导时间长于对照组,苏醒和出室时间短于对照组,均有显著差异(P<0.05)。与对照组相比,试验组注射痛(54.2%vs.2.3%)、低血压(16.4%vs.6.9%)和低氧血症(19.6%vs.14.8%)发生率显著降低(P<0.05)。结论瑞马唑仑用于老年患者无痛胃肠镜检查安全有效,具有苏醒快、不良反应发生率低等优点。

关键词：瑞马唑仑胃镜检查结肠镜检查老年人低血压

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Over 12%efficient kesterite solar cell via back interface engineering

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Journal of Energy Chemistry 2022年第12期75卷 321-329,I0008页

作者： Yunhai Zhao Zixuan Yu Juguang Hu Zhuanghao Zheng Hongli Ma Kaiwen Sun Xiaojing hao Guangxing liang Ping Fan Xianghua Zhang Zhenghua Su Shenzhen Key Laboratory of Advanced Thin Films and Applications Key Laboratory of Optoelectronic Devices and SystemsCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060GuangdongChina CNRS ISCR(Institut des Sciences Chimiques de Rennes)UMR 6226Univ RennesRennes F-35000France School of Photovoltaic and Renewable Energy Engineering UNSW SydneySydney NSW 2052Australia Shenzhen University Institute of Microscale Optoelectronics Shenzhen UniversityShenzhen 518060GuangdongChina

Kesterite Cu_(2)ZnSn(S,Se)_(4)(CZTSSe)has attracted considerable attention as a non-toxic and earthabundant solar cell *** selenization of CZTSSe film at high temperature,the reaction between CZTSSe and Mo is one of the main reasons that result in unfavorable absorber and interface quality,which leads to large open circuit voltage deficit(VOC-def)and low fill factor(FF).Herein,a WO_(3)intermediate layer introduced at the back interface can effectually inhibit the unfavorable interface reaction between absorber and back electrode in the preliminary selenization progress;thus high-quality crystals are *** this back interface engineering,the traditional problems of phase segregation,voids in the absorber and over thick Mo(S,Se)_(2)at the back interface can be well solved,which greatly lessens the recombination in the bulk and at the *** increased minority carrier diffusion length,decreased barrier height at back interface contact and reduced deep acceptor defects give rise to systematic improvement in VOCand FF,finally a 12.66%conversion efficiency for CZTSSe solar cell has been *** work provides a simple way to fabricate highly efficient solar cells and promotes a deeper understanding of the function of intermediate layer at back interface in kesterite-based solar cells.

关键词： Cu_(2)ZnSn(S Se)_(4) WO_(3)intermediate layer Crystal growth Minority carrier diffusion length Interface contact quality

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Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents

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Neuroscience Bulletin 2015年第3期31卷 275-287页

作者： hao Yan lin Tian Qifeng Wang Qiang Zhao Weihua Yue Jun Yan Bing Liu Dai Zhang Peking University Six Hospital Peking University Institute of Mental Health Key Laboratory of Mental Health Ministry of Health (Peking University) LIAMA Center for Computational Medicine National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Department of Radiology The Third Hospital Peking University Peking-Tsinghua Center for Life Sciences PKU-IDG/Mc Govern Institute for Brain Research Peking University

Several lines of evidence suggest that efficient information integration between brain regions is disrupted in schizophrenia. Abnormalities in white matter tracts that interconnect brain regions may be directly relevant to this pathophysiological process. As a complex mental disorder with high heritability, mapping abnormalities in patients and their first- degree relatives may help to disentangle the risk factors for schizophrenia. We established a weighted network model of white matter connections using diffusion tensor imaging in 25 nuclear families with schizophrenic probands （19 patients and 41 unaffected parents） and two unrelated groups of normal controls （24 controls matched with patients and 26 controls matched with relatives）. The patient group showed lower global efficiency and local efficiency. The decreased regional efficiency was localized in hubs such as the bilateral frontal cortices, bilateral anterior cingulate cortices, and left precuneus. The global efficiency was negatively correlated with cognition scores derived from a 5-factor model of schizophrenic *** also found that unaffected parents displayed decreased regional efficiency in the right temporal cortices, left supplementary motor area, left superior temporal pole, and left thalamus. The global efficiency tended to be lower in unaffected parents. Our data suggest that （1） the global efficiency loss in neuroanatomical networks may be associated with the cognitive disturbances in schizophrenia; and （2） genetic vulnerability to schizophrenia may influence the anatomical organization of an individual＇s brain networks.

关键词： network analysis diffusion tensorimaging tractography white matter small-worldarchitecture

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海南热带雨林国家公园优先保护物种名录及其在国家公园管理中的应用

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国家公园（中英文） 2024年第1期2卷 43-49,50-55页

作者：肖繁荣梁伟严岳鸿曾念开郝馨汪继超海南师范大学生命科学学院热带岛屿生态学教育部重点实验室海南省热带动植物生态学重点实验室海口571158 国家林草局深圳市兰科植物保护与利用重点实验室深圳市兰科植物保护研究中心深圳518114 海南大学热带农林学院(农业农村学院、乡村振兴学院) 儋州571737 海南国家公园研究院海口571100

海南热带雨林国家公园是全国首批唯一地处热带且生物多样最高的国家公园。生物多样性保护是国家公园建设的重要任务,海南热带雨林国家公园极其丰富的物种为保护工作带来了机遇和挑战。确定生物多样性保护的优先性是在生物多样性资源分... 详细信息

海南热带雨林国家公园是全国首批唯一地处热带且生物多样最高的国家公园。生物多样性保护是国家公园建设的重要任务,海南热带雨林国家公园极其丰富的物种为保护工作带来了机遇和挑战。确定生物多样性保护的优先性是在生物多样性资源分布不均、受胁程度不同以及人力、物力有限的情况下缓解当前生物多样性丧失的有效手段。为有序地开展生物多样性保护和推动国家公园建设,海南热带雨林国家公园在全国率先开展优先保护物种名录遴选工作,拟定了包含脊椎动物、植物和大型真菌在内的《海南热带雨林国家公园优先保护物种名录》。研究总结名录的遴选方法与结果,阐明名录对国家公园建设和生物多样性保护的重要作用,为我国的国家公园建设提供海南样本。

关键词：国家公园生物多样性保护优先保护热带雨林

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Prospective and long-term evaluation of erect penile length obtained with inflatable penile prosthesis to that induced by intracavernosal injection

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Asian Journal of Andrology 2009年第4期11卷 411-416页

作者： Run Wang Galen E Howard Anthony Hoang Jiu-Hong Yuan hao-Cheng lin Yu-Tian Dai Division of Urology University of Texas Medical School at Houston TX 77030 USA Department of Urology University of Texas MD Anderson Cancer Center Houston TX 77030 USA Department of Urology Affiliated Drum Tower Hospital Nanjing University School of Medicine Nanjing 210008 China

We compared erect penile length after inflatable penile prosthesis （IPP） implantation with that induced by intracavemosal injection （ICI） before surgery. A total of 11 patients with full erections induced by ICI of 0.25 mL of Trimix （papaverine, phentolamine and prostaglandin E 1） at the time of penile color duplex Doppler ultrasonograpby were enrolled in this study. The patients subsequently underwent IPP implantation as the ultimate treatment for their erectile dysfunction （ED）. Erect penile length consequent to IPP implantation was measured at 6 weeks, 6 months and at I year after surgery. The Sexual Health Inventory for Men （SHIM） was administered before, and at 6 months and 1 year after IPP implantation. Erect penile length （mean ± s.c.） as induced by ICI was 13.2 ± 0.4 cm, whereas the lengths attained with IPP were 12.4 ± 0.3, 12.5 ± 0.3 and 12.5 ± 0.4 cm at the sixth week, sixth month and 1-year follow-ups, respectively. There were 0.83 ± 0.25, 0.75 ± 0.20 and 0.74 ± 0.15 cm decreases in erect penile length at 6 weeks, 6 months and 1 year, respectively, after IPP implantation when compared with that after ICI （P 〈 0.05）. The SHIM scores for patients reporting shorter penises were the same as those for patients without complaints at the 6-month and 1-year follow-ups （P 〉 0.05）. To our knowledge, this is the first study to objectively show a significant decrease in erect penile length after IPP implantation when compared with that after ICI. However, this decrease did not affect the effectiveness of IPP in treating ED.

关键词： erectile dysfunction intracavemosal injection length penile prosthesis radical prostatectomy

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深层页岩气吸附模型和物质平衡新方法

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科技和产业 2024年第13期24卷 220-225页

作者：熊亮曹海涛樊浩钱锋江朋宇陈先超中国石化西南油气分公司勘探开发研究院成都610041 成都理工大学能源学院成都610059

准确评价深层页岩气井单井最终可采储量(EUR)对页岩气的高效开发具有重要意义。调研深层页岩气吸附模型,基于各模型对吸附数据的拟合程度优选出考虑深层页岩气吸附因素的T-Langmuir模型。基于T-Langmuir模型表征的深层页岩气吸附特征和... 详细信息

准确评价深层页岩气井单井最终可采储量(EUR)对页岩气的高效开发具有重要意义。调研深层页岩气吸附模型,基于各模型对吸附数据的拟合程度优选出考虑深层页岩气吸附因素的T-Langmuir模型。基于T-Langmuir模型表征的深层页岩气吸附特征和流动物质平衡方程基本原理,建立考虑深层页岩气吸附特征的流动物质平衡新方法,并计算了四川盆地某页岩气井的单井最终可采储量。研究结果表明:T-Langmuir模型在高压条件下拟合效果较好,可以作为深层页岩气的吸附模型。新方法计算的单井最终可采储量为1.397×10^(8) m^(3),比传统方法的计算结果大0.109×10^(8) m^(3),经过和其他方法对比,新方法计算结果更为准确。

关键词：深层页岩气吸附模型流动物质平衡储量计算

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An experimental investigation on decoupling performance for a lateral axis micromachined gyroscope with varying environmental parameters

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Science China(Technological Sciences) 2011年第12期54卷 3415-3423页

作者： CUI Jian LIU XueSong GUO ZhongYang Zhao QianCheng lin LongTao YANG ZhenChuan hao YiLong YAN GuiZhen National Key Laboratory of Science and Technology on Micro/Nano Fabrication Institute of Microelectronics Peking University Beijing 100871 China

This paper carries out an experiment study of decoupling performance for a novel lateral axis micromachined gyroscope with varying environmental parameters. The non-ideal mathematical model for the coupling mechanism of the gyroscope is estab-lished through the gyro dynamic response matrix. The coupling components varying with ambient pressure and temperature induced by stiffness coupling, damping coupling and electrostatic force coupling are semi-analytically discussed. The overall coupling ratio is evaluated via experiments in the custom-built installation. The testing results show that the decoupling per-formance of the gyroscope is sensitive to the environmental parameters and all the non-ideal errors are determined as a function of ambient pressure and temperature. The coupling error varies from 0.05% to 0.25% within the pressure range of 100 Pa-100 kPa. The characteristics of coupling with temperature are measured from 20℃ to 100℃ with a variation from 0.35% to 0.41%. The results also indicate that within the range of measured ambient pressure and temperature, the minimum coupling ratio occurs at 100 Pa and room temperature. The overall performance of the gyroscope is tested under the pressure of about 2000 Pa and room temperature to achieve a relatively low coupling ratio. The scale factor is measured to be 7.8 mV （°）-1 s-1 with nonlinearity about 0.45% in the full-scale range of 600 （°） s-1. The short-term bias stability is approximately 0.06 （°）s-1 （1σ） for 20 min with noise equivalent angular rate evaluated to be 0.077 （°） s-1 Hz-1/2.

关键词： decoupling lateral axis gyroscope pressure temperature quadrature error

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