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Negative Poisson's ratio and peripheral strain of an NPR anchor cable

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Journal of Mountain Science 2022年第8期19卷 2435-2448页

作者： TAO Zhi-gang XU hao-tian REN Shu-lin GUO Long-ji QIN Ke ZHU Yi-fei State Key Laboratory for Geomechanics&Deep Underground Engineering Beijing 100083China School of Mechanics and Civil Engineering China University of Mining&TechnologyBeijing 100083China

Materials with a negative Poisson’s ratio effect perform significantly better than traditional materials for rock mass impact resistance,shear resistance,and energy *** on these advantages,a negative Poisson’s ratio anchor cable(NPR anchor cable)with high elongation and constant resistance was developed and successfully applied in the field of mine disaster ***,theoretical and experimental research on the negative Poisson’s ratio effect and peripheral strain characteristics of NPR anchor cables is currently *** study used several theories and methods,such as static tensile,peripheral strain measurement,and static negative Poisson’s ratio measurement,to investigate the radial deformation law of an NPR anchor cable and the negative Poisson’s ratio *** results elucidated constant resistance changes in an NPR anchor cable during operation,the motion of the constant resistance body in the constant resistance sleeve,and the deformation law of the constant resistance *** Poisson’s ratio characteristics of the NPR anchor cable and its superior energy absorption characteristics were verified and it provided a theoretical and experimental basis for energy absorption mechanisms of an NPR anchor cable.

关键词： NPR anchor cable Static tensile test Negative Poisson’s ratio Energy absorption

挖泥船施工作业三维可视化系统优化设计与应用

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中国港湾建设 2024年第8期44卷 93-98页

作者：庞景墩贺海涛林直郑昊乐中交疏浚技术装备国家工程研究中心有限公司上海200082

随着疏浚工程和疏浚业务的不断发展,对于疏浚施工过程监视效果要求也越来越高。针对现有挖泥船疏浚过程中三维可视化监视存在显示效果差、精度不高等问题,基于Unity3D引擎,设计并开发一套具有普适性的挖泥船施工作业三维可视化系统,实... 详细信息

随着疏浚工程和疏浚业务的不断发展,对于疏浚施工过程监视效果要求也越来越高。针对现有挖泥船疏浚过程中三维可视化监视存在显示效果差、精度不高等问题,基于Unity3D引擎,设计并开发一套具有普适性的挖泥船施工作业三维可视化系统,实现挖泥船关键疏浚机具动作驱动、水下地形生成及渲染、地形实时重构的三维可视化显示。通过实船应用验证,该系统可以有效提高施工效率和质量,提升施工精度,减少漏挖、超挖现象的发生,具有重要的工程应用价值。

关键词：挖泥船三维可视化 Unity3D 地形重构疏浚工程

穿心莲内酯减轻脂多糖诱导的肾小管上皮细胞铁死亡机制

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中国感染控制杂志 2024年第5期23卷 568-573页

作者：张艺馨黄铭曹国栋曾佑成林靓王晓悦程青虹石河子大学第一附属医院重症医学二科新疆石河子832000 伊犁州友谊医院重症医学一科新疆伊犁哈萨克自治州835000 广东省中国人民解放军南部战区总医院重症医学科广东广州440104

目的探讨穿心莲内酯(AG)对脂多糖(LPS)诱导的脓毒症肾小管上皮细胞(HK-2细胞)铁死亡的影响及其作用机制。方法采用LPS处理HK-2细胞,模拟脓毒症HK-2损伤体外模型,进一步用5、10、20、40μmol/L的AG进行干预,将细胞随机分为对照组(Control... 详细信息

目的探讨穿心莲内酯(AG)对脂多糖(LPS)诱导的脓毒症肾小管上皮细胞(HK-2细胞)铁死亡的影响及其作用机制。方法采用LPS处理HK-2细胞,模拟脓毒症HK-2损伤体外模型,进一步用5、10、20、40μmol/L的AG进行干预,将细胞随机分为对照组(Control)、LPS组、LPS+二甲亚砜(DMSO)组、AG组。采用CCK-8法检测细胞活力,筛选出最适LPS和AG浓度;比较各组中细胞形态变化,肾损伤标志物中性粒细胞明胶酶相关脂质运载蛋白(NGAL)和肾损伤分子-1(KIM-1)、丙二醛(MDA)、谷胱甘肽(GSH)和活性氧(ROS)水平,以及铁死亡调控蛋白溶质载体家族7成员11(SLC7A11)、谷胱甘肽过氧化物酶4(GPX4)和铁蛋白(Ferritin)的表达水平,评估AG处理对细胞的保护作用。结果与Control组相比,10μg/mL LPS诱导的HK-2细胞中细胞活力及GSH含量下降,细胞皱缩、贴壁能力差,氧化产物MDA和ROS含量以及肾损伤标志物NGAL和KIM-1水平明显升高,SLC7A11、GPX4蛋白表达水平降低,Ferritin蛋白表达水平增高,差异均有统计学意义(均P<0.05)。而在使用AG干预后,与LPS组相比,细胞活力升高,GSH含量、SLC7A11和GPX4蛋白表达水平升高,而Ferritin蛋白表达水平降低,差异均有统计学意义(均P<0.05);MDA含量和ROS荧光强度以及肾损伤标志物NGAL和KIM-1水平下降,差异均有统计学意义(均P<0.05)。结论AG对LPS诱导的HK-2细胞损伤具有保护作用,其机制可能是激活SLC7A11/GPX4通路,减少氧化应激,上调抗氧化酶活性,减轻细胞铁死亡。

关键词：穿心莲内酯肾小管上皮细胞 HK-2 铁死亡 SLC7A11 Xc-系统机制

Crumbs proteins stabilize the cone mosaics of photoreceptors and improve vision in zebrafish

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Journal of Genetics and Genomics 2021年第1期48卷 52-62页

作者： Qinlong hao Mingjie Zheng Kechao Weng Yumei hao Yao Zhou Yuchen lin Feng Gao Ziqi Kou Shoji Kawamura Ke Yao Pinglong Xu Jinghai Chen Jian Zou Eye Center of the Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310009China The Institute of Translational Medicine Zhejiang UniversityHangzhou 310058China Department of Cardiology The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China Department of Integrated Biosciences Graduate School of Frontier SciencesUniversity of TokyoKashiwaChiba 277-8562Japan Zhejiang Provincial Key Lab of Ophthalmology Hangzhou 310058China MOE Laboratory of Biosystems Homeostasis&Protection and Innovation Center for Cell Signaling Network Life Sciences InstituteZhejiang UniversityHangzhou 310058China

Although the unique organization of vertebrate cone mosaics was first described long ago,both their underlying molecular basis and physiological significance are largely ***,we demonstrate that Crumbs proteins,the key regulators of epithelial apical polarity,establish the planar cellular polarity of photoreceptors in *** heterophilic Crb2a-Crb2b interactions,the apicobasal polarity protein Crb2b restricts the asymmetric planar distribution of Crb2a in *** planar polarized Crumbs proteins thus balance intercellular adhesions and tension between photoreceptors,thereby stabilizing the geometric organization of cone ***,loss of Crb2b in zebrafish induces a nearsightedness-like phenotype in zebrafish accompanied by an elongated eye axis and impairs zebrafish visual perception for *** data reveal a detailed mechanism for cone mosaic homeostasis via previously undiscovered apical-planar polarity coordination and propose a pathogenic mechanism for nearsightedness.

关键词： Crumbs proteins Apical polarity Planar cellular polarity Cone mosaics Nearsightedness Visual perception

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小卫星批生产装配一致性控制方法

先进小卫星技术（中英文）

先进小卫星技术（中英文） 2024年第3期1卷 57-62页

作者：郝佳梁小峰阎梅芝马琦秀王晓敏航天东方红卫星有限公司北京100094

针对微小卫星批量化生产制造过程,分析了批生产质量管理特点和每组星之间的装配质量一致性影响因素.从工程实践的角度,提出了一种适于卫星系统批生产的装配一致性控制方法.该方法通过建立规范化体系、质量重心前移、提高工艺方法稳定性... 详细信息

针对微小卫星批量化生产制造过程,分析了批生产质量管理特点和每组星之间的装配质量一致性影响因素.从工程实践的角度,提出了一种适于卫星系统批生产的装配一致性控制方法.该方法通过建立规范化体系、质量重心前移、提高工艺方法稳定性、固化技术状态、装配流程标准化、实施质量确认制、实行"去型号化"物资管理、引进自动化设备及统筹人员配置等质量控制手段,保证了小卫星批量化生产过程中装配工作的质量一致性.将其应用到卫星批产总装工作后,实践结果表明,卫星装配一致性控制方法能够有效提升批量化生产制造工作质量,大幅提升批次卫星产品的质量一致性,是卫星批量生产研制质量的有力保证.

关键词：小卫星批生产装配一致性控制

Study of stimulated Raman and Brillouin scattering in a finite interaction region under the convective instability condition

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Chinese Science Bulletin 2012年第21期57卷 2747-2751页

作者： hao liang LIU ZhanJu ZHENG ChunYang XIANG Jiang FENG Wu HU XiaoYan LI Bin Institute of Applied Physics and Computational Mathematics Beijing 100094China Center for Applied Physics and Technology Peking UniversityBeijing 100871China Graduate School of China Academy of Engineering Physics Beijing 100088China

We discuss stimulated Raman scattering (SRS) and stimulated Brillouin scattering (SBS) under the convective instability condition with a one-dimensional three-wave interaction (3WI) *** linear theory,we deduce the temporal growth rate,gain exponent,and reflectivity of the backward scattered wave in a finite interaction *** find that the growth rate is not only determined by the laser intensity and plasma density and temperature,but also related to the spatial *** length of the interaction region is important to the gain exponent and backscattering *** simulate the developments and evolutions of SRS and SBS based on the 3WI *** numerical results consist with the linear theory.

关键词：受激拉曼散射稳定条件对流受激布里渊散射等离子体密度线性理论相互作用计算结果

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Journal of Forestry Research 2020年第6期31卷 2435-2444页

作者： Yunyun Wang Jalene M.La.Montagne Fei lin Zuoqiang Yuan Ji Ye Xugao Wang Zhanqing hao CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110016People’s Republic of China Department of Biological Sciences DePaul UniversityChicagoIL 60614USA

Seed distribution and deposition patterns around parent trees are strongly aff ected by functional traits and therefore infl uence the development of plant *** assess the limitations of seed dispersal and the extent to which diaspore and neighbouring parental traits explain seed rain,we used a 9-year seed data set based on 150 seed traps in a 25-ha area of a temperate forest in the Changbai *** 480,598 seeds belonging to 12 families,17 genera,and 26 species were identifi ed,only 54%of the species with mature trees in the community were represented in seeds collected over the 9 years,indicating a limitation in seed *** species were most limited;overstory species were least *** with wind-dispersed seed had the least limitation,while the lowest similarity in species richness was for animal-dispersed species followed by gravity-dispersed species;fl eshy-fruited species had stronger dispersal limitations than dry-fruited *** linear mixed models showed that relative basal area had a signifi cant positive eff ect on seed abundance in traps,while the contribution of diaspore traits was low for nearly all *** results suggest that tree traits had the strongest contribution to seed dispersal and deposition for all functional groups examined *** fi ndings strengthen the knowledge that tree traits are key in explaining seed deposition patterns,at least at the primary dispersal *** improved knowledge of sources of seeds that are dispersed could facilitate greater understanding of seedling and community dynamics in temperate forests.

关键词： Seed rain Dispersal mechanisms Tree traits Basal area Changbai mountain Temperate forest

Advanced Power Module Packaging and Integration Structures for High Frequency Power Conversion：From Silicon to GaN

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电力电子技术 2018年第8期52卷 9-18页

作者： Fang LUO lin liang David Huitink Silke Spiesshoefer Department of Electrical Engineering University of Arkansas Fayetteville 72701 USA Department of Mechanical Engineering University of Arkansas Fayetteville 72701 USA State Key Laboratory of Advanced Electromagnetic Engineering and Technolog

The emerging of commercial high-voltage gallium nitride(GaN) power devices provides extraordinary switching performance over silicone devices, which enables high-voltage power conversion switching at megahertz *** outstanding features also pose strong challenges for device packaging design since the package parasitics can significantly influence the device switching characteristics, and thus can shadow the advantages brought by GaN devices. Designers have been dealing with these challenges brought by high du/dt and high-frequency switching operation even since the silicon(Si) era when fast switching Si MOSFET is first developed and came up with lots of inspiring advanced power module packaging structures to mitigate the *** paper presents a review of advanced power module packaging and integration structures that are suitable for high frequency power *** review covers the heritage from the high frequency Si MOSFET packaging to the state-of-the-art for GaN devices.

关键词：电力行业电力技术电子产品电力管理

Anti-anaphylactic potential of benzoylpaeoniflorin through inhibiting HDC and MAPKs from Paeonia lactiflora

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Chinese Journal of Natural Medicines 2021年第11期19卷 825-835页

作者： ZHONG Wan-Chao LI En-Can hao Rui-Rui ZHANG Jing-Fang JIN Hong-Tao lin Sheng State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China New Drug Safety Evaluation Center Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Beijing Union-Genius Pharmaceutical Technology Co. Ltd.Beijing 100176China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China

Guided by cell-based anti-anaphylactic assay,eighteen cage-like monoterpenoid glycosides(1−18)were obtained from the bioactive fraction of *** *** these,compounds 1,5,6,11,12,15,and 17 significantly reduced the release rate ofβ-HEX and HIS without or with less ***,the most potent inhibitor benzoylpaeoniflorin(5)was selected as the prioritized compound for the study of action of mechanism,and its anti-anaphylactic activity was medicated by dual-inhibiting HDC and MAPK signal ***,molecular docking simulation explained that benzoylpaeoniflorin(5)blocked the conversion of L-histidine to HIS by occupying the HDC active ***,in vivo on PCA using BALB/c mice,benzoylpaeoniflorin(5)suppressed the IgE-mediated PCA reaction in antigen-challenged *** findings indicated that cage-like monoterpenoid glycosides,especially benzoylpaeoniflorin(5),mainly contribute to the anti-anaphylactic activity of *** by dual-inhibiting HDC and MAPK signal ***,benzoylpaeoniflorin(5)may be considered as a novel drug candidate for the treatment of anaphylactic diseases.

关键词： Paeonia lactiflora Anti-anaphylactic action RBL-2H3 HDC MAPKs