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基于贝叶斯压缩感知的CSR稳健参数估计方法

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系统工程与电子技术 2015年第11期37卷 2480-2486页

作者：代林崔琛余剑梁浩电子工程学院通信对抗系安徽合肥230037

针对"完全扰动"情况下压缩感知雷达(compressed sensing radar,CSR)观测矢量和感知矩阵严重失配,进而引起参数估计性能急剧下降的问题,提出了一种基于贝叶斯压缩感知(Bayesian compressed sensing,BCS)的稳健参数估计方法。首先构造"完... 详细信息

针对"完全扰动"情况下压缩感知雷达(compressed sensing radar,CSR)观测矢量和感知矩阵严重失配,进而引起参数估计性能急剧下降的问题,提出了一种基于贝叶斯压缩感知(Bayesian compressed sensing,BCS)的稳健参数估计方法。首先构造"完全扰动"情况下CSR参数估计的稀疏线性模型,并从稀疏矢量的最大后验概率(maximum a posteriori,MAP)出发,推导了完全扰动矩阵服从柯西分布时的优化目标函数;随后通过稀疏矢量和尺度参数的交替迭代,求得稀疏矢量的最优解。与现有重构算法及其改进算法相比,该方法能够有效改善CSR系统应对失配误差的稳健性,提高目标成功检测的概率和参数估计的精度。计算机仿真实验验证了该方法的有效性和鲁棒性。

关键词：压缩感知雷达完全扰动柯西分布 Lorentzian范数交替迭代

Tick-borne Pathogens in Shanxi Province, China

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Biomedical and Environmental Sciences 2021年第5期34卷 410-415页

作者： YANG Xiao Na YANG Hui Jun ZHANG lin HOU Xue Xia MIAO Guang Qing CAO Hong Bing hao Rui E hao Qin State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Shanxi Provincial Center for Disease Control and Prevention Taiyuan 030012ShanxiChina

Ticks are recognized as one of the most important vectors that cause diseases in animals and humans,and have significant public health impacts worldwide[1].They have a wide range of hosts among terrestrial vertebrates,including mammals,birds,*** numerous zoonotic pathogens transmitted by ticks are the causative agents of Lyme disease,rickettsiosis,ehrlichioses,relapsing fever,Q fever,and *** of tick-borne diseases are increasing around the world and some emerging or re-emerging pathogens are being discovered,which pose great challenges for prevention and control.

关键词： prevention Shanxi birds

Endoscopic diagnosis of cervical esophageal heterotopic gastric mucosa with conventional and narrow-band images

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World Journal of Gastroenterology 2014年第1期20卷 242-249页

作者： Chi-liang Cheng Cheng-Hui lin Nai-Jen Liu Jui-Hsiang Tang Yen-lin Kuo Yi-Ning Tsui Department of Gastroenterology Zhongli Evergreen Hospital Department of Digestive Therapeutic Endoscopy Chang Gung Hospital and Chang Gung University

AIM: To compare the diagnostic yield of heterotopic gastric mucosa (HGM) in the cervical esophagus with conventional imaging (CI) and narrow-band imaging (NBI).

关键词： Cervical esophagus Heterotopic gastric mucosa Endoscopic diagnosis Narrow-band imaging Conventional imaging

Efficiency against multidrug resistance by co-delivery of doxorubicin and curcumin with a legumain-sensitive nanocarrier

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Nano Research 2018年第7期11卷 3619-3635页

作者： Sen lin Peiling Xie Mengmeng Luo Qing Li ling Li Jinzhao Zhang Qinxiang Zheng hao Chen Kaihui Nan School of Ophthalmology & Optometry and Eye Hospital Wenzhou Medical University Wenzhou 325027 China Wenzhou Institute of Biomatefials and Engineering Chinese Academy of Science Wenzhou 325000 China School of Biomedical and Engineering Wenzhou Medical University Wenzhou 325027 China

Multidrug resistance proteins （MDRPs）, which are implicated in the mediation of multidrug resistance in tumors, represent the main obstacle to successful chemotherapy. As curcurnin （Cur） exerts inhibitory effects on both the expression and function of MDRPs, a nanocarrier for the co-delivery of Cur and doxorubicin （DOX） was prepared to overcome MDR tumors through their synergistic effects. Owing to the overexpression of legumain in tumors, the release profile of DOX from this nanocarrier was designed to be legumain modulated, which was achieved by bridging DOX to a basic material （chitosan） with a legumain- sensitive peptide. Compared with nanoparticles that only contain DOX, the coadministration of DOX and Cur significantly inhibited multidrug resistance （P 〈 0.05） in a multidrug-resistant cancer cell model （MCF-7/ADR cell line）, with cytotoxicity to normal cells （L929 cell line）. Such inhibition could be ascribed to the increased DOX accumulation in the MCF-7/ADR nucleus. The co-delivery system exhibited good anticancer effects through prolonged circulation time, improved tumor-targeting efficiency, elevation of the tumor inhibition activity, and the suppression of MDRP expression. These data revealed the enormous potential of this co-delivery system for cancer therapy, especially in the later stages where multidrug resistance may develop.

关键词： legumain doxorubicin curcumin co-delivery nanoparticle multidrug resistance

Development of InDel Markers for Brassica rapa Based on a High-resolution Melting Curve

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Horticultural Plant Journal 2021年第1期7卷 31-37页

作者： Rong Chen Lichun Chang Xu Cai JianWu Jianli liang Runmao lin Yong Song Xiaowu Wang College of Horticulture Hunan Agricultural UniversityChangsha 410128China Institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesBeijing 100081China

Brassica rapa is one of the most important leafy vegetable crops with large cultivated area in *** increase the availability of DNA markers in ***,we developed insertion-deletion(InDel)markers utilizing high-resolution melting(HRM)curve *** designed primers for 252 InDels(≥3 bp)evenly distributed in the genome and tested gene polymorphisms with eight *** total,208 markers were specifically amplified,and 148 InDels with polymorphism were genotyped successfully using *** further analyzed the correlation with InDel size,GC number,and predicted the difference in Tm values(Tm)using 208 markers with specific *** found that the success rate of InDel markers was correlated with the GC number of InDel and the predicted-Tm,but not clearly correlated with the length of *** the GC number within InDel was≥8,the successful rate exceeded 90.0%.When the predicted-Tm reached 0.5°C,the success rate was greater than 90.0%,and when it was≥0.6°C,the rate climbed to 100.0%,indicating their role as the optimal parameter for successful development of an applicable InDel *** polymorphic InDel markers can be easily genotyped using *** are of great value in genetic analysis,construction of linkage map,and molecular marker-assisted selection in ***.

关键词： Brassica rapa InDel marker HRM genotyping

Investigation on the properties of compacted silty clay subjected to electro-osmosis using bender element

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Research in Cold and Arid Regions 2023年第6期15卷 253-261页

作者： KangWei Tang Chuang lin hao Wang WeiJun Qin DeCheng Feng Feng Zhang School of Transportation Science and Engineering Harbin Institute of Technology73 Huanghe RoadHarbinHeilongjiang 150090China Laboratoire Navier/CERMES Ecole des Ponts ParisTech6 et 8 Avenue Blaise PascalCite DescartesChamps-sur-Marne77455 Marne La Vallee Cedex 2France Key Laboratory of Transportation Industry for Highway Construction and Maintenance Technology in Seasonal Frozen Soil Areas(Changchun) 4887 Xinglong RoadChangchunJinlin 130102China

The moisture content of subgrade soil in seasonally frozen regions is often higher than its optimum value,leading to a decline in mechanical properties and a reduction in subgrade bearing ***-osmosis has shown promise as a technology for controlling subgrade moisture,but significant heterogeneity has also been observed in treated *** study investigates the impact of electro-osmosis on soil stiffness through a series of bender element tests of compacted *** effects of dry density and supply voltage on the performance of electroosmosis treatment and the layered structure and anisotropy of the soil were *** results show that electro-osmosis treatment increased the shear wave velocity of the soil by 140% compared to untreated saturated soil and by 70% compared to soil with optimum water *** has also been found that layered compaction of soil resulted in a layered structure,with electro-osmosis having a more prominent impact on soil near the cathode,resulting in a more pronounced layered ***,electro-osmosis was found to enhance soil anisotropy,particularly near the *** the dry density and voltage levels can help improve soil *** findings provide insights into the potential use of electro-osmosis in improving soil stiffness,which could benefit various engineering applications.

关键词： Subgrade soil Electro-osmosis Bender element Layered structure Anisotropy

Complement Factor H Displays Opposite Expression Patterns Under Two Situations of Methamphetamine Administration:Acute Exposure and Chronic Dependence

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Neuroscience Bulletin 2020年第12期36卷 1558-1562页

作者： Ming lin Jiamin Xu Zhimin Liu liang Qin Xiaodong Wang Xiaoping Pu National Key Research Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China Department of Molecular and Cellular Pharmacology School of Pharmaceutical SciencesPeking UniversityBeijing 100191China National Institute on Drug Dependence Peking UniversityBeijing 100191China Centre for Imaging and Systems Biology Minzu University of ChinaBeijing 100081China College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China

Dear Editor,Methamphetamine(METH)is a highly addictive central nervous system stimulant that has severe physical and psychological side-effects,including loss of appetite,hyperactivity,dysphoria,and depression[1].Due to its illegal production,distribution,sale,and possession it has become a worldwide *** is directly toxic to dopaminergic and serotoninergic neurons,resulting in excitotoxicity,oxidative stress,and other processes[2].Research on biomolecules associated with these processes will be useful for identifying potential markers,exploring the mechanism of METH dependence,and even developing prevention and treatment strategies.

关键词： prevention identifying burden

Effects of cosolvents on CO_(2) displacement of shale oil and carbon storage

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Petroleum Exploration and Development 2023年第6期50卷 1509-1518页

作者： ZHANG Yifan WANG Lu ZOU Rui ZOU Run MENG Zhan HUANG liang LIU Yisheng LEI hao College of Energy Chengdu University of TechnologyChengdu 610059China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu 610059China School of Petroleum Engineering Southwest Petroleum UniversityChengdu 610500China Research Institute of Exploration and Development Sinopec Jianghan Oilfield CompanyWuhan 430223China

Molecular dynamics method was used to establish composite wall/inorganic nanopores of three pore sizes, three shale oil systems, five CO_(2)-cosolvent systems, and pure CO_(2) system. The process of CO_(2)-cosolvent displacement of crude oil in shale nanopores and carbon storage was simulated and the influencing factors of displacement and storage were analyzed. It is shown that the attraction of the quartz wall to shale oil increases with the degree of hydroxylation. The higher the degree of quartz hydroxylation, the more difficult it is to extract the polar components of shale oil. Nanopore size also has a great impact on shale oil displacement efficiency. The larger the pore size, the higher the shale oil displacement efficiency. The closer the cosolvent molecules are to the polarity of the shale oil, the higher the mutual solubility of CO_(2) and shale oil. The more the non-polar components of shale oil, the lower the mutual solubility of CO_(2) and shale oil with highly polar cosolvent. Ethyl acetate is more effective in stripping relatively high polar shale oil, while dimethyl ether is more effective in stripping relatively low polar shale oil. Kerogen is highly adsorptive, especially to CO_(2). The CO_(2) inside the kerogen is not easy to diffuse and leak, thus allowing for a stable carbon storage. The highest CO_(2) storage rate is observed when dimethyl ether is used as a cosolvent, and the best storage stability is observed when ethyl acetate is used as a cosolvent.

关键词： molecular dynamics shale oil nanopore carbon dioxide cosolvent displacement efficiency storage effect

吲哚菁绿荧光导航的侧方前哨淋巴结活检在腹腔镜直肠癌侧方淋巴结清扫中的临床意义

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中华肿瘤杂志 2024年第2期46卷 140-145页

作者：苏昊徐正包满都拉罗寿梁建伟裴炜关旭刘正姜争张明光赵志勋金伟森周海涛北京大学肿瘤医院暨北京市肿瘤防治研究所恶性肿瘤发病机制及转化研究教育部重点实验室胃肠肿瘤中心北京100142 国家癌症中心国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院结直肠外科北京100021 国家癌症中心国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院胰胃外科北京100021 国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院深圳医院胃肠外科深圳518116 解放军总医院第三医学中心肛肠外科北京100039

目的探讨应用吲哚菁绿(ICG)荧光导航技术的直肠癌侧方前哨淋巴结活检(SLNB)在腹腔镜直肠癌侧方淋巴结清扫(LLND)中的临床意义,评估该技术预测侧方淋巴结(LPLN)状态的准确性和可行性。方法回顾性分析2017年4月至2022年10月中国医学科学... 详细信息

目的探讨应用吲哚菁绿(ICG)荧光导航技术的直肠癌侧方前哨淋巴结活检(SLNB)在腹腔镜直肠癌侧方淋巴结清扫(LLND)中的临床意义,评估该技术预测侧方淋巴结(LPLN)状态的准确性和可行性。方法回顾性分析2017年4月至2022年10月中国医学科学院肿瘤医院结直肠外科在腹腔镜直肠癌LLND术中行ICG荧光导航的侧方SLNB的16例直肠癌患者的临床病理资料。入组患者未行术前新辅助放疗且LPLN可见但未明确转移(在高分辨率MRI图像中,LPLN最大短径为5.0~9.9 mm)。随访观察患者的术后并发症。结果16例患者均在腹腔镜直肠癌LLND术中成功完成ICG荧光导航的侧方SLNB。3例患者行双侧LLND,13例患者行单侧LLND。14例患者侧方前哨淋巴结(SLN)可见明显荧光显像,SLN检出率为87.5%。其中2例患者侧方SLN术中冰冻病理发现肿瘤转移,12例患者侧方SLN术中冰冻病理阴性。在14例侧方SLN荧光显像的患者中,侧方清扫的非前哨淋巴结(NSLB)均为阴性。2例无侧方SLN荧光显像的患者,所有切除的LPLN均为阴性。SLNB的特异度为85.7%,灵敏度、阴性预测值和准确性均为100%。术后1例患者出现切口感染,1例患者出现造口周围皮炎。结论ICG荧光导航的侧方SLNB在预测LPLN状态方面安全可行,并具有良好的准确性,该技术有望替代局部晚期直肠癌的预防性LLND。

关键词：直肠肿瘤侧方淋巴结清扫前哨淋巴结吲哚菁绿荧光导航