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Virologica Sinica 2024年第4期39卷 705-707页

作者： Jie-Mei yu Ze-yin liang yuan-Hui Fu Xiang-Lei Peng Yan-Peng Zheng yu-Jun Dong Jin-Sheng He College of Life Sciences and Bioengineering Beijing Jiaotong UniversityBeijing100044China Department of Hematology Peking University First HospitalBeijing100034China

Dear Editor,Patients undergoing allogeneic hematopoietic stem cell transplantation(HSCT)often experience a significant reduction in immune function due to factors such as severe lymphopenia,immunosuppressive treatment,and the development of graft-versus-host disease,rendering them more susceptible to severe infections(Sahin et al.,2016).Traditional diagnostic approaches are limited in sensitivity,speed,and assay targets,thus failing short of meeting the diagnostic demands(Qu et al.,2022).However,next-generation sequencing(NGS)has greatly improved the accuracy and efficiency of diagnosing various diseases(Schuler et al.,2022),and has been widely utilized for pathogen detection in samples from HSCT patients(Armstrong et al.,2019;Peng et al.,2021).In this study,we employed viral metagenomics analysis using high-throughput sequencing on fecal and tissue samples from a patient with HSCT experiencing severe lingual papillomatosis.

关键词： al. papilloma rendering

Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3543-3560页

作者： Lixin Zhao yuguang Zhu Hua Tao Xiying Chen Feng yin yingyi Zhang Jianfeng Qin Yongyin Huang Bikun Cai Yonghao Lin Jiaxiang Wu yu Zhang Lu liang Ao Shen Xi-Yong yu The Fifth Affiliated Hospital Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical PharmacologyNMPA&State Key LaboratorySchool of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China

Pulmonary fibrosis poses a significant health threat with very limited therapeutic options *** this study,we reported the enhanced expression of mesenchymal homobox 1(MEOX1)in pulmonary fibrosis patients,especially in their fibroblasts and endothelial cells,and confirmed MEOX1 as a central orchestrator in the activation of profibrotic *** high-throughput screening,we identified Ailanthone(AIL)from a natural compound library as the first small molecule capable of directly targeting and suppressing *** demonstrated the ability to inhibit both the activation of fibroblasts and endothelial-to-mesenchymal transition of endothelial cells when challenged by transforming growth factor-b1(TGF-b1).In an animal model of bleomycin-induced pulmonary fibrosis,AIL effectively mitigated the fibrotic process and restored respiratory ***,AIL acted as a suppressor of MEOX1 by disrupting the interaction between the transcription factor JUN and the promoter of MEOX1,thereby inhibiting MEOX1 expression and *** summary,our findings pinpointed MEOX1 as a cell-specific and clinically translatable target in ***,we demonstrated the potent anti-fibrotic effect of AIL in pulmonary fibrosis,specifically through the suppression of JUN-dependent MEOX1 activation.

关键词： Ailanthone MEOX1 Pulmonary fibrosis JUN TGF-b1 High-throughput screening Natural product

Aggressive fibromatosis of the sigmoid colon:A case report

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3716-3722页

作者： Pan-Pan yu Xin-Chun Liu Lu yin Guang yin Department of Gastrointestinal and Anal Surgery The Affiliated Hangzhou First People's HospitalSchool of MedicineWestlake UniversityHangzhou 310006Zhejiang ProvinceChina Department of Gastric Surgery Zhejiang Cancer HospitalHangzhou 310022Zhejiang ProvinceChina Department of Pathology The Affiliated Hangzhou First People's HospitalSchool of MedicineWestlake UniversityHangzhou 310006Zhejiang ProvinceChina

BACKGROUND Aggressive fibromatosis(AF),also known as desmoid tumor or desmoid-type fibromatosis,is a rare soft tissue neoplasm that can occur in almost any part of the *** it is a benign disease,AF is aggressive and infiltrative and has a high recurrence rate after *** sites for intra-abdominal AF are the small bowel mesentery,retroperitoneum,and *** in the colon is extremely *** SUMMARY Here,we report the first case of sigmoid colon AF,which was accidentally discovered in a 27-year-old woman during laparoscopic *** tomography confirmed a slightly enhanced mass in the sigmoid *** colonoscopy did not reveal a mass in the colonic lumen,but a suspected external compress was found in the sigmoid *** disease involving a gastrointestinal stromal tumor was *** patient underwent laparoscopic exploration,and sigmoidectomy with a negative margin was performed to excise the *** immunohistochemistry revealed that the mass was an *** patient recovered well and was recurrence-free at the 30-month follow-up without adjuvant *** AF should be considered in the differential diagnosis of subepithelial colon *** resection alone can achieve good outcomes.

关键词： Aggressive fibromatosis Desmoid tumor Sigmoid mass Subepithelial tumor Case report

Understanding and improving Yangtze River Basin summer precipitation prediction using an optimal multi-Physics ensemble

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Frontiers of Earth Science 2024年第1期18卷 256-277页

作者： Yang ZHAO Fengxue QIAO Xin-Zhong liang Jinhua yu Climate Environment and Sustainability CenterNanjing University of Information Science and TechnologyNanjing 210044China Key Laboratory of Geographic Information Science(Ministry of Education) East China Normal UniversityShanghai 200241China School of Geographic Sciences East China Normal UniversityShanghai 200241China Department of Atmospheric and Oceanic Science University of MarylandCollege Park MD 20740USA Earth System Science Interdisciplinary Center University of MarylandCollege Park MD 20740USA Key Laboratory of Meteorological Disaster(KLME)(Ministry of Education)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science and TechnologyNanjing 210044China

This study employs the regional Climate-Weather Research and Forecasting model(CWRF)to first investigate the primary physical mechanisms causing biases in simulating summer precipitation over the Yangtze River Basin(YRB),and then enhance its predictive ability through an optimal multi-physics ensemble *** CWRF 30-km simulations in China are compared among 28 combinations of varying physics parameterizations during 1980−***-term average summer biases in YRB precipitation are remotely correlated with those of large-scale *** teleconnections of biases are highly consistent with the observed correlation patterns between interannual variations of precipitation and circulations,despite minor shifts in their primary action *** YRB precipitation aligns with a southward shifted East Asian westerly jet,an intensified low-level southerly flow south of YRB,and a south-eastward shifted South Asian high,alongside higher moisture availability over ***,decreased YRB precipitation corresponds to an opposite circulation *** CWRF control configuration using the ensemble cumulus parameterization(ECP),compared to other cumulus schemes,best captures the observed YRB precipitation characteristics and associated circulation *** ECP with the Morrison or Morrison-aerosol microphysics and the CCCMA or CAML radiation schemes enhances the overall CWRF *** to the control CWRF,the ensemble average of these skill-enhanced physics configurations more accurately reproduces YRB summer precipitation’s spatial distributions,interannual anomalies,and associated circulation *** Bayesian Joint Probability calibration to these configurations improves the ensemble’s spatial distributions but compromises its interannual anomalies and teleconnection *** findings highlight substantial potential for refining the representation of climate system physics to improve YRB precipitation *** is notabl

关键词： physics parameterization regional climate model downscaling skill enhancement multi-physics ensemble teleconnection bias reduction

Monotonic mechanical behaviour of compacted completely decomposed granite with various inclusion levels of incineration bottom ash

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第8期25卷 670-679页

作者： Han-Lin WANG Cheng-Shuang yin Qian-Yi ZHANG Qi-Wei LIU Zhen-yu yin Dong-Xing XUAN Askar KHASANOV Research Center for Advanced Underground Space Technologies of Hunan University Changsha 410082China Key Laboratory of Building Safety and Energy Efficiency of the Ministry of Education Hunan UniversityChangsha 410082China College of Civil Engineering Hunan UniversityChangsha 410082China School of Civil Engineering Zhengzhou UniversityZhengzhou 450001China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Department of Applied and Theoretical Mechanics Samarkand State UniversitySamarkandUzbekistan

1 Introduction Completely decomposed granite(CDG)is widely distributed in South China(Xu et al.,2022;Wang et al.,2023).The parent granite rock mass gradually loses features during the weathering process,and thus needs to be reinforced when used(Lan et al.,2003;Dassekpo et al.,2017;Alamanis et al.,2021).On the other hand,considering the huge demand for construction materials and limited natural resources,it is increasingly important to fully utilize solid waste(Gruhler et al.,2019;Anagnostopoulos et al.,2020;Jiang et al.,2022,2023a,2023b).With high strength and environment-friendly characteristics,incineration bottom ash(IBA)seems to be a suitable reinforcement material for CDG(Ahmed and Khalid,2011;Alhassan and Tankó,2012;Toraldo et al.,2013;Lynn et al.,2017;Xuan et al.,2018;Tang et al.,2020).

关键词： incineration behaviour utilize

Investigating the elliptic anisotropy of identified particles in p-Pb collisions with a multi-phase transport model

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Nuclear Science and Techniques 2024年第2期35卷 160-169页

作者： Si-yu Tang liang Zheng Xiao-Ming Zhang Ren-Zhuo Wan School of Mathematical and Physical Sciences Wuhan Textile UniversityWuhan 430200China School of Mathematics and Physics China University of Geosciences(Wuhan)Wuhan 430074China Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China Hubei Key Laboratory of Digital Textile Equipment Wuhan Textile UniversityWuhan 430200China School of Electronic and Electrical Engineering Wuhan Textile UniversityWuhan 430200China

The elliptic azimuthal anisotropy coefficient(v_(2))of the identified particles at midrapidity(|η|<0.8)was investigated in p-Pb collisions at√s_(NN)=5.02 TeV using a multi-phase transport model(AMPT).The calculations of differential v_(2)based on the advanced flow extraction method of light flavor hadrons(pions,kaons,protons,andΛ)in small collision systems were extended to a wider transverse momentum(p_(T))range of up to 8 GeV/c for the first *** string-melting version of the AMPT model provides a good description of the measured p_(T)-differential v_(2)of the mesons but exhibits a slight deviation from the baryon v_(2).In addition,we observed the features of mass ordering at low p_(T)and the approximate number-of-constituentquark(NCQ)scaling at intermediate p_(T).Moreover,we demonstrate that hadronic rescattering does not have a significant impact on v_(2)in p-Pb collisions for different centrality selections,whereas partonic scattering dominates in generating the elliptic anisotropy of the final *** study provides further insight into the origin of collective-like behavior in small collision systems and has referential value for future measurements of azimuthal anisotropy.

关键词： Azimuthal anisotropy Small collision systems Transport model

Fuzzing:Progress,Challenges,and Perspectives

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Computers, Materials & Continua 2024年第1期78卷 1-29页

作者： Zhenhua yu Zhengqi Liu Xuya Cong Xiaobo Li Li yin Institute of Systems Security and Control College of Computer Science and TechnologyXi'an University of Science and TechnologyXi'an710054China School of Mathematics and Information Science Baoji University of Arts and SciencesBaoji721013China Institute of Systems Engineering Macao University of Science and TechnologyTaipaMacaoChina

As one of the most effective techniques for finding software vulnerabilities,fuzzing has become a hot topic in software *** feeds potentially syntactically or semantically malformed test data to a target program to mine vulnerabilities and crash the *** recent years,considerable efforts have been dedicated by researchers and practitioners towards improving fuzzing,so there aremore and more methods and forms,whichmake it difficult to have a comprehensive understanding of the *** paper conducts a thorough survey of fuzzing,focusing on its general process,classification,common application scenarios,and some state-of-the-art techniques that have been introduced to improve its ***,this paper puts forward key research challenges and proposes possible future research directions that may provide new insights for researchers.

关键词： Fuzzing vulnerability software testing software security

Experimental study on the CO_(2) concentration and age of air distribution inside tiny sleeping spaces

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Building Simulation 2024年第4期17卷 591-605页

作者： Jingying Zhang Yanyan Li Haiguo yin Linfeng liang Songmei Zu Le Gao ying Zhang Angui Li School of Building Services Science and Engineering Xi’an University of Architecture and TechnologyXi’anShaanxi710055China

In recent years,rapid urban development has led to capsule hotels,sleep pods,and other tiny sleeping spaces that adapt to people’s fast-paced lives,achieving maximum functionality with a very small ***,due to the small space,human metabolic pollutant(such as CO_(2))is more likely to accumulate,and the air is not easily *** this paper,a full-size experimental platform is set up with three types of ventilation modes to explore the exclusion efficiency of metabolic pollutants and the overall distribution of age of air under these ventilation *** conclusions showed that the mean values of metabolic pollutant exclusion rates for the different ventilation modalities varied very little across the spatial dimensions of the confined space but varied considerably in the area around the *** double-side attached ventilation method was the most effective in removing human metabolic pollutants,especially in the head region(CN≥0.92),while the single-wall attached ventilation method had the best air exchange efficiency(η≥0.85).This suggests an inconsistent distribution of CO_(2) and age of air,which is contrary to general common *** conclusions of this paper can guide the design of ventilation for tiny sleeping spaces.

关键词： attached ventilation mode human metabolic pollutant indoor air quality air exchange efficiency tiny sleeping spaces

Reconstruction of Postinfarcted Cardiac Functions Through Injection of Tanshinone IIA@ Reactive Oxygen Species-Sensitive Microspheres Encapsulated in a Thermoreversible Hydrogel

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Energy & Environmental Materials 2024年第2期7卷 191-203页

作者： Ling yu yubin liang Lei Gao Peipei Chen Zhiqiang yu Minzhou Zhang Aleksander Hinek Shuai Mao Second Clinical College Guangzhou University of Chinese Medicine Department of Critical Care Medicine Guangdong Provincial Hospital of Chinese Medicine Guangdong Provincial Branch of National Clinical Research Centre for Chinese Medicine Cardiology Department of Radiation Medicine and Applied Sciences University of California San Diego Department of Laboratory Medicine Dongguan Institute of Clinical Cancer Research Affiliated Dongguan Hospital Southern Medical University Translational Medicine Hospital for Sick Children

Myocardial damage resulting from acute myocardial infarction often leads to progressive heart failure and sudden death, highlighting the urgent clinical need for effective therapies. Recently, tanshinone IIA has been identified as a promising therapeutic agent for myocardial infarction. However, efficient delivery remains a major issue that limits clinical translation. To address this problem, an injectable thermosensitive poly(lactic acid-co-glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid-co-glycolic acid) gel(PLGA-PEG-PLGA) system encapsulating tanshinone IIA-loaded reactive oxygen species-sensitive microspheres(Gel-MS/tanshinone IIA) has been designed and synthesized in this study. The thermosensitive hydrogel exhibits good mechanical properties after reaching body temperature. Microspheres initially immobilized by the gel exhibit excellent reactive oxygen speciestriggered release properties in a high-reactive oxygen species environment after myocardial infarction onset. As a result, encapsulated tanshinone IIA is effectively released into the infarcted myocardium, where it exerts local antipyroptotic and anti-inflammatory effects. Importantly, the combined advantages of this technique contribute to the mitigation of left ventricular remodeling and the restoration of cardiac function following tanshinone ***, this novel, precision-guided intra-tissue therapeutic system allows for customized local release of tanshinone IIA, presenting a promising alternative treatment strategy aimed at inducing beneficial ventricular remodeling in the post-infarct heart.

关键词： myocardial infarction ROS-sensitive polymer tanshinone IIA thermoreversible hydrogel ventricular remodeling

Development of wet adhesion of honeybee arolium incorporated polygonal structure with three-phase composite interfaces

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Friction 2024年第2期12卷 215-230页

作者： Lulu liang Jieliang ZHAO Qun NIU Li yu Xiangbing WU Wenzhong WANG Shaoze YAN Zhenglei yu School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Division of Intelligent and Biomechanical Systems State Key Laboratory of TribologyDepartment of Mechanical EngineeringTsinghua UniversityBeijing 100084China Key of Bionic Engineering Ministry of EducationJilin UniversityChangchun 130022China

Inspired by the dynamic wet adhesive systems in nature,various artificial adhesive surfaces have been developed but still face different ***,the theoretical mechanics of wet adhesives has never been sufficiently ***,we develop a novel adhesive mechanism for governing wet adhesion and investigate the biological models of honeybee arolium for reproducing the natural wet adhesive ***-nano structures of honeybee arolium and arolium-prints were observed by Cryogenic scanning electron microscopy(Cryo-SEM),and the air pockets were found in the contact interface ***,the adhesive models with a three-phase composite interface(including air pockets,liquid secretion,and hexagonal frames of arolium),were formed to analyze the wet adhesion of honeybee *** results of theoretical calculations and experiments indicated an enhanced adhesive mechanism of the honeybee by liquid self-sucking effects and air-embolism *** these effects,normal and shear adhesion can be adjusted by controlling the proportion of liquid secretion and air pockets in the contact ***,the air-embolism effects contribute to the optimal coupling of smaller normal adhesion with greater shear adhesion,which is beneficial for the high stride frequency of *** works can provide a fresh perspective on the development of bio-inspired wet adhesive surfaces.

关键词： honeybee arolium air pockets wet adhesion a three-phase interface self-sucking effects air-embolism effects