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Intraluminal versus infiltrating gallbladder carcinoma:Clinical presentation,ultrasound and computed tomography

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World Journal of Gastroenterology 2009年第45期15卷 5662-5668页

作者： Tze-Yu Lee Sheung-Fat Ko Chung-Cheng Huang Shu-Hang ng Jiun-Lung liang Hsuan-Ying Huang Min-Chi Chen Shyr-Ming Sheen-Chen Department of Radiology Chang Gung University College of Medicine Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung Hsien 833 Taiwan China Department of Pathology Chang Gung University College of Medicine Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung Hsien 833 Taiwan China Public Health and Biostatistics Consulting Center Chang Gung University College of Medicine Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung Hsien 833 Taiwan China Department of Surgery Chang Gung University College of Medicine Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung Hsien 833 Taiwan China

AIM： To compare clinical presentation and ultrasound （US） and computed tomography （CT） sensitivity between intraluminal and infiltrating gallbladder carcinoma （GBCA）. METHODS： This retrospective study evaluated 65 cases of GBCA that were categorized morphologically into the intraluminaI-GBCA （n = 37） and infiltrating-GBCA （n = 28） groups. The clinical and laboratory findings, presence of gallstones, gallbladder size, T-staging, nodal status, sensitivity of preoperative US and CT studies, and outcome were compared between the two groups. RESULTS： There were no significant differences between the two groups with respect to female predominance, presence of abdominal pain, serum aminotransferases level, T2-T4 staging, and regional metastatic nodes. Compared with the patients with intraluminaI-GBCA, those with infiltrating-GBCA were significantly older （65.49 ± 1.51 years vs 73.07 ± 1.90 years）, had a higher frequency of jaundice （3/37 patients vs 13/28 patients） and fever （3/37 patients vs 10/28 patients）, higher alkaline phosphatase （119.36 ± 87.80 IU/L vs 220.68 ± 164.84 IU/L） and total bilirubin （1.74 ± 2.87 mg/L vs 3.50 ± 3.51 mg/L） levels, higher frequency of gallstones （12/37 patients vs 22/28 patients）, smaller gallbladder size （length, 7.47± 1.70 cm vs 6.47 ± 1.83 cm; width, 4.21 ± 1.43 cm vs 2.67 ± 0.93 cm）, and greater proportion of patients with 〈 12 mo survival （16/37 patients vs 18/28 patients）. The sensitivity for diagnosing intraluminal- GBCA with and without gallstones was 63.6% and 91.3% by US, and 80% and 100% by CT, respectively. The sensitivity for diagnosing infiltrating-GBCA with and without gallstones was 12.5% and 25% by US, and 71.4% and 75% by c-r, respectively. CONCLUSION： In elderly women exhibiting small gallbladder and gallstones on US, especially those with jaundice, fever, high alkaline phosphatase and bilirubin levels, CT may reveal concurrent infiltrating-GBCA.

关键词： Gallbladder neoplasms Carcinoma Ultrasound Computed tomography

NUMERICAL ANALYSIS OF THE PERFORMANCE OF HORIZONTAL AND WAVY SUBSURFACE FLOW CONSTRUCTED WETLANDS

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Journal of Hydrodynamics 2011年第3期23卷 339-347页

作者： WAng Jun HUAng Sui-liang HE Cheng-da ng Chiu-On College of Environmental Science and Engineering Nankai University Tianjin 300071 China Numerical Simulation Group for Water Environment Key Laboratory of Pollution Processes and EnvironmentalCriteria of Ministry of Education Tianjin Key Laboratory of Environmental Remediation and Pollution ControlCollege of Environmental Science and Engineering Nankai University Tianjin 300071 China College of Environmental Science and Engineering Yangzhou University Yangzhou 225009 China Department of Mechanical Engineering The University of Hong Kong Hong Kong China

A three-dimensional numerical model is proposed for modeling the TP transport in the Horizontal Subsurface Flow （HSSF） and Wavy subsurface Flow （WSSF） constructed wetland in this article. Both numerical simulations and physical experiments indicate that the removal efficiency of WSSF is higher than that of HSSF. The difference ofperforrnance in removing pollutants, e.g., Total Phosphorus （TP）, between HSSF and WSSF is numerically analyzed from three interactive aspects, that is, the hydraulic behavior, the substrate and the plant roots. It is shown that the dead zone volume in WSSF is smaller than in HSSF with less short circuiting. The soil in the top layer is more used in WSSF than in HSSF. The TP uptake by the plant roots in WSSF is higher than that in HSSF.

关键词： numerical model constructed wetland hydraulic behavior Retention Time Distribution (RTD) removal efficiency

Estimating canopy closure density and above-ground tree biomass using partial least square methods in Chinese boreal forests

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Journal of Forestry Research 2012年第2期23卷 191-196页

作者： LEI Cheng-liang JU Cun-yong CAI Ti-jiu J1ng Xia WEI Xiao-hua DI Xue-ying School of Forestry Northeast Forestry UniversityHarbin 150040P.R.China College of Geomatics Xi'an University of Science and TechnologyXi'an 710054P.R.China Department of Earth and Environmental Science University of BritishColumbia(Okanagan)3333 University wayKelownaBritish Colum-biaCanadaV1V 1V7.

Boreal forests play an important role in global environment systems. Understanding boreal forest ecosystem structure and function requires accurate monitoring and estimating of forest canopy and biomass. We used partial least square regression （PLSR） models to relate forest parameters, i.e. canopy closure density and above ground tree biomass, to Landsat ETM＋ data. The established models were optimized according to the variable importance for projection （VIP） criterion and the bootstrap method, and their performance was compared using several statistical indices. All variables selected by the VIP criterion passed the bootstrap test （p〈0.05）. The simplified models without insignificant variables （VIP 〈1） performed as well as the full model but with less computation time. The relative root mean square error （RMSE%） was 29% for canopy closure density, and 58% for above ground tree biomass. We conclude that PLSR can be an effective method for estimating canopy closure density and above ground biomass.

关键词： above-ground tree biomass bootstrap method canopy clo- sure density partial least square regression (PLSR) VIP criterion

搭建国际交流合作平台,打造面向东盟职业教育创新高地——广西建设职业技术学院的探索与实践

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教育国际交流

教育国际交流 2024年第5期 45-49页

作者：梁伟陈晓广西建设职业技术学院

职业教育对外开放是新时代教育对外开放的重要组成部分。东盟是海上丝绸之路的重要枢纽,是高质量共建“一带一路”的重点地区,也是构建“双循环”新发展格局的重要节点。广西同东盟国家陆海相邻,是我国面向东盟开放合作的前沿和窗口。... 详细信息

职业教育对外开放是新时代教育对外开放的重要组成部分。东盟是海上丝绸之路的重要枢纽,是高质量共建“一带一路”的重点地区,也是构建“双循环”新发展格局的重要节点。广西同东盟国家陆海相邻,是我国面向东盟开放合作的前沿和窗口。结合广西的区位优势,如何集聚资源,拓展渠道,打造面向东盟职业教育创新高地是当前广西职业教育对外开放合作的重要课题。

关键词：职业教育创新新时代教育海上丝绸之路国际交流合作教育对外开放面向东盟双循环广西职业教育

Absorption Spectroscopy of （8,1） Band in d^3△-a^3П System of CS Radical

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Chinese Journal of Chemical Physics 2012年第5期25卷 513-518,I0003页

作者： Chuan-liang Li Lun-hua Deng Yan zh.ng Ji-lin Wei Ya ng-qin Chen Department of Physics School of Applied ScienceTaiyuan University of Science and TechnoloEyTaiyuan 030024China State Key Laboratory of Precision Spectroscopy and Department of Physics East China NormalUniversityShanghai 200052China

The CS radical was generated by discharging the mixture gas of CS2 and Helium. The Doppler limited spectra of CS were recorded in the region of 12350-12950 cm^-1 using optical heterodyne concentration modulation absorption spectroscopy. Three hundred and twenty-six lines were recorded and assigned to the d^3△-a^3П （8,1） band, in which eighty-three transitions were first observed. A set of improved molecular constants for the d^3△（v=8） and a^3П（v=1） levels were determined by a non-linear least-squares fitting of all the lines to the effective Hamiltonian.

关键词： CS radical Concentration modulation absorption spectroscopy Molecularconstant

An Improvement to Multiple Criteria ABC Inventory Classification Using Shannon Entropy

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Journal of Systems Science & Complexity 2017年第4期30卷 857-865页

作者： zh.ng Shanshan FU Yelin LAI Kin Keung liang liang School of Public Affairs University of Science and Technology of China Department of Industrial and Manufacturing Systems Engineering University of Hong Kong School of Finance Jiangxi University of Finance and Economics International Business School Shaanxi Normal University School of Management Hefei University of Technology

This paper extends the ng-model [ng, 2007] for multiple criteria ABC inventory classification based upon Shannon entropy. The proposed approach determines the common weights associated with all criteria importance rankings, and provides a comprehensive scoring scheme by aggregating all rankings of the criteria importance. A numerical illustration is presented to compare the model with previous studies.

关键词： Inventory multiple criteria analysis Shannon entropy.

A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis

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Journal of Environmental Sciences 2020年第1期32卷 194-204页

作者： zhanwen Cheng Xiaoxing liang Shaojun liang Nuoya Yin Francesco Faiola State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Enuironmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

Air pollution has been linked to many health issues,including skin conditions,especially in *** all the atmospheric pollutants,ultrafine particles have been deemed very dangerous since they can readily penetrate the lungs and skin,and be absorbed into the ***,we employed a human embryonic stem cell(h ESC)-based differentiation system towards keratinocytes,to test the effects of ultrafine carbon particles,which mimic ambient ultrafine particles,at environment related *** found that10 ng/mL to 10μg/mL ultrafine carbon particles down-regulated the expression of the pluripotency marker SOX2 in h ***,1μg/mL to 10μg/mL carbon particle treatments disrupted the keratinocyte differentiation,and up-regulated inflammationand psoriasis-related genes,such as IL-1β,IL-6,CXCL1,CXCL2,CXCL3,CCL20,CXCL8,and S100 A7 and S100 A9,***,our results provide a new insight into the potential developmental toxicity of atmospheric ultrafine particles.

关键词： Human embryonic stem cells(hESCs) Keratinocytes Ultrafine carbon particles Inflammation Psoriasis Developmental toxicity

苦豆碱调节IL-6/JAK1/STAT3信号通路对结直肠癌细胞增殖、凋亡和免疫逃逸的影响

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中国免疫学杂志 2024年第7期40卷 1436-1440页

作者：伊亮李伟东王有周宁武威市凉州医院肛肠外科武威733000 兰州市第一人民医院消化科兰州730050

目的:探讨苦豆碱(ALO)调节IL-6/酪氨酸激酶1(JAK1)/信号转导和转录激活因子3(STAT3)通路对结直肠癌(CRC)细胞行为的影响。方法:SW480分为CK组(正常培养的SW480细胞)、ALO低剂量组(ALO-L组,0.2 mmol/L)、ALO中剂量组(ALO-M组,0.4 mmol/L)、ALO高剂量组(ALO-H组,0.8 mmol/L)、ALO-H+激活剂(IL-6激活剂重组人IL-6蛋白)组(0.8 mmol/L+100 ng/ml)。CCK-8、平板克隆实验检测SW480细胞增殖;流式细胞术检测SW480细胞凋亡;Western blot检测细胞中增殖细胞核抗原(PCNA)、Bcl-2相关X蛋白(Bax)、IL-6、p-JAK1、p-STAT3蛋白表达。将自然杀伤细胞NK-92MI分别与上述5组细胞共培养,并依次命名为CK共培养组、ALO-L共培养组、ALO-M共培养组、ALO-H共培养组、ALO-H+激活剂共培养组,检测共培养细胞上清液中TNF-α、IFN-γ水平及共培养体系中NK-92MI的免疫杀伤率。结果:与CK组相比,ALO-L组、ALO-M组、ALO-H组OD_(450)值、克隆形成率、PCNA、IL-6、p-JAK1、p-STAT3蛋白表达降低,细胞凋亡率、Bax蛋白表达升高,且呈剂量依赖性(P<0.05);与ALO-H组相比,ALO-H+激活剂组SW480细胞OD_(450)值、克隆形成率、PCNA、IL-6、p-JAK1、p-STAT3蛋白表达升高,细胞凋亡率、Bax蛋白表达降低(P<0.05);ALO-L共培养组、ALO-M共培养组、ALO-H共培养组上清中TNF-α、IFN-γ水平、NK-92MI细胞免疫杀伤率高于CK共培养组,且呈剂量依赖性(P<0.05);与ALO-H共培养组相比,ALO-H+激活剂共培养组上清中TNF-α、IFN-γ水平、细胞免疫杀伤率降低(P<0.05)。结论:ALO可能通过抑制IL-6/JAK1/STAT3信号通路抑制SW480细胞增殖、免疫逃逸,促进细胞凋亡。

关键词：苦豆碱结直肠癌白细胞介素-6/酪氨酸激酶1/信号转导和转录激活因子3通路免疫逃逸增殖

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卡瑞利珠单抗联合索拉非尼治疗中晚期肝细胞癌患者甲胎蛋白应答变化及对预后的评价

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肝脏 2024年第7期29卷 784-787,793页

作者：张云江梁亮张东成三台县人民医院肿瘤科四川621100 四川省人民医院肿瘤科雅安市人民医院肿瘤科

目的分析卡瑞利珠单抗联合索拉非尼治疗中晚期肝细胞癌患者甲胎蛋白应答变化及对预后的评价。方法2019年4月至2021年4月四川省三台县人民医院收治的经卡瑞利珠单抗联合索拉非尼治疗的中晚期肝细胞癌患者60例,治疗8个月后根据患者的治疗... 详细信息

目的分析卡瑞利珠单抗联合索拉非尼治疗中晚期肝细胞癌患者甲胎蛋白应答变化及对预后的评价。方法2019年4月至2021年4月四川省三台县人民医院收治的经卡瑞利珠单抗联合索拉非尼治疗的中晚期肝细胞癌患者60例,治疗8个月后根据患者的治疗是否应答分为应答组35例和非应答组25例。比较两组临床病理特征及转归情况。采用Kaplan-Meier生存评估两组生存率。采用多因素Cox回归分析影响中晚期肝细胞癌患者预后的危险因素。结果应答组的血红蛋白水平为(138.2±23.6)g/L,高于非应答组的(122.5±21.2)g/L(Png/mL、(12.3±2.1)μmol/L,低于非应答组的(468.9±71.2)ng/mL、(21.2±4.1)μmol/L(P<0.05)。应答组的甲胎蛋白早期应答率、疾病缓解率、疾病控制率分别为91.4%(32/35)、82.9%(29/35)、37.1%(13/35),非应答组分别为28.0%(7/25)、60.0%(15/25)、12.0%(3/25)(P<0.05)。截止到2021年3月,应答组无进展生存期为9个月,非应答组的无进展生存期为6个月,应答组的总生存期为13个月,非应答组的总生存期为11个月,死亡20例,其中应答组8例,非应答组12例;应答组的生存情况优于非应答组。多因素Cox回归分析结果显示,甲胎蛋白早期应答是影响中晚期肝细胞癌患者预后的独立危险因素(OR=3.511,P<0.05)。结论卡瑞利珠单抗联合索拉非尼治疗中晚期肝癌疗效显著,甲胎蛋白的早期反应对评价患者预后具有较好的应用价值。

关键词：卡瑞利珠单抗索拉非尼中晚期肝细胞癌甲胎蛋白应答变化预后