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Multi-Distributed Speech Emotion Recognition Based on Mel Frequency Cepstogram and Parameter Transfer

Chinese Journal of Electronics 2022年第1期31卷 155-167页

作者： lin Long TAN liang School of Computer Science Sichuan Normal University Institute of Computing Technology Chinese Academy of Sciences

Speech emotion recognition(SER) is the use of speech signals to estimate the state of emotion. At present, machine learning is one of the main research methods of SER, the test and training data S of traditional machine learning all have the same distribution and feature space, but the data of speech is accessed from different environments and devices, with different distribution characteristics in real life. Thus, the traditional machine learning method is applied to the poor performance of SER. This paper proposes a multi-distributed SER method based on Mel frequency cepstogram(MFCC) and parameter transfer. The method is based on single-layer long short-term memory(LSTM), pre-trained inceptionv3 network and multi-distribution corpus. The speech pre-processed MFCC is taken as the input of single-layer LSTM, and input to the pre-trained inception-v3 *** features are extracted through the pre-trained inception-v3 model. Then the features are sent to the newly defined the fully connected layer and classification layer,let the parameters of the fully connected layer be finetuned, finally get the classification result. The experiment proves that the method can effectively complete the classification of multi-distribution speech emotions and is more effective than the traditional machine learning framework of SER.

关键词： multidistribution corpus fully connected layer feature extraction speech signals machine learning method pre-trained inception-v3 model multidistributed speech emotion recognition pre-trained inception-v3 network feature space recurrent neural nets Mel frequency cepstogram parameter transfer single-layer LSTM speech pre-processed MFCC learning (artificial intelligence) speech recognition emotion recognition multidistributed SER method multidistribution speech emotions

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-yu liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Lipid metabolism, amino acid metabolism, and prostate cancer: a crucial metabolic journey

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Asian Journal of Andrology 2024年第2期26卷 123-134页

作者： lin Chen yu-Xin Xu yuan-Shuo Wang Jian-liang Zhou School of Pharmacy Hangzhou Normal UniversityHangzhou 311121China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province Hangzhou Normal UniversityHangzhou 311121China School of Pharmacy Guangxi Medical UniversityNanning530021China

Prostate cancer(PCa)is one of the most common malignancies in males worldwide,and its development and progression involve the regulation of multiple metabolic *** in lipid metabolism affect the proliferation and metastatic capabilities of PCa *** cells increase lipid synthesis and regulate fatty acid oxidation to meet their growth and energy ***,changes occur in amino acid metabolism in *** cells exhibit an increased demand for specific amino acids,and they regulate amino acid transport and metabolic pathways to fulfill their proliferation and survival *** changes are closely associated with disease progression and treatment response in PCa ***,a comprehensive investigation of the metabolic characteristics of PCa is expected to offer novel insights and approaches for the early diagnosis and treatment of this disease.

关键词： amino acid metabolism lipid metabolism metabolic pathways prostate cancer treatment strategies

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Optimization of an annular wave energy converter in a wind-wave hybrid system

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Journal of Hydrodynamics 2023年第2期35卷 338-350页

作者： Bin-zhen Zhou Zhi Zheng yu Wang Peng Jin lin Cui liang Cheng School of Civil Engineering and Transportation South China University of TechnologyGuangzhou510641China School of Marine Science and Engineering South China University of TechnologyGuangzhou510641China National Ocean Technology Center Tianjin300112China

A hybrid system of a spar-type floating offshore wind turbine and a heaving annular wave energy converter(WEC)provides a promising solution for collocated ocean renewable energy *** performance of the hybrid system depends on the dimensions of the *** an optimization method is proposed to determine the outer radius and the draft of the WEC under the wave condition in a randomly chosen operational ***,three candidate models are selected based on three operational conditions of energy harvest:(1)The natural frequency of the system is matched with the peak wave frequency in the target site(referred to as synchronized mode),where the wind turbine and the WEC nearly heave together in a near-resonance condition,(2)The natural frequency of the WEC is matched with the peak wave frequency(ring mode),(3)The maximum wave power is harnessed under the peak wave frequency(target mode).Then the candidate modes are evaluated to obtain an *** show that the extracted wave power under the above operational conditions has an upper bound that can hardly be surpassed by enlarging the dimensions of the WEC *** optimal annual wave energy production is achieved in the synchronized mode because of the superior performance of WEC over a wide bandwidth of effective energy conversion.

关键词： Spar-type wind turbine wave energy converter(WEC) hybrid system model selection optimization

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The lining responses for shallow mountain tunnels subjected to frost heaving

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Journal of Mountain Science 2022年第2期19卷 529-546页

作者： linG Xian-zhang yu yuan TANG liang GENG lin HAN Xiao School of Civil Engineering Harbin Institute of TechnologyHarbin 150090China State Key Laboratory for Geomechanics and Deep Underground Engineering Xuzhou 221008China State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Railway Engineering Research Institute China Academy of Railway Sciences CorporationBeijing 100081China Beijing Tieke Special Engineering Technology Corporation Limited Beijing 100081China

Mountain tunnels in cold regions are vulnerable to adverse effects of freezing ***,it is necessary to identify the lining responses of shallow mountain tunnels subjected to freezing *** quantify the influence of freezing action and key design parameters(such as cross-sectional shape;lining thickness;and waterproof measures)on the lining response,a thermal-hydro-mechanical coupled finite element(FE)model is established and ***,specific consideration is given to the lining internal force and resulting axial *** the influences of the cross-sectional shape,concrete parameters,and waterproof measures on the lining responses are ***,the rectangular tunnel has the worst security;the circular tunnel is the *** the other hand,when the thermal conductivity is less than 2.2[W/(m·K)],a greater thermal conductivity will cause a greater risk of damage to the ***,the drainage plate can reduce the value of minimum axial stresses,whether frozen or not,even eliminating the tensiondamaged ***,this study helps to estimate the lining responses and prevent frost damages for shallow mountain tunnels during freezing period.

关键词： Coupled thermal-hydro-mechanical model Mountain tunnel in the cold region lining responses Cross-sectional shape Freezing action

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World Journal of Gastroenterology 2012年第48期18卷 7175-7183页

作者： yu-Rong Tang Wei-Wei Yang Mei-Lan liang Xin-yu Xu Mei-Feng Wang lin lin Department of Gastroenterology the First Affiliated Hospital of Nanjing Medical University Department of Gastroenterology Nanjing Jiangbei People's HospitalMedical SchoolSoutheast University

AIM:To explore age-related changes in symptoms and quality of life(QoL) of women with irritable bowel syndrome(IBS).METHODS:Two-hundred and fifty-four female adult outpatients with IBS attending the Department of Gastroenterology at the First Affiliated Hospital of Nanjing Medical University between January,2008 and October,2008 were *** with a history of abdominal surgery,mental illness or those who had recently taken psychotropic drugs were excluded.A physician obtained demographic and abdominal symptom *** patients were asked to complete the Zung Self-Rated Anxiety and Depression Scale(SDS/SAS) and the IBS-specific QoL *** patients were divided into six groups according to age,in 10-year increments:18-27 years,28-37 years,38-47 years,48-57 years,58-67 years and 68-75 years(maximum 75 years).Age-related differences of abdominal pain or discomfort were analyzed using ranksum *** in SDS/SAS and IBS-QoL scores between age groups were analyzed using one-way analysis of ***'s correlations evaluated potential associations between IBS symptoms,psychological factors and QoL in each age ***:There were no differences in the distribution of IBS subtypes between age groups(χ2 = 20.516,P = 0.153).Differences in the severity of abdominal pain/discomfort with age were statistically significant(χ2 = 25.638,P < 0.001);patients aged 48-57 years,58-67 years or 68-75 years had milder abdominal pain/discomfort than those in the younger age *** severity of anxiety or depressive symptoms did not differ between age groups(SDS,χ2 = 390.845,P = 0.110;SAS,χ 2 = 360.071,P = 0.220).Differences of IBSQoL scores were statistically significant between age groups(χ2 = 1098.458,P = 0.011).The scores of patients in the 48-57-year group were lower than those in the 18-27-year and 28-37-year groups(48-57-year group vs 18-27-year group,74.88 ± 8.76 vs 79.76 ± 8.63,P = 0.021;48-57-year group vs 28-37-year group,74.88 ± 8.76

关键词： Irritable bowel syndrome Female Age Symptom Quality of life

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超声乳化术后联合及不联合人工晶状体植入术建立后囊膜混浊兔眼模型的比较

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中华实验眼科杂志 2012年第12期30卷 1077-1079页

作者：曹倩李兰李云川张远平查旭戴红梅梁毓琳杨文艳李静华昆明市第一人民医院眼科 650011 昆明医科大学第二附属医院眼科 650101

背景后发性白内障（PCO）的防治是目前研究的热点问题之一。建立PCO动物模型常用的方法为超声乳化术后植入或不植入人工晶状体（IOL），但二者造模的效果评价尚不一致。目的比较兔眼PCO模型建立过程中植入与不植入IOL对PCO的影响。方法... 详细信息

背景后发性白内障（PCO）的防治是目前研究的热点问题之一。建立PCO动物模型常用的方法为超声乳化术后植入或不植入人工晶状体（IOL），但二者造模的效果评价尚不一致。目的比较兔眼PCO模型建立过程中植入与不植入IOL对PCO的影响。方法选择新西兰白兔20只，用随机数字表法将实验动物分为超声乳化联合IOL植入组和超声乳化不植入IOL组，每组10只兔，两组兔右眼超声乳化手术过程一致，术后共随访3个月，裂隙灯下观察2个组术后晶状体的反应及PCO情况，按OdrichPCO分级系统对术眼PCO情况进行分级。结果术后1～3d，超声乳化联合IOL植入组术眼结膜充血、角膜水肿和房水混浊的严重程度均明显比超声乳化不植入IOL组严重，而术后2周至3个月2个组兔眼的炎性反应均消失；术后1d至3个月，2个组兔术眼的瞳孔直径变化及PCO分级一致。术后2个月，超声乳化不植入IOL组及超声乳化联合IOL植入组兔眼1～3级PCO者分别为8只眼和9只眼，0级PCO者分别为2只眼和1只眼，组间差异无统计学意义（P=0．39）。裂隙灯下检查发现2个组实验眼均于术后1个月开始出现PCO，术后2个月PCO的范围扩大并快速发展，术后3个月形成致密纤维化层。结论采用超声乳化联合IOL植入术建立PCO模型的效果与不植入IOL者相同，但后者术后早期的前房炎性反应较轻，可作为研究PCO的理想动物模型。

关键词：动物模型后发性白内障超声乳化术人工晶状体

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Association between FGFR4 gene polymorphism and high-risk HPV infection cervical cancer

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Asian Pacific Journal of Tropical Medicine 2017年第7期10卷 742-746页

作者： Ya-Ping Li lin Zhang yu-liang Zou Yan yu School of Public Health Health Science Center of Xi'an Jiaotong UniversityXi'an 710061ShaanxiChina Department of Gynaecology and Obstetrics Xi'an Central HospitalXi'an 710003ShaanxiChina Department of Neurology Xi'an Central HospitalXi'an 710003ShaanxiChina Department of Gynaecology and Obstetrics the First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061ShaanxiChina

Objective: To discuss the association between FGFR4 gene polymorphism rs351855(Glu388Aly) and the susceptibility and chemotherapeutic effect of cervical cancer infected by high-risk type HPV. Methods: A total of 162 patients with high-risk HPV cervical cancer and 162 healthy women were collected and the genotypes of the FGFR4 rs351855 locus were detected. The genotype distributions in the two groups were compared. The cervical cancer patients were divided into four groups which namely good therapeutic effect group and bad therapeutic effect, recurrence or metastasis and no recurrence or metastasis group respectively, and the risks of different genotype on the curative effect and prognosis were analyzed by Logistic regression. The survival time of patients with different genotypes was compared. Results: There was no statistic difference in FGFR4 rs351855 genotype distribution between the patients group and control group(P>0.05), among which the risk of chemotherapy failure on GA+AA patients was 3.257 times as much as that of the GG patients, and the risk of recurrence or metastasis of GA+AA patients was 2.783 times as much as that of the GG patients. For AA patients, the risk of chemotherapy failure and the risk of relapse and metastasis are 3.833 and 3.406 times, respectively, as much as that that of the GG patients. The overall survival of GA and AA patients was shorter than that of the GG patients, and significant difference was found(x^2=7.098, P=0.029). The difference in overall survival between GA+AA patients and GG patients was almost statistically significant(x^2=3.634, P=0.057). Conclusions: The FGFR4 rs351855 polymorphism is not associated with the susceptibility of high-risk HPV cervical cancer, but patients with gene A was at higher risk of unfavourable chemotherapy prognosis compared with patients with GG.

关键词： Cervical Cancer FGFR4 Polymorphism Prognosis

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A new variable-mode control strategy for LLC resonant converters operating in a wide input voltage range

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Frontiers of Information Technology & Electronic Engineering 2017年第3期18卷 410-422页

作者： Hui-pin lin Xiao-guang JIN liang XIE Jin HU Zheng-yu LU College of Electrical Engineering Zhejiang UniversityHangzhou 310027China

This paper proposes a new variable-mode control strategy that is applicable for LLC resonant converters operating in a wide input voltage range. This control strategy incorporates advantages from full-bridge LLC resonant converters, half-bridge LLC resonant converters, variable-frequency control mode, and phase-shift control mode. Under this control strategy, different input voltages determine the different operating modes of the circuit. When the input voltage is very low, it works in a full-bridge circuit and variable frequency mode(FB_VF mode). When the input voltage rises to a certain level, it shifts to a full-bridge circuit and phase-shifting control mode(FB_PS mode). When the input voltage further increases, it shifts into a half-bridge circuit and variable frequency mode(HB_VF mode). Such shifts are enabled by the digital signal processor(DSP), which means that no auxiliary circuit is needed, just a modification of the software. From light load to heavy load, the primary MOSFET for the LLC resonant converter can realize zero-voltage switching(ZVS), and the secondary rectifier diode can realize zero-current switching(ZCS). With an LLC resonant converter prototype with a 300 W rated power and a 450 V output voltage, as well as a resonant converter with 20–120 V input voltage, the experiments verified the proposed control strategy. Experimental results showed that under this control strategy, the maximum converter efficiency reaches 95.7% and the range of the input voltage expands threefold.

关键词： LLC Full bridge Half bridge Variable frequency Phase shift Wide input voltage range

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Cr-assisted low-temperature densification of(Ti,Zr,Nb,Ta,Mo)C high-entropy carbides with ultrafine grain and enhanced hardness

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Journal of Advanced Ceramics 2024年第6期13卷 780-788页

作者： Yang Liu Jiaji liang Weiming Guo Shikuan Sun yu Tian Hua-Tay lin School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006China State Key Laboratory of High Performance Tools Guangdong University of TechnologyGuangzhou 510006China School of Material Science and Energy Engineering Foshan UniversityFoshan 528000China

While the use of low-melting-point metals as sintering aids for high-entropy carbide(HEC)ceramics has been well established,their existence can compromise hardness due to residual metallic *** study demonstrates an innovative strategy to meet this challenge,where(Ti,Zr,Nb,Ta,Mo)C high-entropy carbide ceramics with ultrafine grains and enhanced hardness are obtained through chromium(Cr)-metal-assisted spark plasma sintering(SPS)at a temperature as low as 1600℃.The results show that the addition of 5 vol%Cr promotes the formation of highly densified single HEC phase ceramics with a high relative density(98.4%)and an ultrafine-grained microstructure(0.17μm).This low-temperature densification mechanism can be attributed to Cr’s solid-solution effect within the matrix and the increased carbon vacancies generated during *** grain size of the(Ti,Zr,Nb,Ta,Mo)C ceramics with 5 vol%Cr metal addition is significantly smaller than that of Cr-free(Ti,Zr,Nb,Ta,Mo)C ceramics sintered at 2000℃(3.03μm)or via traditional low-temperature liquid-phase sintering(1.3–1.5μm).Importantly,the addition of 5 vol%Cr substantially increased the hardness of the ceramics,with a remarkable increase from 23.57 to 28.16 GPa compared to that of the pure(Ti,Zr,Nb,Ta,Mo)C ceramics,owing to the fine-grain strengthening and solid-solution strengthening *** work highlights the uniqueness of Cr metal as a sintering aid in achieving densification and hardness improvements in(Ti,Zr,Nb,Ta,Mo)C ceramics,offering a promising strategy for improving the properties of HEC materials for further development in the near future.

关键词： solid solution sinterability hardness enhancement (Ti,Zr,Nb,Ta,Mo)C high-entropy carbide(HEC)ceramics

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