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2012全国临床微生物与感染免疫学术研讨会

作者： Liu Bing,liang xiaohong,Ma Chunhong,Gao Lifen Institute of Immunology,Shandong University School of Medicine

Background SLE is a typical chronic autoimmune *** evidences support the notion that impaired or delayed clearance of apoptotic cells is respossible for the development of *** was newly identified as an immunomodulatory family in ***-3 is a pattern recognition receptor for recognition and binding of ***,it is found that Tim-3 is also expressed in innate immune cells such as macrophage and dendritic cells,so it can mediate of the uptake,engulfment of apoptotic cells and plays a role in immune *** results showed that relative Tim-3 mRNA expression level was higher in SLE patients,but there was no significant difference. Aims To investigate expression of Tim-3 inPBMC from SLE patients and healthy controls and analyze correlation between Tim-3 expression level and disease activity of SLE. Methods Fresh heparin-treated blood from healthy controls and SLE patients were ***-conjugated anti-human CD14 and PE-conjugated anti-human Tim-3 were used to detect Tim-3 expression by flow cytometric ***-V/PI cells were analyzed by flow cytometry. Results We found that expression of AnnexinV+ cells in peripheral blood from SLE patients was significant higher than that of healthy controls,and the expression of AnnexinV+ cells in peripheral blood positively correlated with SLEDAI scores and negatively correlated with *** of Tim-3 in CD14+ cells from active SLE patients with SLEDAI>5 increased compared with healthy controls,and the expression of Tim-3 in CD14+ cells in peripheral blood positively correlated with *** correlation between CD14+-Tim3+ cells and AnnexinV+ cells was found in peripheral blood from SLE patients. Conclusions Our results suggest that Tim-3 might participate in the pathogenesis of SLE by inducing CD14+ monocytes defects in eliminating apoptotic cells.

关键词： Tim-3 SLE apoptotic cells phagocytosis

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施氮量对酿造高粱产量和氮素利用率的影响

华北农学报 2017年第2期32卷 179-184页

作者：梁晓红刘静曹雄山西省农业科学院经济作物研究所山西汾阳032200

为了实现酿造高粱氮肥合理高效利用,以晋杂22号为试验品种,研究了6种氮肥施用量(0,75,150,225,300,450 kg/hm^2)对酿造高粱产量和氮素利用率的影响。结果表明,在施氮0~450 kg/hm^2,施用氮肥有效地增加了高粱产量和净利润,但随着施氮量... 详细信息

为了实现酿造高粱氮肥合理高效利用,以晋杂22号为试验品种,研究了6种氮肥施用量(0,75,150,225,300,450 kg/hm^2)对酿造高粱产量和氮素利用率的影响。结果表明,在施氮0~450 kg/hm^2,施用氮肥有效地增加了高粱产量和净利润,但随着施氮量的增加产量先升高后降低,其关系可表示为y=-0.037x^2+17.759x+5 874.41(R2=0.878 1)。随着施氮量的增加高粱氮肥偏生产力和氮肥利用率显著降低;氮素吸收效率逐渐降低;氮素利用效率大体呈下降趋势;当施氮量为225 kg/hm^2时,高粱产量、净利润最大,极显著高于不施氮处理,增产率达37.64%;氮肥农学利用率和氮肥偏生产力分别为9.96,36.42 kg/kg,氮肥利用率可达到38.70%,且氮平衡为3.07,大体上满足氮素平衡。综合分析各项指标,施氮量为225 kg/hm^2是酿造高粱晋杂22号实现高产、高效益、较高氮肥利用率的适宜氮量。

关键词：酿造高粱施氮量产量氮素利用率

Hepatitis B virus X protein modulates the apoptosis of hepatoma cell line induced by TRAIL

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Science China(Life Sciences) 2005年第3期48卷 277-286页

作者： liang xiaohong 1 , SUN Wensheng 1 , GAO Lifen 1 , MA Chunhong 1 , HAN Lihui 1 & CHEN Youhai 2 1. Institute of Immunology, Medical School of Shandong University, Jinan 250012, China 2. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia PA19104, USA 1. Institute of Immunology Medical School of Shandong University 250012 Jinan China 2. Department of Pathology and Laboratory Medicine University of Pennsylvania 19104 Philadelphia PA USA

The purpose of this study is to observe the effects of HBx on the apoptosis of hepatoma cells induced by TNF-related apoptosis-inducing ligand (TRAIL) and to study prelimi- nary molecular mechanisms for its effects. In order to set up a model in vitro, BEL7402-HBx cell line, stably expressing HBx mRNA, was established by stable transfection of pcDNA-HBx, which contains HBx gene, into hepatoma cell line BEL7402. Control cell line BEL7402-cDNA3, stably transfected with pcDNA3, was set up simultaneously as a control. Trypan blue exclusion test, caspase 3 activity detection and TUNEL assay were performed to detect the apoptosis of BEL7402, BEL7402-cDNA3, BEL7402-HBx induced by TRAIL. The expression of TRAIL recep- tors in three groups was analyzed by Flow cytometry. In addition, phosphorothioated antisense oligonucleotide against the translation initial region of HBx gene (PS-asODNs/HBx) was used to block the expression of HBx in HepG2.2.15 cells and to further confirm the effects of HBx on TRAIL-induced apoptosis. Trypan blue exclusion test indicated that TRAIL had a dose-dependent cytotoxicity on BEL7402, BEL7402-cDNA3 and BEL7402-HBx cells. Under treatment of the same concentration of TRAIL, BEL7402-HBx had a higher apoptosis rate and a higher level of Caspase 3 activation than BEL7402 and BEL7402-cDNA3. TUENL assay showed that the apoptosis rate of BEL7402-HBx induced by 10 μg/L TRAIL was 41.4%±7.2%, signifi- cantly higher than that of BEL7402 and BEL7402-cDNA3 cells. Blockade of HBx expression in Hep G2.2.15 cells partly inhibited the apoptosis induced by TRAIL. The introduction or blockade of HBx did not change the expression pattern of TRAIL receptors. The present study firstly con- firms the effects of HBx on TRAIL- induced apoptosis from two different points and it is not re- lated with the expression level of TRAIL receptors. This would be useful to further clarify the roles of imbalanced apoptosis in pathogenesis of Hepatitis B and related hepatocellular carc

关键词： apoptosis, TRAIL, hepatitis B virus X protein, phosphorothioated antisense oligonucleotide.

Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： xiaohong Zou Qian Lu Mingcong Tang Jie Wu Kouer Zhang Wenzhi Li Yunxia Hu Xiaomin Xu Xiao Zhang Zongping Shao liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

日僧撰《俱舍論音義》的語料價值——以漢字研究爲中心

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文献语言学 2019年第2期 50-65,204页

作者：梁曉虹日本南山大學

本文以現存日僧所撰《俱舍論音義》三種寫本中之京都大學國文研究室所藏轉寫本(京大轉寫本)爲基本材料,從漢字研究的角度對其展開考察。筆者指出此本雖只是轉寫本,且僅存上册一卷,但因其底本,包括其原本皆不明去向,故即使是轉寫本,作爲... 详细信息

本文以現存日僧所撰《俱舍論音義》三種寫本中之京都大學國文研究室所藏轉寫本(京大轉寫本)爲基本材料,從漢字研究的角度對其展開考察。筆者指出此本雖只是轉寫本,且僅存上册一卷,但因其底本,包括其原本皆不明去向,故即使是轉寫本,作爲資料也頗爲重要。特别是因爲其中含有豐富的引證資料,又以文字音韻訓詁典籍爲多,有不少是中日古代久已散佚的珍貴文獻,故是漢語史研究,特别是漢字研究的重要語料,值得學界關注。

关键词：《俱舍論音義》京大轉寫本高野山本金澤文庫本漢字語料

“無窮會本系”《大般若經音義》“詹”聲俗字考

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汉语史研究集刊 2021年第2期 267-281页

作者：梁曉虹日本南山大學綜合政策學部

本文以"無窮會本系"《大般若經音義》中最具代表性的三種寫本(無窮會圖書館本、天立大學圖書館本、藥師寺本)爲主要資料,對其中四組以"詹"爲聲符的俗字加以考釋,希望由此側面考察漢傳俗字進入日本後的某些發展演變軌跡。

关键词：無窮會本系俗字漢傳俗字訛俗字倭俗字

精益求精,臻于至善——评《一切经音义三种校本合刊》的两次修订

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辞书研究 2023年第6期 97-107页

作者：梁晓虹南山大学日本名古屋4668673

佛经音义是中国佛教纂集中专门解释佛经字、词音义的语言文字类著作,以玄应、慧琳、希麟所作正续《一切经音义》为代表,是唐至宋辽时期语文学成就的集中体现。徐时仪教授整理的《一切经音义三种校本合刊》是我国第一部佛经音义整理著作... 详细信息

佛经音义是中国佛教纂集中专门解释佛经字、词音义的语言文字类著作,以玄应、慧琳、希麟所作正续《一切经音义》为代表,是唐至宋辽时期语文学成就的集中体现。徐时仪教授整理的《一切经音义三种校本合刊》是我国第一部佛经音义整理著作,深受学界重视。2008年至今两次印行,十五年间徐时仪教授陆续校订,在2023年出版的“修订第二版”中做了大规模修改。新版以线装书局影印的高丽大藏经核校全书,修正字头字形及正文字形近千处;补正点校疏失、印刷讹误,酌改标点数十处,补注文字上千条;将2012年修订版所附补注归入相应的正文中。此次修订立足学术前沿,补充新见;追求完备精良,大幅校改;且为研究者提供了研究思路和资料信息。《一切经音义三种校本合刊》及两次修订本凝聚了著者长期研究音义的心血,体现了著者对学术精益求精的态度和臻于至善的追求,裨益学林,尤其对东方学﹑汉学﹑佛学﹑汉语史﹑古籍整理等诸领域研究,意义重大。

关键词：一切经音义合刊修订第二版

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日本俗字初探

汉语史研究集刊

汉语史研究集刊 2023年第2期 206-225页

作者：梁曉虹日本南山大學

本文在江户時代日本學者研究的基礎上對“日本俗字(倭俗字)”展開初步研究。首先對“日本俗字”進行再定義,排除了純“國字”,因爲它們是全新的原創漢字,没有“正字”可對應。日本俗字指在長期的漢字使用過程中產生,經日本人之筆改造漢... 详细信息

本文在江户時代日本學者研究的基礎上對“日本俗字(倭俗字)”展開初步研究。首先對“日本俗字”進行再定義,排除了純“國字”,因爲它們是全新的原創漢字,没有“正字”可對應。日本俗字指在長期的漢字使用過程中產生,經日本人之筆改造漢字而成,不見於漢傳俗字家族中的俗字。關於日本俗字研究,筆者提出了需注意的兩點:其一爲研究資料;其二是要了解日本漢字發展的歷史背景。關於後者,筆者也提出兩點:其一“和樣書道”對日本俗字的產生有一定影響,其二日本人對漢字的接受與認知也是“倭俗字”產生的重要因素。

关键词：日本俗字漢傳俗字倭俗字國字和樣書道

日本早期佛經音義特色考察——以《大乘理趣六波羅蜜經釋文》爲例

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文献语言学 2020年第2期11卷 106-118,205-206页

作者：梁曉虹日本南山大學

《大乘理趣六波羅蜜經釋文》是日本人專爲《大乘理趣六波羅蜜經》撰寫的音義書。根據學界考證,此音義成於平安(794~1185)初期,屬於日僧早期所撰音義。本文將其與慧琳、希麟兩位音義大家所撰同經音義進行比較研究,以考察佛經音義在日本... 详细信息

《大乘理趣六波羅蜜經釋文》是日本人專爲《大乘理趣六波羅蜜經》撰寫的音義書。根據學界考證,此音義成於平安(794~1185)初期,屬於日僧早期所撰音義。本文將其與慧琳、希麟兩位音義大家所撰同經音義進行比較研究,以考察佛經音義在日本早期發展中所呈現出的一些特色。

关键词：《大乘理趣六波羅蜜經》《大乘理趣六波羅蜜經釋文》音義慧琳音義希麟音義