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Beyond fundamental resonance mode:high-order multi-band ALN PMUT for in vivo photoacoustic imaging

Microsystems & Nanoengineering 2022年第6期8卷 205-216页

作者： Junxiang Cai Yiyun Wang Daohuai Jiang Songsong Zhang Yuandong Alex Gu liang lou Fei Gao Tao Wu School of Information Science and Technology ShanghaiTech UniversityShanghaiChina Shanghai Institute of Microsystem and Information Technology ShanghaiChina University of Chinese Academy of Sciences BeijingChina School of Microelectronics Shanghai UniversityShanghaiChina Shanghai IndustrialμTechnology Research Institute ShanghaiChina Shanghai Engineering Research Center of Energy Efficient and Custom AI IC ShanghaiChina

This paper reports on an aluminum nitride(AlN)piezoelectric micromachined ultrasound transducer(PMUT)array for photoacoustic(PA)imaging,where the high-order resonance modes of the PMUT are utilized to improve imaging resolution.A flexural vibration mode(FVM)PMUT is fabricated and applied in a photoacoustic imaging(PAI)***,the microelectromechanical system(MEMS)-based PMUT is suitable for PA endoscopic imaging of blood vessels and bronchi due to its miniature size and high *** importantly,AlN is a nontoxic material,which makes it harmless for biomedical *** the PAI system,the AlN PMUT array is used to detect PA signals,and the acousto–mechanical response is designed and optimized at the PMUT’s fundamental *** this work,we focus on the high-order resonance performance of the PMUT PAI beyond the fundamental *** acoustic and electrical responses of the PMUT’s high-order resonance modes are characterized and *** fundamental and three high-order resonance bandwidths are 2.2,8.8,18.5,and 48.2 *** with the resolution at the fundamental resonance mode,the resolutions at third-and fourth-order resonance modes increase by 38.7%and 76.9%in a phantom *** high-order resonance modes of the AlN PMUT sensor array provide higher central frequency and wider bandwidth for PA signal detection,which increase the resolution of PAI compared to the PMUT working at the fundamental resonance mode.

关键词： resonance fundamental photoacoustic

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A miniaturized transit-time ultrasonic flowmeter based on ScAIN piezoelectric micromachined ultrasonic transducers for small-diameter applications

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Microsystems & Nanoengineering 2023年第2期9卷 47-57页

作者： Yunfei Gao Minkan Chen Zhipeng Wu Lei Yao Zhihao Tong Songsong Zhang Yuandong Alex Gui liang lou School of Microelectronics Shanghai UniversityShanghai 201800China Shanghai IndustrialμTechnology Research Institute Shanghai 201899China

Transit-time ultrasonic flowmeters(TTUFs)are among the most widely used devices for flow ***,traditional TTUFs are usually based on a bulk piezoelectric transducer,which limits their application in small-diameter *** this paper,we developed a miniaturized TTUF based on scandium-doped aluminum nitride(ScAIN)piezoelectric micromachined ultrasonic transducers(PMUTs).The proposed TTUF contains two PMUT-based transceivers and a T-type *** PMUTs contain 13×13 square cells with dimensions of 2.8×2.8 mm^(2).To compensate for the acoustic impedance mismatch with liquid,a layer of polyurethane is added to the surface of the PMUTs as a matching *** PMUT-based transceivers show good transmitting sensitivity(with 0.94 MPaN surface pressure)and receiving sensitivity(1.79 mV/kPa)at a frequency of 1 MHz in ***,the dimensions of the Ttype channel are optimized to achieve a measurement sensitivity of 82 ns/(m/s)and a signal-to-noise ratio(SNR)better than 15 ***,we integrate the fabricated PMUTs into the TDC-GP30 *** experimental results show that the developed TTUF provides a wide range of flow measurements from 2 to 300 L/h in a channel of 4 mm diameter,which is smaller than most reported *** accuracy and repeatability of the TTUF are within 0.2%and 1%,*** proposed TTUF shows great application potential in industrial applications such as medical and Chemical applications.

关键词： piezoelectric flow dimensions

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Regulating the synergy coefficient of composite materials for alleviating self-discharge of supercapacitors

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Journal of Energy Chemistry 2023年第9期84卷 34-40页

作者： Siqi Jing Xiaohui Yan Yige Xiong Taibai Li Junkai Xiong Tao Hu Zhongjie Wang liang lou Xiang Ge Department of Materials and Metallurgy Guizhou UniversityGuiyang 550025GuizhouChina

Supercapacitor is an efficient energy storage device,yet its wider application is still limited by ***,various composite materials have been reported to have improved inhibition on self-discharge,while the evaluation of the synergistic effect in composite materials is ***,pairs of intercalation type pseudocapacitive niobium oxides are pre-lithiated and coupled to construct conjugatedly configured supercapacitors,within which the cathode and anode experience identical reaction environment with single type of charge carrier,thus providing ideal platform to quantify the synergistic effect of composite materials on the self-discharge *** using titanium dioxide as the stabilizer,we have compared how the modes of forming composite would influence the selfdischarge performance of the active composite materials with similar ratio of the constituent ***,core@shell Nb_(2)O_(5)@TiO_(2) composite using TiO_(2) as the shell shows significantly higher synergy coefficient(μ=0.61,defined as the value that evaluates the synergistic effect between composite materials,and can be quantified using the overall performance of the composite,performance of individual component as well as the ratio of the component.) than other control group samples,which corresponds to the highest retained energy of 63% at 100 *** work is expected to provide a general method for quantifying the synergistic effect and guide the design of composite materials with specific mode of forming the composite.

关键词： Pseudocapacitive Synergy coefficient Conjugated supercapacitor Niobium oxide Self-discharge

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Application of methanol synthesis reactor to large-scale plants

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应用化工 2006年第Z1期35卷 260-268页

作者： lou Ren XU Rong-liang lou Shou-lin Hangzhou Linda Chemical Technology Engineering Ltd Hangzhou 310013 China

The developing status of world large-scale methanol production technology is analyzed and Linda's JW low-pressure methanol synthesis reactor with uniform temperature is described. JW serial reactors have been successfully introduced in and applied in Harbin Gasification Plant and the productivity has been increased by 50% and now nine sets of equipments are successfully running in Harbin Gasification Plant,Jiangsu Xinya, Shandong Kenli,Henan Zhongyuan, Handan Xinyangguang,' Shanxi Weihua and Inner Mongolia Tianye. Now it has manufacturing the reactors of 300,000 t/a for Liaoning Dahua. Some solutions for the structure problems of 1000 ～5000 t/d methanol synthesis rectors are put forward.

关键词： methanol synthesis reactor large-scale

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Quorum Sensing:An Emerging Role for Vibrio Infection and Host Defense

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Infectious Microbes & Diseases 2024年第2期6卷 47-55页

作者： Hao-Nan Lin Xian-Hui Huang Xin-Jun Miao Wei-Lin Hu Yong-liang lou Dan-Li Xie The School of Laboratory Medicine&Life Sciences Wenzhou Medical UniversityWenzhouChina Key Laboratory of Laboratory Medicine Ministry of Education of ChinaWenzhouChina Wenzhou Key Laboratory of Sanitary Microbiology WenzhouChina Department of Emergency Wenzhou Central HospitalWenzhouZhejiangChina Department of Microbiology School of MedicineZhejiang UniversityHangzhouChina Zhuji Institute of Biomedical Research School of PharmacyWenzhou Medical UniversityZhujiChina

Quorum sensing(QS)is a mechanism that allows bacteria to regulate various physiological and biochemical functions by secreting,sensing and responding to signaling molecules called autoinducers(AIs).In Vibrio species,QS plays a crucial role in modulating different biological *** can influence the formation of biofilms,which are communities of bacteria encased in a protective *** also controls flagella formation and motility,ensuring that Vibrio *** move efficiently in response to environmental ***ally,QS in Vibrio *** the production of different virulence factors based on cell *** enables the bacteria to adjust their virulence strategies accordingly,enhancing *** also influences the interaction between Vibrio *** their ***ing infection by Vibrio spp.,QS can affect the host immune response and colonization *** the role of QS in these interactions is crucial for unraveling the complex dynamics between Vibrio *** the *** summary,research on QS in Vibrio *** revealed its significance in regulating various biological phenotypes,controlling virulence factor production and affecting host de*** provides valuable insights into the intricate mechanisms underlying microbial behavior,host adaptation and Vibrio ***.

关键词： quorum sensing Vibrio species biological phenotype bacterial virulence host defense

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Nlrc3-like is required for microglia maintenance in zebrafish

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Journal of Genetics and Genomics 2019年第6期46卷 291-299页

作者： Tienan Wang Bo Yan liang lou Xi Lin Tao Yu Shuting Wu Qing Lu Wei Liu Zhibin Huang Mingjie Zhang Wenqing Zhang Zilong Wen Division of Life Science and State Key Laboratory of Molecular Neuroscience Center of Systems Biology and Human Health The Hong Kong University of Science and Technology Clearwater Bay Kowloon Hong Kong China Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education Shanghai Jiao Tong University Shanghai 200240 China Department of Developmental Biology School of Basic Medical Sciences South China University of Technology Guangzhou 510630 China Division of Life Science Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China

Microglia are tissue-resident macrophages residing in the central nervous system (CNS) and play critical roles in removing cellular debris and infectious agents as well as regulating neurogenesis and neuronal activities. Yet, the molecular basis underlying the establishment of microglia pool and the maintenance of their homeostasis in the CNS remain largely undefined. Here we report the identification and characterization of a mutant zebrafish, which harbors a point mutation in the nucleotide-binding oligomerization domain (NOD) like receptor gene nlrc3-like, resulting in the loss of microglia in a temperature sensitive manner. Temperature shift assay reveals that the late onset of nlrc3-like deficiency leads to excessive microglia cell death. Further analysis shows that the excessive microglia death in nlrc3-like deficient mutants is attributed, at least in part, to aberrant activation of canonical inflammasome pathway. Our study indicates that proper regulation of inflammasome cascade is critical for the maintenance of microglia homeostasis.

关键词： Zebrafish Microglia Inflammasome NOD-like receptors

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Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer

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World Journal of Gastroenterology 2024年第14期30卷 2018-2037页

作者： Qi-Long Wu Xiao-Ting Fang Xin-Xin Wan Qing-Yong Ding Yan-Jun Zhang Ling Ji Yong-liang lou Xiang Li School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityKey Laboratory of Laboratory MedicineMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of General Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and Life Sciences Institute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesInstitute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Colorectal cancer(CRC)ranks among the most prevalent malignant tumors *** reports suggest that Fusobacterium nucleatum(***)contributes to the initiation,progression,and prognosis of ***,a short-chain fatty acid derived from the bacterial fermentation of soluble dietary fiber,is known to inhibit various *** study is designed to explore whether *** influences the onset and progression of CRC by impacting the intestinal metabolite butyric *** To investigate the mechanism by which *** affects CRC occurrence and *** Alterations in the gut microbiota of BALB/c mice were observed following the oral administration of ***,DLD-1 and HCT116 cell lines were exposed to sodium butyrate(NaB)and *** in vitro to examine the effects on proliferative proteins and mitochondrial *** Our research indicates that the prevalence of *** in fecal samples from CRC patients is significantly greater than in healthy counterparts,while the prevalence of butyrate-producing bacteria is notably *** mice colonized with ***,the population of butyrate-producing bacteria decreased,resulting in altered levels of butyric acid,a key intestinal metabolite of *** to NaB can impair mitochondrial morphology and diminish mitochondrial membrane potential in DLD-1 and HCT116 CRC ***,this leads to modulated production of adenosine triphosphate and reactive oxygen species,thereby inhibiting cancer cell ***,NaB triggers the adenosine monophosphate-activated protein kinase(AMPK)signaling pathway,blocks the cell cycle in HCT116 and DLD-1 cells,and curtails the proliferation of CRC *** combined presence of *** and NaB attenuated the effects of the *** employing small interfering RNA to suppress AMPK,it was demonstrated that AMPK is essential for NaB’s inhibition of CRC cell *** F.n

关键词： Colorectal cancer Fusobacterium nucleatum Butyric acid Gut microbiota Adenosine monophosphate-activated protein kinase signal pathway

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Development of Quantitative Real-time Polymerase Chain Reaction for the Detection of Vibrio vulnificus Based on Hemolysin (vvhA) Coding System

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Biomedical and Environmental Sciences 2008年第4期21卷 296-301页

作者： ZENG-HUI WU YONG-liang lou YI-YU LU JIE YAN Department of Medical Microbiology and Parasitology College of Medicine Zhejiang University Hangzhou 310058 Zhejiang China Wenzhou Medical College Wenzhou 325035 Zhejiang China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310009 Zhejiang China

Objective To establish a TaqMan real-time fluorescent quantitative PCR to detect Vibrio vulnificus based on the hemolysin gene （vvhA） coding cytolysin. Methods Primers and probes in the conserved region of the vvhA gene sequence were designed for the TaqMan real-time PCR to detect 100 bp amplicon from V. vulnificus DNA. Recombinant plasmid pMD19-vvhA100 was constructed and used as a positive control during the detection. Minimal amplification cycles （Ct value） and fluorescence intensity enhancement （ARn value） were used as observing indexes to optimize the reaction conditions of TaqMan real-time PCR. The TaqMan assay for the detection of Vbirio vulnificus was evaluated in pure culture, mice tissue which artificially contaminated Vibrio vulnificus and clinical samples. Results The established TaqMan real-time PCR showed positive results only for Vibrio vulnificus DNA and pMD19-vvhA100. The standard curve was plotted and the minimum level of the vvhA target from the recombinant plasmid DNA was 103 copies with a Ct value of 37.94±0.19, as the equivalent of 0.01 ng purified genomic DNA of Vibrio vulnificus. The results detected by TaqMan PCR were positive for the 16 clinical samples and all the specimens of peripheral blood and subcutaneous tissue of mice which were infected with Vibrio vulnificus. Conclusion TaqMan real-time PCR is a rapid, effective, and quantitative tool to detect Vibro vulnificus, and can be used in clinical laboratory diagnosis of septicemia and wound infection caused by Vibrio vulnificus.

关键词： Vibrio vulnificus vvhA gene TaqMan probe Real-time quantitative PCR Detection

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冻结管爆破注浆加固技术研究

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矿冶工程 2001年第2期21卷 21-23页

作者：徐颖罗良友淮南工业学院土木工程系安徽淮南232001 江苏徐州大屯煤电集团公司江苏徐州221065

冻结管射孔注浆是在对石油输油井射孔技术和地面注浆技术进行研究的基础上 ,开发出的一种用于煤矿冻结井筒围岩加固和堵水的全新技术。它利用聚能射孔爆破技术 ,在预定地层位置将冻结管射穿 ,同时在地面利用冻结管及射孔弹道对特定地层... 详细信息

冻结管射孔注浆是在对石油输油井射孔技术和地面注浆技术进行研究的基础上 ,开发出的一种用于煤矿冻结井筒围岩加固和堵水的全新技术。它利用聚能射孔爆破技术 ,在预定地层位置将冻结管射穿 ,同时在地面利用冻结管及射孔弹道对特定地层进行注浆充填加固 ,既可实现井壁堵漏 ,又能减少由于地层沉降对井壁的垂直附加力。该技术具有地面注浆不需造孔、井下围岩注浆不用破壁、准备工作简单、安全性好、节省工程费用等优点。

关键词：冻结管爆破射孔注浆加固穿孔爆矿聚能装药

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Interaction between circulating cancer cells and platelets:clinical implication

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Chinese Journal of Cancer Research 2015年第5期27卷 450-460页

作者： Xiao-liang lou Jian Sun Shu-Qi Gong Xue-Feng Yu Rui Gong Huan Deng Molecular Medicine and Genetics Center The Fourth Affiliated Hospital of Nanchang University Department of Pathology The Fourth Affiliated Hospital of Nanchang University Renmin Institute of Forensic Medicine

Metastasis is the main cause of cancer-associated mortality. During this complicated process, some cancer cells, also called circulating tumor cells （CTCs）, detach from primary sites, enter bloodstream and extravasate at metastatic site. Thrombocytosis is frequently observed in patients with metastatic cancers suggesting the important role of platelets in metastasis. Therefore this review focuses on how platelets facilitate the generation of CTCs, protect them from various host attacks, such as immune assaults, apoptosis and shear stress, and regulate CTCs intravasation/extravasation. Platelet-derived cytokines and receptors are involved in this cascade. Identification the mechanisms underlie platelet-CTCs interactions could lead to the development of new platelet-targeted therapeutic strategy to reduce metastasis.

关键词： Circulating tumor cells (CTCs) platelet epithelial-mesenchymal transition (EMT) immunesurveillance metastasis

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