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Event-Triggered Asymmetric Bipartite Consensus Tracking for Nonlinear Multi-Agent Systems Based on Model-Free Adaptive Control

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IEEE/CAA Journal of Automatica Sinica 2023年第3期10卷 662-672页

作者： jiaqi liang Xuhui Bu Lizhi Cui Zhongsheng Hou School of Electrical Engineering and Automation Henan Polytechnic UniversityJiaozuo 454003China School of Automation Qingdao UniversityQingdao 266071China IEEE

In this paper,an asymmetric bipartite consensus problem for the nonlinear multi-agent systems with cooperative and antagonistic interactions is studied under the event-triggered *** the agents described by a structurally balanced signed digraph,the asymmetric bipartite consensus objective is firstly defined,assigning the agents'output to different signs and module *** with the completely unknown dynamics of the agents,a novel event-triggered model-free adaptive bipartite control protocol is designed based on the agents'triggered outputs and an equivalent compact form data *** utilizing the Lyapunov analysis method,the threshold of the triggering condition is ***,the asymptotic convergence of the tracking error is deduced and a sufficient condition is obtained based on the contraction mapping ***,the simulation example further demonstrates the effectiveness of the protocol.

关键词： Asymmetric bipartite consensus tracking eventtriggered model-free adaptive control(MFAC) nonlinear systems signed digraph

Copper stimulates the incidence of antibiotic resistance, metal resistance and potential pathogens in the gut of black soldier fly larvae

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Journal of Environmental Sciences 2021年第9期33卷 150-159页

作者： Nan Wu jiaqi liang Xiaobo Wang Shiyu Xie Xiaoyan Xu College of Engineering and Technology Tianjin Agricultural UniversityTianjin 300384China College of Agronomy and Resource and Environment Tianjin Agricultural UniversityTianjin 300384China

The black soldier fly larvae(BSFL) have been successfully applied to treat various organic ***, the impacts of heavy metals on antibiotic resistance in the BSFL guts are poorly ***, we investigated the effect of copper(exposure concentrations of 0, 100 and 800 mg/kg) on the antibiotic and metal resistance profiles in BSFL guts.A total of 83 antibiotic resistance genes(ARGs), 18 mobile genetic elements(MGEs) and 6 metal resistance genes(MRGs) were observed in larval gut *** to Cu remarkably reduced the diversity of ARGs and MGEs, but significantly enhanced the abundances of gut-associated ARGs and *** levels of MRGs copA, czcA and pbrT were dramatically strengthened after Cu exposure as compared with CK(increased by 2.8–13.5 times).Genera Enterococcus acted as the most predominant potential host of multiple ARG, MGE and MRG ***, high exposure to Cu aggravated the enrichment of potential pathogens in BSFL guts, especially for Escherichia, Enterococcus and Salmonella *** mantel test and procrustes analysis revealed that the gut microbial communities could be a key determinant for antibiotic and metal ***, no significant positive links were observed between MGEs and ARGs or MRGs, possibly suggesting that MGEs did not play a crucial role in shaping the ARGs or MRGs in BSFL guts under the stress of *** findings extend our understanding on the impact of heavy metals on the gut-associated antibiotic and metal resistome of BSFL.

关键词： Black soldier fly Gut microbiome Antibiotic resistance Pathogen Heavy metals

An optical glass plane angle measuring system with photoelectric autocollimator

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Nanotechnology and Precision Engineering 2019年第2期2卷 71-76页

作者： Yinguo Huang Yong Yang jiaqi liang Zhengqing Miao Meirong Zhao Yelong Zheng State Key Laboratory of Precision Measuring Technology and Instruments Tianjin University

Optical glass is the most widely used optical *** is necessary to measure its geometric characteristic quickly and reliably to meet the quality of optical glass.A vision measuring system combining photoelectric autocollimation system with high-precision rotary stage is designed to measure the parallelismand angle of optical glass plane.A novel method is proposed to overcome the difficulty ofmeasuring parallelismof optical *** model of parallelism and angle measurement is established and the feasibility is *** image processing algorithm combining Steger algorithm with the least square method is *** uncertainty of angle measurement system for angle measurement is 3.0″.The system can solve the problem of measuring the angle of optical glass with high precision and has important significance for optical system.

关键词： Optical glass Plane angle Parallelism Photoelectric autocollimation system

VSOLassoBag:a variable-selection oriented LASSO bagging algorithm for biomarker discovery in omic-based translational research

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Journal of Genetics and Genomics 2023年第3期50卷 151-162页

作者： jiaqi liang Chaoye Wang Di Zhang Yubin Xie Yanru Zeng Tianqin Li Zhixiang Zuo Jian Ren Qi Zhao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China State Key Laboratory of Biocontrol School of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Department of Coloproctology Surgery Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesGuangdong Institute of GastroenterologyThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510655China Precision Medicine Institute The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510060China Computer Science Department School of Computer ScienceCarnegie Mellon UniversityPittsburghPA 15213United States

Screening biomolecular markers from high-dimensional biological data is one of the long-standing tasks for biomedical translational *** its advantages in both feature shrinkage and biological interpretability,Least Absolute Shrinkage and Selection Operator(LASSO)algorithm is one of the most popular methods for the scenarios of clinical biomarker ***,in practice,applying LASSO on omics-based data with high dimensions and low-sample size may usually result in an excess number of predictive variables,leading to the overfitting of the ***,we present VSOLassoBag,a wrapped LASSO approach by integrating an ensemble learning strategy to help select efficient and stable variables with high confidence from omics-based *** a bagging strategy in combination with a parametric method or inflection point search method,VSOLassoBag can integrate and vote variables generated from multiple LASSO models to determine the optimal *** application of VSOLassoBag on both simulation datasets and real-world datasets shows that the algorithm can effectively identify markers for either case-control binary classification or prognosis *** addition,by comparing with multiple existing algorithms,VSOLassoBag shows a comparable performance under different scenarios while resulting in fewer features than *** summary,VSOLassoBag,which is available at https://***/VSOLassoBag/under the GPL v3 license,provides an alternative strategy for selecting reliable biomarkers from high-dimensional omics *** user’s convenience,we implement VSOLassoBag as an R package that provides multithreading computing configurations.

关键词： Feature selection LASSO bagging algorithm Biomarker discovery Omics data

Two Photosensitive Dermatitis Outbreaks Caused by Cordierites frondosus—Chuxiong Yi Autonomous Prefecture,Yunnan Province,China,2023

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China CDC weekly 2024年第24期6卷 580-584页

作者： Jiaju Zhong Hongshun Zhang Chengmin Yu Jipin Li Yizhe Zhang jiaqi liang Chengye Sun Qunmei Yao National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and PreventionBeijingChina Department of Emergency Medicine The People’s Hospital of Chuxiong Yi Autonomous PrefectureChuxiong CityYunnan ProvinceChina

What is already known about this topic?Cordierites frondosus(***)is a species of toxic mushroom known to induce symptoms of photosensitive *** is added by this report?In the months of May and June 2023,a total of four patients in Chuxiong Yi Autonomous Prefecture,Yunnan Province,were affected by *** poisoning,occurring over two distinct *** condition of two patients deteriorated after they were re-exposed to sunlight on the seventh day following the initial ***,an additional two patients reported experiencing a mild,needle-like sensation on areas of their skin exposed to the sun,recorded on the twelfth day subsequent to the *** are the implications for public health practice?Given that symptoms of photosensitive dermatitis,a potential severe consequence of *** poisoning,can manifest up to a week post-sun exposure,it is advisable to avoid sunlight for a minimum of two weeks following poisoning.

关键词： Prefecture poisoning breaks

Talaketides A-G,linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces *** 41027

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Chinese Journal of Natural Medicines 2024年第11期22卷 1047-1056页

作者： CHEN Chunmei WANG Xueni FANG Wenxuan liang jiaqi CAI Jian YANG Dehua LUO Xiaowei GAO Chenghai YI Xiangxi LIU Yonghong ZHOU Xuefeng CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaSouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Guangxi Zhuang Yao Medicine Center of Engineering and Technology Guangxi University of Chinese MedicineNanning 530200China Guangxi Key Laboratory of Marine Drugs Institute of Marine DrugsGuangxi University of Chinese MedicineNanning 530200China The National Center for Drug Screening Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Seven novel linear polyketides,talaketides A-G(1-7),were isolated from the rice media cultures of the mangrove sed-iment-derived fungus Talaromyces *** *** these,talaketides A-E(1-5)represented unprecedented unsaturated lin-ear polyketides with an epoxy ring *** structures,including absolute configurations of these compounds,were elucidated through detailed analyses of nuclear magnetic resonance(NMR)and high-resolution mass spectrometry(HR-MS)data,as well as elec-tronic custom distributors(ECD)*** the cytotoxicity screening against prostate cancer cell lines,talaketide E(5)demon-strated a dose-dependent inhibitory effect on prostate cancer PC-3 cell lines,with an IC50 value of 14.44 μmol·***,com-pound 5 significantly inhibited the cloning formation of PC-3 cell lines and arrested the cell cycle in S-phase,ultimately inducing *** findings indicate that compound 5 may serve as a promising lead compound for the development of a potential treat-ment for prostate cancer.

关键词： Mangrove sediment-derived fungus Talaromyces sp.Linear polyketides Cytotoxicity Prostate cancer

Mushroom Poisoning Outbreaks -China, 2022

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China CDC weekly 2023年第3期5卷 45-50,I0001-I0005页

作者： Haijiao Li Yizhe Zhang Hongshun Zhang Jing Zhou jiaqi liang Yu Yin Qian He Shaofeng Jiang Yutao Zhang Yuan Yuan Nan Lang Bowen Cheng Mei Wang Chengye Sun National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and PreventionBeijingChina

Mushroom poisoning has become a serious food safety issue in *** the support of the government,over the past decade,China has gradually established a mushroom poisoning prevention and treatment system involving experts in disease prevention and control,clinical diagnosis and treatment,fungal classification,and basic medicine(1–3).

关键词： prevention diagnosis treatment

An integrative profiling of metabolome and transcriptome in the plasma and skeletal muscle following an exercise intervention in diet-induced obese mice

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Journal of Molecular Cell Biology 2023年第3期15卷 18-31页

作者： Shuang Han Qingqian Wu Mengying Wang Miqi Yang Chen Sun jiaqi liang Xiaozhen Guo Zheyu Zhang Jingya Xu Xinyuan Qiu Cen Xie Siyu Chen Yue Gao Zhuo-Xian Meng Department of Pathology and Pathophysiology and Department of Cardiology of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China Department of Geriatrics Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China Key Laboratory of Disease Proteomics of Zhejiang Province Zhejiang University School of MedicineHangzhou 310058China Department of Big Data in Health Science School of Public Health Zhejiang University School of MedicineHangzhou 310003China State Key Laboratory of Natural Medicines and School of Life Science and Technology China Pharmaceutical UniversityNanjing 211198China State Key Laboratory of Drug Research Shanghai Institute of Material MedicalChinese Academy of SciencesShanghai 201203China Department of Biology and Chemistry College of Liberal Arts and SciencesNational University of Defense TechnologyChangsha 410073China

Exercise intervention at the early stage of type 2 diabetes mellitus(T2DM)can aid in the maintenance of blood glucose homeostasis and prevent the development of macrovascular and microvascular ***,the exercise-regulated pathways that prevent the development of T2DM remain largely *** this study,two forms of exercise intervention,treadmill training and voluntary wheel running,were conducted for high-fat diet(HFD)-induced obese *** observed that both forms of exercise intervention alleviated HFD-induced insulin resistance and glucose *** muscle is recognized as the primary site for postprandial glucose uptake and for responsive alteration beyond exercise *** profiling of the plasma and skeletal muscle in Chow,HFD,and HFD-exercise groups revealed robust alterations in metabolic pathways by exercise intervention in both *** analysis identified nine metabolites,including beta-alanine,leucine,valine,and tryptophan,which were reversed by exercise treatment in both the plasma and skeletal *** analysis of gene expression profiles in the skeletal muscle revealed several key pathways involved in the beneficial effects of exercise on metabolic *** addition,integrative transcriptomic and metabolomic analyses uncovered strong correlations between the concentrations of bioactive metabolites and the expression levels of genes involved in energy metabolism,insulin sensitivity,and immune response in the skeletal *** work established two models of exercise intervention in obese mice and provided mechanistic insights into the beneficial effects of exercise intervention on systemic energy homeostasis.

关键词： type 2 diabetes exercise intervention metabolomics transcriptomics

Cascading failures of spatially embedded cyber physical power system under localized attacks

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Cascading failures of spatially embedded cyber physical powe...