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Unraveling the mechanism of action of Shangxia liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan hao liang Yong-Hong Tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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A time and charge measurement board for muon tomography of high-Z materials

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Nuclear Science and Techniques 2017年第3期28卷 104-108页

作者： Shi-Tao Xiang hao liang State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026 China Department of Modern Physics University of Science and Technology of China Hefei 230026 China

In this paper, a versatile time and charge measurement(MQT) board for muon tomography is described in detail. For time measurement, the general-purpose timeto-digital converter(TDC) chip TDC-GP2 is employed,while for charge measurement, digitization plus numerical integration in field programmable gate array is *** tests demonstrate that the total 32 channels of two MQT boards have a time resolution of superior than100 ps, with excellent linearity for time and charge measurement.

关键词： Time and charge measurement Generalpurpose time-to-digital converter (TDC-GP2) Muon tomography

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Three-dimensionally ordered macro-porous Pt/TiO_2 catalyst used for water-gas shift reaction

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Journal of Natural Gas Chemistry 2008年第4期17卷 403-408页

作者： hao liang Yuan Zhang Yuan Liu Department of Catalysis Science and Technology School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

Three-dimensionally ordered macro-porous （3DOM） Pt/TiO2 catalysts were prepared by template and impregnation methods, and the resultant samples were characterized by using TG-DTA, XRD, SEM, TEM, and TPR techniques. The catalytic performance for water-gas shift （WGS） reaction was tested, and the influences of some conditions, such as reduction temperature of catalysts, the amount of Pt loadings and space velocity on catalytic performance were investigated. It was shown that Pt particles were homogeneously dispersed on 3DOM TiO2. The reduction of TiO2 surface was important for the catalytic performance. The activity test results showed that the 3DOM Pt/TiO2 catalysts exhibited very good catalytic performance for WGS reaction even at high space velocity, which was owing to the better mass transfer of 3DOM porous structure besides the high intrinsic activity of Pt/TiO2.

关键词： three-dimensionally ordered macro-porous water-gas shift platinum titania

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Development of Modified 304 Stainless Steel Resistant to Stress Corrosion Cracking in Chloride Environment

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Journal of Iron and Steel Research International 2002年第2期9卷 39-44页

作者： liang Cheng-hao SHIGEO Tsujikawa Dalian University of Technology The University of Tokyo

The influence of water pollution and welding defects on MIC (microbiologically influenced corrosion) was studied. The open circuit potential (OCP) was measured during MIC test. It was found that OCP shifted to a higher level when the system was inoculated with bacteria while the OCP of those samples in water without bacteria was kept at a low level. The OCP decreased dramatically when MIC started in polluted water. Combination of weld defect heat tint, polluted water and adding bacteria causes MIC happen at high rate. Some elements inside the tubercle were analyzed with EDXA. The pits and biofilm were observed with SEM. Microbiological analysis revealed the difference of bacteria between corroded and uncorroded samples.

关键词： stainless steel microbiologically influenced corrosion open circuit potential shift weld

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On Sullivan's Conjecture on Cycles in 4-free and 5-free Digraphs

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Acta Mathematica Sinica,English Series 2013年第1期29卷 53-64页

作者： hao liang Jun Ming XU Department of Mathematics Southwestern University of Finance and Economics School of Mathematical Sciences University of Science and Technology of China Wentsun Wu Key Laboratory of CAS

For a simple digraph G, let β（G） be the size of the smallest subset X E（G） such that G - X has no directed cycles, and let γ（G） be the number of unordered pairs of nonadjacent vertices in G. A digraph G is called k-free if G has no directed cycles of length at most k. This paper proves that β（G） ≤ 0.3819γ（G） if G is a 4-free digraph, and β（G） ≤ 0.2679γ（G） if G is a 5-free digraph. These improve the results of Sullivan in 2008.

关键词： Digraph directed cycle

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Laser-Induced Electron Fresnel Diffraction in Tunneling and Over-Barrier Ionization

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Chinese Physics Letters 2022年第4期39卷 17-21页

作者： Lei Geng hao liang liang-You Peng State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Center of Quantum Matter Beijing 100871China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Beijing Academy of Quantum Information Sciences Beijing 100193China

Photoelectron momentum distribution in strong-field ionization has a variety of structures that reveal the complicated dynamics of this ***,we identified a low-energy interference structure in the case of a super-intense extreme ultraviolet(XUV)laser pulse and attributed it to the laser-induced electron Fresnel *** structure is determined by the laser-induced electron displacement[Geng et ***.A104(2021)L021102].In the present work,we find that the Fresnel diffraction picture also appears in the tunneling and over-barrier regime of ionization by short ***,the electron displacement is now induced by the electric field component of the laser pulse rather than the magnetic field component in the case of the super-intense XUV *** corresponding modifications to our quantum and semiclassical models,we find that the same physical mechanism of the Fresnel diffraction governs the low-energy interference structures along the laser *** results predicted by the two models agree well with the accurate results from the numerical solution to the time-dependent Schr¨odinger equation.

关键词： equation process Fresnel

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Quasi-periodically Forced Logistic Map with Weak Liouvillean Frequency

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2411-2435页

作者： Jin hao liang Lin Lin FU Department of Applied Mathematics Nanjing Forestry UniversityNanjing 210037P.R.China School of Mathematics and Statistics Shaoguan UniversityShaoguan 512005P.R.China

Consider a class of quasi-periodically forced logistic maps T×[0,1]■:(θ,x)→(θ+ω,c(θ)x(1-x))(T=R/Z),whereωis an irrational frequency and c(θ)is a specific bimodal *** prove that under weak Liouvillean condition on frequency,the strange non-chaotic attractor occurs with negative Lyapunov *** extends the result in[Bjerklov,CMP,2009].

关键词： Quasi-periodically forced logistic map strange non-chaotic attractor weak Liouvillean frequency Lyapunov exponent

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Recognition of wood surface defects with near infrared spectroscopy and machine vision

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Journal of Forestry Research 2019年第6期30卷 2379-2386页

作者： Huiling Yu Yuliang liang hao liang Yizhuo Zhang Northeast Forestry University

To improve the accuracy in recognizing defects on wood surfaces,a method fusing near infrared spectroscopy(NIR)and machine vision was *** gmelinii was selected as the raw material,and the experiments focused on the ability of the model to sort defects into four types:live knots,dead knots,pinholes,and *** images were taken using an industrial camera,and a morphological algorithm was applied to locate the position of the defects.A portable near infrared spectrometer(900–1800 nm)collected the spectra of these *** addition,principal component analysis was utilized on these variables from spectral information and principal component vectors were extracted as the inputs of the *** results show that a back propagation neural network model exhibited better discrimination accuracy of 92.7%for the training set and 92.0%for the test *** research reveals that the NIR fusing machine vision is a feasible tool for detecting defects on board surfaces.

关键词： Wood board surface defects Near infrared spectroscopy Machine vision Accuracy of recognition

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Joint Continuity of Lyapunov Exponent for Finitely Smooth Quasi-periodic Schrodinger Cocycles

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Acta Mathematica Sinica,English Series 2021年第7期37卷 1131-1142页

作者： Jin hao liang Lin Lin FU Department of Applied Mathematics Nanjing Forestry UniversityNanjing 210037P.R.China Department of Mathematics Sun Yat-sen UniversityGuangzhou 510275P.R.China

We prove the joint continuity of Lyapunov exponent in the energy and the Diophantine frequency for quasi-periodic Schrodinger cocycles with the C^(2)cos-type *** particular,the Lyapunov exponent is log-Holder continuo... 详细信息

关键词： Schrodinger cocycle Lyapunov exponent C^(2)cos-type potential

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Hierarchical and Distributed Optimal Control Strategy for Power and Power Quality of Microgrid Based on Finite-Time Consistency

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Energy Engineering 2022年第5期119卷 2065-2080页

作者： Wenjun Wei hao liang College of Automation&Electrical Engineering Lanzhou Jiaotong UniversityLanzhou730070China Key Lab of Opt-Electronic Technology and Intelligent Control of Ministry of Education Lanzhou Jiaotong UniversityLanzhou730070China

Droop control is one of the main control strategies of islanded microgrid(MG),but the droop control cannot achieve reasonable power distribution of microgrid,resulting in frequency and voltage deviation from the rating value,which needs the upper control link to eliminate the ***,at present,most layered control requires a centralized control center,which excessively relies on microgrid central controller(MGCC)and real-time communication among distributed generation(DG),which has certain *** solve the above problems,this paper proposes a hierarchical distributed power and power quality optimization strategy based on multi-agent finite time consistency algorithm(MA-FTCA).Firstly,based on the first layer droop control,MA-FTCA is applied to introduce frequency and voltage compensation to stabilize the system frequency and voltage at the rated ***,in the third layer,the MA-FTCA is adopted to estimate the total active power and total reactive power spare capacity of the system,to realize the reasonable distribution of active power and reactive power output of each DG according to its proportion of spare capacity when the system load side *** control strategy proposed in this paper adopts a completely distributed control method and does not need a centralized control center in each layer of ***,MATLAB/Simulink simulation platform is used to verify the correctness and effectiveness of the proposed optimization strategy.

关键词： Microgrid finite time consistency power distribution hierarchical control

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