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Intelligent Modularized Reconfigurable Mechanisms for Robots:Development and Experiment

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Chinese Journal of Mechanical Engineering 2020年第5期33卷 88-100页

作者： Wenfu Xu liang han Xin Wang han Yuan Bin liang School of Mechanical Engineering and Automation Harbin Institute of TechnologyShenzhen 518055China Department of Automation Tsinghua UniversityBeijing 100084China

With the development of intelligent flexible manufacturing,traditional industrial manipulators with a single configuration are difficult to meet a variety of *** robots have developed rapidly which could change their configurations and end effectors for different *** reconfigurable connecting mechanism(RCM)is a core component of reconfigurable *** this paper,two types of intelligent modularized RCMs with light weight,high payload,and large pose(position and attitude)error tolerance are *** is driven by shape memory alloy(SMA)and recovery *** is locked by steel balls and *** other is driven by electromagnetic coil and locked by permanent magnet and *** locking principle,mechanical system and control system of the two RCMs are detailed *** of them meet the requirements of high precision and high payload in the industrial ***,the developed RCMs are respectively integrated to a practical robot and *** experiment results verified the performance of the two RCMs.

关键词： Reconfigurable connecting mechanisms Shape memory alloy Electromagnetic Reconfigurable manipulator

Convergent Usage of Amino Acids in Human Cancers as A Reversed Process of Tissue Development

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 147-162页

作者： Yikai Luo han liang Graduate Program in Quantitative and Computational Biosciences Baylor College of MedicineHoustonTX 77030USA Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Systems Biology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Genome-and transcriptome-wide amino acid usage preference across different species is a well-studied phenomenon in molecular evolution,but its characteristics and implication in cancer evolution and therapy remain largely ***,we analyzed large-scale transcriptome/proteome profiles,such as The Cancer Genome Atlas(TCGA),the Genotype-Tissue Expression(GTEx),and the Clinical Proteomic Tumor Analysis Consortium(CPTAC),and found that compared to normal tissues,different cancer types showed a convergent pattern toward using biosynthetically low-cost amino *** a pattern can be accurately captured by a single index based on the average biosynthetic energy cost of amino acids,termed energy cost per amino acid(ECPA).With this index,we further compared the trends of amino acid usage and the contributing genes in cancer and tissue development,and revealed their reversed ***,focusing on the liver,a tissue with a dramatic increase in ECPA during development,we found that ECPA represents a powerful biomarker that could distinguish liver tumors from normal liver samples consistently across 11 independent patient cohorts and outperforms any index based on single *** study reveals an important principle underlying cancer evolution and suggests the global amino acid usage as a system-level biomarker for cancer diagnosis.

关键词： Amino acid usage Tissue development Biosynthetic energy Diagnostic biomarker

Evolution of blood-brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2306-2325页

作者： liang han Chen Jiang Jiangsu Key Laboratory of Neuropsychiatric Diseases Research College of Pharmaceutical SciencesSoochow UniversitySuzhou 215123China Key Laboratory of Smart Drug Delivery Ministry of EducationState Key Laboratory of Medical NeurobiologyDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 200032China

Bloode-brain barrier(BBB)strictly controls matter exchange between blood and brain,and severely limits brain penetration of systemically administered drugs,resulting in ineffective drug therapy of brain ***,during the onset and progression of brain diseases,BBB alterations evolve *** this review,we focus on nanoscale brain-targeting drug delivery strategies designed based on BBB evolutions and related applications in various brain diseases including Alzheimer’s disease,Parkinson’s disease,epilepsy,stroke,traumatic brain injury and brain *** advances on optimization of small molecules for BBB crossing and non-systemic administration routes(e.g.,intranasal treatment)for BBB bypassing are not included in this review.

关键词： Blood-brain barrier Brain diseases Brain-targeting Drug delivery systems Nanoparticles

Prediction of nonlocal scale parameter for carbon nanotubes

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Science China(Physics,Mechanics & Astronomy) 2012年第9期55卷 1670-1678页

作者： liang YingJing han Qiang Department of Engineering Mechanics School of Civil Engineering and Transportation South China University of Technology Guangzhou 510640 China

Based on the theory of nonlocal elasticity,a nonlocal shell model accounting for the small scale effect is developed for the bending characteristics of CNTs subjected to the concentrated *** this nonlocal shell model,explicit expressions are derived for the bending *** extract the proper values of nonlocal scale parameter,we have made molecular dynamics(MD) simulations for various radii and lengths of armchair and zigzag CNTs,the results of which are matched with those of nonlocal continuum *** is found that the present nonlocal elastic shell model with its appropriate values of nonlocal scale parameter has the capability to predict the bending behavior of CNTs,which is comparable with the results of MD ***,exact closed form solutions for the nonlocal scale parameter for zigzag and armchair CNTs are *** results show that nonlocal scale parameter is independent of the length of CNTs,and dependent on the radius of CNTs.

关键词： nonlocal elasticity nonlocal scale parameter carbon nanotubes nonlocal shell model molecular dynamics simulation

Current status of lymph node dissection in gastric cancer

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Chinese Journal of Cancer Research 2021年第2期33卷 193-202页

作者： Bin Ke han liang Department of Gastric Cancer Tianjin Medical University Cancer Institute and HospitalTianjin Key Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerNational Clinical Research Center for CancerTianjin 300060China

Gastrectomy with lymph node(LN)dissection has been regarded as the standard surgery for gastric cancer(GC),however,the rational extent of lymphadenectomy remains *** gastrectomy with extended lymphadenectomy beyond D2 is classified as a non-standard gastrectomy,its clinical significance has been evaluated in many *** hard evidence is lacking,D2 plus superior mesenteric vein(No.14 v)LN dissection is recommended when harbor metastasis to No.6 nodes is suspected in the lower stomach,and dissection of splenic hilar(No.10)LN can be performed for advanced GC invading the greater curvature of the upper stomach,and D2 plus posterior surface of the pancreatic head(No.13)LN dissection may be an option in a potentially curative gastrectomy for cancer invading the *** D2+para-aortic nodal dissection(PAND)was not routinely recommended for advanced GC patients,but therapeutic D2 plus PAND may offer a chance of cure in selected patients,preoperative chemotherapy was considered as the standard treatment for GC with para-aortic node *** has been no consensus on the extent of lymphadenectomy for the adenocarcinoma of the esophagogastric junction(AEG)so *** length of esophageal invasion can be used as a reference point for mediastinal LN metastases,and the distance from the esophagogastric junction to the distal end of the tumor is essential for determining the optimal extent of *** quality of lymphadenectomy may influence prognosis in GC *** hospital volume and surgeon volume were important factors for the quality of radical *** of GC surgery may be needed to improve prognosis.

关键词： Gastric cancer lymphadenectomy lymph node prognosis

Coherent thermal radiation in thin films and its application in the emissivity design of multilayer films

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Chinese Science Bulletin 2007年第10期52卷 1426-1431页

作者： liang XinGang han MaoHua School of Aerospace Tsinghua University Beijing 100084 China

The infrared transmission spectra of a 0.54-μm-thick Ge film and a 20-μm-thick Si film were experimentally measured. As the incident radiation was in the wavelength range from 1.5 μm to 10 μm, the Ge film demonstrated a strongly spectral coherence. However, thermal radiation of the Ge film was found to be spatially incoherent due to its extreme thinness. The Si film exhibited significantly spectral and spatial coherence. The results confirmed that thermal radiation of a monolayer film could be coherent spectrally and spatially if the film thickness was comparable with the wavelength. The optical characteristic matrix method was applied to calculate the transmission spectra of the Si and Ge film, and the results agreed well with the measurements. This method was further used to analyze two multilayer films composed of five low emissive layers. Their emissivities were found to be highly emissive at a certain zenith angle, and the emissive peak could be controlled by careful selection of film thickness.

关键词：多层膜发射率设计薄膜相干热辐射 Ge Si

Square-mean Almost Automorphic Solutions to Some Stochastic Evolution Equations I: Autonomous Case

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Acta Mathematicae Applicatae Sinica 2015年第3期31卷 577-590页

作者： Xi-liang LI Yu-liang han Bai-feng LIU School of Mathematics and Information Science Shandong Institute of Business and Technology

This paper concerns the square-mean almost automorphic solutions to a class of abstract semilinear functional integro-differential stochastic evolution equations in real separable Hilbert spaces. Under some suitable assumptions, the existence, uniqueness and asymptotic stability of the square-mean almost automorphic mild solution to some stochastic differential equations are established. As an application, we analyze the almost automorphic mild solution to some stochastic partial functional differential equation which turns out to be in good agreement with our abstract results.

关键词： square-mean almost automorphy integro-differential equations stochastic evolution equations.

Quadrature-free spline method for two-dimensional Navier-Stokes equation

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Applied Mathematics(A Journal of Chinese Universities) 2008年第1期23卷 31-42页

作者： HU Xian-liang han Dan-fu Dept. of Math. Zhejiang Univ. Hangzhou 310027 China.

In this paper, a quadrature-free scheme of spline method for two-dimensional Navier- Stokes equation is derived, which can dramatically improve the efficiency of spline method for fluid problems proposed by Lai and Wenston（2004）. Additionally, the explicit formulation for boundary condition with up to second order derivatives is presented. The numerical simulations on several benchmark problems show that the scheme is very efficient.

关键词： quadrature-free spline method Navier-Stokes equation.

Water-enhanced plastic deformation in felsic rocks

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Science China Earth Sciences 2013年第2期56卷 203-216页

作者： han liang ZHOU YongSheng HE ChangRong State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake Administration State Key Laboratory for Continental Tectonics and Dynamics Institute of GeologyChinese Academy of Geological Sciences

Using Fourier transform infrared spectroscopy(FTIR),we measured water contents in quartz and feldspar for four kinds of felsic rocks,i.e.,undeformed granite,banded granitic gneiss,fine-grained felsic mylonite,and fine-grained quartz-mica schist,collected from Pengguan Complex and Kangding Complex in the Longmenshan tectonic zone,Sichuan,*** absorbance spectra suggest that water in coarse-grained quartz and feldspar of undeformed granite and banded granitic gneiss occurs mainly as hydroxyl in crystal defects,and water in most of fine-grained quartz and feldspar of felsic mylonite is molecular water in inclusions and liquid-type water in grain boundaries,but in some cases it still occurs as hydroxyl in crystal *** content of quartz in undeformed granite is 0.001 wt%-0.009 wt %,and that of feldspar 0.005 wt%-0.02 wt%.The banded granitic gneiss shows water contents of 0.002 wt%-0.011 wt% in quartz and 0.012 wt%-0.036 wt% in *** ribbon and feldspar ribbon in fine-grained felsic mylonite show that their water contents are similar to those of coarse-grained quartz and feldspar in granite,0.002 wt%-0.011 wt%,and 0.004 wt%-0.02 wt%,*** contents of fine-grained quartz and feldspar are respectively 0.004 wt%-0.02 wt% and 0.012 wt%-0.06 wt%.Water content of quartz in fine-grained quartz-mica schist is 0.007 wt%-0.15 wt%.Water-bearing minerals display much higher water contents than those of nominally anhydrous minerals,and the percentage of water-bearing minerals in felsic rocks increases with the strain of *** new data indicate that hydroxyl in crystal defects has basically not been released during the shear deformation,and on the contrary,the increase in molecular water in inclusions and liquid-type water in grain boundaries as well as water-bearing minerals after shear deformation leads to a significant increase of the water content in deformed *** on data of creep tests,it is inferred here that the fine-grained mylo

关键词： Fourier transform infrared spectrum hydroxyl in crystal defects inclusions water grain boundaries water creep strength ductile shear zone