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Serum HIF-1α and VEGF Levels Pre-and Post-TACE in Patients with Primary Liver Cancer

Chinese Medical Sciences Journal 2011年第3期26卷 158-162页

作者： Zhong-zhi Jia Guo-min Jiang yao-liang Feng Department of Interventional Radiography Changzhou Second People＇s Hospital Affiliated to Nanjing Medical UniversityChangzhou 213003China Department of Interventional Radiography First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

Objective To investigate the expression levels of serum hypoxia inducible factor 1 alpha(HIF-1α) and vascular endothelial growth factor(VEGF) pre-and post-transcatheter arterial chemoembolization(TACE) in patients with primary liver cancer(PLC),and correlations between prognosis factors and serum HIF-1α as well as VEGF *** Forty consecutive patients fulfilling diagnostic criteria for PLC undergoing TACE from March 2008 to May 2009 were enrolled into the *** serum HIF-1α and VEGF levels of PLC patients pre-and 1 day,1 week,1 month post-TACE were analyzed using ELISA,and compared with that of 20 healthy *** were divided into complete response(CR) and partial response(PR),stable disease(SD),progressive disease(PD) groups according to the therapeutic *** correlation was used to analyze the correlation between different clinical variables and serum HIF-1α and VEGF levels before TACE,and correlation between serum HIF-1α and VEGF levels was also *** The expression levels of serum HIF-1α and VEGF in PLC patients were 154.94±83.29 and 264.00±148.10 pg/mL pre-TACE,and both of them were significantly higher than those in control group(23.84±8.15 and 69.78±21.42 pg/mL,all P<0.01).One day after TACE,both serum HIF-1α(570.64± 230.87 pg/mL) and VEGF levels(362.07±102.25 pg/mL) reached the peak values(all P<0.01).One week post-TACE,expression levels of them were decreased(198.62±92.11 and 283.52±145.46 pg/mL respectively),but still significantly higher than those before TACE(all P<0.01).The levels of both HIF-1α(133.96±57.02 vs.255.74±123.44 pg/mL) and VEGF(150.96±84.89 vs.368.95±161.90 pg/mL) in CR group 1 month post-TACE were significantly lower than those in PR+SD+PD group(all P<0.01).The level of serum HIF-1α was positively correlated with serum VEGF level(r=0.42,P<0.001).Both serum HIF-1α and VEGF levels were observed to be correlated with portal vein tumor thrombi(P<0.05) and metastasis(P<0.05).

关键词： liver neoplasms transcatheter arterial chemoembolization hypoxia induciblefactor 1 alpha vascular endothelial growth factor

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Stabilization of high-voltage layered oxide cathode by utilizing residual lithium to form NASICON-type nanoscale functional coating

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Nano Research 2023年第4期16卷 5973-5982页

作者： Yabin Shen Yingqiang Wu Dongyu Zhang yao liang Dongming Yin Limin Wang Licheng Wang Jingchao Cao Yong Cheng State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of China(USTC)Hefei 230026China College of Physics Science and Technology Yangzhou UniversityYangzhou 225002China Changsha Research Institute of Mining and Metallurgy Co. LtdChangsha 410012China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China

High-voltage medium-nickel low-cobalt lithium layered oxide cathode materials are becoming a popular development route for high-energy lithium-ion batteries due to their relatively high capacity,low cost,and improved ***,capacity fading derived from surface lithium residue,electrode-electrolyte interfacial side reactions,and bulk structure degradation severely limits large-scale commercial *** this work,an ultrathin and uniform NASICON-type Li_(3)V_(2)(PO_(4))_(3)(LVP)nanoscale functional coating is formed in situ by utilizing residual lithium to enhance the lithium storage performance of LiNi_(0.6)Co0.05Mn_(0.35)O_(2)(NCM)*** GITT and ex-situ EIS and XPS demonstrate exceptional Li+diffusion and conductivity and attenuated interfacial side reactions,improving the electrode-electrolyte interface *** variable temperature in-situ XRD demonstrates delayed phase transition temperature to improve thermal *** battery in-situ XRD displays the singlephase H1-H2 reaction and weakened harmful H3 phase transition,minimizing the bulk mechanical *** improvements are attributed to the removal of surface residual lithium and the formation of NASICON-type Li_(3)V_(2)(PO_(4))_(3)functional coatings with stable structure and high ionic and electronic ***,the obtained NCM@LVP delivers a higher capacity retention rate(97.1%vs.79.6%)after 150 cycles and a superior rate capacity(87 mAh·g^(-1)vs.58 mAh·g^(-1))at a 5 C current density than the pristine NCM under a high cut-off voltage of 4.5 *** work suggests a clever way to utilize residual lithium to form functional coatings in situ to improve the lithium storage performance of high-voltage medium-nickel low-cobalt cathode materials.

关键词： lithium-ion battery high-voltage medium-nickel low-cobalt cathode surface modification residual lithium NASICON-type Li3V2(PO4)3

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Combination of artificial zeolite and microbial fertilizer to improve mining soils in an arid area of Inner Mongolia,China

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Journal of Arid Land 2023年第9期15卷 1067-1083页

作者： LI Wenye ZHANG Jianfeng SONG Shuangshuang liang yao SUN Baoping WU Yi MAO Xiao LIN Yachao School of Soil and Water Conservation Beijing Forestry UniversityBeijing 100083China China ENFI Engineering Co. Ltd.Beijing 100038China PIESAT Information Technology Co. Ltd.Beijing 100195China Key Laboratory of Deep-Earth Dynamics of Ministry of Natural Resources Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China Shanxi Dadi Minji Ecological Environment Co. Ltd.Beijing BranchBeijing 100083China Bureau of Agriculture and Rural Affairs Wangcheng DistrictChangsha 410211China

Restoration of mining soils is important to the vegetation and *** study aimed to explore the variations in soil nutrient contents,microbial abundance,and biomass under different gradients of substrate amendments in mining soils to select effective *** samples were collected from the Bayan Obo mining region in Inner Mongolia Autonomous Region,*** of soil organic matter(SOM),available nitrogen(AN),available phosphorus(AP),available potassium(AK),microbial biomass carbon/microbial biomass nitrogen(MBC/MBN)ratio,biomass,and bacteria,fungi,and actinomycetes abundance were assessed in Agropyron cristatum ***.,Elymus dahuricus Turcz.,and Medicago sativa *** with artificial zeolite(AZ)and microbial fertilizer(MF)applied at T0(0 g/kg),T1(5 g/kg),T2(10 g/kg),and T3(20 g/kg).Redundancy analysis(RDA)and technique for order preference by similarity to ideal solution(TOPSIS)were used to identify the main factors controlling the variation of *** showed that chemical indices and microbial content of restored soils were far greater than those of *** application of AZ significantly increases SOM,AN,and AP by 20.27%,23.61%,and 40.43%,*** significantly increased bacteria,fungi,and actinomycetes abundance by 0.63,3.12,and 1.93 times of control,*** indicated that AN,MBC/MBN ratio,and SOM were dominant predictors for biomass across samples with AZ application,explaining 87.6%of the biomass ***,MBC/MBN ratio,and AK were dominant predictors with MF application,explaining 82.9%of the biomass *** indicated that T2 was the best dosage and the three plant species could all be used to repair mining *** and MF application at T2 concentration in the mining soils with *** was found to be the most appropriate measure.

关键词： amendment arid area mining soils restoration soil nutrition

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Temperature-dependent Raman spectroscopy studies of 1-5-layer WSe2

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Nano Research 2020年第2期13卷 591-595页

作者： Zhonglin Li Yingying Wang Jie Jiang yao liang Bo Zhong Hong Zhang Kai Yu Guangfeng Kan Mingqiang Zou Department of Optoelectronic Science Harbin Institute of Technology at WeihaiWeihai 264209China School of Marine Science and Techmology Harbin Institute of Technology at WeihaiWeihai 264209China School of Materials Science and Engineering Dalian Jiaotong University Dalian 116028China School of Materials Science and Engineering Harbin Institute of Technology at WeihaiWeihai 264209China Chinese Academy of Inspection and Quarantine(CAIQ) No.A3Gaobeidian RoadChaoyang DistrictBeijing 100123China

In this work,Raman measurements of 1-5-layer WSe2 supported on SiO2/Si in the temperature range of 133 to 533 K are reported.A physical model including both volume effect and temperature effect is used to quantitatively understand the nonlinear temperature dependence of E2g^1Raman *** is found this nonlinear dependence of Raman mode mainly originates from thermal expansion effect and three-phonon *** former effect increases with an increase in number of layers,which is inverse for the latter *** temperature-dependent thermal expansion coefficients of 1-5-layer WSe2 are also obtained from Raman *** full width at half maximum(FWHM)of E;g mode is also systematically studied both experimentally and theoretically in the temperature range of 133 to 413 *** is found that the increase in FWHM of E2g^1 mode originates from decaying of E2g^1 *** work will promote the understanding of anharmonic behaviors of phonons in WSe2 flakes with different thicknesses.

关键词： WSe2 thermal expansion coefficients temperature-dependent Raman spectroscopy

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Survey for late-onset hypogonadism among old anti middle-aged males in Shanghai communities

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Asian Journal of Andrology 2012年第2期14卷 338-340页

作者： Kai Sun GuoTQing liang Xiang-Feng Chen Ping Ping Wen-liang yao Shi-Jun Zhang Bo Wang Ying-Hao Sun Zheng Li Department of Urology Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200127China Department of Urology Shanghai Hospital of TCMShanghai 200071China Family Planning Research Institute of Shanghai City Shanghai 200032China Department of Urology Shanghai HospitalSecond Medicinal Military University of PLAChinaShanghai 200433China

This study sought to investigate late-onset hypogonadism （LOH） in old and middle-aged males in Shanghai communities, using symptom score evaluation systems and measurements of sex hormone levels. One thousand cases of males aged 40-70 years were investigated. The aging male symptoms （AMS） scale and androgen deficiency in aging males （ADAM） questionnaire were used at the beginning of the investigation, followed by measurement of the sex hormone-related factors （total testosterone （TT）, free testosterone （fT）, sex hormone-binding globulin （SHBG） and bioavailability of testosterone （Bio-T））. There were 977 valid questionnaires. The LOH-positive rates shown by AMS and ADAM were 59.88% and 84.65%, respectively; values increased with the age of the patients. There were 946 results related to sex hormone measurements, which showed the following results： TT was not related to aging （P〉O.05）; levels of SHBG increased with age; and fT and Bio-T decreased with age. There was a significant difference in fT between LOH-positive and LOH-negative patients, as shown by the ADAM. In summary, TT levels were not related to aging, even though SHBG did increase while fT and Bio-T decreased with aging. Clinically, the diagnosis of LOH cannot be based on serum TT level.

关键词： ADAM AMS late-onset of hypogonadism male aging old and middle-aged males survey

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Therapeutic strategy for traumatic instability of subaxial cervical spine

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Chinese Medical Journal 2008年第15期121卷 1364-1368页

作者： CAO Peng liang Yu GONG yao-cheng ZHENG Tao ZHANG Xin-kai WU Wen-jian Department of Orthopaedics Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai Institute of Traumatology and Orthopaedics Shanghai 200025 China

Background A simple, safe and effective therapeutic strategy for traumatic instability of the subaxial cervical spine, as well as its prognostic assessment, is still controversial. Methods The therapeutic options for 83 patients of traumatic instability of the subaxial cervical spine, whose average age was 35 years, were determined, according to the Allen-Ferguson classification, general health and concomitant traumatic conditions, neurological function, position of compression materials, concomitant traumatic disc herniation/damage, concomitant locked-facet dislocation, the involved numbers and position, and the patients＇ economic conditions. An anterior, posterior or combination approach was used to decompress and reconstruct the cervical spine. No operations with an anterior-posterior-anterior approach were performed. Results The average follow-up was three years and nine months. Distraction-flexion and compression-flexion were the most frequent injury subtypes. There were 46, 28 and 9 cases of anterior, posterior and combination operations, respectively. The average score of the Japanese Orthopaedics Association, visual analog scale and American Spinal Cord Injury Association （ASIA） motor index improved from 11.2, 7.8 and 53.5, respectively, before operation, to 15.3, 2.6 and 67.8, respectively, at final follow-up. For incomplete spinal cord injury （SCI）, the average ASIA neurological function scale was improved by 1-2 levels. Patients with complete SCI had no neurological recovery, but recovery of nerve root function occurred to different extents. After surgery, radiological parameters improved to different extents. Fusion was achieved in all patients and 12 developed complications. Conclusions The best surgical strategy should be determined by the type of subaxial cervical injury, patients＇ general health, local pathological anatomy and neurological function.

关键词： cervical instability disease classification surgical strategy

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航天器用钾热管传热性能的敏感性分析和优化

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航天器工程 2024年第2期33卷 48-54页

作者：韩冶张亚坤柴宝华王泽鸣牟玉鹏刘剑术姚良李小斌李凤臣中国原子能科学研究院北京102413 天津大学机械工程学院天津300350 天津大学先进内燃动力全国重点实验室天津300350

碱金属热管在空间核电源系统中具有重要应用,是航天器辐射散热器的重要组件。文章研究钾热管对充液率、吸液芯层数、吸液芯丝网目数及热负载功率的敏感性,并对上述多参数耦合下钾热管传热性能进行优化。分析结果表明:钾热管温差随充液... 详细信息

碱金属热管在空间核电源系统中具有重要应用,是航天器辐射散热器的重要组件。文章研究钾热管对充液率、吸液芯层数、吸液芯丝网目数及热负载功率的敏感性,并对上述多参数耦合下钾热管传热性能进行优化。分析结果表明:钾热管温差随充液率和吸液芯丝网目数的增加而降低,随吸液芯层数和热负载功率的增加而升高,且钾热管的整体温度和蒸气流速随热负载功率的增加分别升高和降低。钾热管性能对吸液芯层数和热负载功率敏感,优化得到最优参数组合为充液率1.0时7层350目吸液芯和712.475 W的热负载功率。文章采用的分析和优化方法对热管式辐射散热器的工程应用设计具有工程参考价值。

关键词：航天器用钾热管敏感性分析传热性能性能优化

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变温下暗期LED光照对丝棉木金星尺蛾生命活动节律的影响

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昆虫学报 2024年第8期67卷 1106-1114页

作者：程禹朦龚慧蓉罗园霞朱地福梁嘉瑶周舒昱邹可豪涂小云江西师范大学生命科学学院南昌330022

【目的】探明变温下暗期给予不同LED光源对丝棉木金星尺蛾Calospilos suspecta化蛹、羽化、交配、产卵和卵孵化活动节律的影响。【方法】在实验室条件下以光周期14L∶10D为对照组,以暗期分别给予10 h红色LED和10 h黄色LED 2种不同光源... 详细信息

【目的】探明变温下暗期给予不同LED光源对丝棉木金星尺蛾Calospilos suspecta化蛹、羽化、交配、产卵和卵孵化活动节律的影响。【方法】在实验室条件下以光周期14L∶10D为对照组,以暗期分别给予10 h红色LED和10 h黄色LED 2种不同光源照射为处理组(分别记为14L∶10R和14L∶10Y),分别对丝棉木金星尺蛾的化蛹、羽化、交配、产卵和卵孵化进行连续5 d的观察,每小时观察1次,计算化蛹率、羽化率、交配率、产卵率和卵孵化率,并比较这些参数在不同试验组间光期或暗期差异以及各组内光期与暗期间的差异。【结果】红色和黄色LED光照射下丝棉木金星尺蛾化蛹不具明显的节律性,14L∶10D组和14L∶10Y组的化蛹主要发生在光期,化蛹高峰分别在7:00-8:00和18:00-19:00;14L∶10R组主要在暗期化蛹,化蛹高峰在22:00-23:00;但暗期不同LED光处理对平均单时段化蛹率无显著影响。红色和黄色LED光照射下羽化节律亦不明显,14L∶10D组和14L∶10R组的雌雄成虫羽化主要发生在光期,14L∶10Y组雌雄成虫的羽化主要发生在暗期;14L∶10D组和14L∶10R组羽化高峰均在光期开启的第1-2小时;暗期LED光处理显著影响雌成虫平均单时段羽化率,且14L∶10D组光期雌成虫平均单时段羽化率显著高于暗期;暗期两个LED光处理对雄成虫平均单时段羽化率影响不显著。交配行为具有明显的节律性,各组交配行为均主要发生在暗期,交配高峰在光期开启前的1-2 h(4:00-6:00);14L∶10D组和14L∶10Y组暗期平均单时段交配率显著高于光期。产卵亦具有明显的节律性,14L∶10D组和14L∶10R组产卵高峰及4L∶10Y组产卵次高峰均发生在暗期20:00-21:00, 14L∶10Y组产卵高峰在16:00-17:00;暗期不同LED光处理对平均单时段产卵率均无显著影响。卵孵化具有明显的节律性,各组孵化高峰均在光期开始的第1小时;暗期不同LED光处理对平均单时段卵孵化率影响均不显著。【结论】红色和黄色LED处理下,丝棉木金星尺蛾化蛹和羽化不具明显的节律性,而交配、产卵及卵孵化具有明显的节律性,表明丝棉木金星尺蛾有的生命活动节律性受暗期LED光照影响,并因LED光色不同而异。

关键词：丝棉木金星尺蛾 LED光照生命活动昼夜节律光期暗期

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2021—2022年虾类偷死野田村病毒(CMNV)流行情况调查

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渔业科学进展 2024年第5期45卷 195-203页

作者：赵文秀万晓媛夏继涛姚亮徐瑞东王伟余星潼张庆利中国水产科学研究院黄海水产研究所、青岛海洋科技中心海洋渔业科学与食物产出过程功能实验室、农业农村部海水养殖病害防治重点实验室、青岛市海水养殖流行病学与生物安保重点实验室山东青岛266071 水产科学国家级实验教学示范中心、上海海洋大学上海201306

由偷死野田村病毒(covert mortality nodavirus,CMNV)引起的虾类病毒性偷死病(viral covert mortality disease,VCMD)使对虾养殖产业遭受了严重的损失。为掌握近年CMNV在我国主要养殖虾类中的流行情况,本研究2021—2022年间在全国主要... 详细信息

由偷死野田村病毒(covert mortality nodavirus,CMNV)引起的虾类病毒性偷死病(viral covert mortality disease,VCMD)使对虾养殖产业遭受了严重的损失。为掌握近年CMNV在我国主要养殖虾类中的流行情况,本研究2021—2022年间在全国主要虾类养殖地区开展了CMNV流行病学调查和样品采集工作,利用分子生物学、组织病理学和电镜分析等方法对所采集的样品进行了系统分析。期间,从天津、山东、江苏、海南、湖北及新疆等地共采集1299份样品,样品种类包括凡纳对虾(Penaeus vannamei)、罗氏沼虾(Macrobrachium rosenbergii)、日本对虾(***)、中国对虾(***)和克氏原螯虾(Procambarus clarkia)等主要养殖虾类以及养殖池塘中的共生生物。采用TaqMan探针实时荧光定量PCR(TaqMan RT-qPCR)对所采集的样品进行CMNV检测,结果表明,凡纳对虾、罗氏沼虾和日本对虾等主要养殖虾类中均可检测到CMNV阳性,阳性样品采集地包括山东、江苏、海南、新疆、广西和天津等省市;除养殖虾类外,采集的虾类鲜活饵料以及虾类养殖池塘共生生物包括沙蚕(Perinereis aibuhitensis)和卤虫(Artemia sinica)中也可检测到CMNV阳性。2021年和2022年所采集样品中CMNV阳性检出率分别为10.04%(69/687)和11.44%(70/612)。流行病学调查发现,室外池塘养殖对虾中CMNV感染会引起一定程度的累计死亡,室内养殖对虾中CMNV感染主要引起对虾甲壳软化和生长缓慢,通常不会导致其大量死亡。对TaqMan RT-qPCR检测呈阳性的样品进行组织病理和原位杂交分析,患病虾肝胰腺和前中肠盲囊组织中可见嗜酸性病毒包涵体,附肢神经可见空泡化病理损伤,这些发生病理损伤的组织中均有明显CMNV RNA探针紫色杂交信号。本研究结果表明,我国多地养殖虾类以及养殖池塘共生生物中仍存在较高的CMNV阳性检出率,该病毒的流行危害风险仍然较高。建议在甲壳类养殖过程中加强CMNV检测与监测预警,进一步降低其扩散和流行的风险。

关键词：对虾病毒性偷死病(VCMD) 偷死野田村病毒(CMNV) TaqMan探针实时荧光定量流行病学

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单宁酸对红色和绿色豌豆蚜酶活性的影响

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草原与草坪 2024年第3期44卷 217-223页

作者：梁瑶吴宜亭马瑞魏江文姚路刘磊宋丽雯王森山甘肃农业大学植物保护学院甘肃省农作物病虫害生物防治工程实验室甘肃兰州730070

【目的】明确单宁酸对红色和绿色豌豆蚜酶活性的影响。【方法】设不同浓度单宁酸(1 mg/L、3 mg/L、5 mg/L)分别饲喂两种色型的5 d龄豌豆蚜,处理不同时间后测定豌豆蚜体内超氧化物歧化酶(SOD)、过氧化物酶(POD)、羧酸酯酶(CarE)及细胞色... 详细信息

【目的】明确单宁酸对红色和绿色豌豆蚜酶活性的影响。【方法】设不同浓度单宁酸(1 mg/L、3 mg/L、5 mg/L)分别饲喂两种色型的5 d龄豌豆蚜,处理不同时间后测定豌豆蚜体内超氧化物歧化酶(SOD)、过氧化物酶(POD)、羧酸酯酶(CarE)及细胞色素P450s酶(CYP450)活性。【结果】豌豆蚜取食不同浓度单宁酸后,体内4种酶的响应程度不同。红色型豌豆蚜CarE与CYP450酶活性均在24 h处理的单宁酸浓度为3 mg/L时达最大值,分别为(0.029±0.002)μmol/(μg·min)和(0.006±0.0009)μmol/(μg·min),和对照间差异显著(P<0.05);绿色型豌豆蚜SOD与POD酶活性均在72 h处理的单宁酸浓度为3 mg/L时最高,分别达(0.028±0.004)μg/mg和(1.679±0.172)μg/(mg·min),和单宁酸浓度为5 mg/L的处理间差异显著(P<0.05)。【结论】红色和绿色豌豆蚜取食不同浓度单宁酸后,体内SOD、POD、CarE和CYP450酶活性均有不同程度的影响;相同处理时间,同种酶的活性在红绿色型豌豆蚜内的升高或降低程度不同;同种色型豌豆蚜取食不同浓度单宁酸后,体内不同酶的活性变化不同。

关键词：豌豆蚜超氧化物歧化酶过氧化物酶羧酸酯酶

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