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Identification of two compound heterozygous GNRHR mutations in two siblings with congenital hypogonadotropic hypogonadism

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Asian Journal of Andrology 2024年第1期26卷 120-122页

作者： Xiao-Bin Wang Ping Chen Xue-Er Yu Zu-liang yao Ting-Chao Guo Bo-Chen Pan Center for Reproductive Medicine Department of Obstetrics and GynecologyShengjing Hospital of China Medical UniversityShenyang 110004China NuProbe Shanghai 200433China Urology Surgery of The Affiliated Reproductive Hospital of China Medical University and Liaoning Key Laboratory of Reproductive Health Liaoning Research Institute of Family Planning(The Affiliated Reproductive Hospital of China Medical University)Shenyang 110031China NHC Key Laboratory of Reproductive Health and Medical Genetics China Medical UniversityShenyang 110122China

DearEditor,Congenital hypogonadotropic hypogonadism(CHH)is a rare genetic disease characterized by gonadotropin-releasing hormone(GnRH)deficiency or insufficiency and normal hypothalamic-pituitary structures,resulting in defective sexual maturation or/and infertility.!CHH presents as a variety of nonreproductive phenotypes,such as renal hypoplasia,dental hypoplasia,or oculomotor abnormalities.

关键词： pogon compound ism

Bearing mechanism of roof and rib support structure in automatically formed roadway and its support design method

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Journal of Central South University 2024年第7期31卷 2467-2487页

作者： JIANG Bei WANG Ming-zi WANG Qi XIN Zhong-xin XING Xue-yang DENG Yu-song yao liang-di State Key Laboratory for Tunnel Engineering China University of Mining and Technology-BeijingBeijing 100083China Research Center of Geotechnical and Structural Engineering Shandong UniversityJi􀆳nan 250061China College of Civil Engineering and Architecture Shandong University of AeronauticsBinzhou 256600China

Non-pillar mining technology with automatically formed roadway is a new mining method without coal pillar reservation and roadway *** stability control of automatically formed roadway is the key to the successful application of the new *** order to realize the stability control of the roadway surrounding rock,the mechanical model of the roof and rib support structure is established,and the influence mechanism of the automatically formed roadway parameters on the compound force is *** this basis,the roof and rib support structure technology of confined lightweight concrete is proposed,and its mechanical tests under different eccentricity are carried *** results show that the bearing capacity of confined lightweight concrete specimens is basically the same as that of ordinary confined concrete *** bearing capacity of confined lightweight concrete specimens under different eccentricities is 1.95 times higher than those of U-shaped steel *** comparing the test results with the theoretical calculated results of the confined concrete,the calculation method of the bearing capacity for the confined lightweight concrete structure is *** design method of confined lightweight concrete support structure is established,and is successfully applied in the extra-large mine,Ningtiaota Coal Mine,China.

关键词： automatically roadway with non-pillar confined lightweight concrete roof and rib support mechanical model bearing behaviour

Medcheck:A novel software for automated de-formulation of traditional Chinese medicine(TCM)prescriptions by liquid chromatography-mass spectrometry

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Journal of Pharmaceutical Analysis 2024年第6期14卷 930-932页

作者： Xiao-lan Li Jian-qing Zhang Yun Li Xuan-jing Shen Huan-ya Yang Lin Yang Meng Xu Qi-rui Bi Chang-liang yao De-an Guo Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Research Center of TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China b University of Chinese Academy of Sciences Beijing100049China

Prescriptions are the main clinical application of traditional Chinese medicines(TCMs).Common forms include Chinese patent medicines,Kampo formulas,and hospital decoctions.A new pre-scription called“famous classical formulas”is recently developed and expected to boom in the *** constituent me-dicinal plants in prescriptions is critical for new drug development and quality control[1],which could avoid safety issues from adulteration or substandard ingredients,as seen in the notorious Longdan Xiegan Pill event.

关键词： medicines formulation prescription

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质心动能定理在转动问题中不适用吗

物理教学 2024年第5期46卷 53-53,52页

作者：姚亮合肥市第一中学安徽230601

文章用转动定律解释了在转动系统中用质心动能定理的常见错误,证明了质心动能定理在转动过程中的适用。

关键词：转动定律质点系动能定理质心动能定理

Correlation function and the inverse problem in the BD interaction

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Chinese Physics C 2024年第5期48卷 117-123页

作者：李海鹏义景宇肖褚文姚德良梁伟红 Eulogio Oset Department of Physics Guangxi Normal UniversityGuilin 541004China School of Physics and Electronics Hunan UniversityChangsha 410082China Guangxi Key Laboratory of Nuclear Physics and Technology Guangxi Normal UniversityGuilin 541004China School of Physics Central South UniversityChangsha 410083China Departamento de Física Teórica and IFIC Centro Mixto Universidad de Valencia-CSIC Institutos de Investigación de PaternaAptdo.2208546071 ValenciaSpain

We study the correlation functions of the B0D+,B+D0 system,which develops a bound state of approximately 40MeV,using inputs consistent with the Tcc(3875)***,we address the inverse problem starting from these correlation functions to determine the scattering observables related to the system,including the existence of the bound state and its molecular *** important output of the approach is the uncertainty with which these observables can be obtained,considering errors in the B0D+,B+D0 correlation functions typical of current values in correlation *** find that it is possible to obtain scattering lengths and effective ranges with relatively high precision and the existence of a bound *** the pole position is obtained with errors of the order of 50%of the binding energy,the molecular probability of the state is obtained with a very small error of the order of 6%.All these findings serve as motivation to perform such measurements in future runs of high energy hadron collisions.

关键词： meson-meson interaction correlation function BD system scattering observables

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上市房企购地行为与企业资本市场表现

清华大学学报（自然科学版） 2024年第2期64卷 181-188页

作者：陈子潇梁尧刘洪玉清华大学建设管理系北京100084

研究上市房企购地行为与其资本市场表现的关系,有助于上市房企进行市值管理以及资本市场投资者评价、选择上市企业。该文以中国A股上市房企为研究对象,通过回归分析研究房企在2009—2021年间购地数和进入城市数等购地行为对企业投资价... 详细信息

研究上市房企购地行为与其资本市场表现的关系,有助于上市房企进行市值管理以及资本市场投资者评价、选择上市企业。该文以中国A股上市房企为研究对象,通过回归分析研究房企在2009—2021年间购地数和进入城市数等购地行为对企业投资价值和风险的影响。研究结果表明:整个研究期间,上市房企投资价值与进入城市数之间存在倒U形关系,一定范围内企业投资价值随着进入城市数的增多而提高;在2017年以来的市场下行期,进入城市数对房企投资价值的提高效果降低,同时对房企风险的提高效果增大,表明资本市场对房企区域扩张型购地的反应发生了变化;购地数对房企资本市场表现的影响不及进入城市数显著;非国有、小型或上市时长较短房企的资本市场表现受其购地行为的影响更显著。建议房企关注资本市场的反馈并及时调整购地策略;资本市场投资者关注区域深耕型房企;政府要重视市场结构变化,从关注房企投资需求向关注最终空间使用需求的方向转变。

关键词：上市房企购地行为资本市场表现企业投资价值企业风险

氮掺杂生物炭负载CuS活化过硫酸盐去除橙黄G

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中国环境科学 2024年第5期44卷 2483-2494页

作者：陈思良孙雯洪耀良苏州科技大学环境科学与工程学院江苏苏州215009 江苏省水处理技术与材料协同创新中心江苏苏州215009 江苏省分离净化材料与技术工程研究中心江苏苏州215009

以小麦秸秆和尿素为原料,通过热解-共沉淀法制备氮掺杂生物炭负载CuS的复合材料(CuS@NBC),采用X射线衍射仪(XRD)、傅里叶变换红外光谱仪(FT-IR)、扫描电子显微镜(SEM)、全自动比表面及孔隙率分析仪(BET)等手段对CuS@NBC的理化性质进行分... 详细信息

以小麦秸秆和尿素为原料,通过热解-共沉淀法制备氮掺杂生物炭负载CuS的复合材料(CuS@NBC),采用X射线衍射仪(XRD)、傅里叶变换红外光谱仪(FT-IR)、扫描电子显微镜(SEM)、全自动比表面及孔隙率分析仪(BET)等手段对CuS@NBC的理化性质进行分析,并将其用于活化过二硫酸盐(PDS)以降解水中的偶氮染料橙黄G(OG),探究PDS浓度、CuS@NBC浓度和初始pH值等反应条件对OG去除效果的影响,以及CuS@NBC的循环利用性能.结果表明,在OG浓度为50mg/L,CuS@NBC浓度为0.2g/L,PDS浓度为4mmol/L时,OG的去除率和矿化率分别为99.16%和36.79%;在初始pH值为5~9范围内OG具有良好的去除效果;CuS@NBC在循环使用5次后,OG的去除率仍有75.92%.通过自由基淬灭实验和电子顺磁共振(EPR)光谱测试结果表明CuS@NBC/PDS体系中主要活性氧为O_(2)·^(-)和^(1)O_(2).X射线光电子能谱仪(XPS)分析结果表明,CuS@NBC表面的Cu^(+)、C=O、-COOH和石墨氮是活化PDS的主要活性位点.离子共存实验表明,Cl^(-)对OG的去除具有促进作用,NO_(3)^(-)对OG的去除几乎没有影响,而HCO_(3)^(-)和HA对OG的去除具有显著的抑制作用.此外,结合实验结果提出CuS@NBC/PDS体系可能的活化机制.

关键词：生物炭氮掺杂 CuS 橙黄G 过二硫酸盐

地方文化融入高校思政工作的价值功能、现实困境与实践理路——以亳文化为例

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宿州学院学报 2024年第7期39卷 12-16页

作者：姚亮亳州学院经济与管理系安徽亳州236800

亳文化特征鲜明,资源丰富,具有多维育人价值和功能。高校思政工作是帮助大学生塑造正确价值观的重要路径,要立足地方文化,挖掘内容,汲取养分,努力破解地方文化输入与思政工作体系耦合度低、融入路径堵塞、教师文化育人能力欠缺、育人评... 详细信息

亳文化特征鲜明,资源丰富,具有多维育人价值和功能。高校思政工作是帮助大学生塑造正确价值观的重要路径,要立足地方文化,挖掘内容,汲取养分,努力破解地方文化输入与思政工作体系耦合度低、融入路径堵塞、教师文化育人能力欠缺、育人评价机制不完善等现实困境。按照大学生价值观的生成逻辑:“注意—体验—情感—态度—价值观”,创新地方文化融入高校思政工作实践理路,促使高校育人工作提质增效,将立德树人根本任务落实落稳,为中华民族伟大复兴提供人才支撑。

关键词：地方文化思政工作实践理路亳文化

变电站改造关键技术及模拟断路器制作方式研究

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自动化应用 2024年第10期65卷 104-106,109页

作者：梁耀山西华阳集团新能股份有限公司供电运维管理中心山西阳泉045000

以某35 kV/10 kV变电站为分析对象,通过采用负荷临时转接、小电流接地装置故障选线方法、电流互感器极性校验、单相接地故障选线算法、主变方向闭锁保护以及距离校验方法,改善传统变电站运行中的不足。研究表明,变电站在负荷转接中可以... 详细信息

以某35 kV/10 kV变电站为分析对象,通过采用负荷临时转接、小电流接地装置故障选线方法、电流互感器极性校验、单相接地故障选线算法、主变方向闭锁保护以及距离校验方法,改善传统变电站运行中的不足。研究表明,变电站在负荷转接中可以采用临时开闭所,故障选线分析可以运用故障限流谐波算法或故障电流基波选线算法。

关键词：变电站改造技术负荷转接小电流接地选线模拟断路器