检索结果-南通市图书馆

维普期刊数据库博看期刊

Multi-institutional retrospective analysis of FOLFIRI in patients with advanced biliary tract cancers

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2020年第1期12卷 83-91页

作者： Jonathan D Mizrahi Valerie Gunchick Kabir Mody lianchun xiao Phanikeerthi Surapaneni Rachna T Shroff Vaibhav Sahai Division of Cancer Medicine The University of Texas MD Anderson Cancer CenterHoustonTX 77005United States Department of Internal Medicine University of MichiganAnn ArborMI 48109United States Division of Medical Oncology Mayo Clinic Cancer CenterJacksonvilleFL 32224United States University of Arizona Cancer Center University of ArizonaTucsonAZ 85724United States

BACKGROUND Gemcitabine plus platinum is the standard of care first-line treatment for advanced biliary tract cancers(BTC).There is no established second-line therapy,and retrospective reviews report median progression-free survival(PFS)less than 3 mo on second-line therapy.5-Fluorouracil plus irinotecan(FOLFIRI)is a commonly used regimen in patients with BTC who have progressed on gemcitabine plus platinum,though there is a paucity of data regarding its efficacy in this *** To assess the efficacy of FOLFIRI in patients with biliary tract *** We retrospectively identified patients with advanced BTC who were treated with FOLFIRI at MD Anderson,University of Michigan and Mayo Clinic in *** were collected on patient demographics,BTC subtype,response per RECIST v1.1,progression and *** Ninety-eight patients were included of which 74(75%)had metastatic and 24(25%)had locally advanced disease at the time of treatment with *** median age was 60(range,22-86)*** number of patients with extrahepatic cholangiocarcinoma,gall bladder cancer and intrahepatic cholangiocarcinoma were 10,17 and 71,*** was used as 1st,2nd,3rd or 4th–Nth lines in 8,50,36 and 4 patients,*** duration on FOLFIRI in the entire cohort was 2.2(range,0.5-8.4)*** median PFS and overall survival were 2.4(95%confidence interval(CI):1.7-3.1)and 6.6(95%CI:4.7-8.4)mo,*** PFS for patients treated with FOLFIRI in 1st,2nd,3rd or 4th–Nth lines were 3.1,2.5,2.3 and 1.5 mo,*** patients received concurrent bevacizumab(n=13)or EGFR-targeted therapy(n=5)with FOLFIRI,with a median PFS of 2.7 mo(95%CI:1.7-5.1).CONCLUSION In this largest multi-institution retrospective review of 98 patients with BTC treated with FOLFIRI,efficacy appears to be modest with outcomes similar to other cytotoxic chemotherapy regimens.

关键词： Biliary tract neoplasms Fluorouracil Irinotecan Cholangiocarcinoma Retrospective studies

公共数据和企业数据估值与定价模式研究——基于数据产品交易价格计算器的贵州实践探索

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

价格理论与实践 2023年第8期 44-50页

作者：潘伟杰肖连春詹睿叶玉婷贵州省数据流通交易服务中心贵阳大数据交易所普华永道

开展数据估值与定价,健全数据交易平台报价、询价、竞价和定价机制,探索数据价格机制改革,是数据要素市场建设的前沿课题。本文从《中共中央国务院关于构建数据基础制度更好发挥数据要素作用的意见》和《“十四五”数字经济发展规划》出... 详细信息

开展数据估值与定价,健全数据交易平台报价、询价、竞价和定价机制,探索数据价格机制改革,是数据要素市场建设的前沿课题。本文从《中共中央国务院关于构建数据基础制度更好发挥数据要素作用的意见》和《“十四五”数字经济发展规划》出发,全面梳理了贵阳大数据交易所开展公共数据和企业数据估值定价的思路和实践成果,系统总结提炼了贵州推动数据价格机制改革的经验。通过案例分析和经验总结发现,破解数据定价难题的贵州模式,通过定价工具研发和重点行业试点——“技术+市场”双轮驱动,走出了适应产业发展周期的“成本法为基—收益法过渡—市场法校验”数据定价路径,形成了“七个先行”的数据估值定价贵州模式,对全国数据要素市场建设、各级数据交易场所建设具有重要借鉴意义。

关键词：数据定价成本法价格计算器公共数据

HAG方案联合地西他滨治疗骨髓增生异常综合征患者的近、远期疗效观察

在线全文

学校读者我要写书评

暂无评论

中国煤炭工业医学杂志 2022年第1期25卷 77-81页

作者：岳雪王浩凌肖莲春吴旭刘易其四川省西昌市人民医院血液内科 615000

目的观察HAG方案联合地西他滨治疗骨髓增生异常综合征患者的近、远期疗效。方法 2016年3月—2019年3月该院治疗的93例骨髓增生异常综合征患者,根据治疗方案不同分为对照组48例(HAG方案),观察组45例(HAG方案+地西他滨)。二组均治疗1个月... 详细信息

目的观察HAG方案联合地西他滨治疗骨髓增生异常综合征患者的近、远期疗效。方法 2016年3月—2019年3月该院治疗的93例骨髓增生异常综合征患者,根据治疗方案不同分为对照组48例(HAG方案),观察组45例(HAG方案+地西他滨)。二组均治疗1个月,比较二组近、远期疗效,观察毒副反应总发生率及中性粒细胞恢复时间、肺部感染率。结果观察组治疗总有效率高于对照组(80.00%vs.50.00%)(P<0.05)。二组毒副反应总发生率比较差异有统计学意义(13.33%vs.35.42%)(P<0.05)。观察组中性粒细胞恢复时间均短于对照组,观察组肺部感染发生率低于对照组(4.44%vs.18.75%)(P<0.05)。观察组PFS、OS均长于对照组,2年病死率低于对照组(8.89%vs.27.08%)(P<0.05)。结论 HAG方案联合地西他滨治疗骨髓增生异常综合征患者能提高近、远期疗效,且安全性高。

关键词： HAG方案地西他滨骨髓增生异常综合征近期疗效远期疗效

A Possible Abrupt Change in Summer Precipitation over Eastern China around 2009

在线全文

学校读者我要写书评

暂无评论

Journal of Meteorological Research 2017年第2期31卷 397-408页

作者： Yongjian REN lianchun SONG Zunya WANG Ying xiao Bing ZHOU College of Atmospheric Science Nanjing University of Information Science & Technology National Climate Center China Meteorological Administration Hubei Key Laboratory for Heavy Rain Monitoring and Warning Research Institute of Heavy RainChina Meteorological Administration

Historical studies have shown that summer rainfall in eastern China undergoes decadal variations,with three apparent changes in the late 1970s,1992,and the late *** present observational study indicates that summer precipitation over eastern China likely underwent a change in the late 2000s,during which the main spatial pattern changed from negative–positive–negative to positive–negative in the meridional *** change in summer precipitation over eastern China may have been associated with circulation anomalies in the middle/upper troposphere.A strong trough over Lake Baikal created a southward flow of cold air during 2009–15,compared with 1999–2008,while the westward recession of the western Pacific subtropical high strengthened the moisture transport to the north,creating conditions that were conducive for more rainfall in the north during this *** phase shift of the Pacific Decadal Oscillation in the late 2000s led to the Pacific–Japan-type teleconnection wave train shifting from negative to positive phases,resulting in varied summer precipitation over eastern China.

关键词： eastern China summer precipitation interdecadal change Pacific–Japan-type teleconnection

Tropical cyclone hazards analysis based on tropical cyclone potential impact index

在线全文

学校读者我要写书评

暂无评论

Journal of Geographical Sciences 2011年第5期21卷 791-800页

作者： xiao Fengjin YIN Yizhou LUO Yong SONG lianchun YE Dianxiu Beijing Climate Center Beijing 100081 China Institute of Atmospheric Physics CAS Beijing 100029 China

Tropical cyclone,a high energy destructive meteorological system with heavy rainfall and gale triggered massive landslides and windstorms,poses a significant threat to coastal *** this paper we have developed a Tropical Cyclone Potential Impact Index （TCPI） based on the air mass trajectories,disaster information,intensity,duration,and frequency of tropical *** analyzed the spatial pattern and interannual variation of the TCPI over the period 1949-2009,and taking the Super Typhoon Saomai as an example have examined the relationship between the TCPI and direct economic losses,total rainfall,and maximum wind *** results reveal that China＇s TCPI appears to be a weak decreasing trend over the period,which is not significant overall,but significant in some *** the past 20 years,the TCPI decreased in the southern China coastal provinces of Hainan,Guangdong and Guangxi,while it increased in the southeastern coastal provinces of Zhejiang,Fujian and *** highest values of TCPI are mainly observed in Taiwan,Hainan,the coastal areas of Guangdong and Fujian and Zhejiang＇s southern *** TCPI has a good correlation （P=0.01） with direct economic loss,rainfall,and maximum wind speed.

关键词： tropical cyclone potential impact index temporal and spatial variation direct economic losses Typhoon Saomai

Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2019年第6期64卷 370-373页

作者： Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui xiao Cheng Xueli Shi Fengjin xiao Qiufeng Liu lianchun Song Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System Science Tsinghua University AI for Earth Lab Cross-Strait Institute Tsinghua University Department of Environmental Science Policy and Management University of CaliforniaBerkeley State Key Laboratory of Remote Sensing Science Institute of Remote Sensing and Digital Earth Chinese Academy of Sciences Google LLC Institute of Electronics Chinese Academy of Sciences United States Geological Survey National Supercomputing Center in Wuxi Department of Landscape Architecture University of CaliforniaBerkeley State Key Laboratory of Remote Sensing Science College of Global Change and Earth System Science Beijing Normal University National Climate Center China Meteorological Administration

As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations.

关键词： the world strives to reduce timely and higher resolution information is urgently needed

在线全文

学校读者我要写书评

暂无评论

我国现代气候业务现状及未来发展趋势

应用气象学报 2013年第5期24卷 513-520页

作者：宋连春肖风劲李威国家气候中心北京100081

从气候监测诊断、气候预测、气候系统模式、气候评价与灾害风险管理、气候变化业务和气候业务平台等角度,系统概述了我国现代气候业务现状。提出了以气候监测和动力学诊断为基础,以提升气候服务、气候风险管理和应对气候变化能力为目标... 详细信息

从气候监测诊断、气候预测、气候系统模式、气候评价与灾害风险管理、气候变化业务和气候业务平台等角度,系统概述了我国现代气候业务现状。提出了以气候监测和动力学诊断为基础,以提升气候服务、气候风险管理和应对气候变化能力为目标,以发展客观化气候预测技术和定量化气候评估方法为核心的现代气候业务概念。分析了国际气候业务发展趋势及我国气候业务的差距,明确了加强气候系统基本变量监测、提高气候系统模式分辨率和改进物理过程、发展第2代短期气候预测系统、研发气象灾害风险评估方法并建立中国气候服务系统(CFCS)等发展任务。

关键词：现代气候业务发展趋势气候服务客观化定量化

1880—2010年中国东部夏季降水年代际变化特征

在线全文

学校读者我要写书评

暂无评论

大气科学学报 2016年第4期39卷 445-454页

作者：任永建宋连春肖莺南京信息工程大学大气科学学院江苏南京210044 中国气象局国家气候中心北京100081 武汉区域气候中心湖北武汉430074

利用1880—2010年中国东部66站夏季降水数据,开展夏季长序列降水的年代际变化特征研究。结果表明,中国东部夏季降水年代际变化特征显著,华北、江淮和华南地区存在明显的差异。经验正交分解结果表明,偶极型("-+"和"+-")和三极型("+-+"和"... 详细信息

利用1880—2010年中国东部66站夏季降水数据,开展夏季长序列降水的年代际变化特征研究。结果表明,中国东部夏季降水年代际变化特征显著,华北、江淮和华南地区存在明显的差异。经验正交分解结果表明,偶极型("-+"和"+-")和三极型("+-+"和"-+-")分布是中国东部夏季的两种主要降水模态。夏季500 h Pa高度场年代际分量与同期太平洋SST典型相关分析(BP-CCA)得出,太平洋年代际振荡(PDO,Pacific Decadal Oscillation)正位相可以激发出负的PJ型遥相关波列,导致长江中下游地区降水偏多,华北降水偏少;反之亦然。同时,通过滑动相关分析发现,中国东部不同区域的夏季降水对PDO不同位相的响应特征存在差异。

关键词：年代际变化夏季降水中国东部太平洋年代际振荡

在线全文

学校读者我要写书评

暂无评论

基于极性词典的中文微博客情感分类

计算机应用与软件 2014年第1期31卷 34-37,126页

作者：王勇吕学强姬连春肖诗斌北京信息科技大学网络文化与数字传播北京市重点实验室北京100101 新华网络股份有限公司北京100101

微博客是近年来自然语言处理领域研究的热点。主要针对中文微博客中的情感分类展开研究。结合网络新词和基础情感词,同时考虑了情感词的极性情感强弱,构建四个词典,分别是基础情感词典、表情符号词典、否定词词典和双重否定词词典;在情... 详细信息

微博客是近年来自然语言处理领域研究的热点。主要针对中文微博客中的情感分类展开研究。结合网络新词和基础情感词,同时考虑了情感词的极性情感强弱,构建四个词典,分别是基础情感词典、表情符号词典、否定词词典和双重否定词词典;在情感词典的基础上,融合汉语语言学特征和微博情感表达特征,提出一种新的基于极性词典的情感分类方法。实验准确率达到82.2%。实验结果表明,提出的方法可以对中文微博进行较好的情感分类,有一定的应用价值。

关键词：微博客情感分类词典语言学特征