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Nano Research 2023年第1期16卷 999-1008页

作者： Yixiao Li Shaohua Qu Yumeng Xue lianbing zhang Li Shang School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China Northwestern Polytechnical University Chongqing Technology Innovation Center Chongqing 400000China

A thorough understanding of antimicrobial mechanism is of great importance for developing novel,efficient antibacterial *** cationic nanoparticles,such as metal nanoclusters(NCs),represent an attractive type of antibacterial nanoagents,their interactions with bacteria remains largely ***,we report the synthesis of cationic bovine serum albuminprotected AuAgNCs(cBSA-AuAgNCs),which exhibit both near-infrared(NIR)fluorescence properties and significant antimicrobial *** *** and *** as the representative bacteria,we investigated the antimicrobial process of cBSAAuAgNCs in real-time based on their intrinsic fluorescence properties via fluorescence *** results showed that these cBSA-AuAgNCs exert their antimicrobial effects primarily by attaching on the outer membrane of bacteria without obvious internalization,which is significantly different from the antibacterial process of negatively-charged metal *** mechanistic investigation showed that these cationic NCs will cause serious disruption to the bacterial membrane due to strong electrostatic interactions,which then leads to over accumulation of reactive oxygen species(ROS)that finally causes the bactericidal *** study demonstrates the great potential of cationic luminescent metal NCs as novel,traceable antimicrobial agents,which also provides new tools for further understanding microbial interactions of nanomedicines.

关键词： metal nanoclusters antimicrobial agents bacterial imaging near-infrared fluorescence

Self-assembled fluorescent tripeptide nanoparticles for bioimaging and drug delivery applications

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Chinese Chemical Letters 2020年第12期31卷 3195-3199页

作者： Dongjie Fu Dingchang Liu lianbing zhang Leming Sun School of life Sciences Key Laboratory of Space Bioscience&BiotechnologyNorthwestern Polytechnical UniversityXi'an 710072China

Peptide self-assembled nanomaterials have attracted more and more attention due to their wide applications such as drug delive ry,cell imaging,and real-time drug ***,the application of the peptide is still limited by its inherent optical *** we proposed and prepared a series of fluorescent tripeptide nanoparticles(TPNPs)through π-π stacking and zinc *** experimental results show that the nanoparticles(TPNPs1)formed by the self-assembly of the tripeptide tryptophan-tryptophan-tryptophan have the highest fluorescence intensity,uniform and appropriate size,and low ***,there was fluorescence resonance between TPNPs1 and doxorubicin,which has been successfully applied for real-time cell imaging and drug release monitoring.

关键词： Self-assembly Tripeptide Fluorescent nanoparticles Bioimaging Doxorubicin Drug delivery

Detection of amyloid-beta by Fmoc-KLVFF self-assembled fluorescent nanoparticles for Alzheimer’s disease diagnosis

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Chinese Chemical Letters 2021年第3期32卷 1066-1070页

作者： Dingchang Liu Dongjie Fu lianbing zhang Leming Sun School of Life Sciences Key Laboratory of Space Bioscience&BiotechnologyNorthwestern Polytechnical UniversityXi’an 710072China

The abnormal aggregation of amyloid-beta(Aβ)has been widely believed to play an important role in the pathogenesis of Alz heimer’s disease(AD),which is also recognized as one of the main biomarkers for AD *** peptide sequence Lys-Leu-Val-Phe-Phe(KLVFF)is considered as the main driver of the fibrillation of Aβ,which also can be utilized to target Aβand inhibit its *** this study,KLVFF and Fmoc-KLVFF fluorescent nanoparticles were self-assembled through zinc coordination andπ-π*** recognition of Aβaggregates including oligomers and fibrils by fluorescent nanoparticles can be realized through aromatic,hydrophobic,and hydrogen-bond *** fluorescent nanoprobes can distinguish Aβaggregation formats and detect Aβat the limit of 1 pg/mL(S/N=3).Hence,the detection of Aβaggregates by fluorescent peptide nanoparticles has great potential for AD diagnosis and progression prediction.

关键词： Self-assembly Fmoc-KLVFF Fluorescent nanoparticles Amyloid-beta Alzheimer’s disease Diagnosis

Recent Advances of Persistent Luminescence Nanoparticles in Bioapplications

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Nano-Micro Letters 2020年第6期12卷 1-26页

作者： Shuqi Wu Yang Li Weihang Ding Letong Xu Yuan Ma lianbing zhang School of Life Sciences Key Laboratory of Space Bioscience and BiotechnologyNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

Persistent luminescence phosphors are a novel group of promising luminescent materials with afterglow properties after the stoppage of *** the past decade,persistent luminescence nanoparticles(PLNPs)with intriguing optical properties have attracted a wide range of attention in various *** in recent years,the development and applications in biomedical fields have been widely *** to the efficient elimination of the autofluorescence interferences from biotissues and the ultra-long near-infrared afterglow emission,many researches have focused on the manipulation of PLNPs in biosensing,cell tracking,bioimaging and cancer *** achievements stimulated the growing interest in designing new types of PLNPs with desired superior characteristics and multiple *** this review,we summarize the works on synthesis methods,bioapplications,biomembrane modification and biosafety of PLNPs and highlight the recent advances in biosensing,imaging and imaging-guided *** further discuss the new types of PLNPs as a newly emerged class of functional biomaterials for multiple ***,the remaining problems and challenges are discussed with suggestions and prospects for potential future directions in the biomedical applications.

关键词： Persistent luminescence nanoparticles Biosensing Bioimaging Cell tracking Cancer therapy

Kinetically regulated one-pot synthesis of cationic gold nanoparticles and their size-dependent antibacterial mechanism

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Journal of Materials Science & Technology 2023年第31期162卷 145-156页

作者： Chenqiang Shen Yumeng Xue Yixiao Li Mengying Wei Mengyao Wen lianbing zhang Li Shang State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene(NPU)Xi’an 710072China NPU-QMUL Joint Research Institute of Advanced Materials and Structures(JRI-AMAS) Northwestern Polytechnical UniversityXi’an 710072China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China

Cationic gold nanoparticles(cAuNPs)have been regarded as promising candidates for antibacterial applications due to their high surface charge density,favorable biocompatibility,and controllable surface ***,the complicated fabrication process and unclear antibacterial mechanism have greatly hindered the further biomedical application of ***,we have developed a simple and controllable strategy for synthesizing cAuNPs with tailored size and antibacterial behavior by kinetically modulating the reaction ***,a functional ligand,(11-mercaptoundecyl)-N,N,Ntrimethylammonium bromide(MUTAB),was chosen to chemically manipulate the positive surface charge of cAuNPs via a one-step *** size of cAuNPs could be flexibly adjusted from 1.1 to 14.8 nm by simply elevating the stirring speed of the reaction from 0 to 1500 *** studies revealed that the antibacterial effect of cAuNPs was strongly correlated with the particle ***-protected ultrasmall gold nanoclusters(MUTAB-AuNCs)were able to eradicate *** at a concentration as low as 1.25μg mL^(-1),while the minimum inhibitory concentration of MUTAB-AuNPs with a large size for *** was 5μg mL^(-1).Mechanistic investigation revealed that MUTAB-AuNPs were able to damage the bacterial membrane and stimulate the production of reactive oxygen species more effectively than ***,MUTAB-AuNCs were more active in inducing membrane depolarization in contrast to MUTAB-AuNPs,suggesting the unique size-dependent antibacterial manner of *** study presents a new strategy for the controlled preparation of cAuNPs with distinct sizes and antibacterial behavior,laying a valuable foundation for developing efficient cationic NP-based bactericidal agents.

关键词： Gold nanoparticles Size effect Antibacterial mechanism Reactive oxygen species Positive charge

Design of active and stable catalysts by embedding nitrogen-doped carbon oxygen reduction reaction CoxOy nanoparticles into

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Nano Research 2017年第1期10卷 97-107页

作者： Fan Yang Mikel Abadia Chaoqiu Chen Weike Wang Le Li lianbing zhang Celia Rogero Andrey Chuvilin Mato Knez CIC nanoGUNE Consofider Tolosa Hifibidea 76 20018 Donostia-San Sebastian Spain Centro de Fisica de Materials CFM/MPC (CSIC-UPV/EHU) Paseo Manuel de Lardizabal 5 20018 Donostia-San Sebastian Spain School of Life Sciences Northwestern Polytechnical University Xi'an 710072 China Donostia International Physics Center (DIPC) Paseo Manuel de Lardizabal 4 20018 Donostia-San Sebastian Spain IKERBASQUE Basque Foundation for Science Maria Diaz de Haro 3 48013 Bilbao Spain

The oxygen reduction reaction （ORR） is essential in research pertaining to life science and energy. In applications, platinum-based catalysts give ideal reactivity, but, in practice, are often subject to high costs and poor stability. Some costefficient transition metal oxides have exhibited excellent ORR reactivity, but the stability and durability of such alternative catalyst materials pose serious challenges. Here, we present a facile method to fabricate uniform CoxOy nanoparticles and embed them into N-doped carbon, which results in a composite of extraordinary stability and durability, while maintaining its high reactivity. The half-wave potential shows a negative shift of only 21 mV after 10,000 cycles, only one third of that observed for Pt/C （63 mV）. Furthermore, after 100,000 s testing at a constant potential, the current decreases by only 17%, significantly less than for Pt/C （35%）. The exceptional stability and durability results from the system architecture, which comprises a thin carbon shell that prevents agglomeration of the CoxOy nanoparticles and their detaching from the substrate.

关键词： atomic layer deposition cobalt oxide polydopamine oxygen reduction reaction

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邻近铁路营运线工程施工综合控制技术

石家庄铁路职业技术学院学报 2007年第3期6卷 50-55页

作者：张连冰中铁十四局集团有限公司山东济南250014

在营运线旁进行新增铁路施工,由于邻近营运线所以具有高风险,施工控制必须严格,其施工技术有其特殊性。结合江西省某铁路专用线的引入段工程施工实例,对营运线傍宽路基填筑、接长涵洞砌筑、轨道人工铺轨、无缝线路施工及道岔铺设等施工... 详细信息

在营运线旁进行新增铁路施工,由于邻近营运线所以具有高风险,施工控制必须严格,其施工技术有其特殊性。结合江西省某铁路专用线的引入段工程施工实例,对营运线傍宽路基填筑、接长涵洞砌筑、轨道人工铺轨、无缝线路施工及道岔铺设等施工中的质量、安全控制技术进行总结与研讨,以形成系统的综合控制技术,供同行在类似施工中参考。

关键词：营运线施工控制技术安全控制

1.2MW变速恒频直接驱动型风力发电机组技术

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中国水利 2003年第18期 44-45,49页

作者：张连兵新疆金风科技股份有限公司

现代风力发电机组技术的大规模应用是从失速型风力机技术成熟与完善开始的.20世纪70年代末,由丹麦发展起来的三叶片、上风向、定桨矩失速调节的风力机机型从众多类型的风力机中脱颖而出,逐步发展为主导机型.但随着风力机单机容量的不断... 详细信息

现代风力发电机组技术的大规模应用是从失速型风力机技术成熟与完善开始的.20世纪70年代末,由丹麦发展起来的三叶片、上风向、定桨矩失速调节的风力机机型从众多类型的风力机中脱颖而出,逐步发展为主导机型.但随着风力机单机容量的不断增大,变速恒频变桨矩形风力机逐渐占据了主导地位.

关键词：风力发电机组变速恒频风力机叶片 MW 驱动型

高空大跨钢结构连廊深化设计与整体提升技术研究

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铁道建筑技术 2022年第3期 91-94,159页

作者：张连冰中铁建大湾区建设有限公司广东广州511455

结合清华珠三角研究院粤港澳大湾区创新基地项目两塔楼间的高空大跨钢结构连廊的施工,针对施工场地狭小、钢结构连廊自重与几何尺寸较大、安装施工难度大的特点,分析了钢结构连廊深化设计、安装、提升的重难点及采取的深化设计措施;阐... 详细信息

结合清华珠三角研究院粤港澳大湾区创新基地项目两塔楼间的高空大跨钢结构连廊的施工,针对施工场地狭小、钢结构连廊自重与几何尺寸较大、安装施工难度大的特点,分析了钢结构连廊深化设计、安装、提升的重难点及采取的深化设计措施;阐述了钢结构连廊的安装流程、整体提升工艺以及安装、提升关键技术。实践表明:经深化设计的钢结构连廊,现场采用原位拼装、整体液压同步提升技术,避免了高空中拼装、焊接和防腐防火涂料涂装等施工安全隐患,保证了施工质量、工期,可为类似项目提供参考。

关键词：大跨度钢结构连廊深化设计整体提升高空

基于技术管理创新实现钢铁企业系统降本的实践探索

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山西冶金 2022年第1期45卷 173-175,181页

作者：张联兵张存旺首钢长治钢铁有限公司山西长治046031

为建立和完善铁前一体化、钢后一体化协同工作体制机制,牢牢牵住降本这个牛鼻子,通过采取多方降本措施,并利用技术手段消化生产不利因素,以降低铁成本为龙头,各工序齐使劲,使得各工序在降低成本上取得较好效果,实现了效益最大化。

关键词：降成本一体化技术创新