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Scoping review on vector-borne diseases in urban areas:transmission dynamics,vectorial capacity and co-infection

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Infectious Diseases of Poverty 2018年第1期7卷 916-939页

作者： Marcus Eder Fanny Cortes Noemia Teixeira de Siqueira Filha Giovanny Vinicius araujo de Franca Stephanie degroote Cynthia Braga Valery Ridde Celina maria Turchi Martelli Public Health England Sierra Leone Country Office FreetownSierra Leone Aggeu Magalhaes Institute(IAM)/Oswaldo Cruz Foundation(Fiocruz) Avenida Professor Moraes Regos/n.Cidade Universitaria.CEP 50RecifePernambuco 740-465Brazil Universidade de Pernambuco(UPE) RecifePernambucoBrazil Liverpool School Of Tropical Medicine(LSTM) LondonUK Secretariat of Health Surveillance Ministry of HealthBrasiliaBrazil University of Montreal School of Public Health(ESPUM) MontrealQuebecCanada IRD(French Institute For Research on Sustainable development) CEPED(IRD-UniversiteParis Descartes)Universites Paris Sorbonne CitesERL INSERM SAGESUDParisFrance

Background:Transmission dynamics,vectorial capacity,and co-infections have substantial impacts on vector-borne diseases(VBDs)affecting urban and suburban *** key factors can provide insight into priority research areas and offer suggestions for potential *** body:Through a scoping review,we identify knowledge gaps on transmission dynamics,vectorial capacity,and co-infections regarding VBDs in urban ***-reviewed and grey literature published between 2000 and 2016 was *** screened abstracts and full texts to select *** an extraction grid,we retrieved general data,results,lessons learned and recommendations,future research avenues,and practice *** classified studies by VBD and country/continent and identified relevant knowledge *** 773 articles selected for full-text screening,50 were included in the review:23 based on research in the Americas,15 in Asia,10 in Africa,and one each in Europe and *** largest body of evidence concerning VBD epidemiology in urban areas concerned dengue and *** arboviruses covered included chikungunya and West Nile virus,other parasitic diseases such as leishmaniasis and trypanosomiasis,and bacterial rickettsiosis and *** articles retrieved in our review combined transmission dynamics and vectorial capacity;only two combined transmission dynamics and *** review identified significant knowledge gaps on the role of asymptomatic individuals,the effects of co-infection and other host factors,and the impacts of climatic,environmental,and socioeconomic factors on VBD transmission in urban *** included the trade-off from narrowing the search strategy(missing out on classical modelling studies),a lack of studies on co-infections,most studies being only descriptive,and few offering concrete public health *** research is needed on transmission risk in homes and workplaces,given increasingly dynamic and mobil

关键词： Arboviruses Disease vectors Coinfection Urban population Epidemiology Review

Secreted protein acidic and rich in cysteine(SPARC)induces epithelial-mesenchymal transition,enhancing migration and invasion,and is associated with high Gleason score in prostate cancer

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Asian Journal of Andrology 2019年第6期21卷 557-564页

作者： Fernanda Lopez-Moncada maria Jose torres Enrique A Castellon Hector R Contreras department of Basic and Clinic Oncology Faculty of Medic泊eUniversity of ChileSantiago 8389100Chile

Secreted protein acidic and rich in cysteine(SPARC)is a matricellular protein highly expressed in bone tissue that acts as achemoattractant factor promoting the arrival of prostate cancer(PCa)cells to the bone ***,the contribution of SPARCduring the early stages of tumor progression remains *** this study,we show that SPARC is highly expressed in PCa tissueswith a higher Gleason *** stable knockdown and overexpression of SPARC in PC3 and LNCaP cells,respectively,here wedem on strate that en doge nous SPARC induces the epithelial-mesenchymal tran sition(EMT),decreasing E-cadheri n and cytokeratin18 and increasing N-cadheri n and vime ***,SPARC in duces the expression of EMT regulatory tran scription factors Snailfamily transcriptional repressor 1(Snail),Snail family transcriptional repressor 2(Slug),and zinc finger E-box binding homeobox 1(Zeb1).In addition,SPARC knockdown in PC3 cells decreases migration and invasion in vitro,without modifying cell *** results indicate that SPARC might facilitate tumor progression by modifying the cellular phenotype in cancer cells.

关键词： epithelial-mesenchymal transition invasion migration prostate cancer secreted protein acidic and rich in cysteine(SPARC)

Short-term complementary and alternative medicine on quality of life in women with fibromyalgia

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Journal of Integrative Medicine 2016年第1期14卷 29-35页

作者： Paulo araujo Dias Andre Brito Bastos Guimaraes Andrea de Oliveira Albuquerque Karoline Lucas de Oliveira maria Luzete Costa Cavalcante Sergio Botelho Guimaraes Faculty of Medicine Department of SurgeryFederal University of Ceara60430-140FortalezaBrazil Faculty of Pharmacy Dentistry and NursingFederal University of Ceara60430-160FortalezaBrazil

BACKGROUND： Fibromyalgia （FMS） is a syndrome characterized by chronic widespread musculoskeletal pain, whose etiology is not completely understood. Different therapeutic approaches have been used with inconsistent results. This observation does not invalidate the continued search for alternative treatments aimed at improving quality of life （QoL） in FMS. OBJECTIVE： This study compared three classica acupuncture （AC）, electroacupuncture （EAC） and promotion of QoL in FMS patients. traditional Chinese medicine （TCM） therapies： moxibustion （MX） in the management of pain and deSIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： A preliminary, group-assigned, comparative study enrolled 30 women, mean age （46.90_＋9.24） years （range 20-60 years）, who met the 1990 American College of Rheumatology criteria for FMS diagnosis and a pain-pressure threshold （PPT）〈 4 kg/cm2. The study was conducted in a teaching tertiary-care medical institution from May 2010 through April 2012. AC, EAC and MX were delivered for 30 min, once a week, for 8 weeks, bilaterally at Neiguan （PC6）, Hegu （LI4）, Yanglingquan （GB34）, Sanyinjiao （SP6） and Taichong （LR3） acupoints. MAIN OUTCOME MEASURES： Each week, immediately before treatment and after treatment, subjects were tested for PPTs, Wong-Baker Faces Pain Scale （WBFPS; for pain intensity） and Medical Outcomes Study 36-item Short Form Health Survey （SF-36： for QoL）. RESULTS： There was no significant improvement in pain or reduction of tender points in any of the groups studied, at the end of the 8th session. Significant improvement of QoL was perceived in vitality （after AC treatment） and in mental health （after EAC and MX treatments）. CONCLUSION： TCM therapies （AC, EAC and MX） promoted an improvement in the QoL in two areas （vitality and mental health） in FMS women. Further large-scale clinical trials are required to confirm this effect.

关键词： quality of life medicine, Chinese traditional acupuncture therapy women

Impact of sports participation on cardiovascular health markers of children and adolescents: Systematic review and meta-analysis

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World Journal of Clinical Pediatrics 2022年第4期11卷 375-384页

作者： Wesley torres Santiago Maillane-Vanegas Jacqueline Bexiga Urban Romulo araujo Fernandes department of Physical Education Sao Paulo State University-UNESPPresidente Prudente 19060900Sao PauloBrazil

BACKGROUND Cardiovascular diseases have a high prevalence in adults and their development begins in the first decades of *** the other hand,sports participation in childhood and adolescence provides benefits which can delay the onset of these *** To synthesize the available literature on the impact of sports participation on cardiovascular outcomes in children and *** This systematic review was conducted on studies of children and adolescents(aged 8-18 years)who regularly practiced a sport and had reported cardiovascular outcomes(blood pressure and intima-media thickness)*** Medline/PubMed,SciELO,Reference Citation Analysis(https://*** ***/)and Bireme databases were *** In total,3314 publications for blood pressure and 122 publications for intimamedia thickness were identified in the *** exclusions(e.g.,duplicate articles,animal studies and those that did not meet the inclusion criteria),four publications for blood pressure(449 adolescents)and two publications for intimamedia thickness were included(402 adolescents).For blood pressure,all publications were longitudinal in design(follow-up ranging from 12 wk to 12 mo)and involved adolescents aged from 8 years to 18 years of *** intima-media thickness,both publications were longitudinal in design and involved adolescents aged from 11 years to 18 years of *** Sports participation seems to promote benefits to cardiovascular structure and function in ***,studies with adolescents are scarce and further research is needed to understand this phenomenon.

关键词： Pediatrics Adolescents Sports Blood pressure Intima-media thickness

Preprocessing of 2-Dimensional Gel Electrophoresis Images Applied to Proteomic Analysis： A Review

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Genomics, Proteomics & Bioinformatics 2018年第1期16卷 63-72页

作者： Manuel Mauricio Goez maria Constanza torres-Madronero Sarah Rothlisberger Edilson delgado-Trejos Automatics Electronics and Computer Science Research Group Faculty of Engineering Instituto Tecnologico Metropolitano Medellin 050012 Colombia Biomedical Innovation and Research Group Faculty of Applied and Exact Sciences lnstituto Tecnologico Metropolitano Medellin 050012 Colombia Quality Metrology and Production Research Group Faculty of Economic and Management Sciences Instituto Tecnologico Metropolitano Medellin 050012 Colombia

Various methods and specialized software programs are available for processing two- dimensional gel electrophoresis （2-DGE） images. However, due to the anomalies present in these images, a reliable, automated, and highly reproducible system for 2-DGE image analysis has still not been achieved. The most common anomalies found in 2-DGE images include vertical and hor- izontal streaking, fuzzy spots, and background noise, which greatly complicate computational anal- ysis. In this paper, we review the preprocessing techniques applied to 2-DGE images for noise reduction, intensity normalization, and background correction. We also present a quantitative comparison of non-linear filtering techniques applied to synthetic gel images, through analyzing the performance of the filters under specific conditions. Synthetic proteins were modeled into a two-dimensional Gaussian distribution with adjustable parameters for changing the size, intensity, and degradation. Three types of noise were added to the images： Gaussian, Rayleigh, and exponen- tial, with signal-to-noise ratios （SNRs） ranging 8-20 decibels （dB）. We compared the performanceof wavelet, contourlet, total variation （TV）, and wavelet-total variation （WTTV） techniques using parameters SNR and spot efficiency. In terms of spot efficiency, contourlet and TV were more sen- sitive to noise than wavelet and WTTV. Wavelet worked the best for images with SNR ranging 10- 20 dB, whereas WTTV performed better with high noise levels. Wavelet also presented the best per- formance with any level of Gaussian noise and low levels （20-14 dB） of Rayleigh and exponential noise in terms of SNR. Finally, the performance of the non-linear filtering techniques was evaluated using a real 2-DGE image with previously identified proteins marked. Wavelet achieved the best detection rate for the real image.

关键词： Background correction Filtering Noise reduction Preprocessing 2D gel electrophoresis

An overview of plant-autochthonous microorganisms and fermented vegetable foods

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Food Science and Human Wellness 2020年第2期9卷 112-123页

作者： Sebastian torres Hernan Veron Luciana Contreras maria I.Isla Instituto de Bioprospeccion y Fisiologia Vegetal(INBIOFIV)–CONICET TucumanArgentina Facultad de Ciencias Naturales e IML Universidad Nacional de TucumanTucumanArgentina

Fermented plant-based foods and beverages constitute foods of high nutritional and functional value with appreciated health beneficial *** represent a natural and sustainable alternative to counteract the large wastage of vegetables and fruits due to their short shelf ***,the use of controlled fermentation process using autochthonous microorganisms adapted to their vegetable matrix is preferred instead of traditionally spontaneous fermentation to designing fermented vegetable foods with the desirable sensory,technological,nutritional and functional *** review summarizes the autochthonous microorganisms selected as starters for the successful fermentation of vegetables and *** main beneficial properties of autochthonous starters and fermented vegetable products with a focus on human health are revised.

关键词： Plant-autochthonous Microorganisms Fermented vegetable foods Functional foods Lactic acid bacteria Probiotics Probiotic

Plasma Lysophosphatidylcholine and Phospholipase A2 Activity in Chagas Disease Patients: A Comparative Analysis

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Advances in Bioscience and Biotechnology 2024年第8期15卷 462-473页

作者： maria Fernanda Carvalho de araujo Bruna maria Ferreira Iaciura Fillipe araujo de Sá Georgia Correa Atella Laboratrio de Bioqumica de Lipdios e Lipoprotenas Instituto de Bioqumica Mdica Leopoldo de Meis Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Instituto Nacional de Cincia e Tecnologia em Entomologia Molecular (INCT-EM) Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Laboratrio de Sinalizao Celular Instituto de Bioqumica Mdica Leopoldo de Meis Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil

Chagas disease (CD) affects 21 countries in the Americas and is caused by the parasite Trypanosoma cruzi. A key molecule involved in CD is lysophosphatidylcholine (LPC), which has been studied in various contexts: in the saliva of insect vectors, during the establishment of infection in the vertebrate host, and for the parasite itself. This lipid can be produced by the action of phospholipases A2 (PLA2), enzymes that catalyze the hydrolysis of phospholipids releasing fatty acids and lysophospholipids, such as LPC. This study investigates LPC levels and PLA2 activities in the plasma of CD patients and compares these levels with those in healthy individuals and patients with idiopathic dilated cardiomyopathy (IDCM). Plasma from 64 CD patients, 54 healthy individuals, and 16 IDCM patients were analyzed. LPC levels and the activity of two types of phospholipase A2: secreted (sPLA2) and lipoprotein-associated (Lp-PLA2) were measured. LPC levels and sPLA2 activity were similar between CD patients and the control groups. However, there were notable differences in LPC levels and sPLA2 activity between subgroups of CD patients and IDCM patients. This study is the first to identify LPC in patients with CD across various stages of the disease. It also offers new insights into the biochemical changes observed in the plasma of patients with IDCM.

关键词： Lysophosphatidylcholine Phospholipase A2 Plasma Chagas Disease Idiopathic Dilated Cardiomyopathy

Fast preparation route to high-performances textured Sr-doped Ca_3Co_4O_9 thermoelectric materials through precursor powder modification

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Science China Materials 2019年第3期62卷 399-406页

作者： Miguel Angel torres Gustavo Garcia Idoia Urrutibeascoa maria Antonieta Madre Juan Carlos Diez Andres Sotelo ICMA (CSIC-Universidad de Zaragoza) Centro Stirling S. Coop. Mondragon Unibertsitatea

This work presents a short and very efficient method to produce high performance textured Ca_3Co_4O_9 thermoelectric materials through initial powders modification. Microstructure has shown good grain orientation, and low porosity while slightly lower grain sizes were obtained in samples prepared from attrition milled powders. All samples show the high density of around 96% of the theoretical *** similar characteristics are reflected in, approximately,the same electrical resistivity and Seebeck coefficient values for both types of samples. However, in spite of similar power factor(PF) at low temperatures, it is slightly higher at high temperature for the attrition milled samples. On the other hand, the processing time reduction(from 38 to 2 h) when using attrition milled precursors, leads to lower mechanical properties in these samples. All these data clearly point out to the similar characteristics of both kinds of samples, with a drastic processing time decrease when using attrition milled precursors, which is of the main economic importance when considering their industrial production.

关键词： ceramics oxides hot-pressing electrical properties power factor

Bioaccessibility of phenolic compounds from Brazilian grape juices using a digestion model with intestinal barrier passage

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Food Bioscience 2023年第2期52卷 1343-1351页

作者： maria da Conceicao Prudencio Dutra Ana Beatriz Martins da Silva Ederlan de Souza Ferreira Ana Julia de Brito araujo Carvalho Marcos dos Santos Lima Aline Camarao Telles Biasoto Graduate Program in Food Science Faculty of PharmacyFederal University of BahiaSalvadorBahiaBrazil Federal Institute of Education Science and Technology of Sertao PernambucanoLiquid Chromatography LaboratoryCampus IndustrialPetrolinaPernambucoBrazil Brazilian Agricultural Research Corporation Embrapa Semi-arid RegionPetrolinaPernambucoBrazil Brazilian Agricultural Research Corporation Embrapa EnvironmentJaguariunaSao PauloBrazil

Grape juices are rich in bioactive compounds;however,for these compounds to exert their functionality,they must be ***,the present study evaluated a simulated digestion process on the main bioactive compounds of monovarietal grape juices of five Brazilian hybrid cultivars(*** x ***).Characterization of the chemical profiles in liquid chromatography(HPLC-DAD-RID),behaviour of phenolics in the stages of digestion and bioaccessibility through the INFOGEST protocol plus intestinal barrier passage were carried *** the 24 polyphenols identified in the grape juice samples,11 were bioaccessible,with emphasis on the class of *** B2(101-426%),(+)-catechin(169-370%)and gallic acid(61-230%)stood out in all juices,showing that these compounds are key to the functionality of these *** were observed to differ between juices,demonstrating that factors such as the cultivar should be explored more extensively in studies on functional *** study also suggests that quality components such as sugars and organic acids influence the bioaccessibility of beverages.

关键词： Grape cultivars Functional beverages Phytochemicals Digestion simulation Bioactivity