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Interaction of Diet/Lifestyle Intervention and TcF7L2 Genotype on Glycemic control and Adiposity among Overweight or Obese Adults:Big Data from Seven Randomized controlled Trials Worldwide

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Health Data Science 2021年第1期2021卷 174-183页

作者： Tao Huang Zhenhuang Zhuang Yoriko Heianza Dianjianyi Sun Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio Ros liana c.del gobbo Jordi Salas-Salvadó Miguel A.Martínez-González Jan Polak Markku Laakso Arne Astrup Dominique Langin Jorg Hager Gabby Hul Torben Hansen Oluf Pedersen Jean-Michel Oppert Wim H.M.Saris Peter Arner Montserrat cofán Sujatha Rajaram Jaakko Tuomilehto Jaana Lindström Vanessa D.de Mello Alena Stancacova Matti Uusitupa Mathilde Svendstrup Thorkild I.A.Sørensen christopher D.Gardner Joan Sabaté Dolores corella J.Alfredo Martinez Lu Qi Department of Epidemiology&Biostatistics School of Public HealthPeking UniversityChina Department of Global Health School of Public HealthPeking UniversityChina Key Laboratory of Molecular cardiovascular Sciences Ministry of Education China Global Health Institute Peking University China Department of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLAUSA Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMAUSA Department of Endocrinology&Nutrition Institut d’Investigacions Biomèdiques August Pi SunyerHospital ClínicBarcelonaSpain cIBER Fisiopatologia de la Obesidad y Nutrición(cIBERobn) Instituto de Salud Carlos III(ISCIII)MadridSpain Stanford Prevention Research center Stanford UniversityStanford CAUSA Human Nutrition Unit Faculty of Medicine and Health SciencesPere Virgili Health Research InstituteRovira i Virgili UniversityReusSpain University of Navarra Department of Preventive Medicine and Public HealthMedical School&IDISNAPamplonaSpain Department for the Study of Obesity and Diabetes Third Faculty of MedicineCharles UniversityPragueCzech Republic Department of Medicine University of Eastern FinlandKuopioFinland University of copenhagen Department of NutritionExercise and SportsFaculty of ScienceCopenhagenDenmark Institut National de la Santéet de la Recherche Médicale(Inserm) UMR1048Institute of Metabolic and Cardiovascular DiseasesUniversity of Toulouse and Paul Sabatier UniversityToulouseFrance NestléInstitute of Health Sciences LausanneSwitzerland Department of Human Biology NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical Centre+MaastrichtNetherlands Section of Metabolic Genetics Novo Nordisk Foundation Center for Basic Metabolic ResearchFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Sorbonne Université Institute of Cardiometabolism and Nutrition(ICAN)Department of NutritionPitié-Salpêtrière HospitalAssistance Publique-

*** strongest locus which associated with type 2 diabetes(T2D)by the common variant rs7903146 is the transcription factor 7-like 2 gene(TcF7L2).We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TcF7L2 rs7903146 on glycemic traits,body weight,or waist circumference in overweight or obese adults in several randomized controlled trials(RcTs).*** October 2016 to May 2018,a large collaborative analysis was performed by pooling individualparticipant data from 7 *** RcTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese *** treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all *** the joint analysis,a total of 7 eligible RcTs were included(n=4,114).Importantly,we observed a significant effect modification of diet/lifestyle-related interventions on the TcF7L2 variant rs7903146 and changes in fasting *** with the control group,diet/lifestyle interventions were related to lower fasting glucose by-3.06(95%cI,-5.77 to-0.36)mg/dL(test for heterogeneity and overall effect:I^(2)=45:1%,pcopy of the TcF7L2 T risk ***,regardless of genetic risk,diet/lifestyle interventions were associated with lower waist ***,there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TcF7L2 risk *** findings suggest that carrying the TcF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults.

关键词： TcF7L2 weight finding

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Seismic Performance Assessment of a conventional Multi-storey Building

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International Journal of Disaster Risk Science 2017年第3期8卷 237-245页

作者： Giuseppe Marcantonio del gobbo Martin S.Williams Anthony Blakeborough Department of Engineering Science University of OxfordOxford OX1 3PJUK

Recent earthquakes have revealed that conventional seismic design philosophy allows for large levels of nonstructural damage. Nonstructural earthquake damage results in extensive repair costs and lengthy functional disruptions, as nonstructural systems comprise the majority of building investment and are essential to building operations. A better understanding of the expected overall seismic performance of code-compliant buildings is needed. This study investigates the seismic performance of a conventional building. A 16-storey steel office building was designed using a modern seismic structural code(Eurocode 8). This study is the first to assess in detail the substantial earthquake repair costs expected in a modern Eurocode concentric braced frame structure, considering nonstructural systems with the FEMA P-58 procedure. The breakdown of total repair costs by engineering demand parameter and by fragility group is novel. The seismic performance assessment indicated that substantial earthquake repair costs are expected. Limitations of the Eurocode nonstructural damage methodology were revealed in a novel manner using FEMA P-58, as the prescribed drift limits did not minimize nonstructural repair costs. These findings demonstrate the need for design procedures that improve nonstructural seismic performance. The study results provide a benchmark on which to evaluate retrofit alternatives for existing buildings and design options for new structures.

关键词： Eurocode 8 FEMA P-58 Nonstructural systems Seismic performance assessment

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Helicobacter pylori-negative Russell body gastritis:case report

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World Journal of Gastroenterology 2011年第9期17卷 1234-1236页

作者： Alessandro del gobbo Luca Elli Paola Braidotti Franca Di Nuovo Silvano Bosari Solange Romagnoli Department of Medicine Surgery and DentistryDivision of PathologyA.O.San Paolo and Fondazione IRCCS Cà-Granda Ospedale Maggiore PoliclinicoUniversity of Milan Medical School center for Prevention and Diagnosis of celiac Disease Fondazione IRCCS Cà-Granda Ospedale Maggiore PoliclinicoUniversity of Milan Pathology Unit A.O.G.Salvini20024 Garbagnate MilaneseItaly

Russell body gastritis is an unusual form of chronic gastritis characterized by the permeation of lamina propria by numerous plasma cells with eosinophilic cytoplasmic *** few cases have been reported in the literature;the majority of which have shown Helicobacter Pylori(***)infection,thus suggesting a correlation between plasma cell presence and antigenic stimulation by *** present a case of Russell body gastritis in a 78-year-old woman who was undergoing esophagogastroduodenoscopy for epigastric *** biopsy of the gastroesophageal junction showed the presence of cells with periodic acid-Schiff-positive hyaline pink *** staining for *** infection was nega-tive,as well as immunohistochemical *** cells with eosinophilic inclusions stained positive for cD138,cD79a,andκand lambda light chains,which confirmed plasma cell *** particular,κand lambda light chains showed a polyclonal origin and the patient was negative for immunological *** histological observations were confirmed by ultrastructural *** cases reported in the literature associated with *** infection have shown regression of plasma cells after eradication of *** is known about the progression of ***-negative *** unusual morphological appearance of this type of chronic gastritis should not be misinterpreted during routine examination,and it should be distinguished from other common forms of chronic *** is mandatory to exclude neoplastic diseases such as gastric carcinoma, lymphoma and plasmocytoma by immunohistochemistry and electron microscopy,which can help with differential *** long-term effects of plasma cells hyperactivation are still unknown,because cases of gastric tumor that originated in patients affected by Russell body gastritis have not been described in the *** are of the opinion that these patients should be scheduled for endoscopic surveillance.

关键词： Russell body Gastritis Helicobacter Pylori Plasma cells crystalline inclusions

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累及睾丸及相关结构的Rosai-Dorfman病：2例并文献复习

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临床与实验病理学杂志 2014年第6期30卷 702-702页

作者： del gobbo A Moltrasio F Young R H 康锶鹏余英豪不详解放军第180医院病理科泉州362000 南京军区福州总医院病理科福州350025

Rosai-Doffman病（RDD）又名为窦组织细胞增生伴巨大淋巴结病（SHML），通常表现为巨大的、累及双侧的无痛性淋巴结肿大，约25％病例累及结外，而累及男性泌尿生殖道的极为罕见。作者报道2例RDD累及睾丸，同时复习其他睾丸及相关结构RD... 详细信息

Rosai-Doffman病（RDD）又名为窦组织细胞增生伴巨大淋巴结病（SHML），通常表现为巨大的、累及双侧的无痛性淋巴结肿大，约25％病例累及结外，而累及男性泌尿生殖道的极为罕见。作者报道2例RDD累及睾丸，同时复习其他睾丸及相关结构RDD病例（包括文献报道的4例及记录在SHML登记处的7例）的临床病理特点。13例中5例同时累及双侧睾丸，8例还累及淋巴结、肾、皮肤和肾上腺等其他部位。多数病例发生于中年人，1例发生于儿童。

关键词： Rosai-Dorfman病双侧睾丸文献复习结构巨大淋巴结病窦组织细胞增生男性泌尿生殖道临床病理特点

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Renal function after laparoscopic cholecystectomy and analgesia with tramadol and dipyrone or ketorolac

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Health 2013年第11期5卷 35-41页

作者： Tiago Pechutti Medeiros Pedro Thadeu Galvao Vianna Leopoldo Muniz da Silva Lidia Raquel de carvalho Gilberto Elias Wady Leandro gobbo Braz Yara Marcondes Machado castiglia Graduate Program in Anesthesiology Botucatu Medical SchoolUNESP-Universidade Estadual PaulistaBotucatuBrazil Department of Anesthesiology Botucatu Medical SchoolUNESP-Universidade Estadual PaulistaBotucatuBrazil Sao Luiz Hospital Sao PauloBrazil Department of Biostatics Institute of BiosciencesUNESP-Universidade Estadual PaulistaBotucatuBrazil Mercy Hospital Sao CarlosBrazil

Background: Laparoscopic cholecystectomy (Lc) reduces surgical trauma and hospital stay, but requires effective and safe postoperative analgesia. This prospective and double-blind study investigated the effects of analgesia with tramadol combined with either dipyrone or ketorolac on the postoperative renal function of patients submitted to Lc. Methods: Pre-and post-operatively (PO), estimated glomerular filtration rates (GFR), obtained by two formulas dependent on blood cr and one on blood cystatin c values, and tubular enzymuria—alkaline phosphatase (AP), γ-glutamiltransferase (γ-GT)— were determined in well hydrated patients who underwent Lc and analgesia with tramadol combined with either dipyrone (Dipyrone, n = 63) or ketorolac (Ketorolac, n = 63). Upon discharge from the post-anesthetic care unit (PAcU), pain (through Verbal Numerical Scale—VNS) and need for rescue analgesia with morphine were evaluated. Results: There was hemodilution PO, which made GFR profile analysis more difficult—those dependent on cr increased and statistically correlated, but those dependent on cystatin c did not change. There was a significant PO increase in AP in the Dipyrone and Ketorolac groups, and in the product of the both enzymes in the Ketorolac group. Upon PAcU discharge, the Dipyrone group showed signifi cantly higher VNS scores than the Ketorolac group. All patients received morphine PO, and the total dose needed for pain control differed between groups, but without statistical significance. conclusions: The association of tramadol with dipyrone or ketorolac in well hydrated patients submitted to Lc had similar analgesic effectiveness in the PAcU. Postoperatively, the effect on GFR may have been masked by hemodilution, and enzymuria was discreetly enhanced when ketorolac was used.

关键词： Kidney Function Tests Pneumoperitoneum Biological Markers cystatin c Ketorolac Analgesia

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神经生长因子增强小胶质细胞的神经保护作用

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神经损伤与功能重建 2018年第2期13卷 F0003-F0003页

作者：唐颖馨 Rizzi c Tiberi A Giustizieri M Marrone Mc gobbo F carucci NM Meli G Arisi I D'Onofrio M Marinelli S capsoni S cattaneo A BioSNS Laboratory Scuola Normale Superiore European Brain Research Institute-Fondazione Rita Levi Montalcini Section of Human Physiology Department of Biomedical and Specialty Surgical Sciences University of Ferrara

小胶质细胞是脑组织内的防御细胞,但在病理和生理条件下,调控小胶质细胞活化的因子并不十分清楚。本研究发现,神经生长因子(NGF)可以增强小胶质细胞的神经保护和抗炎功能。在体内和体外研究中都发现,小胶质细胞表达NGF受体。原代培养小... 详细信息

小胶质细胞是脑组织内的防御细胞,但在病理和生理条件下,调控小胶质细胞活化的因子并不十分清楚。本研究发现,神经生长因子(NGF)可以增强小胶质细胞的神经保护和抗炎功能。在体内和体外研究中都发现,小胶质细胞表达NGF受体。原代培养小胶质细胞,给予NGF处理,转录本分析结果显示,NGF对小胶质细胞的运动、吞噬和降解吞噬物的能力均产生影响。对功能的研究显示,NGF可增加小胶质细胞的膜运动能力和胞饮作用;在体研究显示,NGF可激活小胶质细胞释放向外整流电流,调节周围谷氨酸能神经元的神经传递。既往研究提示,小胶质细胞有清除脑内Aβ肽的功能,本研究观察了NGF对小胶质细胞吞噬能力的影响。结果显示,NGF可促进小胶质细胞通过Trk A途径清除Aβ,并加速其降解。此外,NGF还可减轻由Aβ导致的炎症激活。特异性激活小胶质细胞还可以减轻由Aβ导致的神经元树突损伤和长时程增强抑制。在对离体脑片的研究中,我们也发现NGF可以促进小胶质细胞吞噬Aβ。综上所述,本研究证实NGF可以促进小胶质细胞活化,活化的小胶质细胞通过抗炎作用减轻Aβ聚集,发挥神经保护作用。

关键词：淀粉胞饮小胶质细胞神经生长因子神经免疫通讯神经炎症神经保护神经营养因子

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Measurement of the integrated luminosity of the Phase 2 data of the Belle Ⅱ experiment

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chinese Physics c 2020年第2期44卷 1-12页

作者： F.Abudinén I.Adachi P.Ahlburg H.Aihara N.Akopov A.Aloisio F.Ameli L.Andricek N.Anh Ky D.M.Asner H.Atmacan T.Aushev V.Aushev T.Aziz K.Azmi V.Babu S.Baehr S.Bahinipati A.M.Bakich P.Bambade Sw.Banerjee S.Bansal V.Bansal M.Barrett J.Baudot A.Beaulieu J.Becker P.K.Behera J.V.Bennett E.Bernieri F.U.Bernlochner M.Bertemes M.Bessner S.Bettarini V.Bhardwaj F.Bianchi T.Bilka S.Bilokin D.Biswas G.Bonvicini A.Bozek M.Bračko P.Branchini N.Braun T.E.Browder A.Budano S.Bussino M.campajola L.cao G.casarosa c.cecchi D.Červenkov M.-c.chang P.chang R.cheaib V.chekelian Y.Q.chen Y.-T.chen B.G.cheon K.chilikin H.-E.cho K.cho S.cho S.-K.choi S.choudhury D.cinabro L.corona L.M.cremaldi S.cunliffe T.czank F.Dattola E.De La cruz-Burelo G.De Nardo M.De Nuccio G.De Pietro R.de Sangro M.Destefanis S.Dey A.De Yta-Hernandez F.Di capua S.Di carlo J.Dingfelder Z.Doležal I.Domínguez Jiménez T.V.Dong K.Dort S.Dubey S.Duell S.Eidelman M.Eliachevitch T.Ferber D.Ferlewicz G.Finocchiaro S.Fiore A.Fodor F.Forti A.Frey B.G.Fulsom M.Gabriel E.Ganiev M.Garcia-Hernandez R.Garg A.Garmash V.Gaur A.Gaz U.Gebauer A.Gellrich J.Gemmler T.Geßler R.Giordano A.Giri B.gobbo R.Godang P.Goldenzweig B.Golob P.Gomis P.Grace W.Gradl E.Graziani D.Greenwald c.Hadjivasiliou S.Halder K.Hara T.Hara O.Hartbrich K.Hayasaka H.Hayashii c.Hearty M.T.Hedges I.Heredia de la cruz M.Hernández Villanueva A.Hershenhorn T.Higuchi E.c.Hill H.Hirata M.Hoek S.Hollitt T.Hotta c.-L.Hsu Y.Hu K.Huang T.Iijima K.Inami G.Inguglia J.Irakkathil Jabbar A.Ishikawa R.Itoh M.Iwasaki Y.Iwasaki S.Iwata P.Jackson W.W.Jacobs D.E.Jaffe E.-J.Jang H.B.Jeon S.Jia Y.Jin c.Joo J.Kahn H.Kakuno A.B.Kaliyar G.Karyan Y.Kato T.Kawasaki H.Kichimi c.Kiesling B.H.Kim c.-H.Kim D.Y.Kim S.-H.Kim Y.K.Kim Y.Kim T.D.Kimmel K.Kinoshita c.Kleinwort B.Knysh P.Kodyš T.Koga I.Komarov T.Konno S.Korpar D.Kotchetkov N.Kovalchuk T.M.G.Kraetzschmar P.Križan R.Kroeger J.F.Krohn P.Krokovny W.Kuehn T.Kuhr M.Kumar R.Kumar K.Kumara S.Kurz A.Kuzmin Y.-J.Kwon S.Lacaprara Y.-T.Lai c.La Licata K.Lalwani L.Lanceri J.S.Lange K.Lautenbach I.-S.Le Beihang University Beijing 100191 Brookhaven National Laboratory UptonNew York 11973 Budker Institute of Nuclear Physics SB RAS Novosibirsk 630090 centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional Mexico City 07360 Faculty of Mathematics and Physics Charles University12116 Prague chiba University Chiba 263-8522 consejo Nacional de ciencia y Tecnología Mexico City 03940 Deutsches Elektronen–Synchrotron 22607 Hamburg Duke University DurhamNorth Carolina 27708 Earthquake Research Institute University of TokyoTokyo 113-0032 Forschungszentrum Jülich 52425 Jülich Department of Physics Fu Jen Catholic UniversityTaipei 24205 Key Laboratory of Nuclear Physics and Ion-beam Application(MOE)and Institute of Modern Physics Fudan UniversityShanghai 200443 II.Physikalisches Institut Georg-August-Universität Göttingen37073 Göttingen Gifu University Gifu 501-1193 The Graduate University for Advanced Studies(SOKENDAI) Hayama 240-0193 Gyeongsang National University Jinju 52828 Department of Physics and Institute of Natural Sciences Hanyang UniversitySeoul 04763 High Energy Accelerator Research Organization(KEK) Tsukuba 305-0801 J-PARc Branch KEK Theory CenterHigh Energy Accelerator Research Organization(KEK)Tsukuba 305-0801 Indian Institute of Science Education and Research Mohali SAS Nagar140306 Indian Institute of Technology Bhubaneswar Satya Nagar 751007 Indian Institute of Technology Hyderabad Telangana 502285 Indian Institute of Technology Madras Chennai 600036 Indiana University BloomingtonIndiana 47408 Institute for High Energy Physics Protvino 142281 Institute of High Energy Physics Vienna 1050 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049 Institute of Particle Physics(canada) VictoriaBritish Columbia V8W 2Y2 Institute of Physics Hanoi Instituto de Fisica corpuscular Paterna 46980 INFN Laboratori Nazionali di Frascati I-00044 Frascati INFN Sezione di Napoli I-80126 Napoli INFN Sezione di Padova I-35131 Padova INFN Sezione di Perugia I-06123 Perugia

From April to July 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron *** is the first data sample of the Belle Ⅱ *** Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is *** work provides a basis for future luminosity measurements at Belle Ⅱ.

关键词： luminosity Bhabha digamma Belle II

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